Macrophage plasticity and polarization: in vivo veritas.

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Published in J Clin Invest on March 01, 2012

Authors

Antonio Sica1, Alberto Mantovani

Author Affiliations

1: Istituto Clinico Humanitas IRCCS, Rozzano, Italy. antonio.sica@humanitasresearch.it

Associated clinical trials:

Evaluation of M1 and M2 Macrophages in Endometriotic Tissue of Women Affected by Endometriosis at Different Stages. | NCT03136978

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Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin. J Exp Med (2005) 1.54

Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family. Cancer Res (2007) 1.54

Tumor-associated macrophages: functional diversity, clinical significance, and open questions. Semin Immunopathol (2013) 1.54

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation. Eur J Immunol (2002) 1.52

Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6. J Immunol (2003) 1.52

Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice. Proc Natl Acad Sci U S A (2002) 1.50

Macrophage plasticity and polarization in liver homeostasis and pathology. Hepatology (2014) 1.48

Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice. J Clin Invest (2004) 1.47

Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood (2003) 1.45

Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis. J Immunol (2007) 1.44

Analysis of the gene expression profile activated by the CC chemokine ligand 5/RANTES and by lipopolysaccharide in human monocytes. J Immunol (2002) 1.42

Inflammation-mediated promotion of invasion and metastasis. Cancer Metastasis Rev (2010) 1.41

Chemokines in cancer related inflammation. Exp Cell Res (2010) 1.40

beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. J Biol Chem (2004) 1.39

Antiviral activity of the long chain pentraxin PTX3 against influenza viruses. J Immunol (2008) 1.39

Increased inflammation in mice deficient for the chemokine decoy receptor D6. Eur J Immunol (2005) 1.37

Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion. Cancer Res (2005) 1.37

The lymphatic system controls intestinal inflammation and inflammation-associated Colon Cancer through the chemokine decoy receptor D6. Gut (2009) 1.36

Anti-Aspergillus fumigatus efficacy of pentraxin 3 alone and in combination with antifungals. Antimicrob Agents Chemother (2004) 1.36

Occurrence of tertiary lymphoid tissue is associated with T-cell infiltration and predicts better prognosis in early-stage colorectal cancers. Clin Cancer Res (2014) 1.36

Macrophage receptors implicated in the "adaptive" form of innate immunity. Microbes Infect (2007) 1.35

Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis. Cytokine Growth Factor Rev (2010) 1.35

Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection. J Immunol (2008) 1.33

Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization. J Biol Chem (2008) 1.33

Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation. Biochemistry (2006) 1.32

The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma. Cancer Res (2008) 1.30

TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization. Trends Immunol (2009) 1.30

Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. Proc Natl Acad Sci U S A (2007) 1.29

Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem (2009) 1.29