Published in PLoS One on May 04, 2011
Golden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathways. PLoS One (2013) 0.92
Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity. PLoS One (2012) 0.86
Blocking protein kinase C signaling pathway: mechanistic insights into the anti-leishmanial activity of prospective herbal drugs from Withania somnifera. BMC Genomics (2012) 0.79
Aminomethylphosphonic acid and methoxyacetic acid induce apoptosis in prostate cancer cells. Int J Mol Sci (2015) 0.78
Methoxyacetic acid suppresses prostate cancer cell growth by inducing growth arrest and apoptosis. Am J Clin Exp Urol (2014) 0.77
Biological effects of soft denture reline materials on L929 cells in vitro. J Tissue Eng (2014) 0.76
Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation. PLoS One (2015) 0.76
Withania somnifera root extract extends lifespan of Caenorhabditis elegans. Ann Neurosci (2013) 0.75
Effects of soft denture liners on L929 fibroblasts, HaCaT keratinocytes, and RAW 264.7 macrophages. Biomed Res Int (2014) 0.75
Ashwagandha (Withania somnifera) supercritical CO2 extract derived withanolides mitigates Bisphenol A induced mitochondrial toxicity in HepG2 cells. Toxicol Rep (2014) 0.75
Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells. Mol Neurobiol (2016) 0.75
Characterization of phthalate exposure among pregnant women assessed by repeat air and urine samples. Environ Health Perspect (2008) 2.75
Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect (2006) 2.73
Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations. Environ Health Perspect (2008) 1.61
Toxicity of methoxyacetic acid in rats. Fundam Appl Toxicol (1983) 1.49
Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling. PLoS One (2010) 1.40
Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect. Clin Cancer Res (2007) 1.32
Chemopreventive promise of targeting the Nrf2 pathway. Drug News Perspect (2007) 1.13
Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses. Cancer Lett (2008) 1.12
Lactational exposure to phthalates in Southern Italy. Environ Int (2008) 0.95
The teratogenicity of methoxyacetic acid in the rat. Toxicol Lett (1984) 0.93
Interactions of methoxyacetic acid with androgen receptor. Toxicol Appl Pharmacol (2008) 0.93
The short-chain fatty acid methoxyacetic acid disrupts endogenous estrogen receptor-alpha-mediated signaling. Environ Health Perspect (2009) 0.92
Toxicant-induced leakage of germ cell-specific proteins from seminiferous tubules in the rat: relationship to blood-testis barrier integrity and prospects for biomonitoring. Toxicol Sci (2010) 0.90
Protein kinase activity is central to rat germ cell apoptosis induced by methoxyacetic acid. Toxicol Pathol (2002) 0.88
Ovarian luteal cell toxicity of ethylene glycol monomethyl ether and methoxy acetic acid in vivo and in vitro. Toxicol Appl Pharmacol (1997) 0.87
N-acetylcysteine prevents MAA induced male germ cell apoptosis: role of glutathione and cytochrome c. FEBS Lett (2002) 0.87
The mechanism of ethylene glycol ether reproductive and developmental toxicity and evidence for adverse effects in humans. Toxicol Lett (2005) 0.87
Deceleration of senescence in normal human fibroblasts by withanone extracted from ashwagandha leaves. J Gerontol A Biol Sci Med Sci (2009) 0.86
Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds. Toxicol Sci (2009) 0.85
Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression. Int J Androl (2007) 0.84
Impact of methoxyacetic acid on mouse Leydig cell gene expression. Reprod Biol Endocrinol (2010) 0.82
Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesis. Reprod Toxicol (2006) 0.81
Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites. Toxicol Appl Pharmacol (2010) 0.81
Methoxyacetic acid and ethoxyacetic acid inhibit mitochondrial function in vitro. J Biochem Toxicol (1986) 0.79
Involvement of caspase 3 mediated apoptosis in hematopoietic cytotoxicity of metabolites of ethylene glycol monomethyl ether. Ind Health (2002) 0.79
The laminin binding protein p40 is involved in inducing limb abnormality of mouse fetuses as the effects of methoxyacetic acid treatment. Toxicol Sci (2003) 0.78
A teratoproteomics analysis: heat shock protein 70 is upregulated in mouse forelimb bud by methoxyacetic acid treatment. Birth Defects Res A Clin Mol Teratol (2005) 0.77
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell (2009) 6.88
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells (2003) 4.47
Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat Cell Biol (2009) 3.05
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle (2009) 2.31
Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). Mol Cell Biol (2004) 2.25
Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med (2012) 1.90
Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes. Mol Cell Biol (2005) 1.66
Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. FEBS Lett (2002) 1.63
An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones (2002) 1.61
Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J Biol Chem (2007) 1.55
Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease. Brain Res (2004) 1.54
Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci U S A (2012) 1.53
Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. Int J Cancer (2006) 1.42
Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling. PLoS One (2010) 1.40
Three faces of mortalin: a housekeeper, guardian and killer. Exp Gerontol (2006) 1.39
On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60. Cell Stress Chaperones (2006) 1.33
Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides. J Biol Chem (2005) 1.33
Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect. Clin Cancer Res (2007) 1.32
Transient aggregation of ubiquitinated proteins is a cytosolic unfolded protein response to inflammation and endoplasmic reticulum stress. J Biol Chem (2012) 1.29
Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species. Free Radic Biol Med (2006) 1.29
Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein. Exp Cell Res (2002) 1.29
Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. Am J Physiol Gastrointest Liver Physiol (2008) 1.27
Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol (2011) 1.23
Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease. Mol Cell Proteomics (2006) 1.21
Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. Am J Physiol Gastrointest Liver Physiol (2009) 1.21
Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements. Arch Biochem Biophys (2008) 1.15
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev (2002) 1.15
Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C delta. Genes Dev (2004) 1.14
Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2. Free Radic Biol Med (2005) 1.13
Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Exp Cell Res (2003) 1.12
Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses. Cancer Lett (2008) 1.12
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems. Biochem Biophys Res Commun (2009) 1.11
Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia. Sheng Li Xue Bao (2007) 1.11
Rapid oxidation of dichlorodihydrofluorescin with heme and hemoproteins: formation of the fluorescein is independent of the generation of reactive oxygen species. FEBS Lett (2002) 1.07
Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. FEBS Lett (2006) 1.06
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60. Biochem J (2005) 1.06
Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts. Biochem Biophys Res Commun (2003) 1.05
Electrophysiologically distinct smooth muscle cell subtypes in rat conduit and resistance pulmonary arteries. J Physiol (2002) 1.04
Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin. Int J Cancer (2011) 1.03
Loss-of-function screening by randomized intracellular antibodies: identification of hnRNP-K as a potential target for metastasis. Proc Natl Acad Sci U S A (2007) 1.03
Targeting the redox sensitive Nrf2-Keap1 defense pathway in cardiovascular disease: protection afforded by dietary isoflavones. Curr Opin Pharmacol (2009) 1.03
Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis. J Biol Chem (2013) 1.03
Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: combinational approach for enhanced differentiation. Cancer Sci (2009) 1.02
Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells. PLoS One (2011) 1.00
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem (2002) 1.00
Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet. J Gastroenterol (2012) 1.00
MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic Acids Res (2011) 0.99
Modulation of antioxidant gene expression by 4-hydroxynonenal: atheroprotective role of the Nrf2/ARE transcription pathway. Redox Rep (2007) 0.98
Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. J Transl Med (2008) 0.98
Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and oxidative stress management functions. Ann N Y Acad Sci (2007) 0.97
Mortalin sensitizes human cancer cells to MKT-077-induced senescence. Cancer Lett (2007) 0.96
Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes. J Biol Chem (2004) 0.95
p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model. J Neurosci (2013) 0.95
Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts. Ann N Y Acad Sci (2006) 0.94
World of small RNAs: from ribozymes to siRNA and miRNA. Differentiation (2004) 0.94
Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells. J Gene Med (2004) 0.94
Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers. Am J Physiol Gastrointest Liver Physiol (2006) 0.94
Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal. FEBS J (2013) 0.94
Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates. Cell Res (2003) 0.93
Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. J Gastroenterol (2012) 0.93
Quantum dots in bio-imaging: Revolution by the small. Biochem Biophys Res Commun (2005) 0.93
Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan. Ann Neurol (2004) 0.92
Mortalin: present and prospective. Exp Gerontol (2002) 0.92
Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation. Biochem Biophys Res Commun (2003) 0.92
Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts. Free Radic Res (2008) 0.91
Vectors for RNA interference. Curr Opin Mol Ther (2004) 0.91
Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity. Biochem Biophys Res Commun (2011) 0.90
Tumor suppression by apoptotic and anti-angiogenic effects of mortalin-targeting adeno-oncolytic virus. J Gene Med (2010) 0.90
Dose and dose-rate effects of low-dose ionizing radiation on activation of Trp53 in immortalized murine cells. Radiat Res (2004) 0.90
Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation. J Biol Chem (2004) 0.90
Nanogel-quantum dot hybrid nanoparticles for live cell imaging. Biochem Biophys Res Commun (2005) 0.90
Limited capacity of the nuclear matrix to bind telomere repeat binding factor TRF1 may restrict the proliferation of mortal human fibroblasts. Hum Mol Genet (2003) 0.90
LIM kinase-2 targeting as a possible anti-metastasis therapy. J Gene Med (2004) 0.90