Published in Mol Cell on February 27, 2009
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p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways. J Biol Chem (2011) 1.82
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Characterization of macroautophagic flux in vivo using a leupeptin-based assay. Autophagy (2011) 1.20
Autophagy-related protein 8 (Atg8) family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway. J Biol Chem (2010) 1.20
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A landscape of driver mutations in melanoma. Cell (2012) 12.61
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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J (2007) 9.65
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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol (2010) 7.62
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Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab (2008) 5.55
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Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science (2011) 5.46
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol (2003) 5.43
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Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76
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Autophagy-deficient mice develop multiple liver tumors. Genes Dev (2011) 4.64
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Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles. Genes Cells (2003) 4.47
Autophagy is required to maintain muscle mass. Cell Metab (2009) 4.46
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab (2008) 4.33
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol (2009) 4.31
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SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature (2011) 4.14
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p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J Biol Chem (2010) 3.84
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Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol (2011) 2.64
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Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol (2009) 2.61
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FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport. J Cell Biol (2010) 2.57
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat Commun (2012) 2.55
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Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med (2012) 2.51