Published in Exp Gerontol on December 09, 2002
Roles of reactive oxygen species in the fate of stem cells. Antioxid Redox Signal (2012) 1.02
Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release. J Virol (2011) 0.97
A global transcriptional view of apoptosis in human T-cell activation. BMC Med Genomics (2008) 0.91
Proteomics in animal models of Alzheimer's and Parkinson's diseases. Ageing Res Rev (2008) 0.88
Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma. PLoS One (2011) 0.84
Proteomic analysis of regenerating mouse liver following 50% partial hepatectomy. Proteome Sci (2009) 0.84
Mortalin, apoptosis, and neurodegeneration. Biomolecules (2012) 0.82
Localization of mitochondrial DNA encoded cytochrome c oxidase subunits I and II in rat pancreatic zymogen granules and pituitary growth hormone granules. Histochem Cell Biol (2005) 0.81
Control of mitochondrial function and cell growth by the atypical cadherin Fat1. Nature (2016) 0.80
Kinetic and structural characterization of human mortalin. Protein Expr Purif (2010) 0.80
Proteomic profiling of differentially expressed proteins from Bax inhibitor-1 knockout and wild type mice. Mol Cells (2012) 0.79
Colocalisation of CD9 and mortalin in CD9-induced mitotic catastrophe in human prostate cancer cells. Br J Cancer (2007) 0.76
Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells. PLoS One (2017) 0.75
Cloning, characterization, and functional studies of a human 40-kDa catecholamine-regulated protein: implications in central nervous system disorders. Cell Stress Chaperones (2009) 0.75
Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq. G3 (Bethesda) (2015) 0.75
Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin. Sci Rep (2017) 0.75
Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells. Oncotarget (2017) 0.75
Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids. Sci Rep (2017) 0.75
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
Regulation of alternative splicing by histone modifications. Science (2010) 7.98
U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol (2002) 6.66
Retracted Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature (2004) 3.12
A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell (2004) 2.95
DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc Natl Acad Sci U S A (2004) 2.51
Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acids Res (2003) 2.31
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle (2009) 2.31
Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs. EMBO Rep (2003) 2.16
Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene (2004) 1.76
Retracted Identification of genes by hybrid ribozymes that couple cleavage activity with the unwinding activity of an endogenous RNA helicase. EMBO Rep (2002) 1.72
Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res (2005) 1.65
A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol (2005) 1.63
Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. FEBS Lett (2002) 1.63
An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones (2002) 1.61
Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J Biol Chem (2007) 1.55
Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J (2004) 1.54
Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J Biol Chem (2002) 1.50
The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA. Chem Rev (1998) 1.49
MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. J Biol Chem (2002) 1.44
Retracted Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells. Nature (2003) 1.44
p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts. Cancer Res (2006) 1.43
Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells. J Gene Med (2004) 1.43
Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. Int J Cancer (2006) 1.42
Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling. PLoS One (2010) 1.40
Three faces of mortalin: a housekeeper, guardian and killer. Exp Gerontol (2006) 1.39
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. J Immunol (2006) 1.35
MRG15 regulates embryonic development and cell proliferation. Mol Cell Biol (2005) 1.35
On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60. Cell Stress Chaperones (2006) 1.33
Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides. J Biol Chem (2005) 1.33
Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect. Clin Cancer Res (2007) 1.32
Sequence-specific interference by small RNAs derived from adenovirus VAI RNA. FEBS Lett (2006) 1.31
Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev (2003) 1.28
Functional analysis of microRNAs during the retinoic acid-induced neuronal differentiation of human NT2 cells. Nucleic Acids Res Suppl (2003) 1.27
Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther (2004) 1.26
Effects on RNAi of the tight structure, sequence and position of the targeted region. Nucleic Acids Res (2004) 1.26
p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells. Cancer Res (2005) 1.25
Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta. Oncogene (2005) 1.25
Control of siRNA expression using the Cre-loxP recombination system. Nucleic Acids Res (2004) 1.24
Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease. Mol Cell Proteomics (2006) 1.21
BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis. Endocrinology (2005) 1.19
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. EMBO J (2004) 1.18
Exploration of human miRNA target genes in neuronal differentiation. Nucleic Acids Symp Ser (Oxf) (2005) 1.18
Microfluidics device for single cell gene expression analysis in Saccharomyces cerevisiae. Yeast (2006) 1.16
Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells. Mol Cell Biol (2006) 1.16
Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs. Antisense Nucleic Acid Drug Dev (2002) 1.15
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev (2002) 1.15
Retracted siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells. Nucleic Acids Res (2003) 1.14
Essential role of ATF-1 in induction of NOX1, a catalytic subunit of NADPH oxidase: involvement of mitochondrial respiratory chain. Biochem J (2005) 1.13
Involvement of template-activating factor I/SET in transcription of adenovirus early genes as a positive-acting factor. J Virol (2006) 1.12
Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Exp Cell Res (2003) 1.12
Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses. Cancer Lett (2008) 1.12
Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation. FEBS Lett (2007) 1.11
MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells. Nucleic Acids Symp Ser (Oxf) (2004) 1.10
Expansion of CUG RNA repeats causes stress and inhibition of translation in myotonic dystrophy 1 (DM1) cells. FASEB J (2010) 1.09
Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi. Int J Cancer (2006) 1.09
Retracted Identification of genes that function in the TNF-alpha-mediated apoptotic pathway using randomized hybrid ribozyme libraries. Nat Biotechnol (2002) 1.08
Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells. J Biol Chem (2004) 1.07
Role of IFI 16 in cellular senescence of human fibroblasts. Oncogene (2004) 1.07
Genetics of cellular senescence. Mech Ageing Dev (2002) 1.07
Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1. J Cell Biol (2006) 1.07
Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease. Neurochem Int (2005) 1.06
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60. Biochem J (2005) 1.06
Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes. Proc Natl Acad Sci U S A (2003) 1.06
Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300. Cancer Sci (2005) 1.05
Strategies for generation of an siRNA expression library directed against the human genome. Oligonucleotides (2003) 1.04
Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components. Nucleic Acids Res (2005) 1.04
Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin. Int J Cancer (2011) 1.03
Loss-of-function screening by randomized intracellular antibodies: identification of hnRNP-K as a potential target for metastasis. Proc Natl Acad Sci U S A (2007) 1.03
Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors. J Biol Chem (2004) 1.03
Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis. J Biol Chem (2013) 1.03
Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: combinational approach for enhanced differentiation. Cancer Sci (2009) 1.02
siRNA induced transcriptional gene silencing in mammalian cells. Cell Cycle (2005) 1.02
A direct and efficient synthesis method for dumbell-shaped linear DNA using PCR in vitro. Nucleic Acids Res Suppl (2003) 1.01
Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells. PLoS One (2011) 1.00
Retraction: Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells. Nature (2003) 1.00
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem (2002) 1.00
MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic Acids Res (2011) 0.99
The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay. Neoplasia (2005) 0.99
Ligand-targeted delivery of therapeutic siRNA. Pharm Res (2006) 0.98
A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries. Nucleic Acids Res (2002) 0.98
Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. J Transl Med (2008) 0.98
Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and oxidative stress management functions. Ann N Y Acad Sci (2007) 0.97
Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts. J Biol Chem (2002) 0.97
Mortalin sensitizes human cancer cells to MKT-077-induced senescence. Cancer Lett (2007) 0.96
Development and application of siRNA expression vector. Nucleic Acids Res Suppl (2002) 0.96
Existence of efficient divalent metal ion-catalyzed and inefficient divalent metal ion-independent channels in reactions catalyzed by a hammerhead ribozyme. Nucleic Acids Res (2002) 0.96
NMR-based reappraisal of the coordination of a metal ion at the pro-Rp oxygen of the A9/G10.1 site in a hammerhead ribozyme. J Am Chem Soc (2004) 0.95
Vector-based in vivo RNA interference: dose- and time-dependent suppression of transgene expression. J Pharmacol Exp Ther (2003) 0.95
Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes. J Biol Chem (2004) 0.95
Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts. Ann N Y Acad Sci (2006) 0.94
MRG15, a component of HAT and HDAC complexes, is essential for proliferation and differentiation of neural precursor cells. J Neurosci Res (2009) 0.94
World of small RNAs: from ribozymes to siRNA and miRNA. Differentiation (2004) 0.94