Published in Proc Natl Acad Sci U S A on December 01, 1978
Concanavalin A stimulates phospholipid methylation and phosphatidylserine decarboxylation in rat mast cells. Proc Natl Acad Sci U S A (1979) 1.79
Phospholipid methylation: a biochemical signal modulating lymphocyte mitogenesis. Proc Natl Acad Sci U S A (1980) 1.52
Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U). Antimicrob Agents Chemother (1987) 1.41
Phospholipid methylation and phospholipase A2 activation in cytotoxicity by human natural killer cells. Proc Natl Acad Sci U S A (1981) 1.39
What is the function of phospholipid N-methylation? Biochem J (1983) 1.19
Phospholipid metabolism, calcium flux, and the receptor-mediated induction of chemotaxis in rabbit neutrophils. J Cell Biol (1982) 1.17
Bradykinin stimulates phospholipid methylation, calcium influx, prostaglandin formation, and cAMP accumulation in human fibroblasts. Proc Natl Acad Sci U S A (1983) 1.06
3-Deazaadenosine-induced disorganization of macrophage microfilaments. Proc Natl Acad Sci U S A (1985) 0.94
Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes. Proc Natl Acad Sci U S A (1980) 0.91
Capping and adenosine metabolism. Genetic and pharmacologic studies. J Exp Med (1980) 0.89
Corticotropin-releasing factor stimulates phospholipid methylation and corticotropin secretion in mouse pituitary tumor cells. Proc Natl Acad Sci U S A (1982) 0.84
Antagonism by taxol of effects of microtubule-disrupting agents on lymphocyte cAMP metabolism and cell function. Proc Natl Acad Sci U S A (1984) 0.83
Differentiation of myoblast cell lines and biological methylation: 3-deazaadenosine stimulates formation of multinucleated myofibers. Proc Natl Acad Sci U S A (1984) 0.81
Antibody- and interferon-dependent killer cells are part of the NK cell receptor positive subpopulation of human peripheral blood cells. Clin Exp Immunol (1983) 0.75
Transport of the anti-varicella-zoster virus agent 6-methoxypurine arabinoside and its 2'-O-valerate prodrug into human erythrocytes. Antimicrob Agents Chemother (1992) 0.75
Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs. Immunology (1968) 11.20
Cell-mediated cytotoxicity, allograft rejection, and tumor immunity. Adv Immunol (1974) 11.12
Quantitative studies on phytohaemagglutinin-induced cytotoxicity by human lymphocytes against homologous cells in tissue culture. Immunology (1967) 3.87
The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine. J Biol Chem (1959) 3.05
Pleiotypic control by adenosine 3':5'-cyclic monophosphate: a model for growth control in animal cells. Proc Natl Acad Sci U S A (1973) 2.49
Role of S-adenosylhomocysteine in adenosinemediated toxicity in cultured mouse T lymphoma cells. Cell (1977) 2.09
Effects of cholera toxin on in vitro models of immediate and delayed hypersensitivity. Further evidence for the role of cyclic adenosine 3',5'-monophosphate. J Clin Invest (1973) 1.94
Adenosine inhibition of lymphocyte-mediated cytolysis: possible role of cyclic adenosine monophosphate. Science (1975) 1.92
Requirement of S-adenosyl-L-methionine-mediated methylation for human monocyte chemotaxis. Proc Natl Acad Sci U S A (1978) 1.89
Early steps in specific tumor cell lysis by sensitized mouse T lymphocytes. I. Resolution and characterization. J Immunol (1975) 1.79
The role of cyclic AMP in the cytolytic activity of lymphocytes. J Immunol (1971) 1.78
Raipid stimulation of protein carboxymethylation in leukocytes by a chemotatic peptide. Nature (1978) 1.77
Enzyme inhibitors. 26. Bridging hydrophobic and hydrophilic regions on adenosine deaminase with some 9-(2-hydroxy-3-alkyl)adenines. J Med Chem (1974) 1.72
Studies on the mechanism of lymphocyte-mediated cytolysis. II. The use of various target cell markers to study cytolytic events. J Immunol (1973) 1.69
Ultrastructure of membrane lesions in immune lysis, osmotic lysis and drug-induced lysis. Fed Proc (1974) 1.64
Nature of lymphocyte-tumor interaction. A general method for cellular immunoabsorption. J Exp Med (1973) 1.42
On the mechanism of T-cell mediated cytolysis. Transplant Rev (1973) 1.42
Subcellualr distribution of protein carboxymethylase and its endogenous substrates in the adrenal medulla: possible role in excitation-secretion coupling. Proc Natl Acad Sci U S A (1976) 1.39
Studies on the mechanism of lymphocyte-mediated cytolysis. VI. A reappraisal of the requirement for protein synthesis during T cell-mediated lysis. J Immunol (1976) 1.32
Mechanism of lymphocyte-mediated cytolysis. The LMC cycle and its role in transplantation immunity. Transplant Rev (1973) 1.32
Studies on the mechanism of lymphocyte-mediated cytolysis. 3. The role of microfilaments and microtubules. J Immunol (1973) 1.31
S-Adenosyl-L-homocysteine hydrolase: analogues of S-adenosyl-L-homocysteine as potential inhibitors. Mol Pharmacol (1977) 1.21
Energy requirements of the binding and lytic steps of T lymphocyte-mediated cytolysis of leukemic cells in vitro. Eur J Immunol (1975) 1.21
Morphological observations on the contact-induced lysis of target cells. Eur J Immunol (1973) 1.13
Analogues of 4-(3,4-dimethoxybenzyl)-2-imidazolidinone as potent inhibitors of rat erythrocyte adenosine cyclic 3',5'-phosphate phosphodiesterase. Mol Pharmacol (1971) 1.12
Cholinergic augmentation of lymphocyte-mediated cytotoxicity. A study of the cholinergic receptor of cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (1974) 1.07
2-Fluoroadenosine 3':5'-monophosphate. A metabolite of 2-fluoroadenosine in mouse cytotoxic lymphocytes. J Biol Chem (1976) 0.99
Interaction of lymphocytes with lipid bilayer membranes: a model for lymphocyte-mediated lysis of target cells. Proc Natl Acad Sci U S A (1975) 0.94
Reversible inhibition of lymphocyte mediated cytolysis by dimethyl sulfoxide (DMSO). J Immunol (1973) 0.93
Inhibition of lymphocyte-mediated cytolysis by adenosine analogs. Biochemical studies concerning mechanism of action. Biochem Pharmacol (1978) 0.92
A comparison of the effects of metabolic inhibitors upon direct and antibody-dependent lymphocyte mediated cytotoxicity. Cell Immunol (1975) 0.92
Protein carboxymethylase and methyl-acceptor proteins in human platelets and erythrocytes. Biochem Pharmacol (1978) 0.89
Suppression of in vivo and in vitro alloimmunity by prostaglandins. Transplant Proc (1977) 0.83
Inhibition of indolethylamine-N-methyltransferase by analogs of S-adenosylhomocysteine. Biochem Pharmacol (1975) 0.78
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93
Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell (1998) 5.92
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev (1998) 3.92
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell (2001) 3.80
Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain. J Exp Med (1997) 2.91
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science (1996) 2.56
Plasmin induces local thrombolysis without causing hemorrhage: a comparison with tissue plasminogen activator in the rabbit. Thromb Haemost (2001) 1.98
Adenosine inhibition of lymphocyte-mediated cytolysis: possible role of cyclic adenosine monophosphate. Science (1975) 1.92
Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. Immunity (1997) 1.70
Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells. J Exp Med (2000) 1.57
TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses. Immunity (1999) 1.56
Mouse virulence of K(L) antigen-containing strains of Escherichia coli. J Bacteriol (1969) 1.52
Brca1 required for T cell lineage development but not TCR loci rearrangement. Nat Immunol (2000) 1.48
Metabolism of 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamide and related five-membered heterocycles to 5'-triphosphates in human blood and L5178Y cells. Biochem Pharmacol (1978) 1.36
3'-azido-3'-deoxythymidine. An unusual nucleoside analogue that permeates the membrane of human erythrocytes and lymphocytes by nonfacilitated diffusion. J Biol Chem (1987) 1.32
Adenine as substrate for purine nucleoside phosphorylase. Can J Biochem (1971) 1.22
In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes. J Immunol (1999) 1.14
Purine nucleobase transport in human erythrocytes. Reinvestigation with a novel "inhibitor-stop" assay. J Biol Chem (1988) 1.09
A conformational study of yeast phenylalanine transfer ribonucleic acid. J Biol Chem (1971) 1.08
Thrombolytic potency of acid-stabilized plasmin: superiority over tissue-type plasminogen activator in an in vitro model of catheter-assisted thrombolysis. J Thromb Haemost (2003) 1.03
Transport and metabolism of 9-beta-D-arabinofuranosylguanine in a human T-lymphoblastoid cell line: nitrobenzylthioinosine-sensitive and -insensitive influx. Cancer Res (1990) 1.02
2-Fluoroadenosine 3':5'-monophosphate. A metabolite of 2-fluoroadenosine in mouse cytotoxic lymphocytes. J Biol Chem (1976) 0.99
Chemotactic peptide induces cAMP elevation in human neutrophils by amplification of the adenylate cyclase response to endogenously produced adenosine. J Biol Chem (1989) 0.96
3-Deazaadenosine-induced disorganization of macrophage microfilaments. Proc Natl Acad Sci U S A (1985) 0.94
Reversible inhibition of lymphocyte mediated cytolysis by dimethyl sulfoxide (DMSO). J Immunol (1973) 0.93
Acyclovir transport into human erythrocytes. J Biol Chem (1988) 0.92
Inhibition of lymphocyte-mediated cytolysis by adenosine analogs. Biochemical studies concerning mechanism of action. Biochem Pharmacol (1978) 0.92
Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes. Proc Natl Acad Sci U S A (1980) 0.91
Serum corticosterone, interleukin-1 and tumour necrosis factor in rat experimental endotoxaemia: comparison between Lewis and Wistar strains. Br J Pharmacol (1993) 0.89
Passive hemagglutination. II. Titration of antibody against determinants unique for aggregated denatured bovine serum albumin and further studies on gelatin. J Immunol (1970) 0.89
Studies on passive hemagglutination. I. Titration of "early" and "late" antibodies with tanned red cells sensitized with native or denatured bovine serum albumin. J Immunol (1969) 0.89
Antibody to Corynebacterium parvum in normal human and animal sera. Infect Immun (1977) 0.89
Imaging inflammation with 99Tcm-labeled chemotactic peptides: analogues with reduced neutropenia. Nucl Med Commun (1996) 0.88
iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1. Circulation (1997) 0.86
Membrane permeation mechanisms of 2',3'-dideoxynucleosides. Biochem Pharmacol (1993) 0.84
Enantiomeric selectivity of carbovir transport. J Biol Chem (1992) 0.84
An assay for inhibitors of nucleoside transport based upon the use of 5-[125I]iodo-2'-deoxyuridine as permeant. Anal Biochem (1986) 0.84
A modified procedure for large-scale preparation of beef liver tRNA. Anal Biochem (1970) 0.84
Antagonism by taxol of effects of microtubule-disrupting agents on lymphocyte cAMP metabolism and cell function. Proc Natl Acad Sci U S A (1984) 0.83
3-deazaadenosine inhibits leukocyte adhesion and ICAM-1 biosynthesis in tumor necrosis factor-stimulated human endothelial cells. J Immunol (1990) 0.82
ATP depletion in human platelets caused by permeabilization with saponin does not prevent serotonin secretion induced by collagen. Biochem Biophys Res Commun (1985) 0.82
Transport of 5-fluorouracil and uracil into human erythrocytes. Biochem Pharmacol (1993) 0.82
Ganciclovir permeation of the human erythrocyte membrane. Biochem Pharmacol (1991) 0.82
Development of specific antibody and in vivo response to antigen in different rat strains: effect of dexamethasone and importance of endogenous corticosteroids. Agents Actions (1993) 0.82
Imidazo[4,5-c]pyridines (3-deazapurines) and their nucleosides as immunosuppressive and antiinflammatory agents. J Med Chem (1986) 0.82
Separation of 6-thiopurine derivatives on DEAE-sephadex columns and in the high-pressure liquid chromatograph. J Chromatogr (1973) 0.82
Effects of calmodulin antagonists on immune mouse lymphocytes. Mol Pharmacol (1984) 0.81
In vivo and in vitro antitumor activity expressed by cells of concomitantly immune mice. Cancer Res (1983) 0.80
Metabolism of tubercidin and formycin to their 3':5'-cyclic nucleotides in mammalian cells. J Biol Chem (1978) 0.80
Iron chelates bind nitric oxide and decrease mortality in an experimental model of septic shock. Proc Natl Acad Sci U S A (1996) 0.80
Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of the cofactor in tyrosine hydroxylation in primary cultures of adrenomedullary chromaffin cells. J Neurochem (1986) 0.80
3-Deazaadenosine 5'-triphosphate: a novel metabolite of 3-deazaadenosine in mouse leukocytes. Biochem Pharmacol (1989) 0.80
Xenogeneic ICAM-1 gene transfer suppresses tumorigenicity and generates protective antitumor immunity. Gene Ther (1996) 0.79
Ca2+ ionophore-induced cyclic adenosine-3',5'-monophosphate elevation in human neutrophils. A calmodulin-dependent potentiation of adenylate cyclase response to endogenously produced adenosine: comparison to chemotactic agents. Biochem Pharmacol (1991) 0.79
Effects of adenosine on neutrophil polarization induced by N-formyl-methionyl-leucyl-phenylalanine, sodium propionate and colchicine. Agents Actions (1989) 0.79
Endogenous corticosteroids modulate lymphoproliferation and susceptibility to experimental allergic encephalomyelitis in the Brown Norway rat. Int Arch Allergy Immunol (1995) 0.78
Inhibition of lymphocyte-mediated cytolysis and cyclic AMP phosphodiesterase by erythro-9-(2-hydroxy-3-nonyl)adenine. J Immunopharmacol (1982) 0.78
Inhibition of lymphocyte-mediated cytolysis by 2-fluoroadenosine--evidence for two discrete mechanisms of drug action. Biochem Pharmacol (1978) 0.78
Immunosuppressive effects of the S-adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine. J Immunopharmacol (1982) 0.78
Immune reaction of tumor-bearing mice to Propionibacterium acnes and the antitumor effect of the bacteria. Cancer Immunol Immunother (1982) 0.78
2',3'-Dideoxythymidine permeation of the human erythrocyte membrane by nonfacilitated diffusion. Biochem Biophys Res Commun (1988) 0.78
Formation of 5'-nucleotides of 6-methylmercaptopurine ribonucleoside in human tissues in vitro. Biochem Pharmacol (1974) 0.78
Metabolic formation of nucleoside-modified analogues of S-adenosylmethionine. Biochem Biophys Res Commun (1979) 0.77
Inhibition of cyclic AMP phosphodiesterase by 5'-deoxy-5'-S-isobutylthioadenosine at biologically active concentrations of drug. Life Sci (1981) 0.77
Nucleoside 3',5'-cyclic monophosphate metabolites of purine analogs. Possible role as physiological mediators. Biochem Pharmacol (1979) 0.77
Targets of nitric oxide in a mouse model of liver inflammation by Corynebacterium parvum. Arch Biochem Biophys (1995) 0.77
Membrane permeation characteristics of 5'-modified thymidine analogs. Mol Pharmacol (1992) 0.77
3-Deazaadenosine. S-adenosylhomocysteine hydrolase-independent mechanism of action in mouse lymphocytes. J Biol Chem (1984) 0.77
Potentiation by homocysteine of adenosine-stimulated elevation of cellular adnosine 3',5'-monophosphate. Biochem Pharmacol (1979) 0.77
Taxol inhibits N-formyl-methionyl-leucyl-phenylalanine (FMLP)-induced human neutrophil polarization and H2O2 production while decreasing [3H]FMLP binding. Agents Actions (1987) 0.77