Published in Proc Natl Acad Sci U S A on May 01, 1973
A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci U S A (1974) 8.74
Cyclic AMP: a mitogenic signal for Swiss 3T3 cells. Proc Natl Acad Sci U S A (1981) 1.83
Pleiotypic control by cyclic AMP: interaction with cyclic GMP and possible role of microtubules. Proc Natl Acad Sci U S A (1973) 1.78
Intracellular cyclic AMP concentration responds specifically to growth regulation by serum. Proc Natl Acad Sci U S A (1974) 1.57
Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin F2alpha. Proc Natl Acad Sci U S A (1975) 1.52
Role of cyclic 3':5'-adenosine monophosphate in the early transport changes induced by serum and insulin in quiescent fibroblasts. Proc Natl Acad Sci U S A (1973) 1.50
Putrescine transport is greatly increased in human fibroblasts initiated to proliferate. J Cell Biol (1976) 1.44
Induction of c-fos and c-myc mRNA by epidermal growth factor or calcium ionophore is cAMP dependent. Proc Natl Acad Sci U S A (1986) 1.41
Pathophysiological effects of Vibrio cholerae and enterotoxigenic Escherichia coli and their exotoxins on eucaryotic cells. Microbiol Rev (1978) 1.39
Kinetics of early changes in phosphate and uridine transport and cyclic AMP levels stimulated by serum in density-inhibited 3T3 cells. Proc Natl Acad Sci U S A (1974) 1.35
Inhibition of lymphocyte-mediated cytolysis by 3-deazaadenosine: evidence for a methylation reaction essential to cytolysis. Proc Natl Acad Sci U S A (1978) 1.35
Selective killing of transformed baby hamster kidney (BHK) cells. Proc Natl Acad Sci U S A (1975) 1.27
Studies of the mechanism by which 3,5,3'- triiodothyronine stimulates 2-deoxyglucose uptake in rat thymocytes in vitro. Role of calcium and adenosine 3':5'-monophosphate. J Clin Invest (1981) 1.03
Effects of adenosine 3':5'-cyclic monophosphate and serum on synthesis of hyaluronic acid in confluent rat fibroblasts. Biochem J (1977) 0.99
Cyclic AMP and cyclic GMP concentrations in serum- and density-restricted fibroblast cultures. Proc Natl Acad Sci U S A (1975) 0.98
Analysis of malignancy in human cells: malignant and transformed phenotypes are under separate genetic control. Proc Natl Acad Sci U S A (1978) 0.96
Adenosine 3': 5'-cyclic monophosphate in young and senescent human fibroblasts during growth and stationary phase in vitro. Effects of prostaglandine E1 and of adrenaline. Biochem J (1974) 0.94
The actions of cyclic AMP, its butyryl derivatives and Na butyrate on the proliferation of malignant trophoblast cells in vitro. Br J Cancer (1977) 0.92
Concomitant effects of insulin on surface membrane conformation and polysome profiles of serum-starved BALB-C 3T3 fibroblasts. J Cell Biol (1974) 0.88
Adenylate cyclase from synchronized neuroblastoma cells: responsiveness to prostaglandin E1, adenosine, and dopamine during the cell cycle. Proc Natl Acad Sci U S A (1977) 0.87
Evidence for unaltered structure and in vivo assembly of microtubules in transformed cells. Proc Natl Acad Sci U S A (1978) 0.84
Effect of theophylline on differentiation of Trypanosoma brucei. Infect Immun (1985) 0.83
Polyamines and cellular adenosine 3' :5'-cyclic monophosphate. Biochem J (1979) 0.80
The role of locomotion in lymphocyte migration. Immunology (1979) 0.79
Phosphoprotein phosphatase activity associated with estrogen-induced protein in rat uterus. Proc Natl Acad Sci U S A (1974) 0.78
Histochemical and ultrastructural studies in fibrodysplasia ossificans progressiva (myositis ossificans progressiva). Am J Pathol (1977) 0.75
Rapid changes in nucleoside transport induced by growth inhibitors. Studies with neoplastic mast cells. J Cell Biol (1974) 0.75
Actions of cyclic AMP, its butyryl derivatives and Na butyrate on the HCG output of malignant trophoblast cells in vitro. Br J Cancer (1978) 0.75
Proliferation of cells and intracellular c-AMP content: comparative investigations of autologous lymphatic cells from palatine tonsils, nasopharyngeal tonsils, and blood. Arch Otorhinolaryngol (1978) 0.75
Cell-type differences in the serum and cyclic AMP-dependent regulation of ornithine decarboxylase activity in two cultured fibroblast types. Biochem J (1982) 0.75
A protein binding assay for adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A (1970) 23.79
Requirement of adenosine 3', 5'-cyclic phosphate for flagella formation in Escherichia coli and Salmonella typhimurium. J Bacteriol (1970) 6.33
Morphological transformation of Chinese hamster cells by dibutyryl adenosine cyclic 3':5'-monophosphate and testosterone. Proc Natl Acad Sci U S A (1971) 6.12
Two compounds implicated in the function of the RC gene of Escherichia coli. Nature (1969) 6.06
Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3':5'-cyclic monphosphate and its derivatives. Proc Natl Acad Sci U S A (1971) 5.31
"Pleiotypic response". Nat New Biol (1971) 4.85
MSI and MSII made on ribosome in idling step of protein synthesis. Nature (1972) 3.89
Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth. Biochem Biophys Res Commun (1971) 3.58
Restoration of contact-inhibited growth to transformed cells by dibutyryl adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A (1971) 3.44
Further changes in differentiation state accompanying the conversion of Chinese hamster cells of fibroblastic form by dibutyryl adenosine cyclic 3':5'-monophosphate and hormones. Proc Natl Acad Sci U S A (1971) 3.23
Difference in the cyclic adenosine 3',5'-monophosphate levels in normal and transformed cells. Nat New Biol (1972) 2.90
Temperature-dependent alterations in sugar transport in cells infected by a temperature-sensitive mutant of Rous sarcoma virus. Proc Natl Acad Sci U S A (1971) 2.83
Effect of dibutyryladenosine 3':5'-cyclic monophosphate on growth and differentiation in Caulobacter crescentus. Proc Natl Acad Sci U S A (1972) 2.73
Morphologic differentiation of mouse neuroblastoma cells induced in vitro by dibutyryl adenosine 3':5'-cyclic monophosphate. Nat New Biol (1971) 2.17
Induction of stalk cell differentiation by cyclic AMP in the cellular slime mold Dictyostelium discoideum. Proc Natl Acad Sci U S A (1970) 2.12
Expression of differentiated functions in mouse neuroblastoma mediated by dibutyryl-cyclic adenosine monophosphate. Nature (1971) 1.87
Regulation of adenosine 3',5'-cyclic monophosphate phosphodiesterase activity in fibroblasts by intracellular concentrations of cyclic adenosine monophosphate (3T3-dibutyryl cyclic AMP-SV40-transformed cells-michaelis constants-L cells-prostaglandin E 1 ). Proc Natl Acad Sci U S A (1972) 1.72
Prostaglandin E 1 effects on adenosine 3':5'-cyclic monophosphate concentration and phosphodiesterase activity in fibroblasts (mouse L cells-tissue culture-enzyme kinetics-prostaglandin homologues). Proc Natl Acad Sci U S A (1972) 1.68
Induction of cytolysis of cultured lymphoma cells by adenosine 3':5'-cyclic monophosphate and the isolation of resistant variants. Proc Natl Acad Sci U S A (1973) 1.61
Adenyl cyclase in normal and transformed fibroblasts in tissue culture. Activation by prostaglandins. J Biol Chem (1971) 1.61
Cyclic AMP in metabolism. Nat New Biol (1971) 1.48
Inhibition of replication in functional mouse adrenal tumor cells by adrenocorticotropic hormone mediated by adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A (1971) 1.34
Morphological differentiation induced by prostaglandin in mouse neuroblastoma cells in culture. Nat New Biol (1972) 1.13
Ribonucleic acid biosynthesis of human cells during amino acid deprivation. J Biol Chem (1969) 1.05
The pleiotypic response in mammalian cells: search for an intracellular mediator. Biochem Biophys Res Commun (1972) 0.98
Adenosine 3',5'-monophosphate and N 6 -2'-O-dibutyryl-adenosine 3',5'-monophosphate transport in cells. Science (1972) 0.94
The action of adenosine 3',5'-monophosphate on the incorporation of leucine into liver proteins. Biochim Biophys Acta (1960) 0.88
Induction of melanocytogenesis in explants of Curassius auratus L the xanthic goldfish by dibutyryl-cAMP. Biochem Biophys Res Commun (1970) 0.82
Effects of dibutryl cyclic-3',5'-AMP and other agents upon luteinization of porcine granulosa cells in culture. Endocrinology (1970) 0.81
How animals move: an integrative view. Science (2000) 5.59
"Pleiotypic response". Nat New Biol (1971) 4.85
Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line. Proc Natl Acad Sci U S A (1966) 4.80
The enzymic synthesis of L-cysteine in Escherichia coli and Salmonella typhimurium. J Biol Chem (1966) 4.26
Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action. Cell (1975) 3.44
Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. Influence of the composition of the medium and adenosine triphosphate dependence. J Biol Chem (1971) 2.83
Glucocorticoid receptors: relations between steroid binding and biological effects. J Mol Biol (1972) 2.70
Relation of steroid structure to enzyme induction in hepatoma tissue culture cells. J Mol Biol (1970) 2.46
Mechanical and metabolic determinants of the preferred step width in human walking. Proc Biol Sci (2001) 2.44
Stimulation of tyrosine aminotransferase synthesis by dexamethasone phosphate in cell culture. J Mol Biol (1968) 2.41
Specific cytoplasmic glucocorticoid hormone receptors in hepatoma tissue culture cells. Proc Natl Acad Sci U S A (1971) 2.35
Tyrosine transaminase induction in mammalian cells in tissue culture. Cold Spring Harb Symp Quant Biol (1966) 2.26
Further evidence for posttranscriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells. Nat New Biol (1972) 2.15
The purification and characterization of O-acetylserine sulfhydrylase-A from Salmonella typhimurium. J Biol Chem (1969) 2.04
Role of DNA and specific cytoplasmic receptors in glucocorticoid action. Proc Natl Acad Sci U S A (1972) 1.97
Purification and characterization of cysteine synthetase, a bifunctional protein complex, from Salmonella typhimurium. J Biol Chem (1969) 1.96
Synthesis and induction of tyrosine aminotransferase in synchronized hepatoma cells in culture. Proc Natl Acad Sci U S A (1969) 1.95
Optimal choice. J Exp Anal Behav (1981) 1.93
Sequential transcription of the genes of the lactose operon and its regulation by protein synthesis. J Biol Chem (1966) 1.84
Pleiotypic control by cyclic AMP: interaction with cyclic GMP and possible role of microtubules. Proc Natl Acad Sci U S A (1973) 1.78
Selection of a variant lymphoma cell deficient in adenylate cyclase. Science (1975) 1.76
Mechanisms of steroid resistance. Cell (1974) 1.76
STRUCTURAL ALTERATIONS IN CRYSTALLINE GLUTAMIC DEHYDROGENASE INDUCED BY STEROID HORMONES. Proc Natl Acad Sci U S A (1960) 1.72
The relationship between glucocorticoid binding and tyrosine aminotransferase induction in hepatoma tissue culture cells. Proc Natl Acad Sci U S A (1970) 1.67
Effect of inhibitors of nucleic acid synthesis on steroid-mediated induction of tyrosine aminotransferase in hepatoma cell cultures. J Mol Biol (1967) 1.64
Tyrosine aminotransferase. Purificaton and characterization. J Biol Chem (1967) 1.62
Free and membrane-bound ribosomes in rat liver. J Biol Chem (1967) 1.62
Evidence for the steroid-induced accumulation of tyrosine-aminotransferase messenger RNA in the absence of protein synthesis. Proc Natl Acad Sci U S A (1968) 1.61
Induction of cytolysis of cultured lymphoma cells by adenosine 3':5'-cyclic monophosphate and the isolation of resistant variants. Proc Natl Acad Sci U S A (1973) 1.61
Mechanism of resistance to steroids: glucocorticoid receptor defect in lymphoma cells. Nat New Biol (1972) 1.58
Glucocorticoid receptors in lymphoma cells in culture: relationship to glucocorticoid killing activity. Science (1971) 1.56
Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth. Science (1975) 1.51
"Superinduction" of tyrosine aminotransferase by actinomycin D: a reevaluation. Cell (1975) 1.50
Energetics of bipedal running. I. Metabolic cost of generating force. J Exp Biol (1998) 1.49
Independent effects of weight and mass on plantar flexor activity during walking: implications for their contributions to body support and forward propulsion. J Appl Physiol (1985) (2008) 1.49
Preferential inhibition by 5-bromodeoxyuridine of the synthesis of tyrosine aminotransferase in hepatoma cell cultures. J Mol Biol (1971) 1.46
Somatic genetic analysis of cyclic AMP action: selection of unresponsive mutants. J Cell Physiol (1975) 1.44
Isolation of lymphoma cell variants resistant to killing by glucocorticoids. Cell (1974) 1.43
Effects of adrenal glucocorticoids on polyoma virus replication. Proc Natl Acad Sci U S A (1973) 1.41
Mechanism of hormonal induction of tyrosine aminotransferase studied by measurement of the concentration of growing enzyme molecules. Proc Natl Acad Sci U S A (1972) 1.41
Tyrosine aminotransferase: enzyme induction independent of adenosine 3', 5'-monophosphate. Science (1968) 1.37
Isolation and chromosomal localization of highly repeated DNA sequences in Drosophila melanogaster. Proc Natl Acad Sci U S A (1971) 1.37
Reversed-phase ion-pair liquid chromatographic procedure for the simultaneous analysis of S-adenosylmethionine, its metabolites and the natural polyamines. J Chromatogr (1982) 1.36
INHIBITION OF THE ENZYMIC OXIDATION OF DPNH BY STER HORMONES. Proc Natl Acad Sci U S A (1959) 1.36
A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proc Natl Acad Sci U S A (1975) 1.36
The role of RNA in the hormonal induction of tyrosine aminotransferase in mammalian cells in tissue culture. J Mol Biol (1967) 1.34
The metabolic code. Science (1975) 1.33
Pleiotrophy in a cysteine-requiring mutant of Samonella typhimurium resulting from altered protein-protein interaction. J Biol Chem (1969) 1.33
Receptors from glucocorticoid-sensitive lymphoma cells and two clases of insensitive clones: physical and DNA-binding properties. Proc Natl Acad Sci U S A (1974) 1.30
Modulation of leg muscle function in response to altered demand for body support and forward propulsion during walking. J Biomech (2009) 1.30
Steroid-induced nuclear binding of glucocorticoid receptors in intact hepatoma cells. J Mol Biol (1973) 1.29
Penguin waddling is not wasteful. Nature (2001) 1.26
Hormone induced modification of the cell surface. Nature (1969) 1.26
Purification and properties of rat liver tyrosine aminotransferase. J Biol Chem (1969) 1.22
Steroid hormone binding to a macromolecule from hepatoma tissue culture cells. J Biol Chem (1969) 1.22
A filter assay for steroid hormone receptors. Biochemistry (1973) 1.21
Superinduction of tyrosine aminotransferase by actinomycin D in rat hepatoma (HTC) cells. J Mol Biol (1970) 1.21
Walking in simulated reduced gravity: mechanical energy fluctuations and exchange. J Appl Physiol (1985) (1999) 1.19
Turnover of ribosomal RNA in rat liver. Science (1965) 1.19
Characterization of a hormone receptor defect in the androgen-insensitivity mutant. Cell (1974) 1.18
Cyclic AMP, a nonessential regulator of the cell cycle. Proc Natl Acad Sci U S A (1975) 1.18
Control of specific gene expression examined in synchronized mammalian cells. Proc Natl Acad Sci U S A (1969) 1.17
Arrangement of the highly reiterated DNA sequences in the centric heterochromatin of Drosophila melanogaster. Evidence for interspersed spacer DNA. J Mol Biol (1972) 1.17
Metabolic cost of generating horizontal forces during human running. J Appl Physiol (1985) (1999) 1.16
Moving cheaply: energetics of walking in the African elephant. J Exp Biol (1995) 1.15
Control of tyrosine aminotransferase synthesis in tissue culture by a factor in serum. Proc Natl Acad Sci U S A (1969) 1.13
Polyamine oxidase in rat tissues. Biochim Biophys Acta (1980) 1.13
The independent effects of gravity and inertia on running mechanics. J Exp Biol (2000) 1.11
Differential effect of 5-bromodeoxyuridine on the concentrations of specific enzymes in hepatoma cells in culture. Proc Natl Acad Sci U S A (1971) 1.11
Early events in glucocorticoid action. Activation of the steroid receptor and its subsequent specific nuclear binding studied in a cell-free system. J Biol Chem (1973) 1.09
Mechanics of running under simulated low gravity. J Appl Physiol (1985) (1991) 1.09
Genetic analysis of cyclic AMP in a mammalian cell. Adv Cyclic Nucleotide Res (1975) 1.09
Regulation of phosphodiesterase synthesis: requirement for cyclic adenosine monophosphate-dependent protein kinase. Science (1973) 1.09
Effect of the androgen-insensitivity mutation on a cytoplasmic receptor for dihydrotestosterone. Nat New Biol (1971) 1.08
Somatic genetic analysis of cyclic AMP action: characterization of unresponsive mutants. J Cell Physiol (1975) 1.07
A new mechanism for steroid unresponsiveness: loss of nuclear binding activity of a steroid hormone receptor. Cell (1974) 1.06
Molecular weight of the subunits, oligomeric and associated forms of bovine liver glutamate dehydrogenase. J Mol Biol (1968) 1.06
The efficiency of human movement--a statement of the problem. Med Sci Sports Exerc (1985) 1.06
Glucocorticoid-induced alteration of the surface membrane of cultured hepatoma cells. J Cell Biol (1970) 1.05
General presence of glucocorticoid receptors in mammalian tissues. Endocrinology (1974) 1.05
Kinetics of steroid induction and deinduction of tyrosine aminotransferase synthesis in cultured hepatoma cells. Proc Natl Acad Sci U S A (1975) 1.03
A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease. Eur J Biochem (1997) 1.02
Synthesis of inducible tyrosine aminotransferase in a cell-free extract from cultured hepatoma cells. Proc Natl Acad Sci U S A (1972) 1.02
Stride length in distance running: velocity, body dimensions, and added mass effects. Med Sci Sports Exerc (1989) 1.01
Cellular site of glucocorticoid-receptor complex formation. Science (1972) 0.99
Cyclic AMP and cyclic GMP concentrations in serum- and density-restricted fibroblast cultures. Proc Natl Acad Sci U S A (1975) 0.98
Regulation of glutamine synthetase by dexamethasone in hepatoma tissue culture cells. J Biol Chem (1978) 0.98
Musculoskeletal adaptations to weightlessness and development of effective countermeasures. Med Sci Sports Exerc (1996) 0.98
The pleiotypic response in mammalian cells: search for an intracellular mediator. Biochem Biophys Res Commun (1972) 0.98
Posttranscriptional control of tyrosine aminotransferase synthesis by insulin. Proc Natl Acad Sci U S A (1970) 0.96
The effect of reduced gravity on the kinematics of human walking: a test of the dynamic similarity hypothesis for locomotion. J Exp Biol (1997) 0.95
Molecular mechanisms of cyclic AMP action: a genetic approach. Recent Prog Horm Res (1976) 0.95
Applied horizontal force increases impact loading in reduced-gravity running. J Biomech (2001) 0.94
Hormones and gene expression. Annu Rev Genet (1970) 0.92
Altered metabolism and endogenous cyclic AMP in cultured cells deficient in cyclic AMP-binding proteins. Nat New Biol (1973) 0.92