The genome of the heartworm, Dirofilaria immitis, reveals drug and vaccine targets.

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Published in FASEB J on August 13, 2012

Authors

Christelle Godel1, Sujai Kumar, Georgios Koutsovoulos, Philipp Ludin, Daniel Nilsson, Francesco Comandatore, Nicola Wrobel, Marian Thompson, Christoph D Schmid, Susumu Goto, Frédéric Bringaud, Adrian Wolstenholme, Claudio Bandi, Christian Epe, Ronald Kaminsky, Mark Blaxter, Pascal Mäser

Author Affiliations

1: Swiss Tropical and Public Health Institute, Basel, Switzerland.

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Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci U S A (1998) 192.97

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ABySS: a parallel assembler for short read sequence data. Genome Res (2009) 43.20

KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res (1999) 40.62

OrthoMCL: identification of ortholog groups for eukaryotic genomes. Genome Res (2003) 33.03

Automatic clustering of orthologs and in-paralogs from pairwise species comparisons. J Mol Biol (2001) 16.47

CEGMA: a pipeline to accurately annotate core genes in eukaryotic genomes. Bioinformatics (2007) 12.21

A molecular evolutionary framework for the phylum Nematoda. Nature (1998) 10.64

De novo assembly and analysis of RNA-seq data. Nat Methods (2010) 9.69

Gene finding in novel genomes. BMC Bioinformatics (2004) 8.64

Genomics. Genome project standards in a new era of sequencing. Science (2009) 7.72

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MAKER: an easy-to-use annotation pipeline designed for emerging model organism genomes. Genome Res (2007) 6.48

InParanoid 7: new algorithms and tools for eukaryotic orthology analysis. Nucleic Acids Res (2009) 5.90

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AUGUSTUS: a web server for gene prediction in eukaryotes that allows user-defined constraints. Nucleic Acids Res (2005) 4.13

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