Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice.

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Published in J Clin Invest on July 18, 2011

Authors

W Joost Lesterhuis1, Cornelis J A Punt, Stanleyson V Hato, Dagmar Eleveld-Trancikova, Bastiaan J H Jansen, Stefan Nierkens, Gerty Schreibelt, Annemiek de Boer, Carla M L Van Herpen, Johannes H Kaanders, Johan H J M van Krieken, Gosse J Adema, Carl G Figdor, I Jolanda M de Vries

Author Affiliations

1: Department of Medical Oncology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands. w.lesterhuis@onco.umcn.nl

Associated clinical trials:

Carcinoembryonic Antigen-loaded Dendritic Cells in Advanced Colorectal Cancer Patients | NCT00228189

Peptide-pulsed vs. RNA-transfected Dendritic Cell Vaccines in Melanoma Patients | NCT00243529

Durvalumab and Chemotherapy Induction Followed by Durvalumab and Radiotherapy in Large Volume Stage III NSCLC (BRIDGE) | NCT04765709

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