PubRank

Eric R Prossnitz

Author PubWeight™ 120.66‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 2005 9.80
2 Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol 2006 5.20
3 G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res 2007 2.71
4 In vivo effects of a GPR30 antagonist. Nat Chem Biol 2009 2.39
5 Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol 2007 2.20
6 Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res 2009 2.16
7 Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging. J Cell Biol 2011 1.91
8 GPR30: a novel indicator of poor survival for endometrial carcinoma. Am J Obstet Gynecol 2007 1.89
9 FRET detection of cellular alpha4-integrin conformational activation. Biophys J 2003 1.88
10 GPR30 predicts poor survival for ovarian cancer. Gynecol Oncol 2009 1.63
11 Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor. J Immunol 2004 1.59
12 Arrestins block G protein-coupled receptor-mediated apoptosis. J Biol Chem 2004 1.53
13 Flow cytometry for high-throughput, high-content screening. Curr Opin Chem Biol 2004 1.50
14 Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Biochem Mol Biol 2011 1.42
15 Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. ACS Chem Biol 2007 1.37
16 Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Mol Pharmacol 2005 1.37
17 The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Cancer Res 2010 1.36
18 Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol 2009 1.32
19 G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils. Am J Physiol Cell Physiol 2006 1.29
20 G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary. Endocrinology 2008 1.27
21 Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes. J Neurosci 2010 1.27
22 Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues. J Endocrinol 2009 1.27
23 Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat. J Cardiovasc Pharmacol 2011 1.24
24 N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. J Biol Chem 2003 1.23
25 Flow cytometric analysis of ligand-receptor interactions and molecular assemblies. Annu Rev Biophys Biomol Struct 2001 1.23
26 The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation. Endocrinology 2008 1.23
27 High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands. J Biomol Screen 2005 1.22
28 Non-genomic regulation of vascular cell function and growth by estrogen. Mol Cell Endocrinol 2009 1.21
29 Estrogen and progesterone receptor status and outcome in epithelial ovarian cancers and low malignant potential tumors. Gynecol Oncol 2009 1.21
30 Alpha4beta1 integrin affinity changes govern cell adhesion. J Biol Chem 2003 1.20
31 Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation. Neurosci Lett 2008 1.19
32 The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function. Vascul Pharmacol 2011 1.18
33 Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780. Pharmacology 2010 1.17
34 Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nuclei. Endocrinology 2007 1.17
35 Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30. J Med Chem 2010 1.16
36 Expression of G protein-coupled receptor 30 in the hamster ovary: differential regulation by gonadotropins and steroid hormones. Endocrinology 2007 1.16
37 Retracted G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells. Environ Health Perspect 2008 1.13
38 Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells. Endocrinology 2011 1.12
39 Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. J Neurosci Res 2009 1.11
40 Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide. Bioconjug Chem 2009 1.10
41 Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform. Nat Protoc 2006 1.07
42 Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry. J Mol Biol 2005 1.07
43 GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinology 2013 1.03
44 Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer. Clin Cancer Res 2010 1.03
45 Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle. Am J Physiol Endocrinol Metab 2011 1.02
46 N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity. J Biol Chem 2002 1.02
47 Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation. J Biol Chem 2004 1.01
48 N-formyl peptide receptors cluster in an active raft-associated state prior to phosphorylation. J Biol Chem 2004 1.01
49 Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases. J Biol Chem 2001 1.01
50 Effects of atrazine on estrogen receptor α- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts. Environ Health Perspect 2015 1.00
51 GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancer. Breast Cancer Res Treat 2009 0.98
52 Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction. Hypertension 2011 0.97
53 High-throughput flow cytometry for drug discovery. Expert Opin Drug Discov 2007 0.95
54 Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs. Org Biomol Chem 2010 0.94
55 High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening. J Biomol Screen 2004 0.93
56 Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. Am J Obstet Gynecol 2010 0.93
57 Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates. J Am Chem Soc 2006 0.93
58 Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH. Cytometry A 2006 0.92
59 Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes. Cytometry A 2009 0.92
60 Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1. Immunology 2011 0.92
61 Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cells. Nucl Med Biol 2007 0.91
62 Adaptor protein-2 interaction with arrestin regulates GPCR recycling and apoptosis. Traffic 2009 0.90
63 Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins. Traffic 2005 0.90
64 Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction. J Biol Chem 2004 0.90
65 High-content screening: flow cytometry analysis. Methods Mol Biol 2009 0.90
66 Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residues. J Immunol 2006 0.89
67 A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system. Cytometry A 2008 0.88
68 Regulation of vascular smooth muscle tone by adipose-derived contracting factor. PLoS One 2013 0.88
69 GPER regulates endothelin-dependent vascular tone and intracellular calcium. Life Sci 2012 0.87
70 Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system. J Biomol Screen 2009 0.87
71 Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasms. Int J Surg Pathol 2011 0.86
72 Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides. Bioconjug Chem 2011 0.86
73 Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers. J Nucl Med 2008 0.86
74 Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalization. Mol Biol Cell 2007 0.86
75 Arrestin variants display differential binding characteristics for the phosphorylated N-formyl peptide receptor carboxyl terminus. J Biol Chem 2002 0.85
76 Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30. Curr Top Med Chem 2009 0.85
77 Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads. Adv Protein Chem 2007 0.85
78 Regulation of N-formyl peptide-mediated degranulation by receptor phosphorylation. J Immunol 2002 0.85
79 The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions. J Immunother 2013 0.82
80 Screening for caspase-3 inhibitors: a new class of potent small-molecule inhibitors of caspase-3. J Biomol Screen 2006 0.82
81 Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides. Anal Biochem 2007 0.81
82 Techniques: GPCR assembly, pharmacology and screening by flow cytometry. Trends Pharmacol Sci 2004 0.81
83 Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents. ACS Chem Biol 2010 0.81
84 Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30. PLoS One 2012 0.81
85 Expression of G protein-coupled receptor 30 in the spinal somatosensory system. Brain Res 2009 0.81
86 A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand. Cytometry A 2009 0.80
87 Enhancement of somatostatin-receptor-targeted (177)Lu-[DOTA(0)-Tyr(3)]-octreotide therapy by gemcitabine pretreatment-mediated receptor uptake, up-regulation and cell cycle modulation. Nucl Med Biol 2008 0.80
88 G protein-coupled estrogen receptor: a new therapeutic target in stroke and traumatic brain/spinal cord injury? Crit Care Med 2012 0.79
89 Non-genomic signaling by steroids. Mol Cell Endocrinol 2009 0.79
90 Estrogen-independent activation of estrogen receptors. Hypertension 2011 0.79
91 Mechanisms of G protein-coupled receptor-mediated degranulation. FEMS Microbiol Lett 2004 0.78
92 Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins. Biochemistry 2003 0.78
93 Testosterone and secondary hypertension: new pieces to the puzzle. Hypertension 2012 0.77
94 Post-high-throughput screening analysis: an empirical compound prioritization scheme. J Biomol Screen 2005 0.77
95 Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorg Med Chem Lett 2013 0.77
96 Prostanoid-mediated contractions of the carotid artery become Nox2-independent with aging. Age (Dordr) 2015 0.77
97 Alike but not the same: anatomic heterogeneity of estrogen receptor-mediated vasodilation. J Cardiovasc Pharmacol 2013 0.76
98 Erratum: G Protein-coupled Estrogen Receptor Protects from Atherosclerosis. Sci Rep 2015 0.76
99 Lung cancer and hormone replacement therapy. Lancet 2010 0.75
100 GPER Mediates Functional Endothelial Aging in Renal Arteries. Pharmacology 2017 0.75