Published in J Biol Chem on December 21, 2001
G-protein signaling: back to the future. Cell Mol Life Sci (2005) 2.38
Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev (2009) 1.88
NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Neuron (2006) 1.83
Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22. Am J Hum Genet (2004) 1.55
Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling. Pharmacol Ther (2006) 1.38
S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner. BMC Cell Biol (2005) 1.07
Transcriptional analysis of the mammalian heart with special reference to its endocrine function. BMC Genomics (2009) 0.95
Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad. Mol Pharmacol (2013) 0.93
Rhes and AGS1/Dexras1 affect signaling by dopamine D1 receptors through adenylyl cyclase. J Neurosci Res (2011) 0.92
Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors. J Biol Chem (2012) 0.88
Ontogeny and dopaminergic regulation in brain of Ras homolog enriched in striatum (Rhes). Brain Res (2008) 0.88
Molecular mechanisms of go signaling. Neurosignals (2009) 0.85
Exploration of sex differences in Rhes effects in dopamine mediated behaviors. Neuropsychiatr Dis Treat (2011) 0.84
PKA modulates iron trafficking in the striatum via small GTPase, Rhes. Neuroscience (2013) 0.84
Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors. Neuroscience (2010) 0.80
Rasd1 modulates the coactivator function of NonO in the cyclic AMP pathway. PLoS One (2011) 0.79
Spatiotemporal expression of Dexras1 after spinal cord transection in rats. Cell Mol Neurobiol (2008) 0.79
Dexamethasone activates transient receptor potential canonical 4 (TRPC4) channels via Rasd1 small GTPase pathway. Pflugers Arch (2014) 0.78
PKA-mediated phosphorylation of Dexras1 suppresses iron trafficking by inhibiting S-nitrosylation. FEBS Lett (2015) 0.78
The stimulus-dependent co-localization of serum- and glucocorticoid-regulated protein kinase (Sgk) and Erk/MAPK in mammary tumor cells involves the mutual interaction with the importin-alpha nuclear import protein. Exp Cell Res (2007) 0.77
Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation. Mol Brain (2016) 0.77
Dysregulated Glycoprotein B Mediated Cell-Cell Fusion Disrupts Varicella-Zoster Virus and Host Gene Transcription During Infection. J Virol (2016) 0.77
Small G Proteins Dexras1 and RHES and Their Role in Pathophysiological Processes. Int J Cell Biol (2014) 0.76
Gαi/o-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years later. Eur J Pharmacol (2015) 0.75
The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels. Channels (Austin) (2015) 0.75
A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science (2005) 9.80
Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol (2006) 5.20
G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Res (2007) 2.71
In vivo effects of a GPR30 antagonist. Nat Chem Biol (2009) 2.39
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. J Endocrinol (2007) 2.20
Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res (2009) 2.16
Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging. J Cell Biol (2011) 1.91
GPR30: a novel indicator of poor survival for endometrial carcinoma. Am J Obstet Gynecol (2007) 1.89
FRET detection of cellular alpha4-integrin conformational activation. Biophys J (2003) 1.88
GPR30 predicts poor survival for ovarian cancer. Gynecol Oncol (2009) 1.63
Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor. J Immunol (2004) 1.59
Arrestins block G protein-coupled receptor-mediated apoptosis. J Biol Chem (2004) 1.53
Flow cytometry for high-throughput, high-content screening. Curr Opin Chem Biol (2004) 1.50
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J Steroid Biochem Mol Biol (2011) 1.42
Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. ACS Chem Biol (2007) 1.37
Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Mol Pharmacol (2005) 1.37
The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Cancer Res (2010) 1.36
Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. J Neuroimmunol (2009) 1.32
G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils. Am J Physiol Cell Physiol (2006) 1.29
Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes. J Neurosci (2010) 1.27
G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary. Endocrinology (2008) 1.27
Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues. J Endocrinol (2009) 1.27
Vasodilation in response to the GPR30 agonist G-1 is not different from estradiol in the mRen2.Lewis female rat. J Cardiovasc Pharmacol (2011) 1.24
Flow cytometric analysis of ligand-receptor interactions and molecular assemblies. Annu Rev Biophys Biomol Struct (2001) 1.23
N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. J Biol Chem (2003) 1.23
The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation. Endocrinology (2008) 1.23
High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands. J Biomol Screen (2005) 1.22
Non-genomic regulation of vascular cell function and growth by estrogen. Mol Cell Endocrinol (2009) 1.21
Estrogen and progesterone receptor status and outcome in epithelial ovarian cancers and low malignant potential tumors. Gynecol Oncol (2009) 1.21
Alpha4beta1 integrin affinity changes govern cell adhesion. J Biol Chem (2003) 1.20
Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation. Neurosci Lett (2008) 1.19
The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function. Vascul Pharmacol (2011) 1.18
Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780. Pharmacology (2010) 1.17
Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nuclei. Endocrinology (2007) 1.17
Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30. J Med Chem (2010) 1.16
Expression of G protein-coupled receptor 30 in the hamster ovary: differential regulation by gonadotropins and steroid hormones. Endocrinology (2007) 1.16
Retracted G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells. Environ Health Perspect (2008) 1.13
Mechanisms of estradiol-induced insulin secretion by the G protein-coupled estrogen receptor GPR30/GPER in pancreatic beta-cells. Endocrinology (2011) 1.12
Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. J Neurosci Res (2009) 1.11
Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide. Bioconjug Chem (2009) 1.10
Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform. Nat Protoc (2006) 1.07
Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry. J Mol Biol (2005) 1.07
GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinology (2013) 1.03
Altered growth hormone, cortisol, and leptin secretion in healthy elderly persons with sarcopenia and mixed body composition phenotypes. J Gerontol A Biol Sci Med Sci (2008) 1.03
Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer. Clin Cancer Res (2010) 1.03
Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle. Am J Physiol Endocrinol Metab (2011) 1.02
N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity. J Biol Chem (2002) 1.02
Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation. J Biol Chem (2004) 1.01
N-formyl peptide receptors cluster in an active raft-associated state prior to phosphorylation. J Biol Chem (2004) 1.01
Effects of atrazine on estrogen receptor α- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts. Environ Health Perspect (2015) 1.00
GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancer. Breast Cancer Res Treat (2009) 0.98
Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction. Hypertension (2011) 0.97
High-throughput flow cytometry for drug discovery. Expert Opin Drug Discov (2007) 0.95
Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs. Org Biomol Chem (2010) 0.94
Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates. J Am Chem Soc (2006) 0.93
High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening. J Biomol Screen (2004) 0.93
Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. Am J Obstet Gynecol (2010) 0.93
Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH. Cytometry A (2006) 0.92
Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1. Immunology (2011) 0.92
Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes. Cytometry A (2009) 0.92
Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cells. Nucl Med Biol (2007) 0.91
Adaptor protein-2 interaction with arrestin regulates GPCR recycling and apoptosis. Traffic (2009) 0.90
High-content screening: flow cytometry analysis. Methods Mol Biol (2009) 0.90
Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins. Traffic (2005) 0.90
Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction. J Biol Chem (2004) 0.90
Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residues. J Immunol (2006) 0.89
A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system. Cytometry A (2008) 0.88
Regulation of vascular smooth muscle tone by adipose-derived contracting factor. PLoS One (2013) 0.88
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system. J Biomol Screen (2009) 0.87
GPER regulates endothelin-dependent vascular tone and intracellular calcium. Life Sci (2012) 0.87
Mesothelin and GPR30 staining among a spectrum of pancreatic epithelial neoplasms. Int J Surg Pathol (2011) 0.86
Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides. Bioconjug Chem (2011) 0.86
Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalization. Mol Biol Cell (2007) 0.86
Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers. J Nucl Med (2008) 0.86
Arrestin variants display differential binding characteristics for the phosphorylated N-formyl peptide receptor carboxyl terminus. J Biol Chem (2002) 0.85
Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads. Adv Protein Chem (2007) 0.85
Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30. Curr Top Med Chem (2009) 0.85
Regulation of N-formyl peptide-mediated degranulation by receptor phosphorylation. J Immunol (2002) 0.85
The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions. J Immunother (2013) 0.82
Screening for caspase-3 inhibitors: a new class of potent small-molecule inhibitors of caspase-3. J Biomol Screen (2006) 0.82
Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents. ACS Chem Biol (2010) 0.81
Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30. PLoS One (2012) 0.81
Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides. Anal Biochem (2007) 0.81
Techniques: GPCR assembly, pharmacology and screening by flow cytometry. Trends Pharmacol Sci (2004) 0.81
Expression of G protein-coupled receptor 30 in the spinal somatosensory system. Brain Res (2009) 0.81
A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand. Cytometry A (2009) 0.80
Enhancement of somatostatin-receptor-targeted (177)Lu-[DOTA(0)-Tyr(3)]-octreotide therapy by gemcitabine pretreatment-mediated receptor uptake, up-regulation and cell cycle modulation. Nucl Med Biol (2008) 0.80
Estrogen-independent activation of estrogen receptors. Hypertension (2011) 0.79
G protein-coupled estrogen receptor: a new therapeutic target in stroke and traumatic brain/spinal cord injury? Crit Care Med (2012) 0.79
Estradiol effects on the growth hormone/insulin-like growth factor-1 axis in amenorrheic athletes. Can J Appl Physiol (2003) 0.79
Non-genomic signaling by steroids. Mol Cell Endocrinol (2009) 0.79
Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins. Biochemistry (2003) 0.78
Mechanisms of G protein-coupled receptor-mediated degranulation. FEMS Microbiol Lett (2004) 0.78
Prostanoid-mediated contractions of the carotid artery become Nox2-independent with aging. Age (Dordr) (2015) 0.77
Post-high-throughput screening analysis: an empirical compound prioritization scheme. J Biomol Screen (2005) 0.77
Testosterone and secondary hypertension: new pieces to the puzzle. Hypertension (2012) 0.77
Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorg Med Chem Lett (2013) 0.77
Alike but not the same: anatomic heterogeneity of estrogen receptor-mediated vasodilation. J Cardiovasc Pharmacol (2013) 0.76
Erratum: G Protein-coupled Estrogen Receptor Protects from Atherosclerosis. Sci Rep (2015) 0.76
Respiratory Failure in the Course of Treatment of Diabetic Ketoacidosis. Clin Diabetes (2014) 0.75