Published in Biochem Biophys Res Commun on February 28, 1990
Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function. EMBO J (1991) 4.59
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J (1993) 4.33
The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string. Cell (1990) 3.40
Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates. EMBO J (1991) 3.23
Identification of cell cycle-regulated genes in fission yeast. Mol Biol Cell (2004) 2.29
p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells. Proc Natl Acad Sci U S A (1991) 2.10
Cell cycle regulation of the p34cdc2 inhibitory kinases. Mol Biol Cell (1994) 1.81
The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control. Genes Dev (1998) 1.70
Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase. Mol Cell Biol (2001) 1.50
Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation. EMBO J (2004) 1.45
Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases. Mol Cell Biol (2005) 1.43
A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25. Mol Biol Cell (2006) 1.31
Stockpiling of Cdc25 during a DNA replication checkpoint arrest in Schizosaccharomyces pombe. Mol Cell Biol (1996) 1.30
A post-transcriptional mechanism contributes to circadian cycling of a per-beta-galactosidase fusion protein. Proc Natl Acad Sci U S A (1991) 1.23
stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe. Genetics (1990) 1.08
Roles of Wee1 and Nim1 protein kinases in regulating the switch from mitotic division to sexual development in Schizosaccharomyces pombe. Mol Cell Biol (1997) 1.01
A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast. Mol Cell Biol (2009) 0.82
The Genomes of Three Uneven Siblings: Footprints of the Lifestyles of Three Trichoderma Species. Microbiol Mol Biol Rev (2016) 0.82
Redundant mechanisms prevent mitotic entry following replication arrest in the absence of Cdc25 hyper-phosphorylation in fission yeast. PLoS One (2011) 0.77
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature (2000) 23.17
Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (1998) 18.23
p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (1993) 13.68
Role of the INK4a locus in tumor suppression and cell mortality. Cell (1996) 11.41
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature (1994) 10.95
RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell (1999) 8.55
Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature (1994) 8.22
Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev (1993) 8.03
Cyclin A is required at two points in the human cell cycle. EMBO J (1992) 7.96
Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (1995) 7.25
Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell (1988) 6.88
Cyclin G is a transcriptional target of the p53 tumor suppressor protein. EMBO J (1994) 6.83
The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell (1988) 6.45
mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell (1991) 6.25
Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature (1993) 5.70
beta Blockade after myocardial infarction: systematic review and meta regression analysis. BMJ (1999) 5.66
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63
D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell (1992) 5.51
Human D-type cyclin. Cell (1991) 5.47
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science (1995) 5.46
Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell (1989) 5.35
Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev (1993) 5.32
Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol Gen Genet (1982) 5.17
Four mating-type genes control sexual differentiation in the fission yeast. EMBO J (1988) 5.00
Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell (1989) 4.68
The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast. EMBO J (1987) 4.45
The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell (1989) 4.43
Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J (1993) 4.33
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A (1996) 4.33
Roles for Nkx3.1 in prostate development and cancer. Genes Dev (1999) 4.30
Cdc25 cell-cycle phosphatase as a target of c-myc. Nature (1996) 4.23
cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Cell (1988) 4.12
p21-containing cyclin kinases exist in both active and inactive states. Genes Dev (1994) 4.08
p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell (1995) 4.08
p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J (1987) 3.91
Functionally homologous cell cycle control genes in budding and fission yeast. Nature (1982) 3.78
The natural history of Hendra and Nipah viruses. Microbes Infect (2001) 3.77
Myc activates telomerase. Genes Dev (1998) 3.74
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev (1993) 3.70
Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61
Construction of an improved host strain for two hybrid screening. Nucleic Acids Res (1994) 3.43
Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase. Cell (1991) 3.37
Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell (1991) 3.34
Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules. EMBO J (1988) 3.27
cdc2 phosphorylation is required for its interaction with cyclin. EMBO J (1991) 3.22
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature (1994) 3.21
Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell (1987) 3.12
A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell (1989) 3.08
Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature (1989) 3.07
A comparison of the reliability of self-reported drug use and sexual behaviors using computer-assisted versus face-to-face interviewing. AIDS Educ Prev (2000) 3.02
CDC25 phosphatases as potential human oncogenes. Science (1995) 2.84
Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol (1993) 2.83
Midwifery and body fluid contamination. BMJ (1992) 2.81
Structural basis for activation of the titin kinase domain during myofibrillogenesis. Nature (1998) 2.80
Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann Rheum Dis (1993) 2.78
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proc Natl Acad Sci U S A (1990) 2.77
Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase. EMBO J (1989) 2.75
Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication. Nature (1989) 2.67
Repression of cyclin D1: a novel function of MYC. Mol Cell Biol (1994) 2.67
Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe. Mol Cell Biol (1986) 2.66
cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. EMBO J (1994) 2.64
Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J (1994) 2.61
Vectors for the construction of gene banks and the integration of cloned genes in Schizosaccharomyces pombe and Saccharomyces cerevisiae. Plasmid (1986) 2.58
Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell (1993) 2.57
Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium. Proc Natl Acad Sci U S A (1997) 2.54
A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. Genome Res (1999) 2.49
The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function. Mol Gen Genet (1986) 2.46
Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast. Nature (1990) 2.46
Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. Proc Natl Acad Sci U S A (1992) 2.43
Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science (1995) 2.42
Association of cdk2 kinase with the transcription factor E2F during S phase. Science (1992) 2.37
Brown adipose tissue in the parametrial fat pad of the mouse. FEBS Lett (1984) 2.36
Involvement of ras in sexual differentiation but not in growth control in fission yeast. EMBO J (1986) 2.31
Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci U S A (1993) 2.31
Deletion of the p16 and p15 genes in human bladder tumors. J Natl Cancer Inst (1995) 2.25
Isolation of chromosomal origins of replication in yeast. Nature (1980) 2.20
Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation. Cell (1993) 2.19
Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control. Cell (1989) 2.16
Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe. Mol Cell Biol (1987) 2.13
Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase. EMBO J (1987) 2.10
Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene (1994) 2.10
The endurance shuttle walking test: a responsive measure in pulmonary rehabilitation for COPD patients. Chron Respir Dis (2006) 2.09
Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin. Cell (1990) 2.08
Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene (1995) 2.05
Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development. Development (1999) 2.04
Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. EMBO J (1993) 2.02
Preparation of interstitial lung cells by enzymatic digestion of tissue slices: preliminary characterization by morphology and performance in functional assays. Immunology (1985) 2.02
The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res (1997) 2.00
A validation study on the use of intra-operative video recording as an objective assessment tool for core ENT surgery. Clin Otolaryngol (2014) 1.98
Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: Results from the LIPID trial. Ann Intern Med (2001) 1.97
Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage. J Exp Med (1989) 1.97