PubRank

Diana Eccles

Author PubWeight™ 196.81‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 2007 29.23
2 Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010 12.27
3 Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet 2002 9.71
4 PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat Genet 2006 9.17
5 Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Nat Genet 2006 7.72
6 Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet 2010 7.62
7 Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet 2009 7.30
8 ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nat Genet 2006 6.67
9 A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet 2010 4.96
10 Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet 2013 4.35
11 A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet 2010 3.86
12 Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet 2013 3.81
13 Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med 2008 3.76
14 GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet 2013 3.42
15 Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet 2008 3.41
16 A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet 2011 3.37
17 Autosomal recessive colorectal adenomatous polyposis due to inherited mutations of MYH. Lancet 2003 3.24
18 Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE. J Natl Cancer Inst 2013 2.93
19 Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer. J Clin Oncol 2013 2.71
20 Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature 2012 2.66
21 A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet 2012 2.45
22 A genome wide linkage search for breast cancer susceptibility genes. Genes Chromosomes Cancer 2006 2.35
23 Pregnancies, breast-feeding, and breast cancer risk in the International BRCA1/2 Carrier Cohort Study (IBCCS). J Natl Cancer Inst 2006 2.25
24 Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 2009 2.13
25 Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer Epidemiol Biomarkers Prev 2011 1.99
26 Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Res 2006 1.77
27 Germline RAD51C mutations confer susceptibility to ovarian cancer. Nat Genet 2012 1.76
28 Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun 2013 1.73
29 Common breast cancer susceptibility loci are associated with triple-negative breast cancer. Cancer Res 2011 1.65
30 A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis. Cancer Prev Res (Phila) 2011 1.64
31 Evaluation of Fanconi Anemia genes in familial breast cancer predisposition. Cancer Res 2003 1.62
32 Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility. Am J Hum Genet 2003 1.58
33 Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice. Proc Natl Acad Sci U S A 2004 1.56
34 Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers. Hum Mol Genet 2011 1.51
35 Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nat Commun 2013 1.36
36 Tumor characteristics as an analytic tool for classifying genetic variants of uncertain clinical significance. Hum Mutat 2008 1.35
37 Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. Carcinogenesis 2013 1.28
38 Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2. J Clin Oncol 2008 1.23
39 Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Res 2011 1.22
40 Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH. Gastroenterology 2009 1.21
41 Prospective observational study of breast cancer treatment outcomes for UK women aged 18-40 years at diagnosis: the POSH study. J Natl Cancer Inst 2013 1.13
42 Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol 2011 1.12
43 The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer. Breast Cancer Res 2008 1.11
44 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Cancer Res 2013 1.06
45 Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas. Nat Genet 2013 1.05
46 RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1. Hum Mutat 2004 1.05
47 Machine learning approaches for the discovery of gene-gene interactions in disease data. Brief Bioinform 2012 1.03
48 Identification of a de novo BRCA1 mutation in a woman with early onset bilateral breast cancer. Fam Cancer 2009 1.03
49 Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet Oncol 2012 1.01
50 Accurate prediction of BRCA1 and BRCA2 heterozygous genotype using expression profiling after induced DNA damage. Clin Cancer Res 2006 0.99
51 Prediction of single-nucleotide substitutions that result in exon skipping: identification of a splicing silencer in BRCA1 exon 6. Hum Mutat 2011 0.99
52 Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA. Hum Genet 2013 0.99
53 Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Hum Mutat 2012 0.98
54 Gene-gene interactions in breast cancer susceptibility. Hum Mol Genet 2011 0.97
55 Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids. PLoS One 2011 0.94
56 Acute chemotherapy-related toxicity is not increased in BRCA1 and BRCA2 mutation carriers treated for breast cancer in the United Kingdom. Clin Cancer Res 2006 0.94
57 Evaluation of RAD50 in familial breast cancer predisposition. Int J Cancer 2006 0.92
58 Analysis of over 10,000 Cases finds no association between previously reported candidate polymorphisms and ovarian cancer outcome. Cancer Epidemiol Biomarkers Prev 2013 0.92
59 Risk of ovarian cancer and the NF-κB pathway: genetic association with IL1A and TNFSF10. Cancer Res 2013 0.89
60 Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 2014 0.89
61 A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2012 0.89
62 Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers. Breast Cancer Res 2012 0.88
63 Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom. Clin Cancer Res 2006 0.86
64 No evidence that GATA3 rs570613 SNP modifies breast cancer risk. Breast Cancer Res Treat 2008 0.84
65 Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev 2011 0.83
66 Large-scale evaluation of common variation in regulatory T cell-related genes and ovarian cancer outcome. Cancer Immunol Res 2014 0.82
67 Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers. Breast Cancer Res 2010 0.82
68 Support Vector Machine classifier for estrogen receptor positive and negative early-onset breast cancer. PLoS One 2013 0.81
69 Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2. PLoS One 2012 0.80
70 Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy. Breast Cancer Res 2015 0.79
71 Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1/S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment. Int J Radiat Oncol Biol Phys 2004 0.79
72 Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men. Sci Rep 2013 0.78
73 Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk. Mol Nutr Food Res 2014 0.77
74 Composite likelihood-based meta-analysis of breast cancer association studies. J Hum Genet 2011 0.76
75 Optimal selection of individuals for BRCA mutation testing. J Clin Oncol 2006 0.75
76 Genome-wide association of breast cancer: composite likelihood with imputed genotypes. Eur J Hum Genet 2010 0.75
77 Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers. J Natl Cancer Inst 2017 0.75
78 Mutation and association analysis of GEN1 in breast cancer susceptibility. Breast Cancer Res Treat 2010 0.75
79 Economic and Practical Factors in Diagnosing HNPCC Using Clinical Criteria, Immunohistochemistry and Microsatellite Instability Analysis. Hered Cancer Clin Pract 2004 0.75