Published in Nature on April 01, 2004
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (2005) 12.35
AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 10.42
The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev (2006) 6.80
AMPK and PPARdelta agonists are exercise mimetics. Cell (2008) 6.39
AMP-activated protein kinase--development of the energy sensor concept. J Physiol (2006) 4.93
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes Dev (2004) 4.84
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science (2009) 4.72
Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27
Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci U S A (2007) 4.24
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature (2008) 3.91
Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell (2011) 3.79
AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest (2006) 3.39
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest (2007) 3.32
Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol (2005) 3.14
Intracellular signalling pathways activated by leptin. Biochem J (2006) 2.93
Leptin targets in the mouse brain. J Comp Neurol (2009) 2.80
Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat Med (2010) 2.76
Circadian rhythms, sleep, and metabolism. J Clin Invest (2011) 2.60
Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila) (2010) 2.60
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. Cell (2013) 2.56
Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab (2009) 2.27
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem (2010) 2.21
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell (2012) 2.20
Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med (2012) 2.13
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol (Oxf) (2009) 2.13
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
AMPK: Lessons from transgenic and knockout animals. Front Biosci (Landmark Ed) (2009) 2.09
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest (2006) 2.09
AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J (2009) 2.09
Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab (2010) 2.08
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol (2006) 2.06
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J Clin Invest (2006) 1.94
Leptin and the central nervous system control of glucose metabolism. Physiol Rev (2011) 1.94
AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol (2010) 1.93
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest (2007) 1.91
The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med (2008) 1.87
Appetite control and energy balance regulation in the modern world: reward-driven brain overrides repletion signals. Int J Obes (Lond) (2009) 1.84
Central nervous system control of metabolism. Nature (2012) 1.83
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci U S A (2006) 1.77
Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol (2011) 1.76
From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A (2007) 1.74
Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci (2008) 1.74
Central and peripheral regulation of food intake and physical activity: pathways and genes. Obesity (Silver Spring) (2008) 1.71
Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci (2009) 1.67
Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke. Stroke (2007) 1.67
Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol (2006) 1.67
Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance. Cell Metab (2012) 1.66
Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. Cell (2015) 1.65
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab (2010) 1.64
Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol Cell Biol (2007) 1.62
Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila. Neuron (2015) 1.62
Neuronal regulation of homeostasis by nutrient sensing. Nat Med (2010) 1.61
Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight. Diabetes (2010) 1.61
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proc Natl Acad Sci U S A (2007) 1.61
Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes (2008) 1.60
The control of food intake: behavioral versus molecular perspectives. Cell Metab (2009) 1.56
AMPK in the brain: its roles in energy balance and neuroprotection. J Neurochem (2009) 1.55
Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiol Behav (2010) 1.54
Targeting the AMPK pathway for the treatment of Type 2 diabetes. Front Biosci (Landmark Ed) (2009) 1.51
AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem (2009) 1.49
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS One (2008) 1.49
Leptin receptor signaling and the regulation of mammalian physiology. Int J Obes (Lond) (2008) 1.48
Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell Metab (2011) 1.48
gp130 receptor ligands as potential therapeutic targets for obesity. J Clin Invest (2007) 1.46
Leptin in human physiology and therapeutics. Front Neuroendocrinol (2010) 1.46
Targeting the CNS to treat type 2 diabetes. Nat Rev Drug Discov (2009) 1.45
Hindbrain lactostasis regulates hypothalamic AMPK activity and metabolic neurotransmitter mRNA and protein responses to hypoglycemia. Am J Physiol Regul Integr Comp Physiol (2013) 1.45
Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells. Biochem Biophys Res Commun (2009) 1.45
Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron (2011) 1.45
Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metab (2016) 1.44
AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. Clin Sci (Lond) (2009) 1.43
APPL1: role in adiponectin signaling and beyond. Am J Physiol Endocrinol Metab (2008) 1.41
Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. J Leukoc Biol (2008) 1.40
Molecular and neural mediators of leptin action. Physiol Behav (2008) 1.40
Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci U S A (2008) 1.38
5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK. Biochem J (2005) 1.35
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metab (2012) 1.35
CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. J Biol Chem (2007) 1.35
Leptin and the systems neuroscience of meal size control. Front Neuroendocrinol (2009) 1.35
Hypothalamic Sirt1 regulates food intake in a rodent model system. PLoS One (2009) 1.34
AMP-activated protein kinase regulation and biological actions in the heart. Circ Res (2012) 1.33
Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes (2009) 1.33
Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. EMBO Rep (2012) 1.32
Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol (2010) 1.32
Maternal high-fat diet during gestation or suckling differentially affects offspring leptin sensitivity and obesity. Diabetes (2012) 1.31
KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC. EMBO J (2006) 1.31
Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochem Biophys Res Commun (2008) 1.31
Dissociation between sensing and metabolism of glucose in sugar sensing neurones. J Physiol (2008) 1.31
Central administration of resveratrol improves diet-induced diabetes. Endocrinology (2009) 1.30
Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab (2014) 1.30
Nutrient-sensing mechanisms across evolution. Cell (2015) 1.30
AMP-activated protein kinase, stress responses and cardiovascular diseases. Clin Sci (Lond) (2012) 1.29
Dorsal hindbrain 5'-adenosine monophosphate-activated protein kinase as an intracellular mediator of energy balance. Endocrinology (2008) 1.29
Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase. Diabetes (2012) 1.28
AMPK at the nexus of energetics and aging. Cell Metab (2014) 1.28
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Cell Mol Life Sci (2010) 1.27
Hypothalamic leptin regulation of energy homeostasis and glucose metabolism. J Physiol (2007) 1.26
Regulation of hypothalamic malonyl-CoA by central glucose and leptin. Proc Natl Acad Sci U S A (2007) 1.26
AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes (2014) 1.25
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab (2005) 13.91
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell (2005) 11.19
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature (2005) 10.10
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med (2006) 9.53
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature (2002) 8.77
Extended longevity in mice lacking the insulin receptor in adipose tissue. Science (2003) 8.53
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab (2007) 6.83
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A (2002) 5.93
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell (2002) 5.01
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med (2010) 4.96
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet (2004) 4.71
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell (2010) 4.62
AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest (2004) 4.54
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest (2003) 4.11
Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol (2005) 4.00
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med (2009) 3.97
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J Clin Invest (2005) 3.95
Role of Akt/protein kinase B in metabolism. Trends Endocrinol Metab (2002) 3.87
SREBP transcription factors: master regulators of lipid homeostasis. Biochimie (2004) 3.85
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A (2007) 3.76
Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature (2013) 3.72
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest (2009) 3.70
Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med (2006) 3.66
PTP1B regulates leptin signal transduction in vivo. Dev Cell (2002) 3.61
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature (2007) 3.57
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab (2005) 3.51
The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes (2007) 3.42
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature (2012) 3.35
Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression. J Biol Chem (2004) 3.17
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J Biol Chem (2003) 2.94
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med (2012) 2.86
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. J Biol Chem (2003) 2.76
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell (2012) 2.75
Safety of air travel following acute myocardial infarction. Aviat Space Environ Med (2002) 2.74
Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab (2007) 2.69
A high-fat, ketogenic diet induces a unique metabolic state in mice. Am J Physiol Endocrinol Metab (2007) 2.64
Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res (2004) 2.62
Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A (2005) 2.60
Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab (2007) 2.53
Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states. Mol Pharmacol (2008) 2.48
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes (2006) 2.43
Thoracic paravertebral block and its effects on chronic pain and health-related quality of life after modified radical mastectomy. Reg Anesth Pain Med (2014) 2.42
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J (2002) 2.41
Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metab (2009) 2.23
Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. J Biol Chem (2003) 2.23
GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes (2007) 2.22
Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem (2010) 2.19
AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol (2002) 2.14
Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem (2006) 2.13
Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Proc Natl Acad Sci U S A (2005) 2.13
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest (2006) 2.09
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood (2005) 2.09
Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem (2008) 2.08
Heliox vs air-oxygen mixtures for the treatment of patients with acute asthma: a systematic overview. Chest (2003) 2.08
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol (2006) 2.06
A critical review of the ability of continuous cardiac output monitors to measure trends in cardiac output. Anesth Analg (2010) 2.05
Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. J Biol Chem (2005) 2.04
Lessons on conditional gene targeting in mouse adipose tissue. Diabetes (2013) 2.04
Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med (2011) 1.95
Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biol Chem (2006) 1.94
Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol Cell Biol (2002) 1.90
Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes. J Biol Chem (2003) 1.90
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes (2008) 1.88
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med (2012) 1.87
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. Biochem J (2002) 1.87
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). J Biol Chem (2004) 1.85
Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab (2007) 1.85
Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest (2005) 1.84
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am J Physiol Endocrinol Metab (2002) 1.82
The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science (2004) 1.80
Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem (2010) 1.80
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. J Lipid Res (2010) 1.79
The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling. Proc Natl Acad Sci U S A (2009) 1.79
Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). J Cell Sci (2002) 1.79
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proc Natl Acad Sci U S A (2007) 1.77
Activation of the cholinergic antiinflammatory pathway ameliorates obesity-induced inflammation and insulin resistance. Endocrinology (2011) 1.77
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood (2010) 1.75
Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab (2005) 1.73
The role of FOXO in the regulation of metabolism. Curr Diab Rep (2009) 1.73
Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. J Biol Chem (2003) 1.72
Cancellation of elective operations on the day of intended surgery in a Hong Kong hospital: point prevalence and reasons. Hong Kong Med J (2012) 1.72
Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab (2007) 1.71