Published in Stem Cells Dev on October 19, 2011
Primary Bovine Extra-Embryonic Cultured Cells: A New Resource for the Study of In Vivo Peri-Implanting Phenotypes and Mesoderm Formation. PLoS One (2015) 0.85
C-kit(+) cells isolated from developing kidneys are a novel population of stem cells with regenerative potential. Stem Cells (2013) 0.82
Transgene Reactivation in Induced Pluripotent Stem Cell Derivatives and Reversion to Pluripotency of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells. Stem Cells Dev (2016) 0.77
hESC expansion and stemness are independent of connexin forty-three-mediated intercellular communication between hESCs and hASC feeder cells. PLoS One (2013) 0.76
Cytokine-free directed differentiation of human pluripotent stem cells efficiently produces hemogenic endothelium with lymphoid potential. Stem Cell Res Ther (2017) 0.75
Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol (2004) 101.91
An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell (2008) 10.34
Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol (2005) 9.58
Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell (2011) 6.82
BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol (2002) 6.20
Protein networks in disease. Genome Res (2008) 5.65
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci (2005) 4.86
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A (2008) 4.13
Wnt signaling: is the party in the nucleus? Genes Dev (2006) 4.10
Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am J Hum Genet (2010) 3.63
Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase. J Cell Physiol (2006) 3.32
Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. Dis Model Mech (2010) 3.17
Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells (2008) 3.14
Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture. Development (2005) 2.98
Stem cells and early lineage development. Cell (2008) 2.77
Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways. PLoS One (2009) 2.18
Genetic dissection of nodal function in patterning the mouse embryo. Development (2001) 2.07
Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells (2006) 1.88
Genome-wide gene and pathway analysis. Eur J Hum Genet (2010) 1.79
Calcium at fertilization and in early development. Physiol Rev (2006) 1.76
Comparison of the gene expression profile of undifferentiated human embryonic stem cell lines and differentiating embryoid bodies. BMC Dev Biol (2005) 1.61
Properties of four human embryonic stem cell lines maintained in a feeder-free culture system. Dev Dyn (2004) 1.60
Assessing self-renewal and differentiation in human embryonic stem cell lines. Stem Cells (2005) 1.58
Stem cells from the Mammalian blastocyst. Stem Cells (2001) 1.56
Identifying disease-specific genes based on their topological significance in protein networks. BMC Syst Biol (2009) 1.54
Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J Cell Biol (2008) 1.52
TRPC4 and TRPC5: receptor-operated Ca2+-permeable nonselective cation channels. Cell Calcium (2003) 1.47
A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells. Stem Cells (2009) 1.46
Gap junctional communication in the preimplantation mouse embryo. Cell (1979) 1.43
Gap junctions: multifaceted regulators of embryonic cortical development. Trends Neurosci (2008) 1.34
Functional analysis of OMICs data and small molecule compounds in an integrated "knowledge-based" platform. Methods Mol Biol (2009) 1.31
Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation. Stem Cells (2007) 1.30
Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells. J Biol Chem (2008) 1.26
Epithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions. Mol Hum Reprod (2006) 1.26
FGF2 specifies hESC-derived definitive endoderm into foregut/midgut cell lineages in a concentration-dependent manner. Stem Cells (2010) 1.21
Cytotrophoblast stem cell lines derived from human embryonic stem cells and their capacity to mimic invasive implantation events. Hum Reprod (2006) 1.18
Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development (2006) 1.17
Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes. Pharmacogenomics J (2010) 1.16
Establishment of human trophoblast progenitor cell lines from the chorion. Stem Cells (2011) 1.15
Calcium signaling in vertebrate embryonic patterning and morphogenesis. Dev Biol (2007) 1.14
Lymphoid enhancer factor 1-mediated Wnt signaling promotes the initiation of trophoblast lineage differentiation in mouse embryonic stem cells. Stem Cells (2008) 1.13
A pure population of ectodermal cells derived from human embryonic stem cells. Stem Cells (2007) 1.13
Role of gap junctions in embryonic and somatic stem cells. Stem Cell Rev (2008) 1.13
Presence of functional gap junctions in human embryonic stem cells. Stem Cells (2004) 1.11
Derivation of human embryonic stem cell lines from biopsied blastomeres on human feeders with minimal exposure to xenomaterials. Stem Cells Dev (2009) 1.07
Restricted ethnic diversity in human embryonic stem cell lines. Nat Methods (2010) 1.02
Paracrine and epigenetic control of trophectoderm differentiation from human embryonic stem cells: the role of bone morphogenic protein 4 and histone deacetylases. Stem Cells Dev (2011) 0.96
Identification and expression analysis of genes associated with bovine blastocyst formation. BMC Dev Biol (2007) 0.95
Developmental potential of rat extraembryonic stem cells. Stem Cells Dev (2009) 0.95
Molecular regulation of blastocyst formation. Anim Reprod Sci (2004) 0.93
Expression of beta human chorionic gonadotrophin by non-trophoblastic non-endocrine 'normal' and malignant epithelial cells. Br J Cancer (1990) 0.93
Cancer hallmarks in induced pluripotent cells: new insights. J Cell Physiol (2010) 0.93
Embryonic stem cells as models of trophoblast differentiation: progress, opportunities, and limitations. Reproduction (2010) 0.86
The choice between epidermal and neural fate: a matter of calcium. Int J Dev Biol (2004) 0.85
Characteristics of genomic signatures derived using univariate methods and mechanistically anchored functional descriptors for predicting drug- and xenobiotic-induced nephrotoxicity. Toxicol Mech Methods (2008) 0.79
Gap junctional intercellular communication in human embryonic stem cells during spontaneous differentiation. Dokl Biol Sci (2009) 0.79
An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36
The genomic landscapes of human breast and colorectal cancers. Science (2007) 38.12
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
Molecular definition of breast tumor heterogeneity. Cancer Cell (2007) 12.67
The genetic landscape of the childhood cancer medulloblastoma. Science (2010) 8.34
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nat Biotechnol (2010) 7.08
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood (2009) 5.72
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome. Nat Genet (2002) 5.55
Pathway mapping tools for analysis of high content data. Methods Mol Biol (2007) 4.87
Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat Med (2006) 4.54
Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46
The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest (2011) 4.41
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A (2008) 4.13
Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99
A molecular role for lysyl oxidase in breast cancer invasion. Cancer Res (2002) 2.65
Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. J Biol Chem (2001) 2.56
Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci U S A (2008) 2.51
ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood (2009) 2.45
The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev (2011) 2.38
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood (2007) 2.30
Paradoxical roles for lysyl oxidases in cancer--a prospect. J Cell Biochem (2007) 2.30
Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer Res (2005) 2.27
Effect of training-sample size and classification difficulty on the accuracy of genomic predictors. Breast Cancer Res (2010) 2.26
A comprehensive functional analysis of tissue specificity of human gene expression. BMC Biol (2008) 2.15
Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am J Pathol (2004) 2.12
Vesicle trafficking plays a novel role in erythroblast enucleation. Blood (2010) 2.07
Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications. Am J Pathol (2007) 1.99
Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism. Cancer Res (2005) 1.95
Maspin regulates different signaling pathways for motility and adhesion in aggressive breast cancer cells. Cancer Biol Ther (2003) 1.85
Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome. Blood (2009) 1.84
Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. EMBO J (2002) 1.84
Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis. Genome Biol (2007) 1.80
The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation. Dev Dyn (2005) 1.78
The emergence of lineage-specific chromosomal topologies from coordinate gene regulation. Proc Natl Acad Sci U S A (2009) 1.78
GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A (2002) 1.77
Science policy. The NIH budget in the "postdoubling" era. Science (2002) 1.74
The paradoxical expression of maspin in ovarian carcinoma. Clin Cancer Res (2002) 1.71
A genetic analysis of chromosome territory looping: diverse roles for distal regulatory elements. Chromosome Res (2003) 1.67
Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment. Proc Natl Acad Sci U S A (2006) 1.67
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development (2002) 1.64
Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development. Blood (2005) 1.64
Tumor cell vasculogenic mimicry: from controversy to therapeutic promise. Am J Pathol (2012) 1.58
Preoperative serum vascular endothelial growth factor levels: significance in ovarian cancer. Clin Cancer Res (2002) 1.57
Survivin is not required for the endomitotic cell cycle of megakaryocytes. Blood (2009) 1.57
Reevaluating cathepsin D as a biomarker for breast cancer: serum activity levels versus histopathology. Cancer Biol Ther (2010) 1.55
Identifying disease-specific genes based on their topological significance in protein networks. BMC Syst Biol (2009) 1.54
Biological functions of maspin. J Cell Physiol (2006) 1.54
Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev Biol (2002) 1.54
Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells. J Exp Med (2007) 1.52
Molecular pathways: vasculogenic mimicry in tumor cells: diagnostic and therapeutic implications. Clin Cancer Res (2012) 1.52
Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling. Blood (2013) 1.52
Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry. Cancer Res (2003) 1.50
Molecular determinants of human uveal melanoma invasion and metastasis. Clin Exp Metastasis (2002) 1.50
Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells. J Natl Cancer Inst (2004) 1.49
Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype. Cancer Res (2010) 1.49
Maspin regulates hypoxia-mediated stimulation of uPA/uPAR complex in invasive breast cancer cells. Cancer Biol Ther (2005) 1.49
Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia. Cancer Res (2005) 1.49
GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol (2009) 1.44
Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. J Biol Chem (2005) 1.44
Differential requirements for survivin in hematopoietic cell development. Proc Natl Acad Sci U S A (2005) 1.43
Differential regulation of EphA2 in normal and malignant cells. Am J Pathol (2003) 1.43
Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration. J Cell Biochem (2008) 1.41
p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinoma. Cancer Biol Ther (2002) 1.41
VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: implications for vasculogenic mimicry. Cancer Biol Ther (2006) 1.41
p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas. Mol Cancer Ther (2004) 1.40
Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood (2003) 1.37
ErbB/EGF signaling and EMT in mammary development and breast cancer. J Mammary Gland Biol Neoplasia (2010) 1.36
Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry. Cancer Res (2003) 1.35
Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood (2012) 1.35
Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells. Prostate (2011) 1.34
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome. Blood (2003) 1.34
Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood (2007) 1.33
Expression of multiple molecular phenotypes by aggressive melanoma tumor cells: role in vasculogenic mimicry. Crit Rev Oncol Hematol (2002) 1.32
Prostatic tumor cell plasticity involves cooperative interactions of distinct phenotypic subpopulations: role in vasculogenic mimicry. Prostate (2002) 1.32
Development and cancer: at the crossroads of Nodal and Notch signaling. Cancer Res (2009) 1.30
Bcl-x(L) and Akt cooperate to promote leukemogenesis in vivo. Oncogene (2003) 1.30
Transcription factor networks in erythroid cell and megakaryocyte development. Blood (2011) 1.29
Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J Clin Invest (2012) 1.29
Isolation of Oct4-expressing extraembryonic endoderm precursor cell lines. PLoS One (2009) 1.29
Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. Blood (2007) 1.28
Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood (2009) 1.28
STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice. J Clin Invest (2007) 1.27
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell (2012) 1.26
A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells. Stem Cells (2005) 1.26
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. Cancer Cell (2011) 1.24
The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr (2005) 1.24
Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner. Mol Cell Biol (2008) 1.22
Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment. Epigenomics (2009) 1.22
Focal adhesion kinase promotes the aggressive melanoma phenotype. Cancer Res (2005) 1.22
Erythroblast enucleation. Stem Cells Int (2011) 1.21
Maspin: molecular mechanisms and therapeutic implications. Cancer Metastasis Rev (2012) 1.21
Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer. Breast Cancer Res (2012) 1.21
Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma. Cell Cycle (2008) 1.20
Functional role of matrix metalloproteinases in ovarian tumor cell plasticity. Am J Obstet Gynecol (2004) 1.20
Molecular insights into Down syndrome-associated leukemia. Curr Opin Pediatr (2007) 1.20
The transcriptomic signature of fasting murine liver. BMC Genomics (2008) 1.19
Influence of the microenvironment on melanoma cell fate determination and phenotype. Cancer Res (2006) 1.18
Drug target prediction and repositioning using an integrated network-based approach. PLoS One (2013) 1.18
Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment. Dev Dyn (2008) 1.18