Published in EMBO J on October 01, 2002
GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A (2003) 3.32
Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev (2004) 2.56
FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J (2005) 2.53
ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood (2009) 2.45
Context-dependent regulation of GATA-1 by friend of GATA-1. Proc Natl Acad Sci U S A (2003) 2.01
Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1. Blood (2005) 1.72
NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J (2009) 1.66
Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development. Blood (2005) 1.64
Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif. Genome Res (2008) 1.58
Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res (2011) 1.48
Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding. Mol Cell Biol (2003) 1.44
FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopenia. J Clin Invest (2004) 1.39
Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development. Mol Cell Biol (2009) 1.31
Transcription factor networks in erythroid cell and megakaryocyte development. Blood (2011) 1.29
Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. Blood (2007) 1.28
Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood (2006) 1.25
Megakaryocyte biology and related disorders. J Clin Invest (2005) 1.23
Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis. EMBO J (2003) 1.23
The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Mol Cell Biol (2004) 1.22
Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis. Genome Res (2014) 1.19
The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol (2008) 1.16
FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. EMBO J (2009) 1.10
FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood (2010) 1.09
Characterization of megakaryocyte GATA1-interacting proteins: the corepressor ETO2 and GATA1 interact to regulate terminal megakaryocyte maturation. Blood (2008) 1.06
Combinatorial regulation of tissue specification by GATA and FOG factors. Development (2012) 1.06
GATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1. Mol Cell Biol (2005) 1.05
Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. Blood (2005) 1.00
Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression. Mol Cell (2012) 1.00
Properties of ets-1 binding to chromatin and its effect on platelet factor 4 gene expression. Mol Cell Biol (2004) 0.99
Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters. Mol Cell Biol (2006) 0.97
Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytes. Blood (2008) 0.96
Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 mice. Clin Exp Immunol (2010) 0.96
Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes. Mol Cell Biol (2010) 0.93
Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals. BMC Genomics (2005) 0.93
Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis. Genome Res (2014) 0.92
Identification of nuclear import and export signals within Fli-1: roles of the nuclear import signals in Fli-1-dependent activation of megakaryocyte-specific promoters. Mol Cell Biol (2005) 0.91
Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain. BMC Genomics (2005) 0.87
DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection. Genome Med (2015) 0.86
Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. Mol Cell Biol (2010) 0.85
Extracellular matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of rapamycin function. Dev Biol (2013) 0.84
GATA family transcriptional factors: emerging suspects in hematologic disorders. Exp Hematol Oncol (2015) 0.84
Global transcriptome and chromatin occupancy analysis reveal the short isoform of GATA1 is deficient for erythroid specification and gene expression. Haematologica (2015) 0.83
Loss of GATA1 and gain of FLI1 expression during thrombocyte maturation. Blood Cells Mol Dis (2010) 0.83
GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development. BMC Dev Biol (2008) 0.82
Genomic landscape of megakaryopoiesis and platelet function defects. Blood (2016) 0.81
The leukemia associated ETO nuclear repressor gene is regulated by the GATA-1 transcription factor in erythroid/megakaryocytic cells. BMC Mol Biol (2010) 0.80
The transcription factor Fli-1 regulates monocyte, macrophage and dendritic cell development in mice. Immunology (2013) 0.79
Human thrombopoiesis depends on Protein kinase Cδ/protein kinase Cε functional couple. Haematologica (2016) 0.79
An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif. Biochem Biophys Res Commun (2007) 0.78
Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy. J Hematol Oncol (2015) 0.78
Friend of GATA (FOG) interacts with the nucleosome remodeling and deacetylase complex (NuRD) to support primitive erythropoiesis in Xenopus laevis. PLoS One (2012) 0.78
Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature. Nucleic Acids Res (2006) 0.77
The identification and structure of an N-terminal PR domain show that FOG1 is a member of the PRDM family of proteins. PLoS One (2014) 0.75
Robust hematopoietic progenitor cell commitment in the presence of a conflicting cue. J Cell Sci (2015) 0.75
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Megakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiation. Stem Cell Investig (2015) 0.75
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (1991) 10.30
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FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell (1997) 5.78
Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A (1996) 5.20
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J (1997) 4.61
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Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood (1999) 2.61
Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity (2000) 2.59
Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers. EMBO J (1999) 2.21
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GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A (2002) 1.77
GATA and Ets cis-acting sequences mediate megakaryocyte-specific expression. Mol Cell Biol (1993) 1.57
The FLI-1 and chimeric EWS-FLI-1 oncoproteins display similar DNA binding specificities. J Biol Chem (1994) 1.56
X-linked thrombocytopenia caused by a novel mutation of GATA-1. Blood (2001) 1.49
Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation. Blood (2001) 1.47
DNA binding specificity studies of four ETS proteins support an indirect read-out mechanism of protein-DNA recognition. J Biol Chem (2000) 1.41
Regulation of expression of murine transferrin receptor 2. Blood (2001) 1.35
Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice. Int J Hematol (2001) 1.32
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FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements. Oncogene (1997) 1.27
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Regulation of the megakaryocytic glycoprotein IX promoter by the oncogenic Ets transcription factor Fli-1. Blood (1999) 1.12
BSAP can repress enhancer activity by targeting PU.1 function. Mol Cell Biol (2000) 1.12
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GATA-1- and FOG-dependent activation of megakaryocytic alpha IIB gene expression. J Biol Chem (2000) 0.93
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Global regulation of erythroid gene expression by transcription factor GATA-1. Blood (2004) 4.22
An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol (2012) 4.15
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature (2013) 3.98
Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Mol Cell (2008) 3.24
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell (2012) 2.87
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res (2009) 2.64
Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J (2004) 2.62
FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J (2005) 2.53
GATA-1-mediated proliferation arrest during erythroid maturation. Mol Cell Biol (2003) 2.52
In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation. Biotechniques (2006) 2.46
ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood (2009) 2.45
An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature (2002) 2.33
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The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13
Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS (2003) 2.12
Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1. Mol Cell Biol (2003) 2.09
Vesicle trafficking plays a novel role in erythroblast enucleation. Blood (2010) 2.07
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Context-dependent regulation of GATA-1 by friend of GATA-1. Proc Natl Acad Sci U S A (2003) 2.01
Distinct functions of dispersed GATA factor complexes at an endogenous gene locus. Mol Cell Biol (2006) 1.94
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Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome. Blood (2009) 1.84
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GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A (2002) 1.77
Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1. Cell (2012) 1.74
Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood (2012) 1.72
NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J (2009) 1.66
Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development. Blood (2005) 1.64
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development (2002) 1.64
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Chromatin loops in gene regulation. Biochim Biophys Acta (2008) 1.57
Survivin is not required for the endomitotic cell cycle of megakaryocytes. Blood (2009) 1.57
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Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells. J Exp Med (2007) 1.52
Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling. Blood (2013) 1.52
Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin. Blood (2004) 1.50
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J (2006) 1.45
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Mitotic bookmarking by transcription factors. Epigenetics Chromatin (2013) 1.38
Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis. Blood (2003) 1.37
The clinical course and genetic defect in the PCFT gene in a 27-year-old woman with hereditary folate malabsorption. J Pediatr (2008) 1.36
Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood (2012) 1.35
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Dissecting molecular steps in chromatin domain activation during hematopoietic differentiation. Mol Cell Biol (2007) 1.34
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome. Blood (2003) 1.34
Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome. Blood (2007) 1.33
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Transcription factor networks in erythroid cell and megakaryocyte development. Blood (2011) 1.29
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Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood (2009) 1.28
Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. Blood (2007) 1.28
STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice. J Clin Invest (2007) 1.27
Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell (2012) 1.26
Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis. Thromb Res (2009) 1.25
Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood (2006) 1.25
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Erythroblast enucleation. Stem Cells Int (2011) 1.21
Molecular insights into Down syndrome-associated leukemia. Curr Opin Pediatr (2007) 1.20
Acetylation of GATA-1 is required for chromatin occupancy. Blood (2006) 1.19
Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets. Blood (2003) 1.18
E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells. J Biol Chem (2004) 1.17
Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials. Cell Host Microbe (2012) 1.16
Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models. J Exp Med (2012) 1.16
Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood (2010) 1.14
Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Blood (2004) 1.13
Do chromatin loops provide epigenetic gene expression states? Curr Opin Genet Dev (2010) 1.12
Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype. Blood (2013) 1.11
FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. EMBO J (2009) 1.10
FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood (2010) 1.09
The relative role of PLCbeta and PI3Kgamma in platelet activation. Blood (2005) 1.09