Published in J Cell Biol on December 01, 1994
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J (1998) 7.59
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem (2007) 4.60
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration. J Cell Biol (1996) 4.56
The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J Cell Biol (1998) 4.38
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol (2000) 4.36
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A (1999) 4.35
Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells. J Cell Biol (1997) 4.27
A novel role for p120 catenin in E-cadherin function. J Cell Biol (2002) 4.01
Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J Cell Biol (2000) 3.88
Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes. Mol Cell Biol (1996) 3.76
p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol (2000) 3.60
Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc Natl Acad Sci U S A (1998) 3.35
Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol Cell Biol (1999) 3.08
The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol (2003) 3.06
The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol (1999) 3.02
Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during Drosophila embryogenesis. J Cell Biol (1996) 2.89
Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus. J Cell Biol (1996) 2.86
Signal transduction by the Wnt family of ligands. Biochem J (1998) 2.66
Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. J Cell Biol (1999) 2.62
Inhibition of beta-catenin-mediated transactivation by cadherin derivatives. Proc Natl Acad Sci U S A (1998) 2.55
EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell (2009) 2.50
NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. J Cell Biol (1997) 2.42
Differential nuclear translocation and transactivation potential of beta-catenin and plakoglobin. J Cell Biol (1998) 2.38
Increased beta-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses (desmoid tumors). Am J Pathol (1997) 2.34
Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells. J Cell Biol (2000) 2.33
Rap1 regulates the formation of E-cadherin-based cell-cell contacts. Mol Cell Biol (2004) 2.31
Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. Mol Cell Biol (1998) 2.29
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol (1996) 2.27
Beta-catenin--a linchpin in colorectal carcinogenesis? Am J Pathol (2002) 2.18
Genotype-phenotype correlations in attenuated adenomatous polyposis coli. Am J Hum Genet (1998) 2.12
An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling. J Cell Biol (1996) 2.09
p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions. J Cell Biol (2003) 2.02
Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Biochem J (2002) 2.02
The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J Cell Biol (1998) 1.97
The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. Mol Cell Biol (1995) 1.96
beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev (2007) 1.96
Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein. Mol Cell Biol (1996) 1.94
Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation. Proc Natl Acad Sci U S A (2002) 1.94
Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo. J Cell Biol (1995) 1.93
Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol Cell Biol (2000) 1.93
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci U S A (2011) 1.92
Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol (2004) 1.92
Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions. J Cell Biol (1996) 1.90
gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes Dev (2000) 1.89
Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases. Mol Biol Cell (1998) 1.87
The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut (2006) 1.86
SARPs: a family of secreted apoptosis-related proteins. Proc Natl Acad Sci U S A (1997) 1.84
Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque. J Cell Biol (1996) 1.80
The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions. J Cell Biol (1996) 1.79
Anchoring junctions as drug targets: role in contraceptive development. Pharmacol Rev (2008) 1.76
Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. Proc Natl Acad Sci U S A (1998) 1.70
beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex. J Cell Biol (1996) 1.70
Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol (2007) 1.68
E-cadherin/β-catenin complex and the epithelial barrier. J Biomed Biotechnol (2011) 1.61
Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin. J Cell Biol (1997) 1.60
Regulation of beta-catenin levels and localization by overexpression of plakoglobin and inhibition of the ubiquitin-proteasome system. J Cell Biol (1997) 1.59
Feedback interactions between cell-cell adherens junctions and cytoskeletal dynamics in newt lung epithelial cells. Mol Biol Cell (2000) 1.58
Genetic interaction between Wnt/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal-ventral axis in the limb. Genes Dev (2003) 1.55
Crystal structure of a full-length beta-catenin. Structure (2008) 1.55
Mammalian LIN-7 PDZ proteins associate with beta-catenin at the cell-cell junctions of epithelia and neurons. EMBO J (2000) 1.53
Tumor suppressor gene E-cadherin and its role in normal and malignant cells. Cancer Cell Int (2003) 1.52
Epithelial-mesenchymal transition mediated tumourigenesis in the gastrointestinal tract. World J Gastroenterol (2008) 1.51
Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Genes Dev (2002) 1.50
The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts. J Cell Biol (2002) 1.49
Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression. Mol Cell Biol (1999) 1.49
Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis. J Cell Biol (1997) 1.45
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Discovering the molecular components of intercellular junctions--a historical view. Cold Spring Harb Perspect Biol (2009) 1.39
Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin. J Cell Biol (1996) 1.36
The role of altered cell-cell communication in melanoma progression. J Mol Histol (2004) 1.34
The binding of plakoglobin to desmosomal cadherins: patterns of binding sites and topogenic potential. J Cell Biol (1996) 1.34
Dissecting interactions between EB1, microtubules and APC in cortical clusters at the plasma membrane. J Cell Sci (2002) 1.33
Desmosomes: new perpetrators in tumour suppression. Nat Rev Cancer (2011) 1.33
Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling. Genes Dev (2014) 1.33
The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci U S A (2002) 1.27
Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases. Br J Cancer (1997) 1.25
Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis. J Cell Biol (1997) 1.25
Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells. Proc Natl Acad Sci U S A (1999) 1.23
Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Hepatology (2010) 1.23
Synergy between Apc min and an activated ras mutation is sufficient to induce colon carcinomas. Mol Cell Biol (1996) 1.21
Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia. Med Mol Morphol (2007) 1.20
Antagonism of cell adhesion by an alpha-catenin mutant, and of the Wnt-signaling pathway by alpha-catenin in Xenopus embryos. J Cell Biol (1997) 1.18
Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex. EMBO J (2001) 1.17
Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice. Dis Model Mech (2011) 1.16
Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. J Cell Biol (2005) 1.13
Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling. Mol Biol Cell (1999) 1.13
Regulation of E-cadherin: does hypoxia initiate the metastatic cascade? Mol Pathol (1999) 1.11
Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma. Mol Cancer (2008) 1.10
Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia. Am J Pathol (2005) 1.10
Dimer asymmetry defines α-catenin interactions. Nat Struct Mol Biol (2013) 1.07
Elevated levels of beta-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro. BMC Musculoskelet Disord (2003) 1.06
Expression of cell adhesion molecules in oesophageal carcinoma and its prognostic value. J Clin Pathol (2005) 1.06
The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila. EMBO J (1999) 1.04
Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers. Gut (1997) 1.01
Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28. Pharmacol Ther (2014) 1.00
Luteinising hormone-releasing hormone analogue reverses the cell adhesion profile of EGFR overexpressing DU-145 human prostate carcinoma subline. Br J Cancer (2005) 1.00
p120-catenin is essential for terminal end bud function and mammary morphogenesis. Development (2012) 0.99
Defining the roles of beta-catenin and plakoglobin in LEF/T-cell factor-dependent transcription using beta-catenin/plakoglobin-null F9 cells. Mol Cell Biol (2007) 0.99
Loss of heterozygosity for defined regions on chromosomes 3, 11 and 17 in carcinomas of the uterine cervix. Br J Cancer (1998) 0.98
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell (1986) 42.45
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
Identification and characterization of the familial adenomatous polyposis coli gene. Cell (1991) 14.46
Identification of FAP locus genes from chromosome 5q21. Science (1991) 11.41
The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J (1989) 10.05
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science (1991) 9.89
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell (1991) 8.75
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol (1991) 8.60
Association of the APC gene product with beta-catenin. Science (1993) 8.20
Cell binding function of E-cadherin is regulated by the cytoplasmic domain. EMBO J (1988) 7.98
Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature (1987) 7.23
Association of the APC tumor suppressor protein with catenins. Science (1993) 7.17
Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature (1993) 6.67
Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol (1989) 6.31
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell (1993) 6.29
Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells. J Cell Biol (1985) 6.09
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol (1993) 5.86
Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc Natl Acad Sci U S A (1990) 5.83
A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science (1991) 5.71
The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell (1991) 5.30
The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Cell (1991) 5.27
Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J Cell Biol (1994) 5.03
Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization. Cell (1992) 5.01
A repeating amino acid motif shared by proteins with diverse cellular roles. Cell (1994) 4.56
E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res (1994) 4.51
Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin. J Cell Biol (1994) 4.30
Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol (1990) 4.05
Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell (1986) 4.01
Identification of a putative cell adhesion domain of uvomorulin. EMBO J (1985) 3.85
Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. Cell (1990) 3.75
The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. Proc Natl Acad Sci U S A (1991) 3.62
Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells. J Cell Biol (1994) 3.61
Molecular linkage between cadherins and actin filaments in cell-cell adherens junctions. Curr Opin Cell Biol (1992) 3.61
The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell (1990) 3.57
The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. Cancer Res (1994) 3.57
Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion. Cell (1992) 3.37
The APC gene product in normal and tumor cells. Proc Natl Acad Sci U S A (1993) 3.25
Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain. Cell (1992) 3.20
p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system. EMBO J (1993) 3.06
Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion. J Cell Biol (1993) 2.95
Submembranous junctional plaque proteins include potential tumor suppressor molecules. J Cell Biol (1993) 2.87
Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Cell Adhes Commun (1994) 2.87
Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell (1991) 2.75
The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J Cell Biol (1992) 2.69
Wild-type but not mutant APC associates with the microtubule cytoskeleton. Cancer Res (1994) 2.65
Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin. J Cell Biol (1992) 2.65
Induction of a secondary body axis in Xenopus by antibodies to beta-catenin. J Cell Biol (1993) 2.50
Plakoglobin and beta-catenin: distinct but closely related. Science (1992) 2.40
E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci U S A (1994) 2.35
Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells. Nature (1994) 2.20
Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein. Proc Natl Acad Sci U S A (1989) 2.12
Mutations of the E-cadherin gene in human gynecologic cancers. Nat Genet (1994) 1.81
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc Natl Acad Sci U S A (1992) 1.70
Desmosomes and hemidesmosomes. Curr Opin Cell Biol (1993) 1.65
Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. Development (1993) 1.42
Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas. Semin Cancer Biol (1993) 1.41
Functional interaction of beta-catenin with the transcription factor LEF-1. Nature (1996) 15.88
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol (1991) 8.60
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell (2001) 8.41
Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science (1998) 8.27
Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol (1989) 6.31
Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol (1993) 5.86
Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta (1994) 5.81
Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol (2000) 4.36
Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol (1990) 4.05
Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin. J Cell Biol (1985) 3.77
New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev (2001) 3.63
The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol (2003) 3.06
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature (1996) 3.00
Differential loss of E-cadherin expression in infiltrating ductal and lobular breast carcinomas. Am J Pathol (1993) 2.84
In vivo distribution and turnover of fluorescently labeled actin microinjected into human fibroblasts. Proc Natl Acad Sci U S A (1979) 2.71
Microinjection of fluorescently labeled proteins into living cells with emphasis on cytoskeletal proteins. Int Rev Cytol (1982) 2.70
E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res (1991) 2.67
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. EMBO J (1992) 2.65
Cell-cell interaction and polarity of epithelial cells: specific perturbation using a monoclonal antibody. Cell (1983) 2.56
E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration. Cancer Res (1993) 2.55
On the mechanism of ATP-induced shape changes in human erythrocyte membranes. II. The role of ATP. J Cell Biol (1977) 2.54
The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J Cell Biol (1993) 2.53
Inhibitory action of transforming growth factor beta on endothelial cells. Proc Natl Acad Sci U S A (1987) 2.50
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J Cell Biol (2000) 2.48
Stress fiber sarcomeres of fibroblasts are contractile. Cell (1980) 2.45
E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci U S A (1994) 2.35
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol (1996) 2.27
Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol (2000) 1.97
Biochemical interactions in the wnt pathway. Biochim Biophys Acta (2000) 1.96
V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift. J Cell Biol (1995) 1.92
Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells. J Cell Biol (1995) 1.91
Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J Cell Biol (1995) 1.91
Transforming growth factor-beta inhibits endothelial cell proliferation. Biochem Biophys Res Commun (1986) 1.86
Epithelial-mesenchymal transitions in cancer progression. Acta Anat (Basel) (1996) 1.84
Snail promotes Wnt target gene expression and interacts with beta-catenin. Oncogene (2008) 1.76
The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element. Proc Natl Acad Sci U S A (1991) 1.74
New surface component of fibroblast's focal contacts identified by a monoclonal antibody. Cell (1982) 1.73
A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc Natl Acad Sci U S A (1992) 1.70
Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development (2001) 1.69
Hot spots in beta-catenin for interactions with LEF-1, conductin and APC. Nat Struct Biol (2000) 1.67
Molecular aspects of mesenchymal-epithelial interactions. Annu Rev Cell Biol (1993) 1.63
Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice. Int J Cancer (1991) 1.61
Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. Oncogene (1995) 1.61
Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas. Cancer Res (2001) 1.60
E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice. Gastroenterology (2000) 1.57
Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis. J Cell Biol (1998) 1.56
Monoacetoxyscirpenol. A new mycotoxin produced by Fusarium roseum Gibbosum. J Agric Food Chem (1976) 1.55
Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility. Oncogene (1999) 1.55
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol (2001) 1.52
Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential. J Biol Chem (2000) 1.50
Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection. Curr Opin Cell Biol (1994) 1.48
Corrugated attachment membrane in WI-38 fibroblasts: alternating fibronectin fibers and actin-containing focal contacts. Proc Natl Acad Sci U S A (1980) 1.43
Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas. Semin Cancer Biol (1993) 1.41
Prognostic value of E-cadherin expression in 413 gastric carcinomas. Int J Cancer (1996) 1.40
RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol Cell Biol (1998) 1.39
Role of morphogenetic factors in metastasis of mammary carcinoma cells. Oncogene (1998) 1.38
Iron in prenatal multivitamin/multimineral supplements. Bioavailability. J Reprod Med (1998) 1.38
The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif. Oncogene (2001) 1.34
Rapid flow cytometric test for the diagnosis of membrane cytoskeleton-associated haemolytic anaemia. Br J Haematol (2000) 1.34
Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cells. J Cell Sci Suppl (1993) 1.34
Mechanisms identified in the transcriptional control of epithelial gene expression. J Biol Chem (1996) 1.29
The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras. J Biol Chem (1994) 1.27
Nutritional interventions for preventing and treating pressure ulcers. Cochrane Database Syst Rev (2003) 1.26
Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. J Biol Chem (2000) 1.22
Cytoplasmic aspartate aminotransferase: syncatalytic sulfhydryl group modification. J Biol Chem (1973) 1.22
Motogenic and morphogenic activity of epithelial receptor tyrosine kinases. J Cell Biol (1996) 1.16
Cell adhesion in invasion and metastasis. Semin Cell Biol (1992) 1.15
Uterotropic activity of cis and trans isomers of zearalenone and zearalenol. Appl Environ Microbiol (1978) 1.13
Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc Natl Acad Sci U S A (1995) 1.13
Effort-reward imbalance and burnout among German nurses in medical compared with psychiatric hospital settings. J Psychiatr Ment Health Nurs (2009) 1.10
Molecular characteristics of HGF-SF and its role in cell motility and invasion. EXS (1993) 1.10
Expression of E-cadherin and catenins in invasive mammary carcinomas. Anticancer Res (1997) 1.10
Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo. Curr Biol (1998) 1.10
Control of cell locomotion: perturbation with an antibody directed against specific glycoproteins. Cell (1985) 1.09
Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: implications for cell adhesion and signaling. Eur J Cancer (1999) 1.07
Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas. Cancer Res (1994) 1.06
Use of thalidomide in patients with myeloma and renal failure may be associated with unexplained hyperkalaemia. Br J Haematol (2003) 1.05
Substances interfering with the gas-liquid chromatographic determination of T-2 mycotoxin. J Assoc Off Anal Chem (1976) 1.05
Intracellular and extracellular components involved in the formation of ventral surfaces of fibroblasts. Cold Spring Harb Symp Quant Biol (1982) 1.02
Differences of E-cadherin expression levels and patterns in primary and metastatic human lung cancer. Clin Exp Metastasis (1994) 1.02
Epithelial differentiation and the control of metastasis in carcinomas. Curr Top Microbiol Immunol (1996) 1.01
Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development. Genomics (1994) 1.01
The Wnt signalling pathway. J Cell Sci (2000) 1.00