Adipose tissue dysregulation in patients with metabolic syndrome.

PubWeight™: 1.25‹?› | Rank: Top 10%

🔗 View Article (PMC 3205887)

Published in J Clin Endocrinol Metab on August 24, 2011

Authors

Andrew A Bremer1, Sridevi Devaraj, Alaa Afify, Ishwarlal Jialal

Author Affiliations

1: Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232, USA.

Articles citing this

Toward a unifying hypothesis of metabolic syndrome. Pediatrics (2012) 1.36

Adipose tissue dysfunction in nascent metabolic syndrome. J Obes (2013) 1.26

Body fat distribution and insulin resistance. Nutrients (2013) 1.11

Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol (2012) 1.09

Increased toll-like receptor activity in patients with metabolic syndrome. Diabetes Care (2012) 1.07

Contributions of adipose tissue architectural and tensile properties toward defining healthy and unhealthy obesity. Am J Physiol Endocrinol Metab (2013) 1.02

Relation of depot-specific adipose inflammation to insulin resistance in human obesity. Nutr Diabetes (2012) 0.95

Role of subcutaneous adipose tissue in the pathogenesis of insulin resistance. J Obes (2013) 0.95

The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer. Cancers (Basel) (2015) 0.93

B lymphocytes in human subcutaneous adipose crown-like structures. Obesity (Silver Spring) (2012) 0.92

Serum IL-12 is increased in Mexican obese subjects and associated with low-grade inflammation and obesity-related parameters. Mediators Inflamm (2013) 0.91

Inflammatory "adiposopathy" in major amputation patients. Ann Vasc Surg (2013) 0.90

Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus. Part Fibre Toxicol (2014) 0.89

Adiponectin Levels Differentiate Metabolically Healthy vs Unhealthy Among Obese and Nonobese White Individuals. J Clin Endocrinol Metab (2015) 0.87

Hepatic crown-like structure: a unique histological feature in non-alcoholic steatohepatitis in mice and humans. PLoS One (2013) 0.87

Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol (2013) 0.86

Acute psychological stress results in the rapid development of insulin resistance. J Endocrinol (2013) 0.86

Obesity-related insulin resistance: implications for the surgical patient. Int J Obes (Lond) (2015) 0.84

Hyperleptinemia is associated with parameters of low-grade systemic inflammation and metabolic dysfunction in obese human beings. Front Integr Neurosci (2013) 0.83

Impact of Obesity and Metabolic Syndrome on Immunity. Adv Nutr (2016) 0.83

Role of MCP-1 on inflammatory processes and metabolic dysfunction following high-fat feedings in the FVB/N strain. Int J Obes (Lond) (2015) 0.82

Metabolic syndrome in the offspring of centenarians: focus on prevalence, components, and adipokines. Age (Dordr) (2012) 0.82

Impact of uremia on human adipose tissue phenotype. J Surg Res (2012) 0.82

Targeting adipose tissue inflammation to treat the underlying basis of the metabolic complications of obesity. Nestle Nutr Inst Workshop Ser (2012) 0.81

Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss. Int J Obes (Lond) (2016) 0.79

Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism. Mol Cell Biol (2015) 0.78

Evaluation of the relationship between circulating omentin-1 concentrations and components of the metabolic syndrome in adults without type 2 diabetes or cardiovascular disease. Diabetol Metab Syndr (2014) 0.78

Time course of histomorphological changes in adipose tissue upon acute lipoatrophy. Nutr Metab Cardiovasc Dis (2012) 0.77

Therapeutic value of brown adipose tissue: Correcting metabolic disease through generating healthy fat. Adipocyte (2012) 0.77

Benefits of healthy adipose tissue in the treatment of diabetes. World J Diabetes (2014) 0.77

Opportunities and challenges in three-dimensional brown adipogenesis of stem cells. Biotechnol Adv (2015) 0.76

Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4. Mol Vis (2017) 0.75

Articles cited by this

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA (2001) 118.65

Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia (1985) 109.13

Inflammation and metabolic disorders. Nature (2006) 33.33

The metabolic syndrome. Lancet (2005) 19.47

The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA (2002) 18.43

Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation (2007) 12.79

The metabolic syndrome. Endocr Rev (2008) 5.33

NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes (2003) 5.11

Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J (2008) 4.74

Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes (1997) 4.15

Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes (2004) 4.04

Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation (2003) 3.73

Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest (1995) 3.44

Persistent increase of prevalence of metabolic syndrome among U.S. adults: NHANES III to NHANES 1999-2006. Diabetes Care (2010) 3.37

Components of the "metabolic syndrome" and incidence of type 2 diabetes. Diabetes (2002) 3.14

Is visceral obesity the cause of the metabolic syndrome? Ann Med (2006) 2.83

Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol (2008) 2.82

Abdominal subcutaneous adipose tissue: a protective fat depot? Diabetes Care (2009) 2.80

Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes (2009) 2.43

Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol (2007) 2.40

The insulin resistance syndrome: definition and dietary approaches to treatment. Annu Rev Nutr (2005) 2.23

Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm (2010) 2.18

Adipokines as novel biomarkers and regulators of the metabolic syndrome. Ann N Y Acad Sci (2010) 2.16

C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis. Circulation (2003) 2.09

Worsening of obesity and metabolic status yields similar molecular adaptations in human subcutaneous and visceral adipose tissue: decreased metabolism and increased immune response. J Clin Endocrinol Metab (2010) 1.92

Cellular hypoxia and adipose tissue dysfunction in obesity. Proc Nutr Soc (2009) 1.71

Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. Circulation (2004) 1.65

Lipodystrophy: metabolic insights from a rare disorder. J Endocrinol (2010) 1.60

Adipose tissue recruitment of leukocytes. Curr Opin Lipidol (2010) 1.60

Adipose tissue gene expression of adiponectin, tumor necrosis factor-α and leptin in metabolic syndrome patients with coronary artery disease. Intern Med (2011) 1.54

The insulin resistance-dyslipidemic syndrome: contribution of visceral obesity and therapeutic implications. Int J Obes Relat Metab Disord (1995) 1.49

Dual role of CCR2 in the constitution and the resolution of liver fibrosis in mice. Am J Pathol (2009) 1.49

Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J Biol Chem (2008) 1.48

Macrophage infiltration into adipose tissue: initiation, propagation and remodeling. Future Lipidol (2008) 1.44

Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM. Diabetes (1996) 1.43

The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness: the Amsterdam Growth and Health Longitudinal Study. Arch Intern Med (2005) 1.25

Decreased number and impaired functionality of endothelial progenitor cells in subjects with metabolic syndrome: implications for increased cardiovascular risk. Atherosclerosis (2010) 1.18

Macrophage conditioned medium induces the expression of C-reactive protein in human aortic endothelial cells: potential for paracrine/autocrine effects. Am J Pathol (2005) 1.10

Diabetes is a proinflammatory state: a translational perspective. Expert Rev Endocrinol Metab (2010) 1.06

Inflammatory genes in epicardial fat contiguous with coronary atherosclerosis in the metabolic syndrome and type 2 diabetes: changes associated with pioglitazone. Diabetes Care (2011) 1.03

Inherited lipodystrophies and the metabolic syndrome. Clin Endocrinol (Oxf) (2007) 0.97

Cardiovascular risk assessment in metabolic syndrome: view from PROCAM. Endocrinol Metab Clin North Am (2004) 0.84

Metabolic syndrome - a new risk factor of coronary heart disease? Diabetes Obes Metab (2003) 0.82

Articles by these authors

Association of apolipoprotein B and nuclear magnetic resonance spectroscopy-derived LDL particle number with outcomes in 25 clinical studies: assessment by the AACC Lipoprotein and Vascular Diseases Division Working Group on Best Practices. Clin Chem (2013) 2.90

Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. J Clin Endocrinol Metab (2007) 2.84

Vitamins E and C are safe across a broad range of intakes. Am J Clin Nutr (2005) 2.72

Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes. Diabetes (2006) 2.65

Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation (2002) 2.50

Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care (2010) 2.39

Adiponectin decreases C-reactive protein synthesis and secretion from endothelial cells: evidence for an adipose tissue-vascular loop. Arterioscler Thromb Vasc Biol (2008) 2.29

High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes (2008) 2.23

C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis. Circulation (2003) 2.09

Is C-reactive protein an innocent bystander or proatherogenic culprit? C-reactive protein promotes atherothrombosis. Circulation (2006) 2.06

C-reactive protein: risk marker or mediator in atherothrombosis? Hypertension (2004) 1.99

Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes. Cytokine (2011) 1.91

Retracted Alpha-lipoic acid supplementation and diabetes. Nutr Rev (2008) 1.86

High glucose induces IL-1beta expression in human monocytes: mechanistic insights. Am J Physiol Endocrinol Metab (2007) 1.85

Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications. Diabetes (2007) 1.84

Validation of an immunoassay for soluble Klotho protein: decreased levels in diabetes and increased levels in chronic kidney disease. Am J Clin Pathol (2012) 1.67

Apolipoprotein B and cardiovascular disease risk: position statement from the AACC Lipoproteins and Vascular Diseases Division Working Group on Best Practices. Clin Chem (2009) 1.57

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. Free Radic Biol Med (2012) 1.54

Development of an in vitro screening assay to test the antiinflammatory properties of dietary supplements and pharmacologic agents. Clin Chem (2005) 1.53

Oxidative stress and atherosclerosis. Pathophysiology (2006) 1.52

Plasma antioxidant capacity in response to diets high in soy or animal protein with or without isoflavones. Am J Clin Nutr (2005) 1.51

Comparison effect of atorvastatin (10 versus 80 mg) on biomarkers of inflammation and oxidative stress in subjects with metabolic syndrome. Am J Cardiol (2008) 1.51

Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}. Diabetes (2005) 1.50

The evolving role of C-reactive protein in atherothrombosis. Clin Chem (2008) 1.48

Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. Am J Physiol Endocrinol Metab (2010) 1.45

Contrasting effects of oral versus transdermal estrogen on serum amyloid A (SAA) and high-density lipoprotein-SAA in postmenopausal women. Arterioscler Thromb Vasc Biol (2004) 1.43

Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndrome. J Clin Endocrinol Metab (2006) 1.42

Human C-reactive protein and the metabolic syndrome. Curr Opin Lipidol (2009) 1.40

Quantification of daratumumab in the serum protein electrophoresis. Clin Chem Lab Med (2016) 1.39

CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol (2010) 1.37

Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy. Arterioscler Thromb Vasc Biol (2011) 1.34

C-reactive protein decreases prostacyclin release from human aortic endothelial cells. Circulation (2003) 1.34

Dietary factors that promote or retard inflammation. Arterioscler Thromb Vasc Biol (2006) 1.32

Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med (2007) 1.30

The biological effects of CRP are not attributable to endotoxin contamination: evidence from TLR4 knockdown human aortic endothelial cells. J Lipid Res (2006) 1.28

Adipose tissue dysfunction in nascent metabolic syndrome. J Obes (2013) 1.26

Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo. Atherosclerosis (2009) 1.26

C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling. J Mol Cell Cardiol (2007) 1.25

Alpha-tocopherol decreases superoxide anion release in human monocytes under hyperglycemic conditions via inhibition of protein kinase C-alpha. Diabetes (2002) 1.24

Binding and internalization of C-reactive protein by Fcgamma receptors on human aortic endothelial cells mediates biological effects. Arterioscler Thromb Vasc Biol (2005) 1.23

Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin Nutr (2002) 1.23

C-reactive protein stimulates superoxide anion release and tissue factor activity in vivo. Atherosclerosis (2008) 1.21

C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production. Arterioscler Thromb Vasc Biol (2006) 1.21

Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States. J Clin Endocrinol Metab (2003) 1.19

Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo. Gastroenterology (2010) 1.18

Metabolic syndrome: an appraisal of the pro-inflammatory and procoagulant status. Endocrinol Metab Clin North Am (2004) 1.17

Innate immunity genes influence the severity of acute appendicitis. Ann Surg (2004) 1.16

C-reactive protein polarizes human macrophages to an M1 phenotype and inhibits transformation to the M2 phenotype. Arterioscler Thromb Vasc Biol (2011) 1.15

Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. AIDS (2013) 1.14

Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease. Am J Clin Nutr (2007) 1.14

Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role. Curr Opin Nephrol Hypertens (2005) 1.14

Elevated interleukin 8 and T-helper 1 and T-helper 17 cytokine levels prior to antiretroviral therapy in participants who developed immune reconstitution inflammatory syndrome during ACTG A5164. J Infect Dis (2012) 1.12

CRP and adiponectin and its oligomers in the metabolic syndrome: evaluation of new laboratory-based biomarkers. Am J Clin Pathol (2008) 1.10

Inflammation, atherosclerosis, and psoriasis. Clin Rev Allergy Immunol (2013) 1.10

Macrophage conditioned medium induces the expression of C-reactive protein in human aortic endothelial cells: potential for paracrine/autocrine effects. Am J Pathol (2005) 1.10

Toll-like receptor status in obesity and metabolic syndrome: a translational perspective. J Clin Endocrinol Metab (2013) 1.09

Correlation of microvascular abnormalities and endothelial dysfunction in Type-1 Diabetes Mellitus (T1DM): a real-time intravital microscopy study. Clin Hemorheol Microcirc (2009) 1.09

Increased toll-like receptor activity in patients with metabolic syndrome. Diabetes Care (2012) 1.07

Diabetes is a proinflammatory state: a translational perspective. Expert Rev Endocrinol Metab (2010) 1.06

Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radic Biol Med (2004) 1.05

Increased chemerin and decreased omentin-1 in both adipose tissue and plasma in nascent metabolic syndrome. J Clin Endocrinol Metab (2013) 1.04

CRP promotes monocyte-endothelial cell adhesion via Fcgamma receptors in human aortic endothelial cells under static and shear flow conditions. Am J Physiol Heart Circ Physiol (2006) 1.04

Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications. Metabolism (2010) 1.02

Failure of vitamin E in clinical trials: is gamma-tocopherol the answer? Nutr Rev (2005) 1.01

Defining the proinflammatory phenotype using high sensitive C-reactive protein levels as the biomarker. J Clin Endocrinol Metab (2005) 1.01

Low vitamin D levels correlate with the proinflammatory state in type 1 diabetic subjects with and without microvascular complications. Am J Clin Pathol (2011) 1.01

High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome. Metabolism (2008) 1.00

C-reactive protein decreases tissue plasminogen activator activity in human aortic endothelial cells: evidence that C-reactive protein is a procoagulant. Arterioscler Thromb Vasc Biol (2005) 1.00

Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans. J Nutr (2002) 0.99

Impaired homocysteine transsulfuration is an indicator of alcoholic liver disease. J Hepatol (2010) 0.99

S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet. Alcohol Clin Exp Res (2007) 0.99

Reduced-calorie orange juice beverage with plant sterols lowers C-reactive protein concentrations and improves the lipid profile in human volunteers. Am J Clin Nutr (2006) 0.98

Coenzyme Q10 supplementation and heart failure. Nutr Rev (2007) 0.98

Simvastatin (40 mg/day), adiponectin levels, and insulin sensitivity in subjects with the metabolic syndrome. Am J Cardiol (2007) 0.98

Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. J Nutr Biochem (2010) 0.97