Published in JAMA on December 04, 2002
Mechanisms Underlying Psychosocial Associations With Ischemic Heart Disease (Kuopio) | NCT00005260
Sleep Loss and Mechanisms of Impaired Glucose Metabolism | NCT00555750
Effects of Pravastatin on Cholesterol, Inflammation and Cognition in Schizophrenia | NCT01082588
Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med (2010) 8.70
Multiple chronic conditions: prevalence, health consequences, and implications for quality, care management, and costs. J Gen Intern Med (2007) 6.14
The metabolic syndrome. Endocr Rev (2008) 5.33
Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation (2008) 4.61
Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry (2007) 3.92
Metabolic syndrome: definitions and controversies. BMC Med (2011) 3.80
Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 3.48
Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J Physiol (2005) 2.86
Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study. Lancet (2009) 2.73
Metabolic syndrome and risk of development of atrial fibrillation: the Niigata preventive medicine study. Circulation (2008) 2.72
Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol (2007) 2.71
Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol (2009) 2.70
Self-reported sleep duration is associated with the metabolic syndrome in midlife adults. Sleep (2008) 2.60
Metabolic syndrome and ischemic stroke risk: Northern Manhattan Study. Stroke (2007) 2.55
Effects of prandial versus fasting glycemia on cardiovascular outcomes in type 2 diabetes: the HEART2D trial. Diabetes Care (2009) 2.50
Women and ischemic heart disease: evolving knowledge. J Am Coll Cardiol (2009) 2.49
Examining the etiology of childhood obesity: The IDEA study. Am J Community Psychol (2009) 2.45
Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom. J Invest Dermatol (2011) 2.36
Instability in the diagnosis of metabolic syndrome in adolescents. Circulation (2007) 2.29
Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study. Circulation (2006) 2.27
Gender differences in the metabolic syndrome and their role for cardiovascular disease. Clin Res Cardiol (2006) 2.22
Cardiovascular mortality after androgen deprivation therapy for locally advanced prostate cancer: RTOG 85-31. J Clin Oncol (2008) 2.20
Presence of the metabolic syndrome in obese adolescents predicts impaired glucose tolerance and nonalcoholic fatty liver disease. J Adolesc Health (2008) 2.16
Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab (2013) 2.16
Uric acid and the development of metabolic syndrome in women and men. Metabolism (2008) 2.09
High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: association with disease characteristics and cardiovascular risk factors. Ann Rheum Dis (2006) 2.00
Suicide attempt in young people: a signal for long-term health care and social needs. JAMA Psychiatry (2014) 1.99
A prevalence of cardiometabolic risk factors among a rural Yoruba south-western Nigerian population: a population-based survey. Cardiovasc J Afr (2010) 1.86
Metabolic syndrome, diabetes, and incidence and progression of coronary calcium: the Multiethnic Study of Atherosclerosis study. JACC Cardiovasc Imaging (2012) 1.85
Effects of lifestyle modification on metabolic syndrome: a systematic review and meta-analysis. BMC Med (2012) 1.82
Effects of etanercept in patients with the metabolic syndrome. Arch Intern Med (2006) 1.82
Aging in adipocytes: potential impact of inherent, depot-specific mechanisms. Exp Gerontol (2007) 1.81
Cardiac markers of pre-clinical disease in adolescents with the metabolic syndrome: the strong heart study. J Am Coll Cardiol (2008) 1.81
Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease. Am J Cardiol (2008) 1.74
Mechanisms linking nonalcoholic fatty liver disease with coronary artery disease. Dig Dis Sci (2011) 1.74
Depressive symptoms and metabolic syndrome: is inflammation the underlying link? Biol Psychiatry (2008) 1.70
The triad of erectile dysfunction, hypogonadism and the metabolic syndrome. Int J Clin Pract (2008) 1.69
Exercise and the metabolic syndrome with weight regain. J Appl Physiol (1985) (2010) 1.66
Impact of metabolic syndrome on cognition and brain: a selected review of the literature. Arterioscler Thromb Vasc Biol (2012) 1.63
Optimal waist circumference cutoff values for metabolic syndrome diagnostic criteria in a Korean rural population. J Korean Med Sci (2010) 1.61
Novel noninvasive breath test method for screening individuals at risk for diabetes. Diabetes Care (2008) 1.57
The association between metabolic syndrome and hepatocellular carcinoma: systemic review and meta-analysis. J Clin Gastroenterol (2014) 1.57
Distinct component profiles and high risk among African Americans with metabolic syndrome: the Jackson Heart Study. Diabetes Care (2008) 1.56
Sleep symptoms predict the development of the metabolic syndrome. Sleep (2010) 1.55
Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project. PLoS One (2014) 1.54
Rodent models for metabolic syndrome research. J Biomed Biotechnol (2010) 1.53
Comparison of usefulness of body mass index versus metabolic risk factors in predicting 10-year risk of cardiovascular events in women. Am J Cardiol (2007) 1.52
Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three-City Study. Diabetes Care (2008) 1.52
The benefits of body weight loss on health-related quality of life. J Chin Med Assoc (2011) 1.51
Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing. J Physiol (2006) 1.50
Prospective study of liver transplant recipients with HCV infection: evidence for a causal relationship between HCV and insulin resistance. Liver Transpl (2008) 1.50
Androgen deprivation therapy for prostate cancer: new concepts and concerns. Curr Opin Endocrinol Diabetes Obes (2007) 1.49
Comparison of different definitions of the metabolic syndrome in relation to cardiovascular mortality in European men and women. Diabetologia (2006) 1.48
Increased Rho kinase activity in a Taiwanese population with metabolic syndrome. J Am Coll Cardiol (2007) 1.46
Urbanization, physical activity, and metabolic health in sub-Saharan Africa. Diabetes Care (2011) 1.46
Can bipolar disorder be viewed as a multi-system inflammatory disease? J Affect Disord (2012) 1.46
Plasminogen activator inhibitor-1 (PAI-1): a key factor linking fibrinolysis and age-related subclinical and clinical conditions. Cardiovasc Ther (2010) 1.46
Disruption of protein kinase A in mice enhances healthy aging. PLoS One (2009) 1.43
Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arterioscler Thromb Vasc Biol (2010) 1.40
Metabolic syndrome and all-cause mortality: a meta-analysis of prospective cohort studies. Eur J Epidemiol (2010) 1.40
Retracted Association of cigarette smoking and metabolic syndrome in a puerto rican adult population. Int J Prev Med (2014) 1.40
Family physician-led, team-based, lifestyle intervention in patients with metabolic syndrome: results of a multicentre feasibility project. CMAJ Open (2017) 1.40
Human C-reactive protein and the metabolic syndrome. Curr Opin Lipidol (2009) 1.40
Metabolic syndrome among Sri Lankan adults: prevalence, patterns and correlates. Diabetol Metab Syndr (2012) 1.39
Dyslipidemic drugs in metabolic syndrome. Indian J Endocrinol Metab (2013) 1.39
Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. Cardiovasc Res (2008) 1.37
Diet soft drink consumption is associated with an increased risk of vascular events in the Northern Manhattan Study. J Gen Intern Med (2012) 1.37
Epicardial perivascular adipose-derived leptin exacerbates coronary endothelial dysfunction in metabolic syndrome via a protein kinase C-beta pathway. Arterioscler Thromb Vasc Biol (2010) 1.35
The vicious circle between oxidative stress and inflammation in atherosclerosis. J Cell Mol Med (2009) 1.35
Extent and management of cardiovascular risk factors in patients with type 2 diabetes and serious mental illness. J Nerv Ment Dis (2006) 1.33
Association between socioeconomic status and metabolic syndrome in women: testing the reserve capacity model. Health Psychol (2008) 1.33
Can body mass index, waist circumference, waist-hip ratio and waist-height ratio predict the presence of multiple metabolic risk factors in Chinese subjects? BMC Public Health (2011) 1.33
Prevalence of metabolic syndrome in the Canadian adult population. CMAJ (2011) 1.32
Objectively measured light-intensity lifestyle activity and sedentary time are independently associated with metabolic syndrome: a cross-sectional study of Japanese adults. Int J Behav Nutr Phys Act (2013) 1.30
Impact of subclinical atherosclerosis on cardiovascular disease events in individuals with metabolic syndrome and diabetes: the multi-ethnic study of atherosclerosis. Diabetes Care (2011) 1.29
Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population. Environ Health Perspect (2008) 1.28
Depressive symptoms and the metabolic syndrome in childhood and adulthood: a prospective cohort study. Health Psychol (2009) 1.27
Association between metabolic syndrome and depressive symptoms in middle-aged adults: results from the Whitehall II study. Diabetes Care (2008) 1.27
Obstructive sleep apnoea is independently associated with the metabolic syndrome but not insulin resistance state. Cardiovasc Diabetol (2006) 1.27
The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans. BMC Med (2009) 1.26
Adipose tissue dysfunction in nascent metabolic syndrome. J Obes (2013) 1.26
The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus. J Cardiometab Syndr (2009) 1.25
Adipose tissue dysregulation in patients with metabolic syndrome. J Clin Endocrinol Metab (2011) 1.25
Metabolic syndrome and cancer. Metab Syndr Relat Disord (2009) 1.24
Metabolic syndrome in South Asians. Indian J Endocrinol Metab (2012) 1.24
The stability of metabolic syndrome in children and adolescents. J Clin Endocrinol Metab (2009) 1.23
Metabolic syndrome, inflammation and atherosclerosis. Vasc Health Risk Manag (2006) 1.23
Abdominal obesity is associated with microalbuminuria and an elevated cardiovascular risk profile in patients with hypertension. Vasc Health Risk Manag (2009) 1.22
APOC3 promoter polymorphisms C-482T and T-455C are associated with the metabolic syndrome. Arch Med Res (2007) 1.22
Impact of 4 different definitions used for the assessment of the prevalence of the Metabolic Syndrome in primary healthcare: The German Metabolic and Cardiovascular Risk Project (GEMCAS). Cardiovasc Diabetol (2007) 1.22
Metabolic syndrome, endothelial dysfunction, and risk of cardiovascular events: the Northern Manhattan Study (NOMAS). Am Heart J (2008) 1.22
Leisure-time physical activity and the metabolic syndrome in the Finnish diabetes prevention study. Diabetes Care (2010) 1.22
Relationship of metabolic syndrome and obstructive sleep apnea. J Clin Sleep Med (2007) 1.21
The progression of cardiometabolic disease: validation of a new cardiometabolic disease staging system applicable to obesity. Obesity (Silver Spring) (2013) 1.21
Association of incident gout and mortality in dialysis patients. J Am Soc Nephrol (2008) 1.20
Obesity, insulin resistance and cancer risk. Yonsei Med J (2005) 1.20
Heritabilities of the metabolic syndrome and its components in the Northern Manhattan Family Study. Diabetologia (2005) 1.20
Apelin is necessary for the maintenance of insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 1.19
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet (2008) 35.06
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Sustained reduction in the incidence of type 2 diabetes by lifestyle intervention: follow-up of the Finnish Diabetes Prevention Study. Lancet (2006) 11.64
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA (2003) 9.06
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
The diabetes risk score: a practical tool to predict type 2 diabetes risk. Diabetes Care (2003) 7.74
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med (2012) 6.39
Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med (2014) 6.12
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
The burden of mortality attributable to diabetes: realistic estimates for the year 2000. Diabetes Care (2005) 5.80
The Finnish Diabetes Prevention Study (DPS): Lifestyle intervention and 3-year results on diet and physical activity. Diabetes Care (2003) 5.48
European population substructure: clustering of northern and southern populations. PLoS Genet (2006) 5.27
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet (2008) 4.84
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet (2008) 4.66
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol (2006) 4.54
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol (2005) 4.49
Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes (2003) 4.44
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol (2005) 3.95
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Age at initiation and frequency of screening to detect type 2 diabetes: a cost-effectiveness analysis. Lancet (2010) 3.92
Lipid-related markers and cardiovascular disease prediction. JAMA (2012) 3.91
Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study. Arch Intern Med (2004) 3.80
Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med (2004) 3.68
Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA (2012) 3.67
Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol (2002) 3.66
The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med (2002) 3.61
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol (2008) 3.28
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care (2004) 3.07
Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial. Ann Intern Med (2004) 3.05
The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med (2006) 3.05
Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28,838 middle-aged men and women. Eur Heart J (2006) 2.94
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Joint effects of physical activity, body mass index, waist circumference and waist-to-hip ratio with the risk of cardiovascular disease among middle-aged Finnish men and women. Eur Heart J (2004) 2.92
Cross-sectional evaluation of the Finnish Diabetes Risk Score: a tool to identify undetected type 2 diabetes, abnormal glucose tolerance and metabolic syndrome. Diab Vasc Dis Res (2005) 2.91
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet (2013) 2.87
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study. Diabetes (2005) 2.82
The validity of the Finnish Hospital Discharge Register and Causes of Death Register data on coronary heart disease. Eur J Cardiovasc Prev Rehabil (2005) 2.78
Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men. Arterioscler Thromb Vasc Biol (2007) 2.74
Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care (2002) 2.69
Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation (2003) 2.63
Physical activity in prevention and treatment of the metabolic syndrome. Appl Physiol Nutr Metab (2007) 2.63
Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes (2006) 2.58
Life course socioeconomic conditions and adult psychosocial functioning. Int J Epidemiol (2002) 2.57
Lifestyle intervention for prevention of type 2 diabetes in primary health care: one-year follow-up of the Finnish National Diabetes Prevention Program (FIN-D2D). Diabetes Care (2010) 2.50
Type 2 diabetes and the risk of Parkinson's disease. Diabetes Care (2007) 2.48
A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14. Diabetes (2004) 2.46
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes. Diabetes (2004) 2.43
Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann Intern Med (2002) 2.41
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet (2012) 2.34
Body mass index, waist circumference, and waist-hip ratio on the risk of total and type-specific stroke. Arch Intern Med (2007) 2.31
Cardiorespiratory fitness and the risk for stroke in men. Arch Intern Med (2003) 2.22
Dietary factors and low-grade inflammation in relation to overweight and obesity. Br J Nutr (2011) 2.16
Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland. Arterioscler Thromb Vasc Biol (2004) 2.15
Serum γ-glutamyltransferase and the risk of heart failure in men and women in Finland. Heart (2012) 2.10
Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation. Arch Intern Med (2004) 2.05