Central Leptin Regulation of Obesity and Fertility.

PubWeight™: 0.81‹?›

🔗 View Article (PMID 23243628)

Published in Curr Obes Rep on December 01, 2012

Authors

Qingchun Tong1, Yong Xu

Author Affiliations

1: The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, Texas, 77030.

Articles cited by this

Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 38.85

The global obesity pandemic: shaped by global drivers and local environments. Lancet (2011) 13.23

Health and economic burden of the projected obesity trends in the USA and the UK. Lancet (2011) 10.73

Identification and expression cloning of a leptin receptor, OB-R. Cell (1995) 9.74

Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics (1997) 9.24

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature (2001) 8.95

Abnormal splicing of the leptin receptor in diabetic mice. Nature (1996) 7.71

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell (1996) 7.45

Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature (1997) 7.33

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron (2004) 7.15

Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med (1999) 6.94

NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science (2005) 6.55

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science (1997) 6.23

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest (2002) 5.83

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature (1998) 5.75

Obesity wars: molecular progress confronts an expanding epidemic. Cell (2004) 5.29

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron (2006) 5.27

Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia (1978) 5.21

Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron (2011) 4.88

Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med (2004) 4.87

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci (2003) 4.83

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci (2008) 3.90

Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest (2001) 3.82

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet (1996) 3.71

Identification of targets of leptin action in rat hypothalamus. J Clin Invest (1996) 3.49

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab (2005) 3.38

Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci (2007) 3.35

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest (2005) 3.29

Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science (1974) 3.20

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab (2007) 3.02

Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology (2007) 2.95

Leptin targets in the mouse brain. J Comp Neurol (2009) 2.80

Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79

Is dopamine a physiologically relevant mediator of feeding behavior? Trends Neurosci (2007) 2.59

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58

Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls. Pediatrics (2010) 2.51

Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J Neurosci (2010) 2.42

The relation of menarcheal age to obesity in childhood and adulthood: the Bogalusa heart study. BMC Pediatr (2003) 2.32

Leptin is a metabolic signal to the reproductive system. Endocrinology (1996) 2.28

Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons. Endocrinology (2004) 2.15

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J Clin Invest (2012) 2.12

Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci U S A (1997) 2.04

Female reproductive maturation in the absence of kisspeptin/GPR54 signaling. Nat Neurosci (2011) 1.96

Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. J Neurosci (2011) 1.93

KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. J Neuroendocrinol (2006) 1.92

Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci (2009) 1.85

Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab (2011) 1.85

Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits. J Neurosci (2011) 1.82

Leptin-dependent control of glucose balance and locomotor activity by POMC neurons. Cell Metab (2009) 1.79

Role of GABA release from leptin receptor-expressing neurons in body weight regulation. Endocrinology (2012) 1.68

Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice. J Clin Invest (2011) 1.65

The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab (2003) 1.64

Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes (2001) 1.62

Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity. Cell Metab (2011) 1.61

Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest (2010) 1.49

Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience (2010) 1.49

Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells. Brain Res (2011) 1.46

Influence of obesity on timing of puberty. Int J Androl (2005) 1.41

Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. Proc Natl Acad Sci U S A (1998) 1.39

Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology (1998) 1.39

Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology (1997) 1.35

Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes (2006) 1.26

Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat Med (2012) 1.22

Leptin: linking obesity, the metabolic syndrome, and cardiovascular disease. Curr Hypertens Rep (2008) 1.22

Leptin in reproduction. Curr Opin Endocrinol Diabetes Obes (2007) 1.19

The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion. J Neurosci (2009) 1.18

Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A (2011) 1.17

Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. Endocrinology (2011) 1.10

Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility. Proc Natl Acad Sci U S A (2012) 1.09

PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling. J Neurosci (2009) 0.99

Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in the sheep. Endocrinology (2000) 0.92

Interactions between feeding behavior and hormones during growth. Ann N Y Acad Sci (1969) 0.92

Leptin(116-130) stimulates prolactin and luteinizing hormone secretion in fasted adult male rats. Neuroendocrinology (1999) 0.91

Neuroendocrine control of energy homeostasis: update on new insights. Prog Brain Res (2010) 0.90

The role of adrenal hyperandrogenism, insulin resistance, and obesity in the pathogenesis of polycystic ovarian syndrome. J Clin Endocrinol Metab (1993) 0.89

Expanding neurotransmitters in the hypothalamic neurocircuitry for energy balance regulation. Protein Cell (2011) 0.84

A significant role of leptin in the generation of steroid-induced luteinizing hormone and prolactin surges in female rats. Biochem Biophys Res Commun (1999) 0.77

Articles by these authors

(truncated to the top 100)

The genome of the cucumber, Cucumis sativus L. Nat Genet (2009) 8.19

A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature (2009) 3.63

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc Natl Acad Sci U S A (2002) 3.01

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58

Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (2011) 2.52

The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions. Nat Genet (2012) 2.33

Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc Natl Acad Sci U S A (2007) 2.03

Feasibility of near-infrared spectroscopic tomography for intraoperative functional cerebral monitoring: a primate study. J Thorac Cardiovasc Surg (2014) 2.02

Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types. BMC Genomics (2010) 1.88

Lysophosphatidic acid induces neointima formation through PPARgamma activation. J Exp Med (2004) 1.86

Identification and mechanism of ABA receptor antagonism. Nat Struct Mol Biol (2010) 1.83

Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Nat Genet (2012) 1.78

Examination performance of graduate entry medical students compared with mainstream students. J R Soc Med (2009) 1.72

rpoB Gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China. J Clin Microbiol (2006) 1.68

Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. PLoS Biol (2008) 1.60

Rapid increase of serum neuron specific enolase level and tachyphylaxis of EGFR-tyrosine kinase inhibitor indicate small cell lung cancer transformation from EGFR positive lung adenocarcinoma? Lung Cancer (2013) 1.59

Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response. Sci Signal (2011) 1.58

Computation of octanol-water partition coefficients by guiding an additive model with knowledge. J Chem Inf Model (2007) 1.49

Elf5 inhibits TGF-β-driven epithelial-mesenchymal transition in prostate cancer by repressing SMAD3 activation. Prostate (2015) 1.47

Risk loci on chromosome 8q24 are associated with prostate cancer in northern Chinese men. J Urol (2011) 1.46

Impact of stone branch number on outcomes of percutaneous nephrolithotomy for treatment of staghorn calculi. J Endourol (2013) 1.45

Iodine-125 seed implantation and deferred transurethral resection of the prostate for patients with lower urinary tract symptoms and localized prostate cancer. Clin Genitourin Cancer (2013) 1.45

A comparison of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion: a literature review and meta-analysis. BMC Musculoskelet Disord (2014) 1.43

Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. Cell Res (2013) 1.42

Decreased regional homogeneity in insula and cerebellum: a resting-state fMRI study in patients with major depression and subjects at high risk for major depression. Psychiatry Res (2010) 1.38

Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron (2011) 1.36

A consensus linkage map for molecular markers and quantitative trait loci associated with economically important traits in melon (Cucumis melo L.). BMC Plant Biol (2011) 1.33

Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA. ChemMedChem (2007) 1.32

Data uncertainty in face recognition. IEEE Trans Cybern (2014) 1.32

A high resolution genetic map anchoring scaffolds of the sequenced watermelon genome. PLoS One (2012) 1.32

Characterization of transcriptome dynamics during watermelon fruit development: sequencing, assembly, annotation and gene expression profiles. BMC Genomics (2011) 1.28

Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endocrinol Metab (2011) 1.27

Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease. Clin Exp Nephrol (2013) 1.25

The role of oxidative stress in the biological responses of lung epithelial cells to cigarette smoke. Biomarkers (2009) 1.24

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology (2009) 1.23

Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Mol Cell Biol (2013) 1.22

Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression. J Biol Chem (2006) 1.22

Near-infrared optical imaging of the breast with model-based reconstruction. Acad Radiol (2002) 1.19

A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res (2010) 1.18

Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol. Mol Cell Biol (2007) 1.18

Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity. J Med Chem (2003) 1.18

Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. J Clin Invest (2013) 1.17

A hybrid model for short-term bacillary dysentery prediction in Yichang City, China. Jpn J Infect Dis (2010) 1.17

The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population. J Affect Disord (2008) 1.17

The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Mol Metab (2013) 1.17

Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus. Proc Natl Acad Sci U S A (2011) 1.17

Lysophosphatidic acid production and action: validated targets in cancer? J Cell Biochem (2004) 1.17

A novel germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men. Prostate (2012) 1.15

Primary mediastinal sarcoma: surgical outcomes of 21 cases. Interact Cardiovasc Thorac Surg (2013) 1.15

Class A scavenger receptor attenuates myocardial infarction-induced cardiomyocyte necrosis through suppressing M1 macrophage subset polarization. Basic Res Cardiol (2011) 1.14

Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study. Arthritis Res Ther (2008) 1.13

Systematic review and meta-analysis of percutaneous nephrolithotomy for patients in the supine versus prone position. J Endourol (2010) 1.10

An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. Cell Res (2013) 1.10

Prevalence of dementia and major dementia subtypes in the Chinese populations: a meta-analysis of dementia prevalence surveys, 1980-2010. J Clin Neurosci (2012) 1.09

Fluorescence lifetime tomography of turbid media based on an oxygen-sensitive dye. Opt Express (2002) 1.09

The prevalence of mild cognitive impairment about elderly population in China: a meta-analysis. Int J Geriatr Psychiatry (2010) 1.08

Planning analysis for locally advanced lung cancer: dosimetric and efficiency comparisons between intensity-modulated radiotherapy (IMRT), single-arc/partial-arc volumetric modulated arc therapy (SA/PA-VMAT). Radiat Oncol (2011) 1.08

Early or up-front radiotherapy improved survival of localized extranodal NK/T-cell lymphoma, nasal-type in the upper aerodigestive tract. Int J Radiat Oncol Biol Phys (2007) 1.08

Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J Med Chem (2013) 1.08

Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity. J Biol Chem (2003) 1.07

Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population. BMC Med Genet (2008) 1.07

Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells. Chin J Cancer Res (2013) 1.07

Formation of NOx from N2 and O2 in catalyst-pellet filled dielectric barrier discharges at atmospheric pressure. Chem Commun (Camb) (2003) 1.06

Manganese superoxide dismutase: beyond life and death. Amino Acids (2010) 1.06

Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. J Clin Invest (2014) 1.05

Diagnosis of bone metastases: a meta-analysis comparing ¹⁸FDG PET, CT, MRI and bone scintigraphy. Eur Radiol (2011) 1.05

Overexpressed microRNA-182 promotes proliferation and invasion in prostate cancer PC-3 cells by down-regulating N-myc downstream regulated gene 1 (NDRG1). PLoS One (2013) 1.04

Transcription regulation of human manganese superoxide dismutase gene. Methods Enzymol (2002) 1.04

A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis. J Natl Cancer Inst (2013) 1.04

Salvage concurrent radio-chemotherapy for post-operative local recurrence of squamous-cell esophageal cancer. Radiat Oncol (2012) 1.04

Collagen alpha1(I) gene (COL1A1) is repressed by RFX family. J Biol Chem (2005) 1.03

Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions. Am J Pathol (2010) 1.03

Thickness-dependent interfacial Coulomb scattering in atomically thin field-effect transistors. Nano Lett (2013) 1.02

Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression. Biochemistry (2008) 1.02

Pharmacologic activation of PKM2 slows lung tumor xenograft growth. Mol Cancer Ther (2013) 1.02

Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation. Cell Metab (2013) 1.02

Rural-to-urban migrants are at high risk of sexually transmitted and viral hepatitis infections in China: a systematic review and meta-analysis. BMC Infect Dis (2014) 1.02

Clinical significance of NUCB2 mRNA expression in prostate cancer. J Exp Clin Cancer Res (2013) 1.01

Prognostication of prostate cancer based on NUCB2 protein assessment: NUCB2 in prostate cancer. J Exp Clin Cancer Res (2013) 1.01

Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors. J Biol Chem (2011) 1.01

Effect of transport stress on respiratory disease, serum antioxidant status, and serum concentrations of lipid peroxidation biomarkers in beef cattle. Am J Vet Res (2004) 1.00

Discovery of 4-tert-butyl-2,6-dimethylphenylsulfur trifluoride as a deoxofluorinating agent with high thermal stability as well as unusual resistance to aqueous hydrolysis, and its diverse fluorination capabilities including deoxofluoro-arylsulfinylation with high stereoselectivity. J Am Chem Soc (2010) 1.00

The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor. J Biol Chem (2010) 1.00

Disrupted resting-state functional connectivity of the hippocampus in medication-naïve patients with major depressive disorder. J Affect Disord (2012) 1.00

Synthesis of migration-resistant hydroxyethoxy analogues of lysophosphatidic acid. Org Lett (2003) 0.99

Gammadelta T cells recognize tumor cells via CDR3delta region. Mol Immunol (2006) 0.99

Identification and characterization of a novel estrogenic ligand actinopolymorphol A. Biochem Pharmacol (2010) 0.99

A multicenter retrospective analysis of survival outcome following postoperative chemoradiotherapy in non-small-cell lung cancer patients with N2 nodal disease. Int J Radiat Oncol Biol Phys (2009) 0.98

Brahma-related gene 1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice. Hepatology (2013) 0.98

Endostar, a recombined humanized endostatin, enhances the radioresponse for human nasopharyngeal carcinoma and human lung adenocarcinoma xenografts in mice. Cancer Sci (2009) 0.98

Using co-variations in the Hb signal to detect visual activation: a near infrared spectroscopic imaging study. Neuroimage (2009) 0.98

PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells. J Cell Sci (2013) 0.98

Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology (2012) 0.98

Myocardin-related transcription factor A mediates OxLDL-induced endothelial injury. Circ Res (2011) 0.97

Pre-osteoblast infiltration and differentiation in highly porous apatite-coated PLLA electrospun scaffolds. Biomaterials (2010) 0.97

HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. J Mol Cell Cardiol (2008) 0.97

Joint Tensor Feature Analysis For Visual Object Recognition. IEEE Trans Cybern (2015) 0.96

Generation of systemic lupus erythematosus-specific induced pluripotent stem cells from urine. Rheumatol Int (2013) 0.96

Photophysical property and photocatalytic activity of new Gd(2)InSbO(7) and Gd(2)FeSbO(7) compounds under visible light irradiation. Int J Mol Sci (2013) 0.96

Identification of PTPsigma as an autophagic phosphatase. J Cell Sci (2011) 0.95