PubRank

Hendrik Luesch

Author PubWeight™ 62.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. J Am Chem Soc 2008 2.34
2 Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. J Am Chem Soc 2008 1.76
3 A small-molecule inducer of the antioxidant response element. Chem Biol 2010 1.65
4 Marine natural products: a new wave of drugs? Future Med Chem 2011 1.57
5 Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol 2010 1.47
6 A genomic screen for activators of the antioxidant response element. Proc Natl Acad Sci U S A 2007 1.44
7 Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp. J Nat Prod 2007 1.42
8 Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides. J Nat Prod 2007 1.32
9 Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation. Mol Pharmacol 2009 1.28
10 Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii. J Nat Prod 2008 1.28
11 Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula. J Nat Prod 2010 1.27
12 Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida. Appl Environ Microbiol 2009 1.17
13 Combinatorial strategies by marine cyanobacteria: symplostatin 4, an antimitotic natural dolastatin 10/15 hybrid that synergizes with the coproduced HDAC inhibitor largazole. Chembiochem 2009 1.14
14 Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. J Pharmacol Exp Ther 2010 1.13
15 Cytotoxic halogenated macrolides and modified peptides from the apratoxin-producing marine cyanobacterium Lyngbya bouillonii from Guam. J Nat Prod 2010 1.13
16 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem 2009 1.09
17 Synthesis and activity of largazole analogues with linker and macrocycle modification. Org Lett 2008 1.07
18 Molassamide, a depsipeptide serine protease inhibitor from the marine cyanobacterium Dichothrix utahensis. J Nat Prod 2010 1.06
19 Total structure determination of grassypeptolide, a new marine cyanobacterial cytotoxin. Org Lett 2008 1.06
20 Largazole: from discovery to broad-spectrum therapy. Nat Prod Rep 2012 1.03
21 Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity. ACS Med Chem Lett 2011 1.02
22 Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena. Mar Drugs 2009 1.01
23 Lyngbyoic acid, a "tagged" fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa. Mol Biosyst 2011 0.97
24 Total synthesis and biological evaluation of grassypeptolide A. Chemistry 2013 0.95
25 Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp. J Nat Prod 2008 0.94
26 Grassypeptolides A-C, cytotoxic bis-thiazoline containing marine cyclodepsipeptides. J Org Chem 2010 0.93
27 Largamides A-C, tiglic acid-containing cyclodepsipeptides with elastase-inhibitory activity from the marine cyanobacterium Lyngbya confervoides. Planta Med 2009 0.93
28 The molecular pharmacology of symplostatin 1: a new antimitotic dolastatin 10 analog. Int J Cancer 2003 0.93
29 Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam. J Nat Prod 2010 0.92
30 Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. J Med Chem 2012 0.92
31 Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida. J Nat Prod 2010 0.92
32 Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway. Free Radic Biol Med 2013 0.91
33 Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radic Biol Med 2009 0.90
34 Biological targets and mechanisms of action of natural products from marine cyanobacteria. Nat Prod Rep 2015 0.90
35 Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells. J Med Chem 2013 0.89
36 Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa. J Nat Prod 2008 0.88
37 Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides. Phytochemistry 2009 0.88
38 Caldora penicillata gen. nov., comb. nov. (cyanobacteria), a pantropical marine species with biomedical relevance. J Phycol 2015 0.88
39 Discovery and mechanism of natural products as modulators of histone acetylation. Curr Drug Targets 2012 0.87
40 Combination therapy for renal cell cancer: what are possible options? Oncology 2011 0.86
41 Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam. J Nat Prod 2011 0.85
42 Veraguamides A-G, cyclic hexadepsipeptides from a dolastatin 16-producing cyanobacterium Symploca cf. hydnoides from Guam. J Nat Prod 2011 0.85
43 Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. Phytochemistry 2011 0.84
44 Total synthesis of grassystatin A, a probe for cathepsin E function. Bioorg Med Chem 2012 0.84
45 Continuing studies on the cyanobacterium Lyngbya sp.: isolation and structure determination of 15-norlyngbyapeptin A and lyngbyabellin D. J Nat Prod 2003 0.83
46 Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma? Oncol Rev 2011 0.83
47 In Vitro and In Vivo Osteogenic Activity of Largazole. ACS Med Chem Lett 2011 0.82
48 Amantelides A and B, Polyhydroxylated Macrolides with Differential Broad-Spectrum Cytotoxicity from a Guamanian Marine Cyanobacterium. J Nat Prod 2015 0.82
49 Activation of the antioxidant response element by specific oxidized metabolites of linoleic acid. Prostaglandins Leukot Essent Fatty Acids 2009 0.81
50 Weapons in disguise--activating mechanisms and protecting group chemistry in nature. Chemistry 2010 0.80
51 Improved total synthesis and biological evaluation of potent apratoxin S4 based anticancer agents with differential stability and further enhanced activity. J Med Chem 2014 0.80
52 Intramolecular modulation of serine protease inhibitor activity in a marine cyanobacterium with antifeedant properties. Mar Drugs 2010 0.80
53 Marine cyanobacterial fatty acid amides acting on cannabinoid receptors. Chembiochem 2012 0.79
54 Bioassay-guided isolation and identification of desacetylmicrocolin B from Lyngbya cf. polychroa. Planta Med 2009 0.79
55 In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem Biol 2013 0.78
56 Cultivated sea lettuce is a multiorgan protector from oxidative and inflammatory stress by enhancing the endogenous antioxidant defense system. Cancer Prev Res (Phila) 2013 0.78
57 Grassypeptolides as natural inhibitors of dipeptidyl peptidase 8 and T-cell activation. Chembiochem 2014 0.78
58 Biological effects of Byrsocarpus coccineus in vitro. Pharm Biol 2010 0.77
59 Combination therapy targeting cancer metabolism. Med Hypotheses 2010 0.77
60 Modular strategies for structure and function employed by marine cyanobacteria: characterization and synthesis of pitinoic acids. Org Lett 2013 0.77
61 Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp. Bioorg Med Chem 2011 0.75
62 Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata. J Nat Prod 2016 0.75
63 Construction and characterization of melanocortin-2 and -4 receptor chimeras. Adv Exp Med Biol 2009 0.75
64 Discovery, Synthesis, and Biological Evaluation of Anaenamides C and D from a New Marine Cyanobacterium, sp. J Nat Prod 2022 0.75
65 Correction to Caylobolide B, a Macrolactone from Symplostatin 1-Producing Marine Cyanobacteria Phormidium spp. from Florida. J Nat Prod 2016 0.75
66 Grassystatins D-F, Potent Aspartic Protease Inhibitors from Marine Cyanobacteria as Potential Antimetastatic Agents Targeting Invasive Breast Cancer. J Nat Prod 2017 0.75
67 Apratyramide, a Marine-Derived Peptidic Stimulator of VEGF-A and Other Growth Factors with Potential Application in Wound Healing. ACS Chem Biol 2017 0.75