Published in J Lipid Res on August 31, 2011
Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism. Biochim Biophys Acta (2013) 0.95
Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58. J Lipid Res (2012) 0.89
KSRP and MicroRNA 145 are negative regulators of lipolysis in white adipose tissue. Mol Cell Biol (2014) 0.86
Comparative gene identification-58 (CGI-58) promotes autophagy as a putative lysophosphatidylglycerol acyltransferase. J Biol Chem (2014) 0.83
Distinct roles for alpha-beta hydrolase domain 5 (ABHD5/CGI-58) and adipose triglyceride lipase (ATGL/PNPLA2) in lipid metabolism and signaling. Adipocyte (2012) 0.81
The anti-obesity effects of green tea in human intervention and basic molecular studies. Eur J Clin Nutr (2014) 0.81
Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM. Nat Commun (2016) 0.81
Comparative gene identification-58/α/β hydrolase domain 5: more than just an adipose triglyceride lipase activator? Curr Opin Lipidol (2014) 0.80
Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation. Cell Rep (2016) 0.79
Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice. Am J Physiol Endocrinol Metab (2013) 0.77
Targeted inhibition of galectin 1 by thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats. Int J Obes (Lond) (2015) 0.76
METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. J Biol Chem (1964) 21.04
Molecular mediators of hepatic steatosis and liver injury. J Clin Invest (2004) 9.40
Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase. Science (2004) 8.58
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol (2008) 8.43
Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab (2006) 6.25
Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res (2007) 6.03
Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. J Lipid Res (2004) 4.67
Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem (2006) 3.74
The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab (2010) 3.61
Regulation of lipolysis in adipocytes. Annu Rev Nutr (2007) 3.15
Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. J Biol Chem (2001) 3.10
Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med (2005) 2.78
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J Cell Biol (2003) 2.77
Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J Biol Chem (2004) 2.76
Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome. Am J Hum Genet (2001) 2.72
Control of adipose triglyceride lipase action by serine 517 of perilipin A globally regulates protein kinase A-stimulated lipolysis in adipocytes. J Biol Chem (2006) 2.45
cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behavior. J Biol Chem (1985) 2.39
CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. J Biol Chem (2004) 2.33
Lipolysis: pathway under construction. Curr Opin Lipidol (2005) 2.32
A simple method to determine fat cell size and number in four mammalian species. Am J Physiol (1971) 2.22
Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem (2006) 2.15
Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans (2003) 2.11
Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss. J Biol Chem (2008) 2.09
The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. J Clin Invest (1990) 2.08
Tumor necrosis factor-alpha stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP. Diabetes (2002) 2.00
Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue. Am J Physiol Gastrointest Liver Physiol (2007) 1.97
Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr Opin Lipidol (2009) 1.87
The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding. J Biol Chem (2008) 1.80
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. J Lipid Res (2010) 1.79
Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols. J Biol Chem (2002) 1.78
CGI-58 facilitates lipolysis on lipid droplets but is not involved in the vesiculation of lipid droplets caused by hormonal stimulation. J Lipid Res (2007) 1.78
Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58). J Biol Chem (2009) 1.72
Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation (2008) 1.71
CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophosphatidic acid. J Biol Chem (2008) 1.65
Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res (1992) 1.64
Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes (2001) 1.62
Bacterial endotoxin stimulates adipose lipolysis via toll-like receptor 4 and extracellular signal-regulated kinase pathway. J Biol Chem (2009) 1.61
Determination of adipocyte size by computer image analysis. J Lipid Res (2002) 1.59
An enzymatic fluorometric micromethod for the determination of glycerol. Clin Chim Acta (1966) 1.56
Innate immunity and adipose tissue biology. Trends Immunol (2010) 1.50
Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol. Biochim Biophys Acta (1986) 1.45
CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase. J Lipid Res (2009) 1.41
The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase. J Biol Chem (2010) 1.30
Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. J Biol Chem (2004) 1.30
A simple and rapid method to assay triacylglycerol in cells and tissues. J Lipid Res (2007) 1.30
Neutral lipid storage disease with fatty liver and cholestasis. J Pediatr Gastroenterol Nutr (1997) 1.27
CGI-58 facilitates the mobilization of cytoplasmic triglyceride for lipoprotein secretion in hepatoma cells. J Lipid Res (2007) 1.16
Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact. J Biol Chem (2003) 1.15
Control of fatty acid and glycerol release in adipose tissue lipolysis. C R Biol (2006) 1.02
Optimized conditions for measuring lipolysis in murine primary adipocytes. J Lipid Res (2006) 0.99
Dorfman--Chanarin syndrome (neutral lipid storage disease): new clinical features. Br J Dermatol (2001) 0.86
Somatotropin regulates adipose tissue metabolism in neonatal swine. J Nutr (1999) 0.80
Feeding, fasting and starvation: factors affecting fuel utilization. Proc Nutr Soc (1995) 0.79
Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01. Science (2010) 10.69
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44
Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science (2011) 7.92
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature (2013) 5.35
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron (2006) 5.27
Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem (2004) 4.89
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron (2011) 4.88
Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol (2008) 4.75
C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Science (2002) 4.03
A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Lett (2006) 3.25
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem (2008) 2.87
Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science (2007) 2.87
Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell (2006) 2.85
Structures from anomalous diffraction of native biological macromolecules. Science (2012) 2.83
Spirometry utilization for COPD: how do we measure up? Chest (2007) 2.77
Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. J Biol Chem (2004) 2.76
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc Natl Acad Sci U S A (2012) 2.69
Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J Lipid Res (2009) 2.55
Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization. Science (2013) 2.48
Structural insight into AMPK regulation: ADP comes into play. Structure (2007) 2.32
Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation. Diabetes (2004) 2.26
Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology (2004) 2.22
The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure (2011) 2.19
Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity (2013) 2.17
Obesity, metabolic syndrome, and prostate cancer. Am J Clin Nutr (2007) 2.14
Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nat Genet (2008) 2.00
Specificity of cell-cell adhesion by classical cadherins: Critical role for low-affinity dimerization through beta-strand swapping. Proc Natl Acad Sci U S A (2005) 1.99
Mutations in the lipase H gene underlie autosomal recessive woolly hair/hypotrichosis. J Invest Dermatol (2008) 1.96
Cadherin-mediated cell-cell adhesion: sticking together as a family. Curr Opin Struct Biol (2003) 1.94
The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion. J Biol Chem (2006) 1.89
Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr Opin Lipidol (2009) 1.87
Liver-specific inhibition of acyl-coenzyme a:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol (2006) 1.83
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance. J Lipid Res (2010) 1.79
Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols. J Biol Chem (2002) 1.78
Disulfide-dependent multimeric assembly of resistin family hormones. Science (2004) 1.76
Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake. J Biol Chem (2005) 1.75
Transforming binding affinities from three dimensions to two with application to cadherin clustering. Nature (2011) 1.73
Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities. Endocrinology (2007) 1.73
Thinking outside the cell: how cadherins drive adhesion. Trends Cell Biol (2012) 1.72
Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes. Diabetes (2005) 1.70
Splice form dependence of beta-neurexin/neuroligin binding interactions. Neuron (2010) 1.68
Two-step adhesive binding by classical cadherins. Nat Struct Mol Biol (2010) 1.67
Insulin resistance and prostate cancer risk. J Natl Cancer Inst (2003) 1.61
Tubby proteins: the plot thickens. Nat Rev Mol Cell Biol (2004) 1.52
Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains. Proc Natl Acad Sci U S A (2013) 1.51
Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest (2010) 1.49
Identification of a transiently exposed VE-cadherin epitope that allows for specific targeting of an antibody to the tumor neovasculature. Blood (2005) 1.48
Hydrophobic sequences target and anchor perilipin A to lipid droplets. J Lipid Res (2004) 1.47
Cooperativity between trans and cis interactions in cadherin-mediated junction formation. Proc Natl Acad Sci U S A (2010) 1.46
Biliary sterol secretion is not required for macrophage reverse cholesterol transport. Cell Metab (2010) 1.45
Retracted Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein. J Neurosci (2013) 1.44
Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice. Diabetes (2007) 1.42
CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase. J Lipid Res (2009) 1.41
Interleukin-6 regulates human adipose tissue lipid metabolism and leptin production in vitro. J Clin Endocrinol Metab (2004) 1.38
T-cadherin structures reveal a novel adhesive binding mechanism. Nat Struct Mol Biol (2010) 1.37
Sequence and structural determinants of strand swapping in cadherin domains: do all cadherins bind through the same adhesive interface? J Mol Biol (2008) 1.31
Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle. Am J Physiol Cell Physiol (2005) 1.29
Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport. Annu Rev Physiol (2011) 1.28
Fixation methods for the study of lipid droplets by immunofluorescence microscopy. J Histochem Cytochem (2003) 1.28
Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. J Biol Chem (2005) 1.26
Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle. Am J Physiol Endocrinol Metab (2007) 1.26
The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor. Mol Microbiol (2005) 1.26
The central domain is required to target and anchor perilipin A to lipid droplets. J Biol Chem (2002) 1.26
Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis. J Lipid Res (2010) 1.26
Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics. Front Microbiol (2012) 1.24
Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins. Structure (2008) 1.24
Impact of a health promotion program on employee health risks and work productivity. Am J Health Promot (2007) 1.22
P-cadherin is a p63 target gene with a crucial role in the developing human limb bud and hair follicle. Development (2008) 1.20
Total costs of IBS: employer and managed care perspective. Am J Manag Care (2005) 1.19
Optimization of protein production in mammalian cells with a coexpressed fluorescent marker. Structure (2004) 1.16
Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue. Obesity (Silver Spring) (2008) 1.15
Structural genomics target selection for the New York consortium on membrane protein structure. J Struct Funct Genomics (2009) 1.14
Perilipin expression in human adipose tissues: effects of severe obesity, gender, and depot. Obes Res (2003) 1.14
Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins. Nat Struct Mol Biol (2011) 1.14
Identification of novel serological biomarkers for inflammatory bowel disease using Escherichia coli proteome chip. Mol Cell Proteomics (2009) 1.14
Scavenger receptor class B type I is a plasma membrane cholesterol sensor. Circ Res (2012) 1.13
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. Proc Natl Acad Sci U S A (2013) 1.12
A Mendelian locus on chromosome 16 determines susceptibility to doxorubicin nephropathy in the mouse. Proc Natl Acad Sci U S A (2005) 1.11
Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization. J Biol Chem (2010) 1.11
Adiponectin deficiency limits tumor vascularization in the MMTV-PyV-mT mouse model of mammary cancer. Clin Cancer Res (2009) 1.11
Biliary and nonbiliary contributions to reverse cholesterol transport. Curr Opin Lipidol (2012) 1.10
Primary care patients reporting concerns about their gambling frequently have other co-occurring lifestyle and mental health issues. BMC Fam Pract (2006) 1.09
BBS7 is required for BBSome formation and its absence in mice results in Bardet-Biedl syndrome phenotypes and selective abnormalities in membrane protein trafficking. J Cell Sci (2013) 1.08
Functional dissection of the C. elegans cell adhesion molecule SAX-7, a homologue of human L1. Mol Cell Neurosci (2007) 1.08
Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure (2008) 1.07
The amino and carboxyl termini of perilipin a facilitate the storage of triacylglycerols. J Biol Chem (2003) 1.07
The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins. J Struct Funct Genomics (2010) 1.07
Lifestyle screening: development of an acceptable multi-item general practice tool. N Z Med J (2004) 1.07
De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts. Proc Natl Acad Sci U S A (2013) 1.06
PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J Physiol Endocrinol Metab (2010) 1.06
Leptin receptor modulation of adiposity and fertility. Trends Endocrinol Metab (2009) 1.05
Case finding of lifestyle and mental health disorders in primary care: validation of the 'CHAT' tool. Br J Gen Pract (2008) 1.05
CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action. Diabetes (2012) 1.04