Published in Acta Pharmacol Sin on September 12, 2011
Friend or foe: the role of microRNA in chemotherapy resistance. Acta Pharmacol Sin (2013) 1.11
Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells. Cancer Med (2015) 0.89
The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells. PLoS One (2014) 0.79
Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks. Neoplasia (2015) 0.79
Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe. Oncotarget (2015) 0.79
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
The serial cultivation of human diploid cell strains. Exp Cell Res (1961) 25.11
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res (1965) 21.61
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007) 16.95
BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature (2005) 16.87
Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet (2009) 16.58
Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell (2005) 12.73
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol (2008) 11.43
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature (2006) 11.18
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell (2006) 11.01
A survey of telomerase activity in human cancer. Eur J Cancer (1997) 10.84
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature (2009) 8.70
Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell (2008) 7.65
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature (2009) 6.85
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell (2008) 6.84
Autophagy mediates the mitotic senescence transition. Genes Dev (2009) 6.80
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell (2002) 6.76
Pancreatic cancers require autophagy for tumor growth. Genes Dev (2011) 6.17
Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J (1995) 6.03
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature (2003) 6.01
Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell (2006) 4.74
Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev (2009) 4.69
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev (1994) 4.64
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol (1998) 4.59
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol (2005) 4.29
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci (2005) 3.96
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest (2010) 3.47
Telomerase and cancer therapeutics. Nat Rev Cancer (2008) 3.46
Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell (2011) 3.37
CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev (2010) 3.24
DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res (2002) 3.22
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem (2006) 3.00
Myc and the cell cycle. Front Biosci (1998) 2.88
MicroRNAs and their target gene networks in breast cancer. Breast Cancer Res (2010) 2.83
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene (2006) 2.74
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res (1999) 2.67
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci U S A (2006) 2.64
Many roads lead to oncogene-induced senescence. Oncogene (2008) 2.43
Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells. Cancer Sci (2008) 2.39
MicroRNA profiling of human gastric cancer. Mol Med Rep (2011) 2.26
Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem (2003) 2.14
Oncogene-induced senescence: putting the brakes on tumor development. Cancer Res (2006) 2.04
Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc Natl Acad Sci U S A (2001) 1.96
The first molecular details of ALT in human tumor cells. Hum Mol Genet (2005) 1.93
Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts. Cancer Res (1999) 1.86
Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res (2005) 1.84
Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1). Oncogene (2010) 1.67
Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction. J Biol Chem (2002) 1.62
Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. Cancer Res (1995) 1.61
The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer Res (2010) 1.60
p53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts. Cancer Res (2006) 1.43
Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity. Cancer Res (2006) 1.43
Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem (2002) 1.40
The identification of senescence-specific genes during the induction of senescence in prostate cancer cells. Neoplasia (2005) 1.39
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma. Nat Med (2010) 1.35
miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway. Hepatology (2010) 1.31
Cancerous miRNAs and their regulation. Cell Cycle (2008) 1.29
Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells. Am J Physiol Heart Circ Physiol (2008) 1.25
Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. J Biol Chem (2009) 1.20
Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes. Blood (2009) 1.20
MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion. Cancer Biol Ther (2010) 1.17
Targeting the cell cycle for cancer therapy. Br J Cancer (2002) 1.12
MicroRNAs in solid tumors. J Surg Res (2008) 1.11
HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma. Cancer Res (2001) 1.09
The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena. Nucleic Acids Res (1994) 1.04
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. Cancer Res (2010) 1.02
The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2. Oncogene (1998) 1.00
Senescence induces a proangiogenic switch in human peritoneal mesothelial cells. Rejuvenation Res (2008) 0.99
Antisense Bcl-xl down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity. Clin Cancer Res (2003) 0.98
Induction of accelerated senescence by gamma radiation in human solid tumor-derived cell lines expressing wild-type TP53. Radiat Res (2005) 0.96
Senescent cells are resistant to death despite low Bcl-2 level. Mech Ageing Dev (2001) 0.94
Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells. Cancer Res (1998) 0.94
Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism. Cancer Res (1997) 0.93
Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo. Br J Cancer (2008) 0.89
Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice. EMBO Rep (2008) 0.87
Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes. Exp Cell Res (1999) 0.86
Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent. Proc Natl Acad Sci U S A (2010) 0.86
Oncogene-induced cellular senescence. Adv Anat Pathol (2010) 0.85
Expression of p53 and bcl-2 in clinically localized prostate cancer before and after neo-adjuvant hormonal therapy. Oncol Res (2000) 0.85
p53: guardian of cellular senescence. J Pathol (1996) 0.84
The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression. Biochem J (2008) 0.82
14-3-3sigma negatively regulates the cell cycle, and its down-regulation is associated with poor outcome in intrahepatic cholangiocarcinoma. Hum Pathol (2007) 0.81
Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process. Proc Natl Acad Sci U S A (2011) 0.81
The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway. Blood (2011) 0.81
Additive effects of C(2)-ceramide on paclitaxel-induced premature senescence of human lung cancer cells. Life Sci (2010) 0.79
Water-soluble benzoheterocycle triosmium clusters as potential inhibitors of telomerase enzyme. J Inorg Biochem (2005) 0.77
Pectenotoxin-2 represses telomerase activity in human leukemia cells through suppression of hTERT gene expression and Akt-dependent hTERT phosphorylation. FEBS Lett (2008) 0.77
Images in clinical medicine. Palmar-plantar rash with cytarabine therapy. N Engl J Med (2011) 0.76
Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells. Acta Pharmacol Sin (2011) 0.87
UHRF1 inhibits MDR1 gene transcription and sensitizes breast cancer cells to anticancer drugs. Breast Cancer Res Treat (2010) 0.82