SIP-ing the elixir of youth.

Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell (2011) 2.10

Adapting proteostasis for disease intervention. Science (2008) 13.22

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science (2005) 11.31

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2010) 11.29

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature (2007) 6.61

The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell (2011) 6.05

Opposing activities protect against age-onset proteotoxicity. Science (2006) 5.85

Biological and chemical approaches to diseases of proteostasis deficiency. Annu Rev Biochem (2009) 5.23

Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem (2008) 5.22

Automated approach for quantitative analysis of complex peptide mixtures from tandem mass spectra. Nat Methods (2004) 4.62

New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet (2005) 4.18

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol (2013) 3.88

Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science (2002) 3.85

Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature (2009) 3.83

Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science (2007) 3.46

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature (2011) 3.32

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell (2009) 2.87

XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. Cell (2013) 2.20

RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature (2012) 2.11

The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci (2008) 2.10

SMK-1, an essential regulator of DAF-16-mediated longevity. Cell (2006) 2.10

Aging as an event of proteostasis collapse. Cold Spring Harb Perspect Biol (2011) 2.06

Protein homeostasis and aging in neurodegeneration. J Cell Biol (2010) 1.76

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature (2012) 1.75

A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature (2009) 1.71

C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Cell (2008) 1.65

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans. Nat Commun (2013) 1.42

Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Mol Cell (2011) 1.39

The trifecta of aging in Caenorhabditis elegans. Exp Gerontol (2006) 1.35

Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. Aging Cell (2006) 1.32

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol (2013) 1.30

Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science (2006) 1.27

Signals of youth: endocrine regulation of aging in Caenorhabditis elegans. Trends Endocrinol Metab (2009) 1.27

Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS One (2009) 1.25

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell (2009) 1.13

Temporal requirements of heat shock factor-1 for longevity assurance. Aging Cell (2012) 1.04

Uncoupling of longevity and telomere length in C. elegans. PLoS Genet (2005) 1.04

Metabolism, ubiquinone synthesis, and longevity. Genes Dev (2005) 1.03

Expanding the genetic code of Caenorhabditis elegans using bacterial aminoacyl-tRNA synthetase/tRNA pairs. ACS Chem Biol (2012) 1.01

Sir2 deletion prevents lifespan extension in 32 long-lived mutants. Aging Cell (2011) 1.01

A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis. Protein Sci (2009) 0.98

Analysis of aging in Caenorhabditis elegans. Methods Cell Biol (2012) 0.95

A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues. Biochemistry (2011) 0.94

Retracted SMK-1/PPH-4.1-mediated silencing of the CHK-1 response to DNA damage in early C. elegans embryos. J Cell Biol (2007) 0.92

FOXO4 is necessary for neural differentiation of human embryonic stem cells. Aging Cell (2013) 0.85

Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx. ACS Chem Biol (2008) 0.82

Mitochondria and aging: dilution is the solution. Cell Metab (2007) 0.81

MAPping innate immunity. Proc Natl Acad Sci U S A (2004) 0.78

PPTR-1 counterAkts insulin signaling. Cell (2009) 0.77

Ageing: beneficial miscommunication. Nature (2013) 0.76