Published in PLoS Pathog on September 08, 2011
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity (2012) 2.85
Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease. Annu Rev Immunol (2013) 2.47
Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat Rev Microbiol (2012) 2.18
Chitinase dependent control of protozoan cyst burden in the brain. PLoS Pathog (2012) 1.68
Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy. PLoS Pathog (2012) 1.44
A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation. J Exp Med (2013) 1.28
Regulation of inflammation by interleukin-4: a review of "alternatives". J Leukoc Biol (2012) 1.20
Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Cancer Res (2013) 1.06
An inside job: hacking into Janus kinase/signal transducer and activator of transcription signaling cascades by the intracellular protozoan Toxoplasma gondii. Infect Immun (2011) 1.06
Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates. J Immunol (2012) 1.01
Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection. BMC Genomics (2014) 1.01
Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15. Infect Immun (2013) 0.98
Structural and evolutionary adaptation of rhoptry kinases and pseudokinases, a family of coccidian virulence factors. BMC Evol Biol (2013) 0.98
TH1/TH2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism? Front Immunol (2014) 0.94
Protein kinases of Toxoplasma gondii: functions and drug targets. Parasitol Res (2013) 0.93
Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling. Int J Parasitol (2011) 0.91
CXCR3-dependent CD4⁺ T cells are required to activate inflammatory monocytes for defense against intestinal infection. PLoS Pathog (2013) 0.91
The impact of Toll-like-receptor-9 on intestinal microbiota composition and extra-intestinal sequelae in experimental Toxoplasma gondii induced ileitis. Gut Pathog (2014) 0.90
Toxoplasma gondii triggers phosphorylation and nuclear translocation of dendritic cell STAT1 while simultaneously blocking IFNγ-induced STAT1 transcriptional activity. PLoS One (2013) 0.89
STAT3-dependent transactivation of miRNA genes following Toxoplasma gondii infection in macrophage. Parasit Vectors (2013) 0.89
SAG2A protein from Toxoplasma gondii interacts with both innate and adaptive immune compartments of infected hosts. Parasit Vectors (2013) 0.89
Toxoplasma gondii development of its replicative niche: in its host cell and beyond. Eukaryot Cell (2014) 0.89
Nucleotide-oligomerization-domain-2 affects commensal gut microbiota composition and intracerebral immunopathology in acute Toxoplasma gondii induced murine ileitis. PLoS One (2014) 0.88
Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis. Infect Immun (2014) 0.88
Infection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes. JAKSTAT (2012) 0.88
GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response. Infect Immun (2014) 0.87
Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity. PLoS Pathog (2011) 0.85
Genetic manipulation in Δku80 strains for functional genomic analysis of Toxoplasma gondii. J Vis Exp (2013) 0.84
Have it your way: how polymorphic, injected kinases and pseudokinases enable Toxoplasma to subvert host defenses. PLoS Pathog (2013) 0.83
Toxoplasma gondii virulence factor ROP18 inhibits the host NF-κB pathway by promoting p65 degradation. J Biol Chem (2014) 0.83
Seroprevalence and risk factors of Toxoplasma gondii infection in sheep and goats slaughtered for human consumption in Central Ethiopia. BMC Res Notes (2014) 0.82
The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection. MBio (2016) 0.82
Long-Term Relationships: the Complicated Interplay between the Host and the Developmental Stages of Toxoplasma gondii during Acute and Chronic Infections. Microbiol Mol Biol Rev (2015) 0.82
Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca(2+) mobilization. Front Microbiol (2013) 0.81
Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines. Trends Parasitol (2013) 0.81
Co-existence of classical and alternative activation programs in macrophages responding to Toxoplasma gondii. Int J Parasitol (2013) 0.81
Lower expression of inducible nitric oxide synthase and higher expression of arginase in rat alveolar macrophages are linked to their susceptibility to Toxoplasma gondii infection. PLoS One (2013) 0.81
Non-replicating Toxoplasma gondii reverses tumor-associated immunosuppression. Oncoimmunology (2013) 0.81
Partial protective effect of intranasal immunization with recombinant Toxoplasma gondii rhoptry protein 17 against toxoplasmosis in mice. PLoS One (2014) 0.80
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity. PLoS Genet (2016) 0.79
MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice. PLoS Pathog (2013) 0.79
Toxoplasma gondii prevalent in China induce weaker apoptosis of neural stem cells C17.2 via endoplasmic reticulum stress (ERS) signaling pathways. Parasit Vectors (2015) 0.79
Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses. Infect Immun (2014) 0.79
Transcriptomic analysis of global changes in cytokine expression in mouse spleens following acute Toxoplasma gondii infection. Parasitol Res (2015) 0.79
Comparative studies of macrophage-biased responses in mice to infection with Toxoplasma gondii ToxoDB #9 strains of different virulence isolated from China. Parasit Vectors (2013) 0.78
Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis? Parasite Immunol (2015) 0.78
K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells. PLoS Pathog (2016) 0.78
Hammondia hammondi harbors functional orthologs of the host-modulating effectors GRA15 and ROP16 but is distinguished from Toxoplasma gondii by a unique transcriptional profile. Eukaryot Cell (2014) 0.77
The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading. mSphere (2016) 0.77
Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection. Infect Immun (2015) 0.77
Phagocyte responses to protozoan infection and how Toxoplasma gondii meets the challenge. PLoS Pathog (2012) 0.77
Transcriptional and Linkage Analyses Identify Loci that Mediate the Differential Macrophage Response to Inflammatory Stimuli and Infection. PLoS Genet (2015) 0.77
Trefoil factor 2 negatively regulates type 1 immunity against Toxoplasma gondii. J Immunol (2012) 0.76
Forward genetics screens using macrophages to identify Toxoplasma gondii genes important for resistance to IFN-γ-dependent cell autonomous immunity. J Vis Exp (2015) 0.76
Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection. Parasit Vectors (2016) 0.75
Manipulation of IL-10 gene expression by Toxoplasma gondii and its products. Med J Islam Repub Iran (2016) 0.75
The gene expression level of IFN-γR1 and IFN-γR2 in a murine model treated with Toxoplasma gondii and its products. Gastroenterol Hepatol Bed Bench (2016) 0.75
Z-DNA Binding Protein Mediates Host Control of Toxoplasma gondii Infection. Infect Immun (2016) 0.75
Toxoplasma Effectors Targeting Host Signaling and Transcription. Clin Microbiol Rev (2017) 0.75
Functional Characterization of Rhoptry Kinome in the Virulent Toxoplasma gondii RH Strain. Front Microbiol (2017) 0.75
In astrocytes the accumulation of the immunity-related GTPases Irga6 and Irgb6 at the vacuole of Toxoplasma gondii is dependent on the parasite virulence. ScientificWorldJournal (2013) 0.75
TLR signaling. Cell Death Differ (2006) 9.24
Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun (1988) 8.17
Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction. J Clin Microbiol (1989) 5.85
Recombination-mediated PCR-directed plasmid construction in vivo in yeast. Nucleic Acids Res (1997) 5.03
The JAK-STAT signaling pathway: input and output integration. J Immunol (2007) 4.92
TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science (2005) 4.86
Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature (2006) 4.50
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol (2008) 4.31
Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science (2006) 4.23
Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog (2009) 4.12
Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clin Microbiol Rev (1998) 4.03
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med (1997) 3.62
Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production. J Immunol (2001) 3.25
Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii. J Immunol (2006) 3.24
Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. Eur J Immunol (1995) 3.17
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12
Tracking STAT nuclear traffic. Nat Rev Immunol (2006) 2.99
Manipulation of host-cell pathways by bacterial pathogens. Nature (2007) 2.89
Dynamics of neutrophil migration in lymph nodes during infection. Immunity (2008) 2.70
Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole. EMBO J (2001) 2.62
Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. Annu Rev Microbiol (2008) 2.42
Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining. Eukaryot Cell (2009) 2.41
Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines. J Immunol (2001) 2.41
Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype. J Immunol (2004) 2.35
CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain. Blood (2005) 2.22
Population biology of Toxoplasma gondii and its relevance to human infection: do different strains cause different disease? Curr Opin Microbiol (2002) 2.21
Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection. J Immunol (2003) 2.18
A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3. J Exp Med (2009) 2.11
Evasion of innate immunity by parasitic protozoa. Nat Immunol (2002) 2.08
Pathogen subversion of cell-intrinsic innate immunity. Nat Immunol (2007) 1.97
Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii. J Immunol (2007) 1.95
Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6. J Biol Chem (2010) 1.87
Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli. Gut (2007) 1.85
IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol (2005) 1.83
Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-kappa B. J Immunol (2001) 1.76
IFN-gamma overproduction and high level apoptosis are associated with high but not low virulence Toxoplasma gondii infection. J Immunol (2001) 1.76
Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation. Mol Cell Biol (2004) 1.76
Mitogen- and antigen-specific proliferation of T cells in murine toxoplasmosis is inhibited by reactive nitrogen intermediates. Infect Immun (1994) 1.66
Paradigm shifts in the cell biology of STAT signaling. Semin Cell Dev Biol (2008) 1.61
Dissemination of Toxoplasma gondii to immunoprivileged organs and role of Toll/interleukin-1 receptor signalling for host resistance assessed by in vivo bioluminescence imaging. Cell Microbiol (2005) 1.53
Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii. J Immunol (2004) 1.49
TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite. J Immunol (2008) 1.47
Reduced expression of the inducible nitric oxide synthase after infection with Toxoplasma gondii facilitates parasite replication in activated murine macrophages. Int J Parasitol (2003) 1.46
Toxoplasma gondii dysregulates IFN-gamma-inducible gene expression in human fibroblasts: insights from a genome-wide transcriptional profiling. J Immunol (2007) 1.44
Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation. J Neuroinflammation (2010) 1.41
Toxoplasma gondii lacks the enzymes required for de novo arginine biosynthesis and arginine starvation triggers cyst formation. Int J Parasitol (2004) 1.39
Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol (2008) 1.39
Comparison between two amplification sets for molecular diagnosis of toxoplasmosis by real-time PCR. J Clin Microbiol (2006) 1.32
Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis. PLoS Negl Trop Dis (2009) 1.29
Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling. J Immunol (2006) 1.27
Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages. J Immunol (2006) 1.26
Toxoplasma gondii interferes with lipopolysaccharide-induced mitogen-activated protein kinase activation by mechanisms distinct from endotoxin tolerance. J Immunol (2004) 1.25
Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation. J Immunol (2009) 1.22
Toxoplasma gondii triggers Gi-dependent PI 3-kinase signaling required for inhibition of host cell apoptosis. J Cell Sci (2006) 1.19
Impairment of the cellular immune response in acute murine toxoplasmosis: regulation of interleukin 2 production and macrophage-mediated inhibitory effects. Infect Immun (1994) 1.14
Activation-mediated CD4+ T cell unresponsiveness during acute Toxoplasma gondii infection in mice. Int Immunol (1996) 1.11
Dysregulation of macrophage signal transduction by Toxoplasma gondii: past progress and recent advances. Parasite Immunol (2009) 1.07
Interactions between TLR7 and TLR9 agonists and receptors regulate innate immune responses by astrocytes and microglia. Glia (2010) 1.06
Initiation and termination of NF-kappaB signaling by the intracellular protozoan parasite Toxoplasma gondii. J Cell Sci (2005) 1.04
Diverse mechanisms employed by Toxoplasma gondii to inhibit IFN-gamma-induced major histocompatibility complex class II gene expression. Microbes Infect (2006) 1.01
TLR9-dependent induction of intestinal alpha-defensins by Toxoplasma gondii. J Immunol (2010) 0.99
Rho proteins are negative regulators of TLR2, TLR3, and TLR4 signaling in astrocytes. J Neurosci Res (2009) 0.88
Toll-like receptor initiated host defense against Toxoplasma gondii. J Biomed Biotechnol (2009) 0.88
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature (2012) 4.41
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12
De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Nature (2002) 3.04
Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response. Cell Host Microbe (2008) 2.80
Gut commensal bacteria direct a protective immune response against Toxoplasma gondii. Cell Host Microbe (2009) 2.67
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host Microbe (2010) 2.57
Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining. Eukaryot Cell (2009) 2.41
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med (2013) 2.39
Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism. Nat Rev Immunol (2006) 2.24
Cross-talk in the innate immune system: neutrophils instruct recruitment and activation of dendritic cells during microbial infection. J Immunol (2003) 2.18
p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. Infect Immun (2005) 1.93
IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol (2005) 1.83
Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A (2011) 1.80
Castration eliminates conspecific aggression in group-housed CD1 male surveillance mice (Mus musculus). J Am Assoc Lab Anim Sci (2012) 1.72
Exposure to the fish parasite Anisakis causes allergic airway hyperreactivity and dermatitis. J Allergy Clin Immunol (2006) 1.70
Screening for Toxoplasma gondii-regulated transcriptional responses in lipopolysaccharide-activated macrophages. Infect Immun (2006) 1.67
Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant. J Immunol (2005) 1.62
Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4. PLoS Pathog (2011) 1.61
Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation. Int Immunol (2011) 1.58
Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. J Immunol (2006) 1.53
Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections. J Immunol (2010) 1.53
Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog (2012) 1.52
Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J Exp Med (2012) 1.49
TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite. J Immunol (2008) 1.47
B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity (2012) 1.47
Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines. J Immunol (2008) 1.45
Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells. Nat Immunol (2012) 1.41
Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection. Eukaryot Cell (2011) 1.40
Toxoplasma gondii lacks the enzymes required for de novo arginine biosynthesis and arginine starvation triggers cyst formation. Int J Parasitol (2004) 1.39
Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol (2008) 1.39
Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci U S A (2010) 1.37
Understanding the multiple functions of Gr-1(+) cell subpopulations during microbial infection. Immunol Res (2008) 1.30
Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease. PLoS One (2012) 1.28
Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication. J Immunol (2009) 1.28
Efficacy and limitations of an ATP-based monitoring system. J Am Assoc Lab Anim Sci (2010) 1.27
Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages. J Immunol (2006) 1.26
Toxoplasma gondii triggers release of human and mouse neutrophil extracellular traps. Infect Immun (2011) 1.25
Toxoplasma gondii interferes with lipopolysaccharide-induced mitogen-activated protein kinase activation by mechanisms distinct from endotoxin tolerance. J Immunol (2004) 1.25
UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii. J Biol Chem (2010) 1.25
p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection. J Immunol (2005) 1.24
Microbial antigen triggers rapid mobilization of TNF-alpha to the surface of mouse neutrophils transforming them into inducers of high-level dendritic cell TNF-alpha production. J Immunol (2005) 1.24
STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. Infect Immun (2004) 1.23
Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation. J Immunol (2009) 1.22
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity. Eur J Immunol (2009) 1.19
Toxoplasma gondii triggers Gi-dependent PI 3-kinase signaling required for inhibition of host cell apoptosis. J Cell Sci (2006) 1.19
IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms. Proc Natl Acad Sci U S A (2012) 1.19
NK cells enhance dendritic cell response against parasite antigens via NKG2D pathway. J Immunol (2007) 1.16
Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge. J Immunol (2012) 1.16
Innate responses to Toxoplasma gondii in mice and humans. Trends Parasitol (2011) 1.15
B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice. J Immunol (2012) 1.13
Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism. J Immunol (2011) 1.11
A novel mouse model of Schistosoma haematobium egg-induced immunopathology. PLoS Pathog (2012) 1.11
Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii. Infect Immun (2009) 1.10
Mechanism of entry determines the ability of Toxoplasma gondii to inhibit macrophage proinflammatory cytokine production. Infect Immun (2002) 1.08
Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii. Infect Immun (2010) 1.08
Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger. Immunol Cell Biol (2011) 1.07
Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Cancer Res (2013) 1.06
An inside job: hacking into Janus kinase/signal transducer and activator of transcription signaling cascades by the intracellular protozoan Toxoplasma gondii. Infect Immun (2011) 1.06
TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function. Eur J Immunol (2011) 1.04
Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation. J Immunol (2009) 1.03
Functional analysis of RNA structures present at the 3' extremity of the murine norovirus genome: the variable polypyrimidine tract plays a role in viral virulence. J Virol (2010) 1.03
Differential localization of processed fragments of Plasmodium falciparum serine repeat antigen and further processing of its N-terminal 47 kDa fragment. Parasitol Int (2002) 1.02
TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens. Proc Natl Acad Sci U S A (2013) 1.02
IL-4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates. J Leukoc Biol (2013) 1.01
CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses. J Immunol (2003) 1.01
The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell Cycle (2012) 1.00
Human immunoglobulin G mediates protective immunity and identifies protective antigens against larval Strongyloides stercoralis in mice. J Infect Dis (2004) 0.99
Mouse neutrophils require JNK2 MAPK for Toxoplasma gondii-induced IL-12p40 and CCL2/MCP-1 release. J Immunol (2007) 0.96
Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite. Proc Natl Acad Sci U S A (2006) 0.96
Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin. J Immunol (2013) 0.95
TH1-dominant granulomatous pathology does not inhibit fibrosis or cause lethality during murine schistosomiasis. Am J Pathol (2006) 0.94
Long-term immunity to lethal acute or chronic type II Toxoplasma gondii infection is effectively induced in genetically susceptible C57BL/6 mice by immunization with an attenuated type I vaccine strain. Infect Immun (2009) 0.93
Sedation or inhalant anesthesia before euthanasia with CO2 does not reduce behavioral or physiologic signs of pain and stress in mice. J Am Assoc Lab Anim Sci (2012) 0.93
Neutrophils cast extracellular traps in response to protozoan parasites. Front Immunol (2012) 0.93
CD73-generated adenosine facilitates Toxoplasma gondii differentiation to long-lived tissue cysts in the central nervous system. Proc Natl Acad Sci U S A (2012) 0.91
CXCR3-dependent CD4⁺ T cells are required to activate inflammatory monocytes for defense against intestinal infection. PLoS Pathog (2013) 0.91
Toxoplasma gondii triggers phosphorylation and nuclear translocation of dendritic cell STAT1 while simultaneously blocking IFNγ-induced STAT1 transcriptional activity. PLoS One (2013) 0.89
Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice. Microb Pathog (2008) 0.88
Toxoplasma gondii inhibits covalent modification of histone H3 at the IL-10 promoter in infected macrophages. PLoS One (2009) 0.88
Genetic identification of essential indels and domains in carbamoyl phosphate synthetase II of Toxoplasma gondii. Int J Parasitol (2008) 0.87
TGF-β-responsive myeloid cells suppress type 2 immunity and emphysematous pathology after hookworm infection. Am J Pathol (2012) 0.87
CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun (2010) 0.86
Apoptosis and the balance of homeostatic and pathologic responses to protozoan infection. Infect Immun (2003) 0.86
Phosphoinositide-3-kinase-dependent, MyD88-independent induction of CC-type chemokines characterizes the macrophage response to Toxoplasma gondii strains with high virulence. Infect Immun (2007) 0.86