Published in Trends Parasitol on September 01, 2011
Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway. J Immunol (2014) 2.11
Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends Parasitol (2011) 1.53
Immune-neural connections: how the immune system's response to infectious agents influences behavior. J Exp Biol (2013) 1.48
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity (2012) 1.40
Astrocytic TGF-β signaling limits inflammation and reduces neuronal damage during central nervous system Toxoplasma infection. J Immunol (2014) 0.97
Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin. J Immunol (2013) 0.95
Toxoplasma on the brain: understanding host-pathogen interactions in chronic CNS infection. J Parasitol Res (2012) 0.95
Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy. Autophagy (2016) 0.84
Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii. PLoS Pathog (2015) 0.84
SNPs in toll-like receptor (TLR) genes as new genetic alterations associated with congenital toxoplasmosis? Eur J Clin Microbiol Infect Dis (2012) 0.83
Prime-boost vaccination with toxoplasma lysate antigen, but not with a mixture of recombinant protein antigens, leads to reduction of brain cyst formation in BALB/c mice. PLoS One (2015) 0.83
Paneth cells: targets of friendly fire. Nat Immunol (2013) 0.82
Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines. Trends Parasitol (2013) 0.81
MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice. PLoS Pathog (2013) 0.79
Use and abuse of dendritic cells by Toxoplasma gondii. Virulence (2012) 0.79
Towards vaccine against toxoplasmosis: evaluation of the immunogenic and protective activity of recombinant ROP5 and ROP18 Toxoplasma gondii proteins. Parasitol Res (2015) 0.78
Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice. Am J Clin Exp Immunol (2013) 0.78
Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii. Mucosal Immunol (2014) 0.78
STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways. PLoS Biol (2016) 0.76
Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages. PLoS One (2015) 0.75
Immunization with Toxoplasma gondii GRA17 Deletion Mutant Induces Partial Protection and Survival in Challenged Mice. Front Immunol (2017) 0.75
Blood-stage malaria of Plasmodium chabaudi induces differential Tlr expression in the liver of susceptible and vaccination-protected Balb/c mice. Parasitol Res (2016) 0.75
Toxoplasma gondii Infection Induces High Mobility Group Box 1 Released from Mouse Macrophages. Front Microbiol (2017) 0.75
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity (1998) 18.12
Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol (2009) 14.33
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med (1983) 14.08
Toxoplasmosis. Lancet (2004) 13.96
Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol (1989) 12.08
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol (2007) 12.00
Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science (1988) 7.96
Decoding the patterns of self and nonself by the innate immune system. Science (2002) 7.19
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci U S A (1993) 6.87
In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas. J Exp Med (1997) 6.53
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol (2006) 5.35
Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med (2010) 4.98
Pyogenic bacterial infections in humans with MyD88 deficiency. Science (2008) 4.92
TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science (2005) 4.86
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science (2006) 4.44
The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci U S A (2005) 4.42
Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science (2006) 4.23
Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol (1992) 4.02
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med (1997) 3.62
Toxoplasmosis: A history of clinical observations. Int J Parasitol (2009) 3.39
Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med (2009) 3.32
Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol (2010) 3.25
Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii. J Immunol (2006) 3.24
Success and virulence in Toxoplasma as the result of sexual recombination between two distinct ancestries. Science (2001) 3.21
Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice. J Immunol (1989) 3.20
Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol (2003) 3.18
In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol (1996) 3.15
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12
Endogenous ligands of TLR2 and TLR4: agonists or assistants? J Leukoc Biol (2010) 2.85
Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii. PLoS Biol (2010) 2.83
Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response. Cell Host Microbe (2008) 2.80
Gut commensal bacteria direct a protective immune response against Toxoplasma gondii. Cell Host Microbe (2009) 2.67
Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol (2002) 2.67
p47 GTPases: regulators of immunity to intracellular pathogens. Nat Rev Immunol (2004) 2.52
IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J Immunol (2004) 2.37
A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis. J Leukoc Biol (2003) 2.29
In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity (2002) 2.23
Population biology of Toxoplasma gondii and its relevance to human infection: do different strains cause different disease? Curr Opin Microbiol (2002) 2.21
Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response. Immunity (2006) 2.05
Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection. J Immunol (2000) 2.00
Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii. J Immunol (2007) 1.95
Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coli. Gut (2007) 1.85
IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages. J Immunol (2005) 1.83
TLR9 is required for the gut-associated lymphoid tissue response following oral infection of Toxoplasma gondii. J Immunol (2006) 1.80
Oral infection of C57BL/6 mice with Toxoplasma gondii: a new model of inflammatory bowel disease? J Infect Dis (2002) 1.73
Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in mice. PLoS Genet (2009) 1.66
Class I major histocompatibility complex presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondii. Infect Immun (2005) 1.66
TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection. Int Immunol (2003) 1.62
Dissemination of Toxoplasma gondii to immunoprivileged organs and role of Toll/interleukin-1 receptor signalling for host resistance assessed by in vivo bioluminescence imaging. Cell Microbiol (2005) 1.53
Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii. J Immunol (2004) 1.49
TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite. J Immunol (2008) 1.47
NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells. Infect Immun (2010) 1.46
Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines. J Immunol (2008) 1.45
Studies on the role of interleukin-12 in acute murine toxoplasmosis. Immunology (1995) 1.43
T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A (2008) 1.43
Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol (2008) 1.39
Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci U S A (2010) 1.37
P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages. J Immunol (2010) 1.33
The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens. Mamm Genome (2010) 1.28
Neutrophils, dendritic cells and Toxoplasma. Int J Parasitol (2004) 1.26
Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages. J Immunol (2006) 1.26
Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun (2007) 1.26
UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii. J Biol Chem (2010) 1.25
Interleukin-18 (IL-18) enhances innate IL-12-mediated resistance to Toxoplasma gondii. Infect Immun (2000) 1.21
The Toxoplasma gondii-shuttling function of dendritic cells is linked to the parasite genotype. Infect Immun (2009) 1.20
The role of cytokines and their signaling pathways in the regulation of immunity to Toxoplasma gondii. Int Rev Immunol (2002) 1.16
The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms. Proc Natl Acad Sci U S A (2006) 1.12
Roles of glycosylphosphatidylinositols of Toxoplasma gondii. Induction of tumor necrosis factor-alpha production in macrophages. J Biol Chem (2003) 1.11
Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells. J Immunol (2010) 1.07
Activation of the P2X(7) receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages. Microbes Infect (2010) 1.03
Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis. Genes Immun (2010) 1.03
Toll-like receptors and their role in host resistance to Toxoplasma gondii. Immunol Lett (2008) 0.99
Early response of mucosal epithelial cells during Toxoplasma gondii infection. J Immunol (2009) 0.96
Toxoplasma gondii: evidence for interleukin-12-dependent and-independent pathways of interferon-gamma production induced by an attenuated parasite strain. Exp Parasitol (1996) 0.93
Candidate gene analysis of ocular toxoplasmosis in Brazil: evidence for a role for toll-like receptor 9 (TLR9). Mem Inst Oswaldo Cruz (2009) 0.93
Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology. J Immunol (2008) 0.92
A gut feeling for microbes: getting it going between a parasite and its host. Cell Host Microbe (2009) 0.79
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature (2012) 4.41
Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response. Cell Host Microbe (2008) 2.80
Gut commensal bacteria direct a protective immune response against Toxoplasma gondii. Cell Host Microbe (2009) 2.67
Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A (2011) 1.80
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control. PLoS Pathog (2011) 1.67
Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant. J Immunol (2005) 1.62
Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4. PLoS Pathog (2011) 1.61
Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections. J Immunol (2010) 1.53
Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon. PLoS Pathog (2012) 1.52
B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity (2012) 1.47
Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines. J Immunol (2008) 1.45
Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells. Nat Immunol (2012) 1.41
Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci U S A (2010) 1.37
UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii. J Biol Chem (2010) 1.25
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity. Eur J Immunol (2009) 1.19
B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice. J Immunol (2012) 1.13
Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism. J Immunol (2011) 1.11
Functional analysis of RNA structures present at the 3' extremity of the murine norovirus genome: the variable polypyrimidine tract plays a role in viral virulence. J Virol (2010) 1.03
TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens. Proc Natl Acad Sci U S A (2013) 1.02
Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin. J Immunol (2013) 0.95
Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs. J Immunol (2010) 0.86
Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit. PLoS One (2012) 0.83
CCR5 N-terminal region plays a critical role in HIV-1 inhibition by Toxoplasma gondii-derived cyclophilin-18. J Biol Chem (2005) 0.78
Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo. Microbes Infect (2009) 0.77
IL-6 signaling SOCS critical for IL-12 host response to Toxoplasma gondii. Future Microbiol (2012) 0.75