Published in Chem Biol on September 23, 2011
Activated ClpP kills persisters and eradicates a chronic biofilm infection. Nature (2013) 3.69
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring. EMBO J (2012) 1.31
Artificial activation of toxin-antitoxin systems as an antibacterial strategy. Trends Microbiol (2012) 1.15
Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity. J Am Chem Soc (2014) 0.98
A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity. Chembiochem (2014) 0.83
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease. Mol Microbiol (2016) 0.81
Antibiotics: Killing the survivors. Nature (2013) 0.80
Structure, Biology, and Therapeutic Application of Toxin-Antitoxin Systems in Pathogenic Bacteria. Toxins (Basel) (2016) 0.78
Chemical activators of ClpP: turning Jekyll into Hyde. Chem Biol (2011) 0.75
Bacterial proteases, untapped antimicrobial drug targets. J Antibiot (Tokyo) (2016) 0.75
Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P. J Nat Prod (2016) 0.75
Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH. Int J Pept (2012) 0.75
Uncoupling conformational states from activity in an allosteric enzyme. Nat Commun (2017) 0.75
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature (2007) 75.09
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
The genetic landscape of a cell. Science (2010) 16.52
An oestrogen-receptor-alpha-bound human chromatin interactome. Nature (2009) 12.16
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell (2010) 7.51
Urinary-cell mRNA profile and acute cellular rejection in kidney allografts. N Engl J Med (2013) 7.40
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell (2007) 7.05
Distribution and three-dimensional structure of AIDS virus envelope spikes. Nature (2006) 6.78
CAPRI: a Critical Assessment of PRedicted Interactions. Proteins (2003) 6.36
Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis. Curr Biol (2005) 5.99
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A (2009) 5.86
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science (2006) 5.52
ACLAME: a CLAssification of Mobile genetic Elements. Nucleic Acids Res (2004) 5.44
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
Predialysis nephrology care of older patients approaching end-stage renal disease. Arch Intern Med (2011) 5.11
Crystal structure of metarhodopsin II. Nature (2011) 5.05
Fusion transcripts and transcribed retrotransposed loci discovered through comprehensive transcriptome analysis using Paired-End diTags (PETs). Genome Res (2007) 4.99
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell (2005) 4.95
Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol (2008) 4.66
Electrochemical energy storage for green grid. Chem Rev (2011) 4.48
Towards a transgenic model of Huntington's disease in a non-human primate. Nature (2008) 4.47
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell (2012) 4.18
A census of human soluble protein complexes. Cell (2012) 3.90
Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA (2009) 3.86
Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death. JAMA (2010) 3.85
Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke (2008) 3.81
Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance. Curr Biol (2003) 3.77
Up-to-date catalogues of yeast protein complexes. Nucleic Acids Res (2008) 3.69
Altitude and all-cause mortality in incident dialysis patients. JAMA (2009) 3.62
The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab (2010) 3.61
The aMAZE LightBench: a web interface to a relational database of cellular processes. Nucleic Acids Res (2004) 3.39
HEN1 functions pleiotropically in Arabidopsis development and acts in C function in the flower. Development (2002) 3.24
Assessment of blind predictions of protein-protein interactions: current status of docking methods. Proteins (2003) 3.21
Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions. Proc Natl Acad Sci U S A (2003) 3.02
Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis. JAMA (2011) 3.02
Tube Formation in Nanoscale Materials. Nanoscale Res Lett (2008) 2.83
Complex and oriented ZnO nanostructures. Nat Mater (2003) 2.75
Comparative mortality risk of anemia management practices in incident hemodialysis patients. JAMA (2010) 2.71
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell (2011) 2.68
The increasing prevalence of atrial fibrillation among hemodialysis patients. J Am Soc Nephrol (2011) 2.61
Diabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies. Eur J Cancer (2011) 2.59
Age-related changes of nuclear architecture in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2005) 2.57
Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology (2007) 2.53
Assessment of CAPRI predictions in rounds 3-5 shows progress in docking procedures. Proteins (2005) 2.52
Challenges in the development of high protein concentration formulations. J Pharm Sci (2004) 2.52
Docking and scoring protein complexes: CAPRI 3rd Edition. Proteins (2007) 2.48
iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence. Database (Oxford) (2010) 2.47
Primary fascial closure with mesh reinforcement is superior to bridged mesh repair for abdominal wall reconstruction. J Am Coll Surg (2013) 2.42
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell (2010) 2.40
Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu. Arch Neurol (2005) 2.39
NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses. PLoS Pathog (2009) 2.32
Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors. J Clin Oncol (2011) 2.29
Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol (2011) 2.26
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine. Proc Natl Acad Sci U S A (2002) 2.24
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol Cell (2003) 2.20
Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A (2010) 2.16
Effect of c-erbB2 overexpression on prognosis in osteosarcoma: evidence from eight studies. Tumour Biol (2014) 2.14
Reduced incidence of breast cancer-related lymphedema following mastectomy and breast reconstruction versus mastectomy alone. Plast Reconstr Surg (2012) 2.13
Novel features of the polysaccharide-digesting gliding bacterium Flavobacterium johnsoniae as revealed by genome sequence analysis. Appl Environ Microbiol (2009) 2.11
HIV-specific IL-21 producing CD4+ T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control. J Immunol (2010) 2.10
Lipofilling of the Breast Does Not Increase the Risk of Recurrence of Breast Cancer: A Matched Controlled Study. Plast Reconstr Surg (2016) 2.05
Interaction landscape of membrane-protein complexes in Saccharomyces cerevisiae. Nature (2012) 2.05
Evidence for pore formation in host cell membranes by ESX-1-secreted ESAT-6 and its role in Mycobacterium marinum escape from the vacuole. Infect Immun (2008) 2.05
Polymorphic variation of CYP11B2 predicts postoperative resolution of hypertension in patients undergoing adrenalectomy for aldosterone-producing adenomas. Int J Urol (2012) 2.04
Patterns of second-line uterotonic use in a large sample of hospitalizations for childbirth in the United States: 2007-2011. Anesth Analg (2014) 2.04
Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg (2009) 2.04
Cortical thinning in persons at increased familial risk for major depression. Proc Natl Acad Sci U S A (2009) 2.04
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood (2009) 1.99
Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans. Mol Biol Cell (2002) 1.98
Association between Agent Orange exposure and nonmelanotic invasive skin cancer: a pilot study. Plast Reconstr Surg (2014) 1.97
Mmp-9 deficiency enhances collagenase-induced intracerebral hemorrhage and brain injury in mutant mice. J Cereb Blood Flow Metab (2004) 1.97
Descending command systems for the initiation of locomotion in mammals. Brain Res Rev (2007) 1.97
Identifying functional modules in the physical interactome of Saccharomyces cerevisiae. Proteomics (2007) 1.96
Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog (2009) 1.96
Trends in the use and outcomes of implantable cardioverter-defibrillators in patients undergoing dialysis in the United States. Am J Kidney Dis (2011) 1.92
Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J Cell Biol (2008) 1.92
Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. Chem Biol (2012) 1.91
Signal transduction during cold, salt, and drought stresses in plants. Mol Biol Rep (2011) 1.89
Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase. Chem Biol (2004) 1.89
The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab (2005) 1.89
Targeted disruption of G0/G1 switch gene 2 enhances adipose lipolysis, alters hepatic energy balance, and alleviates high-fat diet-induced liver steatosis. Diabetes (2013) 1.87
Docking and scoring protein interactions: CAPRI 2009. Proteins (2010) 1.86
A regulatory toolbox of MiniPromoters to drive selective expression in the brain. Proc Natl Acad Sci U S A (2010) 1.85
Fabrication of fully transparent nanowire transistors for transparent and flexible electronics. Nat Nanotechnol (2007) 1.85
Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle. Proc Natl Acad Sci U S A (2011) 1.83
Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein. J Biol Chem (2011) 1.83
ClpP: a distinctive family of cylindrical energy-dependent serine proteases. FEBS Lett (2007) 1.83
Systematic evaluation of genetic variants in the inflammation pathway and risk of lung cancer. Cancer Res (2007) 1.82
Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage, 2000-2004. Arthritis Rheum (2013) 1.80
Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol Endocrinol (2005) 1.79
A structural basis for Mg2+ homeostasis and the CorA translocation cycle. EMBO J (2006) 1.78
Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet (2013) 1.77
Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care (2013) 1.77
Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat Immunol (2005) 1.75
An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell. Mol Syst Biol (2009) 1.75
Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin Exp Nephrol (2009) 1.74
Brain anomalies in children exposed prenatally to a common organophosphate pesticide. Proc Natl Acad Sci U S A (2012) 1.72
The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation. Cell Microbiol (2006) 1.72