Published in Nat Immunol on September 07, 2008
Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol (2010) 8.87
Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol (2013) 7.10
A homozygous CARD9 mutation in a family with susceptibility to fungal infections. N Engl J Med (2009) 5.20
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature (2009) 5.00
Signalling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol (2009) 4.98
Immunogenic and tolerogenic cell death. Nat Rev Immunol (2009) 4.34
The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol (2010) 4.26
Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol (2010) 4.07
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature (2009) 3.93
The sterile inflammatory response. Annu Rev Immunol (2010) 3.45
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Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol (2010) 2.38
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Uric acid promotes an acute inflammatory response to sterile cell death in mice. J Clin Invest (2010) 1.97
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Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity (2010) 1.78
The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice. J Clin Invest (2012) 1.69
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Programmed necrosis in the cross talk of cell death and inflammation. Annu Rev Immunol (2014) 1.27
CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol (2009) 1.26
A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritis. J Immunol (2011) 1.25
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The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev (2009) 1.23
The Dectin-2 family of C-type lectins in immunity and homeostasis. Cytokine (2009) 1.20
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Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL. Proc Natl Acad Sci U S A (2013) 1.16
Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13
Regulation of NF-κB by the CARD proteins. Immunol Rev (2012) 1.12
Innate immune cells in liver inflammation. Mediators Inflamm (2012) 1.11
Stimulation of anti-tumor immunity by photodynamic therapy. Expert Rev Clin Immunol (2011) 1.11
C-type lectins, fungi and Th17 responses. Cytokine Growth Factor Rev (2010) 1.10
Self and nonself recognition through C-type lectin receptor, Mincle. Self Nonself (2010) 1.08
Mincle is a long sought receptor for mycobacterial cord factor. J Exp Med (2009) 1.06
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Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway. PLoS Pathog (2012) 1.04
Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium? Front Microbiol (2011) 1.04
Macrophages in tuberculosis: friend or foe. Semin Immunopathol (2013) 1.04
C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America. J Immunol (2014) 1.04
TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury. PLoS One (2013) 1.03
Molecular recognition of paired receptors in the immune system. Front Microbiol (2012) 1.03
Defining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate. Glycobiology (2014) 1.02
Enterocyte shedding and epithelial lining repair following ischemia of the human small intestine attenuate inflammation. PLoS One (2009) 1.02
Signalling C-type lectin receptors, microbial recognition and immunity. Cell Microbiol (2014) 1.02
Pattern recognition receptors and central nervous system repair. Exp Neurol (2014) 1.02
Within the Enemy's Camp: contribution of the granuloma to the dissemination, persistence and transmission of Mycobacterium tuberculosis. Front Immunol (2013) 1.02
Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection. PLoS Pathog (2014) 1.02
Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus. PLoS One (2010) 1.00
Sensing of cell death by myeloid C-type lectin receptors. Curr Opin Immunol (2013) 1.00
C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation. J Biol Chem (2014) 0.98
Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection. Infect Immun (2012) 0.97
Recognition of the mycobacterial cord factor by Mincle: relevance for granuloma formation and resistance to tuberculosis. Front Immunol (2013) 0.96
Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines. Cell Death Differ (2013) 0.95
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections. Clin Dev Immunol (2011) 0.95
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns. Front Immunol (2014) 0.95
Functional roles of Syk in macrophage-mediated inflammatory responses. Mediators Inflamm (2014) 0.95
Signalling versatility following self and non-self sensing by myeloid C-type lectin receptors. Immunobiology (2014) 0.94
Inhibitory C-type lectin receptors in myeloid cells. Immunol Lett (2010) 0.94
A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology (2012) 0.94
Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses. J Biol Chem (2015) 0.94
Pathogenic fungus Microsporum canis activates the NLRP3 inflammasome. Infect Immun (2013) 0.93
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol (2015) 0.92
The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis. J Immunol (2011) 0.92
The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response. PLoS One (2015) 0.91
Fungal glycans and the innate immune recognition. Front Cell Infect Microbiol (2014) 0.91
Sensing necrosis with Mincle. Nat Immunol (2008) 0.90
Glycerol monomycolate is a novel ligand for the human, but not mouse macrophage inducible C-type lectin, Mincle. J Biol Chem (2014) 0.90
Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J Immunol (2014) 0.89
Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. Diabetes (2011) 0.89
Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition. Eur J Immunol (2015) 0.88
Macrophage immunoregulatory pathways in tuberculosis. Semin Immunol (2014) 0.88
Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke. Sci Rep (2013) 0.88
Using an agent-based model to analyze the dynamic communication network of the immune response. Theor Biol Med Model (2011) 0.87
ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes. J Immunol (2012) 0.87
Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease. J Immunol (2016) 0.86
Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity (2006) 6.93
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol (2005) 6.48
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. Immunity (2008) 4.21
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol (2007) 4.12
Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol (2007) 4.11
Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity (2010) 3.66
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity (2003) 3.36
Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol (2010) 2.70
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med (2012) 2.58
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity (2008) 2.42
Effects of resin hydrophilicity on water sorption and changes in modulus of elasticity. Biomaterials (2005) 2.32
C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc Natl Acad Sci U S A (2009) 2.25
Role for hydrogen peroxide in flow-induced dilation of human coronary arterioles. Circ Res (2003) 2.09
Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channels. Circ Res (2003) 2.01
The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest (2008) 1.82
Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development. Nat Immunol (2005) 1.75
Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation. Immunity (2011) 1.75
Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res (2007) 1.74
Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin Exp Nephrol (2009) 1.74
Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics (2007) 1.73
Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Nat Med (2002) 1.73
Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog (2012) 1.68
Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease. Chem Biol (2011) 1.68
Accidental exposures to blood and body fluid in the operation room and the issue of underreporting. Am J Infect Control (2009) 1.66
Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J Exp Med (2004) 1.64
The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model. Int Immunol (2004) 1.63
Septum-directed secretion in the filamentous fungus Aspergillus oryzae. Mol Microbiol (2011) 1.61
Cutting edge: TLR2 directly triggers Th1 effector functions. J Immunol (2007) 1.61
CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node. J Immunol (2009) 1.57
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med (2007) 1.55
Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J (2007) 1.54
DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes. Proc Natl Acad Sci U S A (2005) 1.53
CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4. Int Immunol (2005) 1.50
Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain. J Cell Sci (2009) 1.49
Therapeutic effect of local administration of low-dose simvastatin-conjugated gelatin hydrogel for fracture healing. J Bone Miner Res (2012) 1.48
Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. J Immunol (2005) 1.47
Effective suppression of hippocampal seizures in rats by direct hippocampal cooling with a Peltier chip. J Neurosurg (2008) 1.45
Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. J Immunol (2002) 1.44
CRYBA4, a novel human cataract gene, is also involved in microphthalmia. Am J Hum Genet (2006) 1.41
Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med (2002) 1.39
Relation between VE/VCO2 slope and maximum phonation time in chronic heart failure patients. Medicine (Baltimore) (2014) 1.39
The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med (2005) 1.39
CARD9 versus CARMA1 in innate and adaptive immunity. Trends Immunol (2009) 1.36
The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med (2004) 1.35
In-frame dystrophin following exon 51-skipping improves muscle pathology and function in the exon 52-deficient mdx mouse. Mol Ther (2010) 1.33
Bodywide skipping of exons 45-55 in dystrophic mdx52 mice by systemic antisense delivery. Proc Natl Acad Sci U S A (2012) 1.32
Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters. Immunol Rev (2009) 1.32
Aβ secretion and plaque formation depend on autophagy. Cell Rep (2013) 1.32
A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28. Nat Immunol (2011) 1.30
CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med (2012) 1.28
Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol (2012) 1.28
The immunological synapse, TCR microclusters, and T cell activation. Curr Top Microbiol Immunol (2010) 1.26
NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling. Proc Natl Acad Sci U S A (2004) 1.25
Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation. Immunity (2010) 1.24
Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9. J Immunol (2008) 1.23
GPVI levels in platelets: relationship to platelet function at high shear. Blood (2003) 1.23
Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood (2012) 1.23
The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation. Blood (2006) 1.23
Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. J Cell Biol (2004) 1.22
Direct binding targets of the stringent response alarmone (p)ppGpp. Mol Microbiol (2012) 1.22
Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Am J Physiol Heart Circ Physiol (2005) 1.22
A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation. Immunity (2008) 1.20
Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance. Blood (2005) 1.18
Identification of distinct ligands for the C-type lectin receptors Mincle and Dectin-2 in the pathogenic fungus Malassezia. Cell Host Microbe (2013) 1.17
Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development. Genes Cells (2002) 1.17
Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils. Nat Immunol (2008) 1.16
A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science (2006) 1.16
Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen. Blood (2004) 1.15
Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells. Blood (2011) 1.14
Water content and apparent stiffness of non-caries versus caries-affected human dentin. J Biomed Mater Res B Appl Biomater (2005) 1.13
Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β. Immunity (2013) 1.13
National surveillance of species distribution in blood isolates of Candida species in Japan and their susceptibility to six antifungal agents including voriconazole and micafungin. J Antimicrob Chemother (2003) 1.12
Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury. Am J Physiol Renal Physiol (2013) 1.11
Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization. Exp Cell Res (2009) 1.10
Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR). Int Immunol (2004) 1.10
Bach2 maintains T cells in a naive state by suppressing effector memory-related genes. Proc Natl Acad Sci U S A (2013) 1.08
An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis. J Cell Biol (2009) 1.08
Molecular basis for pre-TCR-mediated autonomous signaling. Trends Immunol (2006) 1.08
Self and nonself recognition through C-type lectin receptor, Mincle. Self Nonself (2010) 1.08
Nephrotoxic nephritis is mediated by Fcgamma receptors on circulating leukocytes and not intrinsic renal cells. Kidney Int (2002) 1.07
Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palate. Dev Biol (2005) 1.07
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci U S A (2011) 1.07
IRAK-4--a shared NF-kappaB activator in innate and acquired immunity. Trends Immunol (2006) 1.07
Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer. Hum Immunol (2012) 1.05
Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system. J Exp Med (2002) 1.05
Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors. Blood (2012) 1.05
In vitro evaluation of the antimicrobial activity of a new resin-based endodontic sealer against endodontic pathogens. J Oral Sci (2008) 1.04
Prolonged use of dexmedetomidine in an infant with respiratory failure following living donor liver transplantation. Paediatr Anaesth (2006) 1.04
Designed ferromagnetic, ferroelectric Bi(2)NiMnO(6). J Am Chem Soc (2005) 1.04
Importance of murine Vdelta1gammadelta T cells expressing interferon-gamma and interleukin-17A in innate protection against Listeria monocytogenes infection. Immunology (2008) 1.04