Published in Nature on October 05, 2011
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife (2012) 5.18
A two-domain elevator mechanism for sodium/proton antiport. Nature (2013) 2.05
The ABCs of membrane transporters in health and disease (SLC series): introduction. Mol Aspects Med (2013) 1.32
Viral entry of hepatitis B and D viruses and bile salts transportation share common molecular determinants on sodium taurocholate cotransporting polypeptide. J Virol (2014) 1.27
SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers. Mol Aspects Med (2013) 1.26
Membrane protein structure determination - the next generation. Biochim Biophys Acta (2013) 1.23
Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide. J Virol (2013) 1.16
The solute carrier family 10 (SLC10): beyond bile acid transport. Mol Aspects Med (2013) 1.11
Structural basis of the alternating-access mechanism in a bile acid transporter. Nature (2013) 1.08
Sodium taurocholate cotransporting polypeptide mediates woolly monkey hepatitis B virus infection of Tupaia hepatocytes. J Virol (2013) 1.01
Structure and transport mechanism of the sodium/proton antiporter MjNhaP1. Elife (2014) 0.99
Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades. J Lipid Res (2014) 0.99
Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters. Pflugers Arch (2013) 0.97
Orientational preferences of neighboring helices can drive ER insertion of a marginally hydrophobic transmembrane helix. Mol Cell (2012) 0.95
Revealing the ligand binding site of NhaA Na+/H+ antiporter and its pH dependence. J Biol Chem (2012) 0.95
NTCP and beyond: opening the door to unveil hepatitis B virus entry. Int J Mol Sci (2014) 0.95
Molecular modeling and ligand docking for solute carrier (SLC) transporters. Curr Top Med Chem (2013) 0.95
Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights. J Gen Physiol (2014) 0.94
A model-structure of a periplasm-facing state of the NhaA antiporter suggests the molecular underpinnings of pH-induced conformational changes. J Biol Chem (2012) 0.92
Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2). J Lipid Res (2012) 0.91
Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters. Nat Struct Mol Biol (2016) 0.91
Measurement of the equilibrium relative humidity for common precipitant concentrations: facilitating controlled dehydration experiments. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.88
SLC classification: an update. Clin Pharmacol Ther (2013) 0.88
Rapid expression screening of eukaryotic membrane proteins in Pichia pastoris. Protein Sci (2013) 0.84
Highlights from recently determined structures of membrane proteins: a focus on channels and transporters. Curr Opin Struct Biol (2012) 0.84
Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters. Elife (2014) 0.81
Transmembrane domain V plays a stabilizing role in the function of human bile acid transporter SLC10A2. Biochemistry (2013) 0.80
Putative irreversible inhibitors of the human sodium-dependent bile acid transporter (hASBT; SLC10A2) support the role of transmembrane domain 7 in substrate binding/translocation. Pharm Res (2012) 0.80
Structure of urea transporters. Subcell Biochem (2014) 0.79
Elevating the alternating-access model. Nat Struct Mol Biol (2016) 0.79
Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake. Am J Physiol Gastrointest Liver Physiol (2013) 0.78
Functional transformations of bile acid transporters induced by high-affinity macromolecules. Sci Rep (2014) 0.78
Structural insights into the transport of small molecules across membranes. Curr Opin Struct Biol (2014) 0.78
Homologue gene of bile acid transporters ntcp, asbt, and ost-alpha in rainbow trout Oncorhynchus mykiss: tissue expression, effect of fasting, and response to bile acid administration. Fish Physiol Biochem (2013) 0.77
Mechanistic interpretation of conventional Michaelis-Menten parameters in a transporter system. Eur J Pharm Sci (2014) 0.77
A generic protocol for protein crystal dehydration using the HC1b humidity controller. Acta Crystallogr D Struct Biol (2016) 0.77
NhaA antiporter functions using 10 helices, and an additional 2 contribute to assembly/stability. Proc Natl Acad Sci U S A (2015) 0.76
The STM4195 gene product (PanS) transports coenzyme A precursors in Salmonella enterica. J Bacteriol (2015) 0.75
Structural and functional analysis of transmembrane segment IV of the salt tolerance protein Sod2. J Biol Chem (2013) 0.75
Dissecting the proton transport pathway in electrogenic Na(+)/H(+) antiporters. Proc Natl Acad Sci U S A (2017) 0.75
Rhodococcus jostii porin A (RjpA) functions in cholate uptake. Appl Environ Microbiol (2013) 0.75
Raoult's law revisited: accurately predicting equilibrium relative humidity points for humidity control experiments. J Appl Crystallogr (2017) 0.75
TP Atlas: integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan. J Struct Funct Genomics (2012) 0.75
Transmembrane domain II of the human bile acid transporter SLC10A2 coordinates sodium translocation. J Biol Chem (2013) 0.75
The Na+-taurocholate cotransporting polypeptide (NTCP/SLC10A1) ortholog in the marine skate, Leucoraja erinacea is not a physiological bile salt transporter. Am J Physiol Regul Integr Comp Physiol (2017) 0.75
The diversity of membrane transporters encoded in bacterial arsenic-resistance operons. PeerJ (2015) 0.75
Fluorophore Absorption Size Exclusion Chromatography (FA-SEC): An Alternative Method for High-Throughput Detergent Screening of Membrane Proteins. PLoS One (2016) 0.75
The Ec-NhaA antiporter switches from antagonistic to synergistic antiport upon a single point mutation. Sci Rep (2016) 0.75
Transcriptional Profile during Deoxycholate-Induced Sporulation in a Clostridium perfringens Isolate Causing Foodborne Illness. Appl Environ Microbiol (2016) 0.75
Bile Acid Uptake Transporters as Targets for Therapy. Dig Dis (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46
Use of TLS parameters to model anisotropic displacements in macromolecular refinement. Acta Crystallogr D Biol Crystallogr (2001) 21.01
Developments in the CCP4 molecular-graphics project. Acta Crystallogr D Biol Crystallogr (2004) 13.53
Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels. J Mol Biol (1996) 13.17
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters. Nature (2005) 12.56
Methods used in the structure determination of bovine mitochondrial F1 ATPase. Acta Crystallogr D Biol Crystallogr (1996) 11.90
Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT. Acta Crystallogr D Biol Crystallogr (2004) 10.96
Simple allosteric model for membrane pumps. Nature (1966) 7.78
Detection, delineation, measurement and display of cavities in macromolecular structures. Acta Crystallogr D Biol Crystallogr (1994) 7.53
Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins. Structure (2006) 4.79
Electron-density map interpretation. Methods Enzymol (1997) 4.44
Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH. Nature (2005) 3.74
Metal-ligand geometry relevant to proteins and in proteins: sodium and potassium. Acta Crystallogr D Biol Crystallogr (2002) 3.55
Mechanism for alternating access in neurotransmitter transporters. Proc Natl Acad Sci U S A (2008) 3.24
Microscale fluorescent thermal stability assay for membrane proteins. Structure (2008) 2.95
Optimization of membrane protein overexpression and purification using GFP fusions. Nat Methods (2006) 2.78
Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1. Science (2010) 2.52
Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli. FEBS Lett (2001) 2.28
Valence screening of water in protein crystals reveals potential Na+ binding sites. J Mol Biol (1996) 2.23
GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae. Nat Protoc (2008) 2.06
Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. J Biol Chem (1994) 1.77
Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2). J Clin Invest (1997) 1.75
Improving diffraction by humidity control: a novel device compatible with X-ray beamlines. Acta Crystallogr D Biol Crystallogr (2009) 1.73
Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol (1998) 1.63
Benchmarking membrane protein detergent stability for improving throughput of high-resolution X-ray structures. Structure (2011) 1.62
Structural perspectives on secondary active transporters. Trends Pharmacol Sci (2010) 1.53
The enlightening encounter between structure and function in the NhaA Na+-H+ antiporter. Trends Biochem Sci (2008) 1.52
The sodium bile salt cotransport family SLC10. Pflugers Arch (2003) 1.50
Discontinuous membrane helices in transport proteins and their correlation with function. J Struct Biol (2007) 1.38
Computational models for drug inhibition of the human apical sodium-dependent bile acid transporter. Mol Pharm (2009) 1.26
The solute carrier family SLC10: more than a family of bile acid transporters regarding function and phylogenetic relationships. Naunyn Schmiedebergs Arch Pharmacol (2006) 1.23
Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE-/- mice by SC-435. J Lipid Res (2003) 1.21
Bile acid uptake via the human apical sodium-bile acid cotransporter is electrogenic. J Biol Chem (1998) 1.13
RSPS version 4.0: a semi-interactive vector-search program for solving heavy-atom derivatives. Acta Crystallogr D Biol Crystallogr (2000) 1.09
Multiconformation continuum electrostatics analysis of the NhaA Na+/H+ antiporter of Escherichia coli with functional implications. Proc Natl Acad Sci U S A (2006) 1.08
Conformations of NhaA, the Na+/H+ exchanger from Escherichia coli, in the pH-activated and ion-translocating states. J Mol Biol (2009) 1.06
Membrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domains. Biochemistry (2006) 1.03
Structure-based functional study reveals multiple roles of transmembrane segment IX and loop VIII-IX in NhaA Na+/H+ antiporter of Escherichia coli at physiological pH. J Biol Chem (2008) 1.03
Transmembrane domain VII of the human apical sodium-dependent bile acid transporter ASBT (SLC10A2) lines the substrate translocation pathway. Mol Pharmacol (2006) 1.01
Bile acid transport systems as pharmaceutical targets. Eur J Clin Invest (1996) 0.98
Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin Liver Dis (1996) 0.98
Identification of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporter. J Biol Chem (2006) 0.95
Bile acid transport and regulating functions in the human biliary epithelium. Hepatology (2001) 0.95
Transport of taurocholate by mutants of negatively charged amino acids, cysteines, and threonines of the rat liver sodium-dependent taurocholate cotransporting polypeptide Ntcp. Eur J Biochem (2003) 0.93
Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor. Biochemistry (2002) 0.92
Membrane insertion scanning of the human ileal sodium/bile acid co-transporter. Biochemistry (1999) 0.91
Effects of 2164U90 on ileal bile acid absorption and serum cholesterol in rats and mice. J Lipid Res (1995) 0.87
Structure and mechanism of the lactose permease of Escherichia coli. Science (2003) 10.57
Architecture of the photosynthetic oxygen-evolving center. Science (2004) 9.94
Architecture of succinate dehydrogenase and reactive oxygen species generation. Science (2003) 4.40
Global topology analysis of the Escherichia coli inner membrane proteome. Science (2005) 4.11
Structure of the human histamine H1 receptor complex with doxepin. Nature (2011) 3.48
Structure and molecular mechanism of a nucleobase-cation-symport-1 family transporter. Science (2008) 3.39
The X-ray crystal structures of wild-type and EQ(I-286) mutant cytochrome c oxidases from Rhodobacter sphaeroides. J Mol Biol (2002) 3.19
Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY. EMBO J (2006) 2.92
Structural determination of wild-type lactose permease. Proc Natl Acad Sci U S A (2007) 2.83
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nat Methods (2010) 2.77
Molecular basis of proton motive force generation: structure of formate dehydrogenase-N. Science (2002) 2.61
Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1. Science (2010) 2.52
Overcoming barriers to membrane protein structure determination. Nat Biotechnol (2011) 2.49
High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2007) 2.15
Rationalizing membrane protein overexpression. Trends Biotechnol (2006) 2.07
GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae. Nat Protoc (2008) 2.06
Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2. EMBO J (2010) 2.05
A two-domain elevator mechanism for sodium/proton antiport. Nature (2013) 2.05
G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody. Nature (2012) 1.82
Alternating access mechanism in the POT family of oligopeptide transporters. EMBO J (2012) 1.75
Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase. Proc Natl Acad Sci U S A (2003) 1.66
Benchmarking membrane protein detergent stability for improving throughput of high-resolution X-ray structures. Structure (2011) 1.62
Overcoming the challenges of membrane protein crystallography. Curr Opin Struct Biol (2008) 1.57
Rationalizing alpha-helical membrane protein crystallization. Protein Sci (2008) 1.53
Clustering procedures for the optimal selection of data sets from multiple crystals in macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2013) 1.48
Structural basis of biological N2O generation by bacterial nitric oxide reductase. Science (2010) 1.44
Low 25-hydroxyvitamin D levels and cognitive impairment in hemodialysis patients. Clin J Am Soc Nephrol (2013) 1.44
Lactose permease as a paradigm for membrane transport proteins (Review). Mol Membr Biol (2004) 1.43
Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358. Cancer Res (2007) 1.42
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction. J Biol Chem (2005) 1.38
Experimentally based topology models for E. coli inner membrane proteins. Protein Sci (2004) 1.37
The lactose permease of Escherichia coli: overall structure, the sugar-binding site and the alternating access model for transport. FEBS Lett (2003) 1.36
Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor. J Med Chem (2011) 1.30
Defining the role of the Escherichia coli chaperone SecB using comparative proteomics. J Biol Chem (2005) 1.28
Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures. Nature (2013) 1.26
Architecture of NarGH reveals a structural classification of Mo-bisMGD enzymes. Structure (2004) 1.26
Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity. Structure (2004) 1.23
Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily. Curr Opin Struct Biol (2004) 1.22
Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus. EMBO J (2005) 1.21
Molecular mechanism of energy conservation in polysulfide respiration. Nat Struct Mol Biol (2008) 1.14
Crystal structure of A3B3 complex of V-ATPase from Thermus thermophilus. EMBO J (2009) 1.14
Ion binding and selectivity of the rotor ring of the Na+-transporting V-ATPase. Proc Natl Acad Sci U S A (2008) 1.13
Crystal structure of glucansucrase from the dental caries pathogen Streptococcus mutans. J Mol Biol (2011) 1.13
Interaction and stoichiometry of the peripheral stalk subunits NtpE and NtpF and the N-terminal hydrophilic domain of NtpI of Enterococcus hirae V-ATPase. J Biol Chem (2008) 1.11
Structure of the rotor ring modified with N,N'-dicyclohexylcarbodiimide of the Na+-transporting vacuolar ATPase. Proc Natl Acad Sci U S A (2011) 1.10
Crystal structure of the central axis DF complex of the prokaryotic V-ATPase. Proc Natl Acad Sci U S A (2011) 1.09
Targeting, insertion, and localization of Escherichia coli YidC. J Biol Chem (2002) 1.08
Optimizing membrane protein overexpression in the Escherichia coli strain Lemo21(DE3). J Mol Biol (2012) 1.07
The structure of the efflux pump AcrB in complex with bile acid. Mol Membr Biol (2008) 1.07
Formate dehydrogenase--a versatile enzyme in changing environments. Curr Opin Struct Biol (2003) 1.05
Protonmotive force generation by a redox loop mechanism. FEBS Lett (2003) 1.03
The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates. Proc Natl Acad Sci U S A (2012) 1.02
Breaking the barriers in membrane protein crystallography. Int J Biochem Cell Biol (2013) 1.00
Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms. J Mol Biol (2007) 0.99
Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort. Neurosci Lett (2011) 0.98
Structure of Escherichia coli succinate:quinone oxidoreductase with an occupied and empty quinone-binding site. J Biol Chem (2009) 0.97
Insights into how nucleotide-binding domains power ABC transport. Structure (2009) 0.97
Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains. Acta Crystallogr D Biol Crystallogr (2007) 0.96
Membrane protein complexes. Curr Opin Struct Biol (2002) 0.96
Tricks of the trade used to accelerate high-resolution structure determination of membrane proteins. FEBS Lett (2010) 0.95
Evaluation of the Pichia pastoris expression system for the production of GPCRs for structural analysis. Microb Cell Fact (2011) 0.95
Complex II from a structural perspective. Curr Protein Pept Sci (2004) 0.93
The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1. J Synchrotron Radiat (2010) 0.91
Insights into outer membrane protein crystallization. Mol Membr Biol (2008) 0.90
Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity. Biochemistry (2009) 0.90
Reconstitution in vitro of the catalytic portion (NtpA3-B3-D-G complex) of Enterococcus hirae V-type Na+-ATPase. Biochem Biophys Res Commun (2009) 0.88
Predicting gestational trophoblastic neoplasia (GTN): is urine hCG the answer? Gynecol Oncol (2011) 0.87
Crystallization of small proteins assisted by green fluorescent protein. Acta Crystallogr D Biol Crystallogr (2010) 0.87
Generation of functional antibodies for mammalian membrane protein crystallography. Curr Opin Struct Biol (2013) 0.87
Advanced method for high-throughput expression of mutated eukaryotic membrane proteins in Saccharomyces cerevisiae. Biochem Biophys Res Commun (2008) 0.86
Crystal structure of neoculin: insights into its sweetness and taste-modifying activity. J Mol Biol (2006) 0.86
Variation in proton donor/acceptor pathways in succinate:quinone oxidoreductases. FEBS Lett (2003) 0.85
Production of the stable human histamine H₁ receptor in Pichia pastoris for structural determination. Methods (2011) 0.85
A purified C-terminally truncated human adenosine A(2A) receptor construct is functionally stable and degradation resistant. Protein Expr Purif (2010) 0.84
Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae. Microb Cell Fact (2012) 0.84
High-throughput construction of expression system using yeast Pichia pastoris, and its application to membrane proteins. Protein Expr Purif (2010) 0.83
Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.83
Stabilizing the heterologously expressed uric acid-xanthine transporter UapA from the lower eukaryote Aspergillus nidulans. Mol Membr Biol (2012) 0.83
Perturbation of the quinone-binding site of complex II alters the electronic properties of the proximal [3Fe-4S] iron-sulfur cluster. J Biol Chem (2011) 0.83
Purification, crystallisation and preliminary crystallographic studies of succinate:ubiquinone oxidoreductase from Escherichia coli. Biochim Biophys Acta (2002) 0.82
Using rational screening and electron microscopy to optimize the crystallization of succinate:ubiquinone oxidoreductase from Escherichia coli. Acta Crystallogr D Biol Crystallogr (2003) 0.82
Crystallization of the chaperonin GroEL-GroES complex from Thermus thermophilus HB8. Acta Crystallogr D Biol Crystallogr (2003) 0.82