Published in PLoS One on September 27, 2011
The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence. Genes Dev (2012) 1.33
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. Proc Natl Acad Sci U S A (2012) 1.28
Genetics and epigenetics of aging and longevity. Cell Cycle (2014) 1.07
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. Cell Rep (2014) 1.05
The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med (2013) 1.01
Integrated analysis of recurrent properties of cancer genes to identify novel drivers. Genome Biol (2013) 0.91
Pharmacological levels of Withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells. PLoS One (2014) 0.87
Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention. Curr Cancer Drug Targets (2013) 0.87
Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem (2014) 0.86
Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis. Mol Cell Proteomics (2014) 0.82
Mammalian lysine histone demethylase KDM2A regulates E2F1-mediated gene transcription in breast cancer cells. PLoS One (2014) 0.82
Histone methylation and aging: lessons learned from model systems. Biochim Biophys Acta (2014) 0.79
Histone demethylase lysine demethylase 5B in development and cancer. Oncotarget (2016) 0.79
Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers. Cancer Biol Ther (2012) 0.78
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases. Aging Dis (2016) 0.77
Rb1 mRNA expression in developing mouse teeth. Gene Expr Patterns (2012) 0.77
Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity. PLoS Genet (2016) 0.75
Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy. BMC Genomics (2014) 0.75
Epigenetic gene regulation by histone demethylases: emerging role in oncogenesis and inflammation. Oral Dis (2016) 0.75
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
Chromatin modifications and their function. Cell (2007) 55.98
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature (2005) 16.87
Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
The essence of senescence. Genes Dev (2010) 8.21
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev (2007) 6.77
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell (2010) 6.47
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev (2000) 5.80
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev (2008) 5.25
Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer (2008) 5.19
Dynamic regulation of histone lysine methylation by demethylases. Mol Cell (2007) 5.14
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell (2006) 4.74
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell (2007) 4.34
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum Mol Genet (2000) 3.87
Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. Cancer Cell (2010) 3.81
The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell (2007) 3.79
Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev (2000) 3.74
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell (2007) 3.68
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2. Genes Dev (2008) 3.10
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev (2009) 3.04
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev (2009) 2.98
ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell (2009) 2.93
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc Natl Acad Sci U S A (2007) 2.45
Many roads lead to oncogene-induced senescence. Oncogene (2008) 2.43
Cellular senescence in vivo: a barrier to tumorigenesis. Curr Opin Cell Biol (2008) 2.30
Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem (2003) 2.14
A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J Biol Chem (1999) 2.09
Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi. Aging Cell (2007) 2.07
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus. EMBO J (2007) 1.99
Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol (2007) 1.97
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene (2007) 1.92
Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit. J Cell Biol (2007) 1.72
Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev (2004) 1.72
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes. Oncogene (2006) 1.60
E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest. Cancer Cell (2002) 1.59
Functional analysis of the transcription repressor PLU-1/JARID1B. Mol Cell Biol (2007) 1.57
Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc Natl Acad Sci U S A (2008) 1.55
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc Natl Acad Sci U S A (2009) 1.54
Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. J Biol Chem (2003) 1.50
TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J Biol Chem (2001) 1.46
A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence. Mol Cell Biol (2009) 1.23
Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas. Mod Pathol (2005) 1.16
TSPYL5 suppresses p53 levels and function by physical interaction with USP7. Nat Cell Biol (2010) 1.13
Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells. J Invest Dermatol (2006) 1.10
Rb/E2F: a two-edged sword in the melanocytic system. Cancer Metastasis Rev (2005) 1.06
The Rb/chromatin connection and epigenetic control: opinion. Oncogene (2001) 1.04
Deficiency of a novel retinoblastoma binding protein 2-homolog is a consistent feature of sporadic human melanoma skin cancer. Lab Invest (1999) 0.92
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell (2007) 11.21
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature (2012) 9.39
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
Statistical methods for analysis of high-throughput RNA interference screens. Nat Methods (2009) 4.76
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling. Cell (2012) 4.01
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res (2008) 3.70
The ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol (2007) 3.63
A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity. Cell (2005) 3.35
ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell (2009) 2.93
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors. Nat Chem Biol (2006) 2.91
A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients. Cancer Res (2005) 2.65
The Ebola virus VP35 protein is a suppressor of RNA silencing. PLoS Pathog (2007) 2.48
Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1. Nature (2007) 2.19
Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. J Am Chem Soc (2007) 2.10
shRNA libraries and their use in cancer genetics. Nat Methods (2006) 1.66
Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition. Int J Cancer (2013) 1.60
Analysis of the MammaPrint breast cancer assay in a predominantly postmenopausal cohort. Clin Cancer Res (2008) 1.48
Using functional genetics to understand breast cancer biology. Cold Spring Harb Perspect Biol (2010) 1.39
Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1. EMBO J (2008) 1.36
Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell (2005) 1.34
A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway. PLoS One (2009) 1.29
A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response. Breast Cancer Res Treat (2011) 1.26
A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. Cell (2011) 1.14
Biological functions of the genes in the mammaprint breast cancer profile reflect the hallmarks of cancer. Biomark Insights (2010) 1.11
A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency. J Pathol (2012) 1.00
Screening for modulators of cisplatin sensitivity: unbiased screens reveal common themes. Cell Cycle (2011) 0.88
Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling. J Cell Mol Med (2012) 0.88
Vorinostat combined with bexarotene for treatment of cutaneous T-cell lymphoma: in vitro and phase I clinical evidence supporting augmentation of retinoic acid receptor/retinoid X receptor activation by histone deacetylase inhibition. Leuk Lymphoma (2012) 0.88
Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade. Mol Cancer Res (2010) 0.87
Exploration of synthetic lethal interactions as cancer drug targets. Future Oncol (2010) 0.86
Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle. Cancer Lett (2002) 0.85
Estrogen receptor splice variants as a potential source of false-positive estrogen receptor status in breast cancer diagnostics. Breast Cancer Res Treat (2013) 0.83
A regression model for estimating DNA copy number applied to capture sequencing data. Bioinformatics (2012) 0.83
Using large-scale RNAi screens to identify novel drug targets for cancer. IDrugs (2010) 0.80
Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen. Clin Cancer Res (2009) 0.80
VAV3 mediates resistance to breast cancer endocrine therapy. Breast Cancer Res (2014) 0.78
The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling. Mol Cell Biol (2013) 0.78
Reaction to American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J Clin Oncol (2008) 0.75
Radical Sabbaticals. Cell (2015) 0.75