Published in Proc Natl Acad Sci U S A on February 04, 2008
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat Struct Mol Biol (2008) 3.80
The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J Biol Chem (2008) 2.00
Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol (2011) 1.81
A new world of Polycombs: unexpected partnerships and emerging functions. Nat Rev Genet (2013) 1.67
Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health. Epigenetics (2010) 1.63
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc Natl Acad Sci U S A (2009) 1.54
FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway. Mol Cell (2011) 1.49
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer. Genes Cancer (2011) 1.47
KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia. Blood (2011) 1.43
Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming. Nat Cell Biol (2012) 1.35
Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. J Biol Chem (2011) 1.31
ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Biochem Soc Trans (2013) 1.30
KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs. J Clin Invest (2013) 1.21
Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells. J Biol Chem (2011) 1.12
The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress. Mol Cell Biol (2008) 1.12
SnoN functions as a tumour suppressor by inducing premature senescence. EMBO J (2009) 1.09
KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest (2013) 1.07
Histone demethylases and cancer. Adv Cancer Res (2009) 1.05
Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines. Proc Natl Acad Sci U S A (2013) 1.04
Vitamin D and the epigenome. Front Physiol (2014) 1.04
Epigenetic control of aging. Antioxid Redox Signal (2010) 1.02
The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence. PLoS One (2011) 0.98
Chromatin modifications: the driving force of senescence and aging? Aging (Albany NY) (2009) 0.96
NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer Res (2014) 0.90
Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. Blood (2015) 0.88
Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention. Curr Cancer Drug Targets (2013) 0.87
Chromatin and oxygen sensing in the context of JmjC histone demethylases. Biochem J (2014) 0.87
Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis. J Clin Invest (2016) 0.87
Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer. J Proteome Res (2013) 0.83
Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells. J Biol Chem (2014) 0.80
The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy. PLoS One (2014) 0.80
A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster. Mech Dev (2014) 0.79
Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers. Cancer Biol Ther (2012) 0.78
KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Oncogene (2016) 0.78
JMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein. Cell Death Differ (2015) 0.78
Lysine-specific histone demethylases in normal and malignant hematopoiesis. Exp Hematol (2016) 0.76
Association between EZH2 expression, silencing of tumor suppressors and disease outcome in solid tumors. Cell Cycle (2016) 0.75
Histone demethylases and their roles in cancer epigenetics. J Med Oncol Ther (2016) 0.75
Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo. Onco Targets Ther (2017) 0.75
The language of covalent histone modifications. Nature (2000) 44.92
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol (2005) 12.70
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
Cellular senescence in cancer and aging. Cell (2007) 9.04
Histone modifications in transcriptional regulation. Curr Opin Genet Dev (2002) 8.10
Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet (2005) 6.85
JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet (2006) 6.65
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell (1999) 5.93
Telomere states and cell fates. Nature (2000) 5.71
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature (2006) 4.74
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet (2006) 4.43
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell (2007) 3.68
Conformational dynamics of the chromatin fiber in solution: determinants, mechanisms, and functions. Annu Rev Biophys Biomol Struct (2001) 3.51
Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell (2007) 3.23
Leukaemia disease genes: large-scale cloning and pathway predictions. Nat Genet (1999) 3.19
INK4a/ARF: a multifunctional tumor suppressor locus. Mutat Res (2005) 3.08
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev (2003) 2.76
Swi6/HP1 recruits a JmjC domain protein to facilitate transcription of heterochromatic repeats. Mol Cell (2006) 2.72
What has senescence got to do with cancer? Cancer Cell (2005) 2.55
Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Mol Cell Biol (1993) 2.37
Human cell senescence as a DNA damage response. Mech Ageing Dev (2005) 2.26
JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature (2007) 2.20
JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta. Trends Biochem Sci (2001) 2.16
p53: good cop/bad cop. Cell (2002) 2.11
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBO J (2006) 1.88
A novel jmjC domain protein modulates heterochromatization in fission yeast. Mol Cell Biol (2003) 1.70
Unwinding chromatin for development and growth: a few genes at a time. Trends Genet (2007) 1.57
Virus-host interactions and the pathogenesis of murine and human oncogenic retroviruses. Curr Top Microbiol Immunol (1991) 1.47
The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin. EMBO J (2007) 1.40
Cell cycle control and beyond: emerging roles for the retinoblastoma gene family. Oncogene (2006) 1.29
Not just a CDK inhibitor: regulation of transcription by p21(WAF1/CIP1/SDI1). Cell Cycle (2002) 1.10
Destabilizing heterochromatin: Does Swi6/HP1 make the choice? Mol Cell (2006) 0.79
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res (2009) 6.74
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell (2010) 4.02
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res (2003) 3.58
The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity (2009) 3.58
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature (2010) 3.55
Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell (2010) 3.53
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res (2007) 3.13
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal (2009) 2.38
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Res (2011) 2.35
c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo. Circ Res (2005) 2.23
Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance. J Biol Chem (2004) 2.21
AKT signaling in normal and malignant cells. Oncogene (2005) 2.14
Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity (2002) 1.99
Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. EMBO J (2002) 1.98
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci U S A (2012) 1.97
Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. J Immunol (2007) 1.88
Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology (2013) 1.85
Regulation of the Akt kinase by interacting proteins. Oncogene (2005) 1.71
Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell (2002) 1.71
TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells. J Exp Med (2009) 1.58
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc Natl Acad Sci U S A (2009) 1.54
Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. EMBO J (2003) 1.54
FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway. Mol Cell (2011) 1.49
Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res (2011) 1.48
A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res (2009) 1.48
Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase. Proc Natl Acad Sci U S A (2003) 1.47
Tpl2/cot signals activate ERK, JNK, and NF-kappaB in a cell-type and stimulus-specific manner. J Biol Chem (2005) 1.45
Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794. J Biol Chem (2007) 1.41
Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells. Nucleic Acids Res (2004) 1.34
Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. J Exp Med (2008) 1.33
Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production. J Immunol (2009) 1.24
VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. FASEB J (2008) 1.14
Tumor progression locus-2 is a critical regulator of pancreatic and lung inflammation during acute pancreatitis. J Biol Chem (2007) 1.14
Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment. J Immunol (2003) 1.12
The JmjC domain histone demethylase Ndy1 regulates redox homeostasis and protects cells from oxidative stress. Mol Cell Biol (2008) 1.12
Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. J Biol Chem (2005) 1.10
Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. J Cell Physiol (2008) 1.10
Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration. Cancer Res (2008) 1.08
Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes. Am J Physiol Endocrinol Metab (2002) 1.06
Histone demethylases and cancer. Adv Cancer Res (2009) 1.05
Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. Proc Natl Acad Sci U S A (2012) 1.04
Differential roles of tau class glutathione S-transferases in oxidative stress. J Biol Chem (2004) 1.03
The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2. J Virol (2002) 1.03
The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. Proc Natl Acad Sci U S A (2012) 1.02
Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. Microb Cell Fact (2011) 1.01
Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells. Proc Natl Acad Sci U S A (2008) 0.99
TPL2 kinase is a suppressor of lung carcinogenesis. Proc Natl Acad Sci U S A (2013) 0.99
Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol (2006) 0.96
AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. FASEB J (2013) 0.96
Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res (2013) 0.95
Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice. J Immunol (2009) 0.95
Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide. Proc Natl Acad Sci U S A (2005) 0.94
Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast. J Biol Chem (2007) 0.91
Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae. Microb Cell Fact (2012) 0.87
Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis. J Clin Invest (2016) 0.87
iPSC-derived fibroblasts demonstrate augmented production and assembly of extracellular matrix proteins. In Vitro Cell Dev Biol Anim (2012) 0.87
Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer. J Proteome Res (2007) 0.86
Tumor progression locus 2 mediates signal-induced increases in cytoplasmic calcium and cell migration. Sci Signal (2011) 0.85
Effects of hypoxia and hypercapnia on surfactant protein expression proliferation and apoptosis in A549 alveolar epithelial cells. Life Sci (2005) 0.85
The tyrosine kinase Syk regulates TPL2 activation signals. J Biol Chem (2005) 0.85
Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol (2014) 0.84
Engineering monoterpene production in yeast using a synthetic dominant negative geranyl diphosphate synthase. ACS Synth Biol (2014) 0.83
Antioxidant small molecules confer variable protection against oxidative damage in yeast mutants. J Agric Food Chem (2008) 0.82
The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties. EMBO J (2011) 0.82
Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice. J Leukoc Biol (2013) 0.79
Akt1, EMSY, BRCA2 and type I IFN signaling: a novel arm of the IFN response. Transcription (2012) 0.77
Differential splicing generates Tvl-1/RFXANK isoforms with different functions. J Biol Chem (2002) 0.77
Expression of Bax in yeast affects not only the mitochondria but also vacuolar integrity and intracellular protein traffic. FEBS Lett (2004) 0.76
Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol (2017) 0.75