Modulation of autophagic activity by extracellular pH.

PubWeight™: 0.80‹?›

🔗 View Article (PMC 3242796)

Published in Autophagy on November 01, 2011

Authors

Teng Xu1, Hang Su, Suthakar Ganapathy, Zhi-Min Yuan

Author Affiliations

1: Department of Radiation Oncology, Cancer Therapy & Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Articles cited by this

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62

Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 20.60

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (2003) 18.51

Autophagy: process and function. Genes Dev (2007) 15.21

Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet (2009) 14.06

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res (1989) 12.85

How to interpret LC3 immunoblotting. Autophagy (2007) 12.30

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell (2006) 11.79

Autophagy and the integrated stress response. Mol Cell (2010) 11.21

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol (2004) 8.85

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev (2011) 7.43

Cell biology: autophagy and cancer. Nature (2007) 4.40

A microenvironmental model of carcinogenesis. Nat Rev Cancer (2008) 4.40

The effects of extracellular pH on immune function. J Leukoc Biol (2001) 3.23

Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res (1996) 3.11

Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res (2006) 3.10

Adaptive therapy. Cancer Res (2009) 2.81

The regulation and modulation of pH in the nervous system. Prog Neurobiol (1990) 2.56

Hypoxia-induced autophagy: cell death or cell survival? Curr Opin Cell Biol (2009) 2.45

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death Differ (2008) 2.45

Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res (2007) 2.39

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med (2009) 2.13

The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res (2009) 1.92

Acidic stress promotes a glioma stem cell phenotype. Cell Death Differ (2010) 1.79

Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res (2011) 1.76

Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. J Biol Chem (2001) 1.72

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity. Int J Cancer (2010) 1.58

Extracellular pH regulates bone cell function. J Nutr (2008) 1.18

Proton dynamics in cancer. J Transl Med (2010) 1.14

pH distributions in spontaneous and isotransplanted rat tumours. Br J Cancer (1988) 1.12

Flow cytometric calibration of intracellular pH measurements in viable cells using mixtures of weak acids and bases. Cytometry (1996) 0.88

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet (2003) 3.38

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem (2002) 2.68

A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis (2008) 2.37

DNA damage-induced MDMX degradation is mediated by MDM2. J Biol Chem (2003) 2.03

RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity. Cancer Res (2007) 1.70

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo. Proc Natl Acad Sci U S A (2011) 1.66

Critical contribution of the MDM2 acidic domain to p53 ubiquitination. Mol Cell Biol (2003) 1.49

Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. PLoS One (2010) 1.41

EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. Front Biosci (2008) 1.40

Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis. Clin Cancer Res (2008) 1.35

c-Abl stabilizes p73 by a phosphorylation-augmented interaction. Cancer Res (2003) 1.30

c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading. J Biol Chem (2006) 1.29

Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. Cancer Res (2005) 1.28

Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation. Biochem J (2011) 1.25

Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage. J Biol Chem (2005) 1.23

Green tea polyphenols: biology and therapeutic implications in cancer. Front Biosci (2007) 1.22

Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis. Mol Cancer (2008) 1.10

Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. J Biol Chem (2008) 1.06

Facile synthesis of the Li-rich layered oxide Li1.23Ni0.09Co0.12Mn0.56O2 with superior lithium storage performance and new insights into structural transformation of the layered oxide material during charge-discharge cycle: in situ XRD characterization. ACS Appl Mater Interfaces (2014) 1.05

Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL. Mol Cell Biol (2003) 1.04

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output. EMBO J (2010) 1.03

p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm. Mol Cell Biol (2002) 1.02

Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Cancer Res (2008) 1.02

MDM2 and MDMX: Alone and together in regulation of p53. Transl Cancer Res (2012) 1.00

Inhibition of p53 DNA binding function by the MDM2 protein acidic domain. J Biol Chem (2011) 0.99

Biogenic potassium salt particles as seeds for secondary organic aerosol in the Amazon. Science (2012) 0.97

Biomedical Teleacupuncture between China and Austria Using Heart Rate Variability-Part 2: Patients with Depression. Evid Based Complement Alternat Med (2012) 0.97

Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. Am J Hum Genet (2009) 0.93

c-Abl regulates early growth response protein (EGR1) in response to oxidative stress. Oncogene (2005) 0.92

Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation. J Biol Chem (2002) 0.92

Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl. Mol Cell Biol (2002) 0.92

Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant. Radiat Res (2009) 0.88

c-Abl-dependent molecular circuitry involving Smad5 and phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2-induced osteogenesis. J Biol Chem (2013) 0.87

A phosphotyrosine switch determines the antitumor activity of ERβ. J Clin Invest (2014) 0.86

Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms. Mol Cancer Ther (2008) 0.86

Small molecule-induced mitochondrial disruption directs prostate cancer inhibition via UPR signaling. Oncotarget (2013) 0.84

A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection. J Biol Chem (2014) 0.84

Effective modulation of CD4(+)CD25 (+high) regulatory T and NK cells in malignant patients by combination of interferon-α and interleukin-2. Cancer Immunol Immunother (2012) 0.83

Gender differences in socio-demographic and clinical characteristics of methamphetamine inpatients in a Chinese population. Drug Alcohol Depend (2012) 0.83

Clinical and immunopathological features of Moyamoya disease. PLoS One (2012) 0.83

A nonluminescent and highly virulent Vibrio harveyi strain is associated with "bacterial white tail disease" of Litopenaeus vannamei shrimp. PLoS One (2012) 0.81

Secretion of rat tracheal epithelial cells induces mesenchymal stem cells to differentiate into epithelial cells. Cell Biol Int (2012) 0.81

Stochastic modeling and simulation of the p53-MDM2/MDMX loop. J Comput Biol (2009) 0.81

Apoptosis detection for adherent cell populations in time-lapse phase-contrast microscopy images. Med Image Comput Comput Assist Interv (2012) 0.81

Hierarchical Mn₂O ₃Hollow Microspheres as Anode Material of Lithium Ion Battery and Its Conversion Reaction Mechanism Investigated by XANES. ACS Appl Mater Interfaces (2015) 0.79

p21/Cyclin E pathway modulates anticlastogenic function of Bmi-1 in cancer cells. Int J Cancer (2014) 0.77

Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes. Oncogene (2005) 0.77

The Body Mass Index, Blood Pressure, and Fasting Blood Glucose in Patients With Methamphetamine Dependence. Medicine (Baltimore) (2016) 0.77

A newly synthesized sinapic acid derivative inhibits endothelial activation in vitro and in vivo. Mol Pharmacol (2013) 0.76

Cardiac hybrid SPECT/CTA imaging to detect "functionally relevant coronary artery lesion": a potential gatekeeper for coronary revascularization? Ann Nucl Med (2013) 0.76

Immunological suppression of head and neck carcinoma by dendritic cell tumor fusion vaccine. Oncol Lett (2013) 0.76

Identification and characterization of receptor-interacting protein 2 as a TNFR-associated factor 3 binding partner. Gene (2013) 0.76

Primary empty sella associated with pituitary adenoma diagnosed by inferior petrosal sinus blood sampling. Chin Med J (Engl) (2015) 0.75

Time-Dependent Serum Brain-Derived Neurotrophic Factor Decline During Methamphetamine Withdrawal. Medicine (Baltimore) (2016) 0.75

Increased BDNF may not be associated with cognitive impairment in heroin-dependent patients. Medicine (Baltimore) (2017) 0.75

Video sensor-based complex scene analysis with Granger causality. Sensors (Basel) (2013) 0.75

[Eosinophil could predict the prognosis of patients with bloodstream infection: a retrospective analysis of 305 cases]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue (2017) 0.75

Cell-sensitive microscopy imaging for cell image segmentation. Med Image Comput Comput Assist Interv (2014) 0.75

[Ethyl acetate-soluble chemical constituents from branch of Hypericum petiolulatum]. Zhongguo Zhong Yao Za Zhi (2015) 0.75

[Clinical outcome of arthroscopic excision of the os subfibulare in ankle pain]. Zhongguo Gu Shang (2016) 0.75

Bioactivity, toxicity and dissipation of hexaconazole enantiomers. Chemosphere (2013) 0.75

Prokaryotic expression, purification and functional characterization of recombinant human RIP2. Mol Biol Rep (2012) 0.75

Relationship of Lymph Node Micrometastasis and Micropapillary Component and Their Joint Influence on Prognosis of Patients With Stage I Lung Adenocarcinoma. Am J Surg Pathol (2017) 0.75

Direct evidence of visible surface plasmon excitation in ITO film coated on LiNbO<sub>3</sub> slabs. Opt Express (2017) 0.75

Tracking changes of hexabromocyclododecanes during refining process in peanut, corn and soybean oils. J Agric Food Chem (2017) 0.75

[An experimental study on the basic fibroblast growth factor slow-releasing microsphere for knee osteoarthritis in the rabbit]. Zhonghua Wai Ke Za Zhi (2011) 0.75

[Expression of angiogenin in COS-7 cells and analysis of its biological activity]. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2008) 0.75

Kinetics and structural changes of Li-rich layered oxide 0.5Li2MnO3·0.5LiNi(0.292)Co(0.375)Mn(0.333)O2 material investigated by a novel technique combining in situ XRD and a multipotential step. ACS Appl Mater Interfaces (2014) 0.75

Interactive Cell Segmentation Based on Active and Semi-Supervised Learning. IEEE Trans Med Imaging (2015) 0.75

[Autologous peripheral blood stem cell transplantation combined with autologous bone marrow transplantation for treating refractory lymphoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2009) 0.75

The absorption and fluorescence spectra of 4-(3-methoxybenzylidene)-2-methyl-oxazalone interpreted by Franck-Condon simulation in various pH solvent environments. Phys Chem Chem Phys (2020) 0.75

[Significance of functional assay of multidrug resistance for prediction of chemotherapy outcomes in acute leukemia]. Ai Zheng (2003) 0.75

A dicranopteris-like Fe-Sn-Sb-P alloy as a promising anode for lithium ion batteries. Chem Commun (Camb) (2012) 0.75

[Clinical observation of 100 patients with malignant lymphoma treating with different preconditioning regimens followed by autologous hematopoietic stem cell transplantation]. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2012) 0.75

[Synergism between Ang-2 and VEGF and its application of anti-angiogenesis in tumor therapy - review]. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2007) 0.75

An online monitoring system for atmospheric nitrous acid (HONO) based on stripping coil and ion chromatography. J Environ Sci (China) (2013) 0.75

Atmospheric protein chemistry influenced by anthropogenic air pollutants: nitration and oligomerization upon exposure to ozone and nitrogen dioxide. Faraday Discuss (2017) 0.75

[Retrospective analysis for 104 cases of early-stage Hodgkin's Lymphoma treated with different modality therapies]. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2012) 0.75

The effects of different core-shell structures on the electrochemical performances of Si-Ge nanorod arrays as anodes for micro-lithium ion batteries. ACS Appl Mater Interfaces (2014) 0.75