Published in Cancer Res on July 01, 2006
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest (2007) 4.71
Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvasc Res (2007) 3.64
Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res (2009) 3.40
Reactive oxygen species in cancer. Free Radic Res (2010) 3.20
Acidity generated by the tumor microenvironment drives local invasion. Cancer Res (2013) 2.63
Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation (2010) 2.53
A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res (2009) 2.30
Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxid Redox Signal (2011) 2.04
Disrupting proton dynamics and energy metabolism for cancer therapy. Nat Rev Cancer (2013) 1.93
The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res (2009) 1.92
The tumor microenvironment and metastatic disease. Clin Exp Metastasis (2008) 1.91
Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? J Bioenerg Biomembr (2007) 1.83
Imaging angiogenesis and the microenvironment. APMIS (2008) 1.77
Imaging pH and metastasis. NMR Biomed (2011) 1.67
Surface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticles. ACS Nano (2010) 1.61
Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol (2011) 1.50
Protons make tumor cells move like clockwork. Pflugers Arch (2009) 1.48
Acidic extracellular microenvironment and cancer. Cancer Cell Int (2013) 1.47
Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis (2008) 1.44
Histone acetylation regulates intracellular pH. Mol Cell (2012) 1.30
pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol Membr Biol (2010) 1.29
Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis. J Cell Mol Med (2009) 1.28
Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells. J Biol Chem (2009) 1.28
Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol (2015) 1.24
Reduction of metastasis using a non-volatile buffer. Clin Exp Metastasis (2011) 1.21
Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts. Cancer Res (2008) 1.20
Collagen I but not Matrigel matrices provide an MMP-dependent barrier to ovarian cancer cell penetration. BMC Cancer (2008) 1.17
pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution. J Physiol (2007) 1.13
Targeting the metabolic microenvironment of tumors. Adv Pharmacol (2012) 1.11
Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil. Oncotarget (2015) 1.11
Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors. Front Physiol (2014) 1.11
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors. Front Physiol (2013) 1.10
Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae. Genome Biol (2012) 1.09
In vivo pH imaging with (99m)Tc-pHLIP. Mol Imaging Biol (2012) 1.09
Estrogen decrease in tight junctional resistance involves matrix-metalloproteinase-7-mediated remodeling of occludin. Endocrinology (2006) 1.08
Proton pump inhibitors as anti vacuolar-ATPases drugs: a novel anticancer strategy. J Exp Clin Cancer Res (2010) 1.05
Role of myoepithelial cells in breast tumor progression. Front Biosci (Landmark Ed) (2010) 1.03
Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. Cancer Chemother Pharmacol (2010) 1.03
Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation. PLoS One (2011) 1.03
Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study. Mol Cancer (2010) 1.03
Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK). PLoS One (2011) 1.01
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs). J Bioenerg Biomembr (2012) 1.00
Proteases and sFlt-1 release in the human placenta. Placenta (2010) 1.00
Bicarbonate and dichloroacetate: evaluating pH altering therapies in a mouse model for metastatic breast cancer. BMC Cancer (2011) 0.98
The Na⁺/H⁺ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells. Oncotarget (2015) 0.98
Role of pHi, and proton transporters in oncogene-driven neoplastic transformation. Philos Trans R Soc Lond B Biol Sci (2014) 0.97
Acid-mediated tumor proteolysis: contribution of cysteine cathepsins. Neoplasia (2013) 0.96
Acidic pH via NF-κB favours VEGF-C expression in human melanoma cells. Clin Exp Metastasis (2013) 0.96
RNAi-mediated abrogation of cathepsin B and MMP-9 gene expression in a malignant meningioma cell line leads to decreased tumor growth, invasion and angiogenesis. Int J Oncol (2007) 0.94
The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity. Front Immunol (2013) 0.94
Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model. J Cancer Sci Ther (2011) 0.94
Metastasis in melanoma xenografts is associated with tumor microvascular density rather than extent of hypoxia. Neoplasia (2010) 0.93
Acidic extracellular pH promotes activation of integrin α(v)β(3). PLoS One (2011) 0.92
Acidosis promotes invasiveness of breast cancer cells through ROS-AKT-NF-κB pathway. Oncotarget (2014) 0.92
Lactate-modulated induction of THBS-1 activates transforming growth factor (TGF)-beta2 and migration of glioma cells in vitro. PLoS One (2013) 0.91
Noninvasive multiparametric imaging of metastasis-permissive microenvironments in a human prostate cancer xenograft. Cancer Res (2009) 0.90
Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells. PLoS One (2013) 0.89
Contribution of acidic melanoma cells undergoing epithelial-to-mesenchymal transition to aggressiveness of non-acidic melanoma cells. Clin Exp Metastasis (2014) 0.89
Metabolic changes during ovarian cancer progression as targets for sphingosine treatment. Exp Cell Res (2013) 0.88
Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers. PLoS One (2013) 0.88
In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity. PLoS One (2012) 0.88
Ecology meets cancer biology: the cancer swamp promotes the lethal cancer phenotype. Oncotarget (2015) 0.86
Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold. Inorg Chem (2013) 0.86
Investigating mechanisms of alkalinization for reducing primary breast tumor invasion. Biomed Res Int (2013) 0.85
Inhibition of cancer cell proliferation and breast tumor targeting of pHLIP-monomethyl auristatin E conjugates. Mol Pharm (2015) 0.85
Neutralizing TIMP1 restores fecundity in a rat model of endometriosis and treating control rats with TIMP1 causes anomalies in ovarian function and embryo development. Biol Reprod (2010) 0.84
Live-cell imaging of tumor proteolysis: impact of cellular and non-cellular microenvironment. Biochim Biophys Acta (2011) 0.84
Examining the relationship between diet-induced acidosis and cancer. Nutr Metab (Lond) (2012) 0.84
RNA interference targeting CD147 inhibits the proliferation, invasiveness, and metastatic activity of thyroid carcinoma cells by down-regulating glycolysis. Int J Clin Exp Pathol (2015) 0.84
HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4). Cell Signal (2013) 0.83
Dentin matrix degradation by host matrix metalloproteinases: inhibition and clinical perspectives toward regeneration. Front Physiol (2013) 0.83
Mechanisms of buffer therapy resistance. Neoplasia (2014) 0.83
Optical molecular imaging detects changes in extracellular pH with the development of head and neck cancer. Int J Cancer (2012) 0.83
Proton pump inhibitors and histamine 2 blockers are associated with improved overall survival in patients with head and neck squamous carcinoma. Cancer Prev Res (Phila) (2014) 0.82
An independent endocytic pathway stimulates different monocyte subsets by the a2 N-terminus domain of vacuolar-ATPase. Oncoimmunology (2013) 0.82
Chromatin: a capacitor of acetate for integrated regulation of gene expression and cell physiology. Curr Opin Genet Dev (2014) 0.82
Acidic extracellular pH promotes epithelial mesenchymal transition in Lewis lung carcinoma model. Cancer Cell Int (2014) 0.82
The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions. Proc Natl Acad Sci U S A (2015) 0.81
Metabolism and its sequelae in cancer evolution and therapy. Cancer J (2015) 0.81
AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer. Oncotarget (2015) 0.81
Modeling and simulation of chemomechanics at the cell-matrix interface. Cell Adh Migr (2008) 0.80
Cancer stem cell metabolism: a potential target for cancer therapy. Mol Cancer (2016) 0.80
Increased H⁺ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. Elife (2015) 0.80
Prolactin-Stat5 signaling in breast cancer is potently disrupted by acidosis within the tumor microenvironment. Breast Cancer Res (2013) 0.80
TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells. Oncogene (2015) 0.80
Kinetic characterization of lactate dehydrogenase in normal and malignant human breast tissues. Cancer Cell Int (2015) 0.80
Utilizing hydrogen sulfide as a novel anti-cancer agent by targeting cancer glycolysis and pH imbalance. Br J Pharmacol (2014) 0.80
Modulation of autophagic activity by extracellular pH. Autophagy (2011) 0.80
A double-headed cathepsin B inhibitor devoid of warhead. Protein Sci (2008) 0.79
Chemoresistance to concanamycin A1 in human oral squamous cell carcinoma is attenuated by an HDAC inhibitor partly via suppression of Bcl-2 expression. PLoS One (2013) 0.79
PSMA ligand conjugated PCL-PEG polymeric micelles targeted to prostate cancer cells. PLoS One (2014) 0.79
Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors. J Am Chem Soc (2015) 0.79
Acid-triggered release via dePEGylation of fusogenic liposomes mediated by heterobifunctional phenyl-substituted vinyl ethers with tunable pH-sensitivity. Bioconjug Chem (2012) 0.79
Growth and remodelling for profound circular wounds in skin. Biomech Model Mechanobiol (2014) 0.79
Increased Expression of Beige/Brown Adipose Markers from Host and Breast Cancer Cells Influence Xenograft Formation in Mice. Mol Cancer Res (2015) 0.79
Towards longitudinal mapping of extracellular pH in gliomas. NMR Biomed (2016) 0.79
The Proton-Sensing G-Protein Coupled Receptor GPR4 Promotes Angiogenesis in Head and Neck Cancer. PLoS One (2016) 0.78
The Roles of Acidosis in Osteoclast Biology. Front Physiol (2016) 0.78
Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development. Biomed Res Int (2016) 0.78
Structural and agonist properties of XCL2, the other member of the C-chemokine subfamily. Cytokine (2014) 0.78
Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis. Clin Cancer Res (2007) 2.40
Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination. Int J Cancer (2010) 1.30
Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor. Cancer Res (2002) 1.26
The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products. Cancer Res (2005) 1.23
Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts. Cancer Res (2002) 1.08
Associations between radiocurability and interstitial fluid pressure in human tumor xenografts without hypoxic tissue. Clin Cancer Res (2010) 0.96
Metastasis in melanoma xenografts is associated with tumor microvascular density rather than extent of hypoxia. Neoplasia (2010) 0.93
Radiocurability is associated with interstitial fluid pressure in human tumor xenografts. Neoplasia (2009) 0.91
Assessment of tumor radioresponsiveness and metastatic potential by dynamic contrast-enhanced magnetic resonance imaging. Int J Radiat Oncol Biol Phys (2011) 0.90
Dynamic contrast-enhanced-MRI of tumor hypoxia. Magn Reson Med (2011) 0.89
Assessment of fraction of hypoxic cells in human tumor xenografts with necrotic regions by dynamic contrast-enhanced MRI. Radiat Res (2008) 0.86
Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts. Int J Radiat Oncol Biol Phys (2004) 0.85
Magnetic resonance imaging of tumor necrosis. Acta Oncol (2010) 0.84
Assessment of hypoxia and radiation response in intramuscular experimental tumors by dynamic contrast-enhanced magnetic resonance imaging. Radiother Oncol (2011) 0.84
Dynamic contrast-enhanced magnetic resonance imaging of human cervical carcinoma xenografts: pharmacokinetic analysis and correlation to tumor histomorphology. Radiother Oncol (2010) 0.84
Quantitative assessment of hypoxia in melanoma xenografts by dynamic contrast-enhanced magnetic resonance imaging: intradermal versus intramuscular tumors. Radiother Oncol (2010) 0.83
Microenvironment-associated lymph node metastasis of human cervical carcinoma xenografts. Acta Oncol (2012) 0.83
pO₂ fluctuation pattern and cycling hypoxia in human cervical carcinoma and melanoma xenografts. Int J Radiat Oncol Biol Phys (2012) 0.83
Assessment of microvascular density, extracellular volume fraction, and radiobiological hypoxia in human melanoma xenografts by dynamic contrast-enhanced MRI. J Magn Reson Imaging (2007) 0.82
Connective tissue of cervical carcinoma xenografts: associations with tumor hypoxia and interstitial fluid pressure and its assessment by DCE-MRI and DW-MRI. Acta Oncol (2013) 0.82
Differentiation between hypoxic and non-hypoxic experimental tumors by dynamic contrast-enhanced magnetic resonance imaging. Radiother Oncol (2011) 0.81
Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI. Magn Reson Med (2006) 0.81
DW-MRI in assessment of the hypoxic fraction, interstitial fluid pressure, and metastatic propensity of melanoma xenografts. BMC Cancer (2014) 0.79
Dynamic contrast-enhanced magnetic resonance imaging of the metastatic potential of melanoma xenografts. Int J Radiat Oncol Biol Phys (2012) 0.78
Detection of different hypoxic cell subpopulations in human melanoma xenografts by pimonidazole immunohistochemistry. Radiat Res (2008) 0.77
Assessment of tumor hypoxia and interstitial fluid pressure by gadomelitol-based dynamic contrast-enhanced magnetic resonance imaging. Radiother Oncol (2011) 0.77
Interstitial fluid pressure and vascularity of intradermal and intramuscular human tumor xenografts. Int J Radiat Oncol Biol Phys (2011) 0.76
Assessment of hypoxia in human cervical carcinoma xenografts by dynamic contrast-enhanced magnetic resonance imaging. Int J Radiat Oncol Biol Phys (2009) 0.76