PubRank

Svante Pääbo

Author PubWeight™ 321.28‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nat Genet 2007 20.22
2 Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature 2010 8.99
3 Sequencing and analysis of Neanderthal genomic DNA. Science 2006 8.06
4 Intra- and interspecific variation in primate gene expression patterns. Science 2002 7.92
5 A high-coverage genome sequence from an archaic Denisovan individual. Science 2012 7.89
6 The evolution of gene expression levels in mammalian organs. Nature 2011 7.16
7 A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing. Cell 2008 6.98
8 Analysis of one million base pairs of Neanderthal DNA. Nature 2006 6.17
9 Patterns of damage in genomic DNA sequences from a Neandertal. Proc Natl Acad Sci U S A 2007 6.12
10 Molecular evolution of FOXP2, a gene involved in speech and language. Nature 2002 5.89
11 Genomewide comparison of DNA sequences between humans and chimpanzees. Am J Hum Genet 2002 5.80
12 Targeted retrieval and analysis of five Neandertal mtDNA genomes. Science 2009 5.79
13 Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Science 2005 5.68
14 A genome-wide comparison of recent chimpanzee and human segmental duplications. Nature 2005 5.51
15 Deep proteome and transcriptome mapping of a human cancer cell line. Mol Syst Biol 2011 5.48
16 Fine-scale recombination patterns differ between chimpanzees and humans. Nat Genet 2005 5.00
17 Evidence for gradients of human genetic diversity within and among continents. Genome Res 2004 4.70
18 Early allelic selection in maize as revealed by ancient DNA. Science 2003 4.38
19 From micrograms to picograms: quantitative PCR reduces the material demands of high-throughput sequencing. Nucleic Acids Res 2007 4.26
20 The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature 2010 3.90
21 Accelerated evolution of conserved noncoding sequences in humans. Science 2006 3.87
22 Regional patterns of gene expression in human and chimpanzee brains. Genome Res 2004 3.84
23 No evidence of Neandertal mtDNA contribution to early modern humans. PLoS Biol 2004 3.81
24 Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae. Nature 2005 3.74
25 A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 2009 3.63
26 A neutral explanation for the correlation of diversity with recombination rates in humans. Am J Hum Genet 2003 3.57
27 Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania. Am J Hum Genet 2011 3.53
28 A neutral model of transcriptome evolution. PLoS Biol 2004 3.44
29 Genomic sequencing of Pleistocene cave bears. Science 2005 3.40
30 The derived FOXP2 variant of modern humans was shared with Neandertals. Curr Biol 2007 3.39
31 Multiplexed DNA sequence capture of mitochondrial genomes using PCR products. PLoS One 2010 3.35
32 Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary. BMC Evol Biol 2008 3.21
33 Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA. Nucleic Acids Res 2009 3.09
34 A complete mtDNA genome of an early modern human from Kostenki, Russia. Curr Biol 2009 3.09
35 Evolution of primate gene expression. Nat Rev Genet 2006 3.04
36 Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proc Natl Acad Sci U S A 2006 3.03
37 Neanderthals in central Asia and Siberia. Nature 2007 2.64
38 Temporal patterns of nucleotide misincorporations and DNA fragmentation in ancient DNA. PLoS One 2012 2.60
39 Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates. PLoS Biol 2004 2.56
40 Generation times in wild chimpanzees and gorillas suggest earlier divergence times in great ape and human evolution. Proc Natl Acad Sci U S A 2012 2.54
41 The bonobo genome compared with the chimpanzee and human genomes. Nature 2012 2.49
42 Targeted investigation of the Neandertal genome by array-based sequence capture. Science 2010 2.49
43 The Neandertal genome and ancient DNA authenticity. EMBO J 2009 2.46
44 Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments. Proc Natl Acad Sci U S A 2013 2.45
45 Natural selection on the olfactory receptor gene family in humans and chimpanzees. Am J Hum Genet 2003 2.44
46 The date of interbreeding between Neandertals and modern humans. PLoS Genet 2012 2.35
47 Why do human diversity levels vary at a megabase scale? Genome Res 2005 2.33
48 FUNC: a package for detecting significant associations between gene sets and ontological annotations. BMC Bioinformatics 2007 2.32
49 DNA analysis of an early modern human from Tianyuan Cave, China. Proc Natl Acad Sci U S A 2013 2.31
50 Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Curr Biol 2008 2.27
51 Human specific loss of olfactory receptor genes. Proc Natl Acad Sci U S A 2003 2.23
52 Absence of the TAP2 human recombination hotspot in chimpanzees. PLoS Biol 2004 2.22
53 The Neandertal type site revisited: interdisciplinary investigations of skeletal remains from the Neander Valley, Germany. Proc Natl Acad Sci U S A 2002 1.98
54 Lineage-specific expansions of retroviral insertions within the genomes of African great apes but not humans and orangutans. PLoS Biol 2005 1.82
55 Transcriptional neoteny in the human brain. Proc Natl Acad Sci U S A 2009 1.78
56 Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Proc Natl Acad Sci U S A 2010 1.76
57 Aging and gene expression in the primate brain. PLoS Biol 2005 1.76
58 Mitochondrial DNA of an Iberian Neandertal suggests a population affinity with other European Neandertals. Curr Biol 2006 1.69
59 Reconstructing the DNA methylation maps of the Neandertal and the Denisovan. Science 2014 1.69
60 Demographic history and genetic differentiation in apes. Curr Biol 2006 1.69
61 Optimization of 454 sequencing library preparation from small amounts of DNA permits sequence determination of both DNA strands. Biotechniques 2009 1.67
62 Molecular breeding of polymerases for amplification of ancient DNA. Nat Biotechnol 2007 1.63
63 MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates. PLoS Biol 2011 1.57
64 Nuclear gene sequences from a late pleistocene sloth coprolite. Curr Biol 2003 1.55
65 Lack of phylogeography in European mammals before the last glaciation. Proc Natl Acad Sci U S A 2004 1.55
66 Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex. Neuron 2008 1.54
67 Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. Proc Natl Acad Sci U S A 2014 1.47
68 Evolution of bitter taste receptors in humans and apes. Mol Biol Evol 2004 1.45
69 Comparison of protein and mRNA expression evolution in humans and chimpanzees. PLoS One 2007 1.42
70 Evidence for a complex demographic history of chimpanzees. Mol Biol Evol 2004 1.41
71 MicroRNA expression and regulation in human, chimpanzee, and macaque brains. PLoS Genet 2011 1.40
72 Functionality of intergenic transcription: an evolutionary comparison. PLoS Genet 2006 1.39
73 Metabolic changes in schizophrenia and human brain evolution. Genome Biol 2008 1.39
74 Toward a neutral evolutionary model of gene expression. Genetics 2005 1.38
75 Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal. Proc Natl Acad Sci U S A 2012 1.36
76 Human and chimpanzee gene expression differences replicated in mice fed different diets. PLoS One 2008 1.35
77 Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-Seq. PLoS Comput Biol 2010 1.33
78 A late Neandertal femur from Les Rochers-de-Villeneuve, France. Proc Natl Acad Sci U S A 2005 1.30
79 Patterns of coding variation in the complete exomes of three Neandertals. Proc Natl Acad Sci U S A 2014 1.29
80 Computational challenges in the analysis of ancient DNA. Genome Biol 2010 1.27
81 Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res 2012 1.27
82 Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol Cell Biol 2003 1.25
83 Differences in DNA methylation patterns between humans and chimpanzees. Curr Biol 2004 1.24
84 Ancient DNA analyses reveal high mitochondrial DNA sequence diversity and parallel morphological evolution of late pleistocene cave bears. Mol Biol Evol 2002 1.23
85 Extensive linkage disequilibrium in small human populations in Eurasia. Am J Hum Genet 2002 1.20
86 Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans. Horm Behav 2007 1.19
87 Gene expression becomes heterogeneous with age. Curr Biol 2006 1.18
88 Genetic architecture of tameness in a rat model of animal domestication. Genetics 2009 1.15
89 Primer extension capture: targeted sequence retrieval from heavily degraded DNA sources. J Vis Exp 2009 1.14
90 Positive selection on gene expression in the human brain. Curr Biol 2006 1.14
91 Evidence for reproductive isolation between cave bear populations. Curr Biol 2004 1.13
92 Ancient DNA damage. Cold Spring Harb Perspect Biol 2013 1.13
93 Sudden replacement of cave bear mitochondrial DNA in the late Pleistocene. Curr Biol 2007 1.11
94 Rapid metabolic evolution in human prefrontal cortex. Proc Natl Acad Sci U S A 2011 1.09
95 A recent evolutionary change affects a regulatory element in the human FOXP2 gene. Mol Biol Evol 2012 1.08
96 Complete mitochondrial genomes reveal neolithic expansion into Europe. PLoS One 2012 1.06
97 A comparison of brain gene expression levels in domesticated and wild animals. PLoS Genet 2012 1.04
98 Bonobos fall within the genomic variation of chimpanzees. PLoS One 2011 1.03
99 The joint allele-frequency spectrum in closely related species. Genetics 2007 1.01
100 The population history of extant and extinct hyenas. Mol Biol Evol 2005 0.99
101 Systematic analysis of gene expression in human brains before and after death. Genome Biol 2005 0.98
102 X-chromosome as a marker for population history: linkage disequilibrium and haplotype study in Eurasian populations. Eur J Hum Genet 2005 0.97
103 The rise and fall of the chemoattractant receptor GPR33. J Biol Chem 2005 0.92
104 Linkage disequilibrium extends across putative selected sites in FOXP2. Mol Biol Evol 2009 0.91
105 Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees. Mol Biol Evol 2003 0.89
106 Comparative population genomics of the ejaculate in humans and the great apes. Mol Biol Evol 2013 0.89
107 Functional analysis of human and chimpanzee promoters. Genome Biol 2005 0.89
108 Analysis of human accelerated DNA regions using archaic hominin genomes. PLoS One 2012 0.87
109 Evolution of neuronal and endothelial transcriptomes in primates. Genome Biol Evol 2010 0.85
110 Suggested guidelines for invasive sampling of hominid remains. J Hum Evol 2008 0.84
111 Expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight. Physiol Genomics 2013 0.84
112 Neandertals. Curr Biol 2006 0.83
113 Analysis of candidate genes for lineage-specific expression changes in humans and primates. J Proteome Res 2014 0.78
114 Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight. Neurogenetics 2011 0.78
115 Reply to Gibb and Hills: Divergence times, generation lengths and mutation rates in great apes and humans. Proc Natl Acad Sci U S A 2013 0.76
116 A comprehensive functional analysis of ancestral human signal peptides. Mol Biol Evol 2010 0.76
117 Sequential DEXAS: a method for obtaining DNA sequences from genomic DNA and blood in one reaction. Nucleic Acids Res 2003 0.75
118 Dorcas Cummings Lecture. Cold Spring Harb Symp Quant Biol 2015 0.75
119 A functional test of Neandertal and modern human mitochondrial targeting sequences. Biochem Biophys Res Commun 2010 0.75
120 Imagine: an interview with Svante Pääbo. Interview by Jane Gitschier. PLoS Genet 2008 0.75