Published in Cell on December 27, 2002
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Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol Cell (2009) 1.72
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Protein structure prediction for the male-specific region of the human Y chromosome. Proc Natl Acad Sci U S A (2004) 1.43
Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat Struct Mol Biol (2012) 1.42
Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A (2008) 1.39
Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain. Mol Cell Biol (2006) 1.39
Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease? J Virol (2005) 1.37
The genome of the amoeba symbiont "Candidatus Amoebophilus asiaticus" reveals common mechanisms for host cell interaction among amoeba-associated bacteria. J Bacteriol (2009) 1.36
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Deubiquitinases as a signaling target of oxidative stress. Cell Rep (2012) 1.25
Crystal structure of human otubain 2. EMBO Rep (2004) 1.24
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7. Nat Chem Biol (2012) 1.20
Molecular mechanisms of ubiquitin-dependent membrane traffic. Annu Rev Biophys (2011) 1.19
Comparative genomics suggests an independent origin of cytoplasmic incompatibility in Cardinium hertigii. PLoS Genet (2012) 1.19
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Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells. Nat Commun (2013) 1.16
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Structural studies of NF-κB signaling. Cell Res (2010) 1.07
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Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation. Proc Natl Acad Sci U S A (2010) 1.01
Predicting zinc binding at the proteome level. BMC Bioinformatics (2007) 1.01
The role of deadenylation in the degradation of unstable mRNAs in trypanosomes. Nucleic Acids Res (2009) 1.01
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PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications. Cell Biochem Biophys (2011) 1.00
The structure of human ubiquitin in 2-methyl-2,4-pentanediol: a new conformational switch. Protein Sci (2011) 1.00
Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity. Anal Biochem (2005) 0.98
Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzyme. J Mol Biol (2007) 0.97
An atomic structure of the human 26S proteasome. Nat Struct Mol Biol (2016) 0.96
Papain-like protease 1 from transmissible gastroenteritis virus: crystal structure and enzymatic activity toward viral and cellular substrates. J Virol (2010) 0.95
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Deubiquitylase, deSUMOylase, and deISGylase activity microarrays for assay of substrate preference and functional modifiers. Mol Cell Proteomics (2010) 0.91
USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains. J Biol Chem (2011) 0.91
Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2. Proteins (2010) 0.91
The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway. Mol Cell (2012) 0.90
A role for intersubunit interactions in maintaining SAGA deubiquitinating module structure and activity. Structure (2012) 0.90
Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity. Biochemistry (2013) 0.89
Modes of p53 regulation. Cell (2009) 9.31
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature (2002) 7.71
Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol (2004) 6.76
A cryptic protease couples deubiquitination and degradation by the proteasome. Nature (2002) 6.21
Acetylation is indispensable for p53 activation. Cell (2008) 5.70
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell (2006) 5.64
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SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell (2007) 5.30
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell (2006) 5.28
Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science (2003) 5.23
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem (2007) 5.21
Proteasomes and their kin: proteases in the machine age. Nat Rev Mol Cell Biol (2004) 5.14
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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell (2005) 5.04
Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell (2012) 4.96
SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab (2008) 4.89
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell (2005) 4.60
Non-transcriptional control of DNA replication by c-Myc. Nature (2007) 4.55
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab (2005) 4.14
Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell (2003) 4.07
A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol Cell (2004) 4.05
Structural basis for sequence-specific recognition of DNA by TAL effectors. Science (2012) 3.64
Designing superoleophobic surfaces. Science (2007) 3.56
Acetylation of p53 inhibits its ubiquitination by Mdm2. J Biol Chem (2002) 3.37
The mammalian Mediator complex and its role in transcriptional regulation. Trends Biochem Sci (2005) 3.25
How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer (2008) 3.17
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14
Non-invasive prenatal measurement of the fetal genome. Nature (2012) 3.11
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Structure of the protein phosphatase 2A holoenzyme. Cell (2006) 3.07
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
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Acetylation inactivates the transcriptional repressor BCL6. Nat Genet (2002) 3.00
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol (2006) 3.00
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 2.75
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol (2005) 2.72
A local mechanism mediates NAD-dependent protection of axon degeneration. J Cell Biol (2005) 2.64
Single-stranded siRNAs activate RNAi in animals. Cell (2012) 2.64
Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature (2005) 2.63
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Nat Struct Biol (2002) 2.60
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med (2010) 2.54
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Structure and mechanism of an amino acid antiporter. Science (2009) 2.40
Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80. Mol Cell (2009) 2.39
Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science (2002) 2.36
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
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Nearly finished genomes produced using gel microdroplet culturing reveal substantial intraspecies genomic diversity within the human microbiome. Genome Res (2013) 2.29
Noncarious cervical lesions and abfractions: a re-evaluation. J Am Dent Assoc (2003) 2.28
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature (2009) 2.25
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat Struct Mol Biol (2012) 2.18
K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J (2009) 2.17
tRNA binds to cytochrome c and inhibits caspase activation. Mol Cell (2010) 2.14
A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. J Biol Chem (2005) 2.10
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem (2008) 2.09
Structure of a site-2 protease family intramembrane metalloprotease. Science (2007) 2.08
Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature (2005) 2.08
Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature (2009) 2.07
The etiology and prevalence of gingival recession. J Am Dent Assoc (2003) 2.06
Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood (2006) 2.06
Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat Struct Mol Biol (2004) 2.03
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The structural basis for activation of plant immunity by bacterial effector protein AvrPto. Nature (2007) 1.95
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Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91
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Structural basis of ultraviolet-B perception by UVR8. Nature (2012) 1.86
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Structure of a presenilin family intramembrane aspartate protease. Nature (2012) 1.76