Published in Mol Biochem Parasitol on October 19, 2011
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Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrob Agents Chemother (2013) 0.97
Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viability. PLoS Negl Trop Dis (2013) 0.95
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Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation. PLoS Biol (2008) 2.08
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum. J Biol Chem (2005) 1.95
SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania. Mol Biol Cell (2004) 1.95
Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet (2005) 1.94
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryot Cell (2003) 1.94
MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling. Eur J Immunol (2003) 1.82
Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends Parasitol (2003) 1.74
Toward global metabolomics analysis with hydrophilic interaction liquid chromatography-mass spectrometry: improved metabolite identification by retention time prediction. Anal Chem (2011) 1.71
IDEOM: an Excel interface for analysis of LC-MS-based metabolomics data. Bioinformatics (2012) 1.67
Genetic characterization of glucose transporter function in Leishmania mexicana. Proc Natl Acad Sci U S A (2003) 1.64
MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks. Nucleic Acids Res (2010) 1.47
Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum. BMC Biol (2013) 1.46
Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. J Biol Chem (2005) 1.44
Development of novel drugs for human African trypanosomiasis. Future Microbiol (2011) 1.44
Diamidines for human African trypanosomiasis. Curr Opin Investig Drugs (2010) 1.42
A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathog (2010) 1.39
The Leishmania-macrophage interaction: a metabolic perspective. Cell Microbiol (2007) 1.37
PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria. J Biol Chem (2006) 1.36
Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends Parasitol (2005) 1.34
Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Res (2004) 1.34
Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase. Proc Natl Acad Sci U S A (2006) 1.34
Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites. J Biol Chem (2003) 1.34
Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides. J Biol Chem (2007) 1.33
The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes. Antimicrob Agents Chemother (2004) 1.33
LeishCyc: a biochemical pathways database for Leishmania major. BMC Syst Biol (2009) 1.32
The natural progression of Gambiense sleeping sickness: what is the evidence? PLoS Negl Trop Dis (2008) 1.31
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A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments. BMC Bioinformatics (2007) 1.29
New surveyor tools for charting microbial metabolic maps. Nat Rev Microbiol (2008) 1.28
Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation. Anal Chem (2012) 1.28
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proc Natl Acad Sci U S A (2012) 1.26
Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. J Biol Chem (2008) 1.26
Waking up to sleeping sickness. Trends Parasitol (2003) 1.25
Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance. Mol Pharmacol (2006) 1.25
Precision mapping of the metabolome. Trends Biotechnol (2006) 1.25
Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with Orbitrap mass spectrometry for metabolomic studies of human urine. Anal Chem (2012) 1.24
A large gene family for putative variant antigens shared by human and rodent malaria parasites. Proc Biol Sci (2002) 1.23
Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host Microbe (2012) 1.22
Biosynthesis of mycobacterial phosphatidylinositol mannosides. Biochem J (2004) 1.22
Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Antimicrob Agents Chemother (2002) 1.21
The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan. J Biol Chem (2007) 1.19
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. J Antimicrob Chemother (2013) 1.18
Design and synthesis of a series of melamine-based nitroheterocycles with activity against Trypanosomatid parasites. J Med Chem (2005) 1.15
Modification of glycopeptidolipids by an O-methyltransferase of Mycobacterium smegmatis. Microbiology (2002) 1.15
mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics (2012) 1.13
Separation of parasites from human blood using deterministic lateral displacement. Lab Chip (2011) 1.12
Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against Trypanosoma brucei. PLoS Negl Trop Dis (2012) 1.12
Compartmentalization of lipid biosynthesis in mycobacteria. J Biol Chem (2005) 1.11
Function of phosphatidylinositol in mycobacteria. J Biol Chem (2005) 1.10
Molecular mimicry in Campylobacter jejuni: role of the lipo-oligosaccharide core oligosaccharide in inducing anti-ganglioside antibodies. FEMS Immunol Med Microbiol (2007) 1.10
McArthur revisited: fluorescence microscopes for field diagnostics. Trends Parasitol (2007) 1.10
Identification of a novel protein with a role in lipoarabinomannan biosynthesis in mycobacteria. J Biol Chem (2006) 1.09
Isotopomer profiling of Leishmania mexicana promastigotes reveals important roles for succinate fermentation and aspartate uptake in tricarboxylic acid cycle (TCA) anaplerosis, glutamate synthesis, and growth. J Biol Chem (2011) 1.09
Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii. J Biol Chem (2011) 1.09
Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrob Agents Chemother (2011) 1.08
PyMS: a Python toolkit for processing of gas chromatography-mass spectrometry (GC-MS) data. Application and comparative study of selected tools. BMC Bioinformatics (2012) 1.08
DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity. J Med Chem (2006) 1.08
The plastidic DNA replication enzyme complex of Plasmodium falciparum. Mol Biochem Parasitol (2005) 1.06
Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan reveals two lipomannan pools in corynebacterineae. J Biol Chem (2008) 1.04
Systems biology: the next frontier for bioinformatics. Adv Bioinformatics (2011) 1.04
Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage. Antimicrob Agents Chemother (2003) 1.04
Intracellular trafficking of glycosylphosphatidylinositol (GPI)-anchored proteins and free GPIs in Leishmania mexicana. Biochem J (2002) 1.04
MetaNetter: inference and visualization of high-resolution metabolomic networks. Bioinformatics (2007) 1.03
Comprehensive profiling and quantitation of amine group containing metabolites. Anal Chem (2011) 1.03
A unique thymic fibroblast population revealed by the monoclonal antibody MTS-15. J Immunol (2007) 1.03
Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain (2009) 1.02
In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Negl Trop Dis (2013) 1.02
Pentose phosphate metabolism in Leishmania mexicana. Mol Biochem Parasitol (2003) 1.01
Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry. Rapid Commun Mass Spectrom (2011) 1.00
Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites. Proc Natl Acad Sci U S A (2013) 1.00
Progressive peak clustering in GC-MS Metabolomic experiments applied to Leishmania parasites. Bioinformatics (2006) 0.99
Alveolate mitochondrial metabolic evolution: dinoflagellates force reassessment of the role of parasitism as a driver of change in apicomplexans. Mol Biol Evol (2012) 0.99
Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining. Metabolomics (2010) 0.97
Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrob Agents Chemother (2013) 0.97
Evidence that intracellular stages of Leishmania major utilize amino sugars as a major carbon source. PLoS Pathog (2010) 0.97
Serum amyloid P colocalizes with apolipoproteins in human atheroma: functional implications. J Lipid Res (2007) 0.97
Mannose metabolism is required for mycobacterial growth. Biochem J (2003) 0.97
Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. J Biol Chem (2003) 0.96
Chewing the fat on natural killer T cell development. J Exp Med (2006) 0.96
Oocyst wall formation and composition in coccidian parasites. Mem Inst Oswaldo Cruz (2009) 0.96
Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks. Bioanalysis (2014) 0.96
Increasing the mass accuracy of high-resolution LC-MS data using background ions: a case study on the LTQ-Orbitrap. Proteomics (2008) 0.95
Trypanocidal activity of melamine-based nitroheterocycles. Antimicrob Agents Chemother (2004) 0.95
Developmental changes in lysosome morphology and function Leishmania parasites. Int J Parasitol (2002) 0.95
Methylation of GPLs in Mycobacterium smegmatis and Mycobacterium avium. J Bacteriol (2004) 0.95
Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics. Angew Chem Int Ed Engl (2014) 0.93
Inositol lipid metabolism in mycobacteria: biosynthesis and regulatory mechanisms. Biochim Biophys Acta (2011) 0.92
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Negl Trop Dis (2011) 0.92
Identification of plant-like galactolipids in Chromera velia, a photosynthetic relative of malaria parasites. J Biol Chem (2011) 0.92
The molecular basis of Leishmania pathogenesis. Int J Parasitol (2007) 0.92
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Mol Pharmacol (2011) 0.91
Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter. Biochem Pharmacol (2004) 0.91
Multiple roles of proline transport and metabolism in trypanosomatids. Front Biosci (Landmark Ed) (2012) 0.91
Role of hexosamine biosynthesis in Leishmania growth and virulence. Mol Microbiol (2008) 0.90
The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Mol Microbiol (2013) 0.90
Central carbon metabolism of Leishmania parasites. Parasitology (2010) 0.90
Leishmania beta-1,2-mannan is assembled on a mannose-cyclic phosphate primer. Proc Natl Acad Sci U S A (2006) 0.89
Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfatase by aryl sulfamates. Chembiochem (2008) 0.89