Published in Small GTPases on July 01, 2011
Endocytosis and cancer. Cold Spring Harb Perspect Biol (2013) 1.40
Universal allosteric mechanism for Gα activation by GPCRs. Nature (2015) 1.21
Topological and functional properties of the small GTPases protein interaction network. PLoS One (2012) 0.98
Rho GTPases, oxidation, and cell redox control. Small GTPases (2014) 0.87
PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. J Cell Biol (2015) 0.85
Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis. Cells (2016) 0.83
IAPs as E3 ligases of Rac1: shaping the move. Small GTPases (2012) 0.79
Rho GTPases: Regulation and roles in cancer cell biology. Small GTPases (2016) 0.78
Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion. Elife (2017) 0.75
Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol (2009) 13.01
RING domain E3 ubiquitin ligases. Annu Rev Biochem (2009) 12.55
Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer (2007) 10.27
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem (2009) 6.23
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol (2006) 6.11
The emerging shape of the ESCRT machinery. Nat Rev Mol Cell Biol (2007) 6.05
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev (1998) 5.31
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science (2003) 5.19
A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell (1997) 4.68
The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science (2009) 4.63
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell (2006) 4.43
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol Cell (2006) 4.36
GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol (2005) 4.13
The role of ubiquitin in NF-kappaB regulatory pathways. Annu Rev Biochem (2009) 3.86
Mechanisms, regulation and consequences of protein SUMOylation. Biochem J (2010) 3.22
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev (2009) 3.13
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res (2008) 2.81
CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion. Cell (2002) 2.77
FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma. Oncogene (2005) 2.66
The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity. Nat Neurosci (2004) 2.56
RhoGDI: multiple functions in the regulation of Rho family GTPase activities. Biochem J (2005) 2.50
Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. Dev Cell (2001) 2.46
Endocytosis: the DUB version. Trends Cell Biol (2006) 2.39
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem (2008) 2.22
Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep (2008) 2.19
Ras history: The saga continues. Small GTPases (2010) 2.18
Rho and Ras GTPases in axon growth, guidance, and branching. Cold Spring Harb Perspect Biol (2010) 2.17
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell (2005) 2.17
Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. J Lipid Res (2006) 2.05
Ubiquitin-binding domains and their role in the DNA damage response. DNA Repair (Amst) (2009) 2.02
Deubiquitinases in the regulation of NF-κB signaling. Cell Res (2010) 2.00
The UIM domain of Hrs couples receptor sorting to vesicle formation. J Cell Sci (2003) 1.97
FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy. PLoS One (2010) 1.97
SUMOylation of the GTPase Rac1 is required for optimal cell migration. Nat Cell Biol (2010) 1.95
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. Mol Cell (2009) 1.84
Differential modification of Ras proteins by ubiquitination. Mol Cell (2006) 1.80
NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. J Biol Chem (2008) 1.74
The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain. J Biol Chem (2006) 1.68
Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons. Trends Cell Biol (2005) 1.65
Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway. Expert Rev Mol Med (2008) 1.64
Novel substrates and functions for the ubiquitin-like molecule NEDD8. Biochem Soc Trans (2008) 1.63
Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines. Nat Neurosci (2009) 1.58
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron (2010) 1.57
APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase. Mol Cell (2008) 1.54
Ras/MAPK signaling from endomembranes. Mol Oncol (2009) 1.51
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Sci Signal (2011) 1.43
Retracted Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity. EMBO J (2007) 1.42
The therapeutic potential of deubiquitinating enzyme inhibitors. Biochem Soc Trans (2010) 1.41
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. Mol Biol Cell (2007) 1.30
Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem. Curr Med Chem (2008) 1.27
Feedback regulation of Ras signaling by Rabex-5-mediated ubiquitination. Curr Biol (2010) 1.27
Fbw7 and Usp28 regulate myc protein stability in response to DNA damage. Cell Cycle (2007) 1.26
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells. J Biol Chem (2008) 1.24
BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. PLoS Pathog (2009) 1.24
Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells. J Biol Chem (2009) 1.23
Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2). J Biol Chem (2011) 1.22
Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes. EMBO J (2008) 1.21
Regulators of G protein signaling proteins as targets for drug discovery. Prog Mol Biol Transl Sci (2010) 1.20
A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes. J Immunol (2006) 1.18
RAS: target for cancer therapy. Cancer Invest (2008) 1.18
Rac GTPase instructs nuclear factor-kappaB activation by conveying the SCF complex and IkBalpha to the ruffling membranes. Mol Biol Cell (2003) 1.18
The delivery of endocytosed cargo to lysosomes. Biochem Soc Trans (2009) 1.17
Hydrophobic modifications of Ras proteins by isoprenoid groups and fatty acids--More than just membrane anchoring. Biochim Biophys Acta (2006) 1.17
The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. Cancer Res (2010) 1.14
USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. J Biol Chem (2009) 1.14
Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways. J Cell Physiol (2009) 1.14
Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons. J Biol Chem (2008) 1.10
Differential oncogenic potential of activated RAS isoforms in melanocytes. Oncogene (2007) 1.09
Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila. Curr Biol (2010) 1.07
Compartmentalized signalling: Ras proteins and signalling nanoclusters. FEBS J (2009) 1.06
Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF. J Biol Chem (2001) 1.03
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Mol Cell Biol (2010) 1.03
H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation. J Cell Sci (2009) 1.02
Activated Rac1, but not the tumorigenic variant Rac1b, is ubiquitinated on Lys 147 through a JNK-regulated process. FEBS J (2007) 1.02
Thalidomide versus bortezomib based regimens as first-line therapy for patients with multiple myeloma: a systematic review. Am J Hematol (2011) 1.01
Involvement of Rabring7 in EGF receptor degradation as an E3 ligase. Biochem Biophys Res Commun (2007) 1.00
The interplay between clathrin-coated vesicles and cell signalling. Semin Cell Dev Biol (2007) 1.00
Bortezomib. Recent Results Cancer Res (2010) 0.99
Ubiquitin-mediated proteasomal degradation of Rho proteins by the CNF1 toxin. Methods Enzymol (2006) 0.99
A new map to understand deubiquitination. Biochem Soc Trans (2010) 0.99
Proteasome inhibitors: recent advances and new perspectives in medicinal chemistry. Curr Top Med Chem (2010) 0.98
CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells. Mol Biol Cell (2006) 0.98
Pupylation versus ubiquitylation: tagging for proteasome-dependent degradation. Cell Microbiol (2010) 0.97
Retracted The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity. J Biol Chem (2007) 0.95
XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway. EMBO J (2007) 0.94
Rac1, but not Rac1B, stimulates RelB-mediated gene transcription in colorectal cancer cells. J Biol Chem (2006) 0.93
Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway. Biol Chem (2008) 0.93
Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression. Breast Cancer Res (2009) 0.93
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. Nat Commun (2011) 0.89
The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells. J Biol Chem (2005) 0.88
Delayed onset of positive feedback activation of Rab5 by Rabex-5 and Rabaptin-5 in endocytosis. PLoS One (2010) 0.87
The small GTPase Rac interacts with ubiquitination complex proteins Cullin-1 and CDC23. Int J Mol Med (2001) 0.87
The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1. Genes Cells (2005) 0.86
The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. J Biol Chem (2010) 0.86
Strategies for the identification of ubiquitin ligase inhibitors. Biochem Soc Trans (2010) 0.85
Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1. Biochem Biophys Res Commun (2009) 0.85
SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2. J Neurochem (2007) 0.85
Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays. Assay Drug Dev Technol (2010) 0.84
Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Biochem Biophys Res Commun (2007) 0.84
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat Med (2003) 2.20
Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase. J Virol (2007) 1.67
SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation. Mol Cell Biol (2005) 1.36
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction. J Immunol (2002) 1.29
The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3. Blood (2007) 1.27
Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. J Biol Chem (2003) 1.25
Deacetylase activity is required for recruitment of the basal transcription machinery and transactivation by STAT5. Mol Cell Biol (2003) 1.24
Siglec-E is up-regulated and phosphorylated following lipopolysaccharide stimulation in order to limit TLR-driven cytokine production. J Immunol (2009) 1.23
SOCS: role in inflammation, allergy and homeostasis. Trends Immunol (2004) 1.21
Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2. J Biol Chem (2008) 1.20
Multiplex immunoassay for serological diagnosis of Mycobacterium bovis infection in cattle. Clin Vaccine Immunol (2008) 1.19
SOCS3 targets Siglec 7 for proteasomal degradation and blocks Siglec 7-mediated responses. J Biol Chem (2006) 1.16
The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression. Cancer Res (2010) 1.14
USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity. J Biol Chem (2009) 1.14
Retracted Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization. Immunity (2012) 1.12
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover. Blood (2006) 1.12
A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production. J Exp Med (2003) 1.11
Antibody-mediated inhibition of cathepsin S blocks colorectal tumor invasion and angiogenesis. Clin Cancer Res (2009) 1.07
The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence. Genomics (2005) 1.06
Matching SOCS with function. Nat Immunol (2003) 1.05
DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation. J Biol Chem (2003) 1.03
Regulation of CD4+ T-cell polarization by suppressor of cytokine signalling proteins. Immunology (2012) 1.01
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses. J Exp Med (2011) 1.01
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling. Biochem J (2004) 0.98
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases. J Biol Chem (2005) 0.98
CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression. J Leukoc Biol (2008) 0.94
Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization. Int J Cancer (2013) 0.93
Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF. PLoS One (2010) 0.90
SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases. Haematologica (2009) 0.89
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility. Nat Commun (2011) 0.89
Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment. Mol Cancer Ther (2008) 0.89
The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected. J Biol Chem (2010) 0.86
Inhibition of Cathepsin S by Fsn0503 enhances the efficacy of chemotherapy in colorectal carcinomas. Biochimie (2011) 0.86
The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster. BMC Genomics (2010) 0.86
The suppressors of cytokine signalling E3 ligases behave as tumour suppressors. Biochem Soc Trans (2008) 0.85
The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression. J Immunol (2004) 0.85
Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2. J Immunol (2013) 0.85
Enhanced antitumor activity of the photosensitizer meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate through encapsulation in antibody-targeted chitosan/alginate nanoparticles. Biomacromolecules (2013) 0.84
Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes. FEBS Lett (2013) 0.84
Vasodilator-stimulated phosphoprotein regulates inside-out signaling of beta2 integrins in neutrophils. J Immunol (2010) 0.84
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27. J Immunol (2012) 0.83
Regulation of cellular responses by deubiquitinating enzymes: an update. Front Biosci (Landmark Ed) (2012) 0.83
Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity. Mol Cancer (2011) 0.81
A highly potent and specific MET therapeutic protein antagonist with both ligand-dependent and ligand-independent activity. Mol Cancer Ther (2013) 0.81
A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses. Br J Haematol (2009) 0.80
Stable expression and purification of a functional processed Fab' fragment from a single nascent polypeptide in CHO cells expressing the mCAT-1 retroviral receptor. J Immunol Methods (2011) 0.80
The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis. Oncotarget (2013) 0.80
Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11. FEBS Lett (2010) 0.79
Unlocking the Doors to Patient Satisfaction in Pediatric Orthopaedics. J Pediatr Orthop (2016) 0.77
Expression and purification of diagnostically sensitive mycobacterial (Mycobacterium bovis) antigens and profiling of their humoral immune response in a rabbit model. Res Vet Sci (2010) 0.77
New interleukins: are there any more? Curr Opin Infect Dis (2003) 0.77
Cytokine signalling and disease. Expert Opin Ther Targets (2001) 0.77
Mulitvariate cluster analysis of a human hepatic cytochrome P450 database. Eur J Clin Pharmacol (2002) 0.76