Published in Biochem Biophys Res Commun on July 25, 2009
A computational tool for quantitative analysis of vascular networks. PLoS One (2011) 1.79
Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction. Exp Cell Res (2013) 0.89
The murine allantois: a model system for the study of blood vessel formation. Blood (2012) 0.87
Ubiquitination: Added complexity in Ras and Rho family GTPase function. Small GTPases (2011) 0.85
Rap1 signaling in endothelial barrier control. Cell Adh Migr (2014) 0.84
NEDD4-1 regulates migration and invasion of glioma cells through CNrasGEF ubiquitination in vitro. PLoS One (2013) 0.80
The expression of diacylglycerol kinase theta during the organogenesis of mouse embryos. BMC Dev Biol (2013) 0.80
Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A (2013) 3.10
Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep (2008) 2.90
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci U S A (2007) 2.59
Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell (2003) 2.54
Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol (2010) 2.52
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med (2009) 2.39
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. J Clin Invest (2002) 2.26
VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment. Arterioscler Thromb Vasc Biol (2008) 1.90
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res (2004) 1.84
Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J Biol Chem (2010) 1.77
Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev (2003) 1.62
Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis. Carcinogenesis (2009) 1.62
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest (2012) 1.54
Prior to the oral therapy, what do we know about HCV-4 in Egypt: a randomized survey of prevalence and risks using data mining computed analysis. Medicine (Baltimore) (2014) 1.53
Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades. Mol Biol Cell (2007) 1.44
Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. J Clin Invest (2011) 1.44
Bariatric Bypass Surgery to Resolve Complicated Childhood Morbid Obesity: Case Report Study. Medicine (Baltimore) (2015) 1.38
Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma. FASEB J (2010) 1.35
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. Mol Biol Cell (2007) 1.30
Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized on the plasma membrane of living cells. Chemphyschem (2003) 1.26
Structural basis for conformational dynamics of GTP-bound Ras protein. J Biol Chem (2010) 1.26
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester. Cancer Res (2008) 1.25
Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. Oncogene (2002) 1.24
Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo. J Biol Chem (2002) 1.21
Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases. J Biol Chem (2005) 1.21
Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells. J Biol Chem (2012) 1.20
Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells. Biol Cell (2008) 1.19
Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest (2008) 1.18
Vascular development and patterning: making the right choices. Curr Opin Genet Dev (2003) 1.14
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Natl Acad Sci U S A (2004) 1.10
Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon. Mol Cell Biol (2005) 1.08
Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers. J Biol Chem (2011) 1.07
Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans. Dev Biol (2004) 1.05
Requirement of activated Cdc42-associated kinase for survival of v-Ras-transformed mammalian cells. Mol Cancer Res (2005) 1.03
Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome. Biochem Biophys Res Commun (2009) 1.02
DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4. Circ Res (2010) 1.02
Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants. FEBS Lett (2012) 1.00
Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli. BMC Dev Biol (2008) 0.99
Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. J Exp Med (2002) 0.98
Neuronal lineage-specific induction of phospholipase Cepsilon expression in the developing mouse brain. Eur J Neurosci (2003) 0.96
Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics. Biochem Biophys Res Commun (2008) 0.95
Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites. Cell Signal (2004) 0.94
Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect. Eur J Neurosci (2009) 0.94
Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3. Blood (2002) 0.94
Dynamic polymorphism of Ras observed by single molecule FRET is the basis for molecular recognition. Biochem Biophys Res Commun (2006) 0.92
PLCε cooperates with the NF-κB pathway to augment TNFα-stimulated CCL2/MCP1 expression in human keratinocyte. Biochem Biophys Res Commun (2011) 0.91
Crucial role of phospholipase Cepsilon in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity. J Immunol (2009) 0.91
Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. J Cell Sci (2009) 0.89
Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells. Cell Signal (2012) 0.88
Screening esophagus during routine ultrasound: medical and cost benefits. Eur J Gastroenterol Hepatol (2015) 0.88
Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells. Cell Signal (2013) 0.88
Detailed structural analysis of lipids directly on tissue specimens using a MALDI-SpiralTOF-Reflectron TOF mass spectrometer. PLoS One (2012) 0.87
Critical function of the Ras-associating domain as a primary Ras-binding site for regulation of Saccharomyces cerevisiae adenylyl cyclase. J Biol Chem (2001) 0.87
Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells. J Cell Biol (2008) 0.87
Structural analysis of triacylglycerols by using a MALDI-TOF/TOF system with monoisotopic precursor selection. J Am Soc Mass Spectrom (2012) 0.87
Phospholipase Cɛ has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC. Lab Invest (2011) 0.87
RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures. Neurosci Res (2011) 0.87
Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10. BMC Cell Biol (2009) 0.86
Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations. J Biol Chem (2004) 0.86
Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia (2013) 0.86
Enhancement of ultraviolet B-induced skin tumor development in phospholipase Cε-knockout mice is associated with decreased cell death. Carcinogenesis (2010) 0.86
Overexpression of phospholipase Cε in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration. Eur J Immunol (2010) 0.85
EphrinB2-EphB4 signals regulate formation and maintenance of funnel-shaped valves in corneal lymphatic capillaries. Invest Ophthalmol Vis Sci (2013) 0.85
Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. PLoS One (2012) 0.85
NS5A sequence heterogeneity of hepatitis C virus genotype 4a predicts clinical outcome of pegylated-interferon-ribavirin therapy in Egyptian patients. J Clin Microbiol (2012) 0.84
Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases. J Biol Chem (2011) 0.84
Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1. Biochem Biophys Res Commun (2007) 0.84
Phospholipase Cepsilon guanine nucleotide exchange factor activity and activation of Rap1. Methods Enzymol (2006) 0.84
Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J Exp Med (2011) 0.83
Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1. J Biol Chem (2007) 0.83
Renal biopsy is a helpful tool for the diagnosis of POEMS syndrome. Int J Hematol (2012) 0.82
Calf production from vitrified bovine sexed embryos following in-straw dilution. Anim Sci J (2010) 0.82
H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts. J Biol Chem (2002) 0.81
Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice. Biochem Biophys Res Commun (2012) 0.81
Protective effect of boswellic acids versus pioglitazone in a rat model of diet-induced non-alcoholic fatty liver disease: influence on insulin resistance and energy expenditure. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.80
Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. Biochem Biophys Res Commun (2003) 0.80