Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.

Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med (2011) 4.09

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nat Rev Drug Discov (2010) 2.90

Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages. Nat Rev Mol Cell Biol (2012) 2.53

Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Mol Cell Proteomics (2010) 2.43

Signaling to NF-kappaB: regulation by ubiquitination. Cold Spring Harb Perspect Biol (2010) 2.15

A20: from ubiquitin editing to tumour suppression. Nat Rev Cancer (2010) 2.08

Emerging principles in protease-based drug discovery. Nat Rev Drug Discov (2010) 2.05

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell (2013) 2.05

Deubiquitinases in the regulation of NF-κB signaling. Cell Res (2010) 2.00

The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol (2010) 1.96

The ubiquitin landscape at DNA double-strand breaks. J Cell Biol (2009) 1.86

MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling. J Exp Med (2010) 1.84

Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Mol Cell Proteomics (2010) 1.79

Regulation of NF-κB by deubiquitinases. Immunol Rev (2012) 1.78

Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease. Circ Res (2010) 1.78

The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev (2010) 1.74

The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73

Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module. Cell (2010) 1.66

A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination. J Cell Biol (2011) 1.59

The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer. Cell Cycle (2012) 1.56

The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2. Cell Div (2011) 1.48

Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease. J Biol Chem (2011) 1.48

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21. EMBO Rep (2011) 1.47

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA. Nat Immunol (2012) 1.45

Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals. Mol Cell Proteomics (2010) 1.43

The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking. J Neurochem (2015) 1.42

Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat Struct Mol Biol (2012) 1.42

Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42

The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance. Dev Cell (2015) 1.41

Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome. J Biol Chem (2012) 1.40

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood (2013) 1.38

"Depupylation" of prokaryotic ubiquitin-like protein from mycobacterial proteasome substrates. Mol Cell (2010) 1.37

Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem Biol (2011) 1.35

Enzymatic blockade of the ubiquitin-proteasome pathway. PLoS Biol (2011) 1.33

Regulation of NF-κB signaling by the A20 deubiquitinase. Cell Mol Immunol (2012) 1.33

On terminal alkynes that can react with active-site cysteine nucleophiles in proteases. J Am Chem Soc (2013) 1.32

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications. Apoptosis (2010) 1.31

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nat Commun (2014) 1.31

An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochem Biophys (2011) 1.30

Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. J Biol Chem (2010) 1.28

Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev (2011) 1.28

Assembly, analysis and architecture of atypical ubiquitin chains. Nat Struct Mol Biol (2013) 1.27

Dop functions as a depupylase in the prokaryotic ubiquitin-like modification pathway. EMBO Rep (2010) 1.27

Ubiquitin makes its mark on immune regulation. Immunity (2010) 1.25

Deubiquitinases as a signaling target of oxidative stress. Cell Rep (2012) 1.25

Protease signalling: the cutting edge. EMBO J (2012) 1.24

K63 polyubiquitination is a new modulator of the oxidative stress response. Nat Struct Mol Biol (2015) 1.24

The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. J Biol Chem (2010) 1.22

Polarity proteins and cell-cell interactions in the testis. Int Rev Cell Mol Biol (2009) 1.21

Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. Nat Immunol (2012) 1.20

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin. EMBO J (2014) 1.20

The antiviral activities of ISG15. J Mol Biol (2013) 1.20

WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. J Biol Chem (2010) 1.20

Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nat Cell Biol (2014) 1.17

Regulation of A20 and other OTU deubiquitinases by reversible oxidation. Nat Commun (2013) 1.17

Balancing act: deubiquitinating enzymes in the nervous system. Trends Neurosci (2011) 1.17

A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. Nat Cell Biol (2010) 1.17

Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells. Nat Commun (2013) 1.16

The role of ubiquitin and the 26S proteasome in plant abiotic stress signaling. Front Plant Sci (2014) 1.15

The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25. Sci Signal (2014) 1.15

Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. EMBO Rep (2012) 1.15

USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J Clin Invest (2012) 1.15

USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. PLoS Biol (2012) 1.13

Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response. PLoS Pathog (2012) 1.13

Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. J Biol Chem (2010) 1.12

Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. J Biol Chem (2012) 1.12

Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases. Expert Rev Mol Med (2011) 1.12

Proteasomal and lysosomal protein degradation and heart disease. J Mol Cell Cardiol (2013) 1.12

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J Biol Chem (2010) 1.10

OTUB1 modulates c-IAP1 stability to regulate signalling pathways. EMBO J (2013) 1.09

Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance. J Immunol (2011) 1.09

A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol (2010) 1.08

The various roles of ubiquitin in Wnt pathway regulation. Cell Cycle (2010) 1.08

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth. Oncotarget (2014) 1.08

The deubiquitinating enzyme AMSH3 is required for intracellular trafficking and vacuole biogenesis in Arabidopsis thaliana. Plant Cell (2010) 1.08

Systematic analysis of the physiological importance of deubiquitinating enzymes. PLoS One (2012) 1.08

PBRM1 and BAP1 as novel targets for renal cell carcinoma. Cancer J (2013) 1.07

A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells. J Biol Chem (2012) 1.06

Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. Mol Biol Cell (2012) 1.06

The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases. J Biol Chem (2011) 1.06

Uncovering ubiquitin and ubiquitin-like signaling networks. Chem Rev (2011) 1.06

APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage. J Cell Biol (2011) 1.06

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol (2014) 1.06

Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. J Proteome Res (2012) 1.05

Ubiquitylation, neddylation and the DNA damage response. Open Biol (2015) 1.04

The deubiquitinating enzyme USP8 promotes trafficking and degradation of the chemokine receptor 4 at the sorting endosome. J Biol Chem (2010) 1.04

USP8 is a novel target for overcoming gefitinib resistance in lung cancer. Clin Cancer Res (2013) 1.04

A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity. EMBO J (2011) 1.04

Role of ubiquitylation and USP8-dependent deubiquitylation in the endocytosis and lysosomal targeting of plasma membrane KCa3.1. FASEB J (2011) 1.04

Ubiquitin receptors and protein quality control. J Mol Cell Cardiol (2012) 1.04

Ubiquitin-specific protease 2 regulates hepatic gluconeogenesis and diurnal glucose metabolism through 11β-hydroxysteroid dehydrogenase 1. Diabetes (2012) 1.04

Roles of p97-associated deubiquitinases in protein quality control at the endoplasmic reticulum. Curr Protein Pept Sci (2012) 1.03

BRCA1 tumor suppressor network: focusing on its tail. Cell Biosci (2012) 1.03

Deubiquitylating enzymes and DNA damage response pathways. Cell Biochem Biophys (2013) 1.03

State of the APC/C: organization, function, and structure. Crit Rev Biochem Mol Biol (2011) 1.02

A transcriptome signature distinguished sporadic from postradiotherapy radiation-induced sarcomas. Carcinogenesis (2011) 1.02

An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes. Front Mol Neurosci (2014) 1.01

USP9X expression correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma. Diagn Pathol (2013) 1.00

Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format. Assay Drug Dev Technol (2010) 1.00

PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications. Cell Biochem Biophys (2011) 1.00

The ubiquitin system. Annu Rev Biochem (1998) 43.36

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11

Mechanisms underlying ubiquitination. Annu Rev Biochem (2001) 18.87

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev (2002) 16.10

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature (2004) 12.41

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell (2000) 10.90

Recognition of the polyubiquitin proteolytic signal. EMBO J (2000) 10.12

A genomic and functional inventory of deubiquitinating enzymes. Cell (2005) 9.36

Regulation and function of IKK and IKK-related kinases. Sci STKE (2006) 8.98

Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu Rev Cell Dev Biol (2003) 8.13

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science (2002) 7.49

Polyubiquitin chains: polymeric protein signals. Curr Opin Chem Biol (2004) 7.10

Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol (2001) 6.96

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell (2005) 6.29

A cryptic protease couples deubiquitination and degradation by the proteasome. Nature (2002) 6.21

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature (2003) 6.11

Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta (2004) 6.03

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature (2003) 6.00

A new protease required for cell-cycle progression in yeast. Nature (1999) 5.44

Proteasomes and their kin: proteases in the machine age. Nat Rev Mol Cell Biol (2004) 5.14

Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13

Multiple associated proteins regulate proteasome structure and function. Mol Cell (2002) 4.97

Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science (2002) 4.95

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene (1998) 4.88

Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76

Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol (2006) 4.67

Mechanism and function of deubiquitinating enzymes. Biochim Biophys Acta (2004) 4.54

Histone ubiquitination: triggering gene activity. Mol Cell (2008) 4.42

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol Cell (2005) 4.40

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33

The yeast ubiquitin genes: a family of natural gene fusions. EMBO J (1987) 4.25

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell (2008) 4.04

The Fanconi Anemia/BRCA pathway: new faces in the crowd. Genes Dev (2005) 3.90

Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system. Cell (2004) 3.84

Modification in reverse: the SUMO proteases. Trends Biochem Sci (2007) 3.84

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Mol Cell (2008) 3.60

The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell (2006) 3.46

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem Biol (2002) 3.43

A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. EMBO J (2001) 3.42

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell (2008) 3.42

Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem Sci (2003) 3.37

Regulation of ubiquitin-dependent processes by deubiquitinating enzymes. FASEB J (1997) 3.34

Diverse polyubiquitin interaction properties of ubiquitin-associated domains. Nat Struct Mol Biol (2005) 3.27

A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol Cell (2007) 3.27

The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol Cell Biol (2000) 3.24

Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell (2006) 3.21

Ubiquitin-mediated activation of TAK1 and IKK. Oncogene (2007) 3.14

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature (2008) 3.11

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell (2006) 3.10

The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences. EMBO J (1985) 3.06

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains. Nature (2008) 2.94

Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell (2006) 2.87

Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome. J Biol Chem (2004) 2.85

BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res (2008) 2.81

Structural basis for the specificity of ubiquitin C-terminal hydrolases. EMBO J (1999) 2.79

Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J Biol Chem (2004) 2.75

The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast. Mol Biol Cell (1999) 2.73

A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. EMBO J (2006) 2.69

AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol (2004) 2.58

Human USP3 is a chromatin modifier required for S phase progression and genome stability. Curr Biol (2007) 2.54

Regulation of cell cycle progression and gene expression by H2A deubiquitination. Nature (2007) 2.52

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity. J Virol (2005) 2.49

Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription. J Biol Chem (2003) 2.48

Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet (2002) 2.46

A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Mol Cell (2005) 2.43

Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone. Mol Cell (2006) 2.41

Endocytosis: the DUB version. Trends Cell Biol (2006) 2.39

hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J (2006) 2.35

Metabolism of the polyubiquitin degradation signal: structure, mechanism, and role of isopeptidase T. Biochemistry (1995) 2.31

Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. Mol Biol Cell (2005) 2.31

IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. Mol Cell Biol (2007) 2.31

Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution. EMBO J (1997) 2.29

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Mol Biol Cell (2007) 2.28

Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export. Nat Cell Biol (2008) 2.27

Transcriptional regulation by histone ubiquitination and deubiquitination. Genes Dev (2003) 2.27

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module. Mol Cell (2008) 2.27

A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism. J Biol Chem (1996) 2.26

Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH. J Mol Biol (2006) 2.22

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. Biochemistry (1998) 2.18

Protein partners of deubiquitinating enzymes. Biochem J (2008) 2.15

Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. Mol Cell (2008) 2.15

Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths. J Biol Chem (1997) 2.14

The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily. Nucleic Acids Res (1987) 2.11

A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions. Trends Biochem Sci (2005) 2.11

Kinetic and mechanistic studies on the hydrolysis of ubiquitin C-terminal 7-amido-4-methylcoumarin by deubiquitinating enzymes. Biochemistry (1998) 2.10

A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J Biol Chem (2007) 2.09

A field guide to ubiquitylation. Cell Mol Life Sci (2004) 2.09

The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem (2008) 2.09

Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides. J Biol Chem (1985) 2.08

The SAGA continues: expanding the cellular role of a transcriptional co-activator complex. Oncogene (2007) 2.04

In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome. EMBO J (1997) 2.03

Proteasome-associated proteins: regulation of a proteolytic machine. Biol Chem (2005) 2.01

A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae. Trends Biochem Sci (2000) 2.01

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3. J Cell Biol (2006) 2.00

SseL, a Salmonella deubiquitinase required for macrophage killing and virulence. Proc Natl Acad Sci U S A (2007) 1.99

A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation. Mol Cell (2007) 1.98

Molecular recognition of p53 and MDM2 by USP7/HAUSP. Nat Struct Mol Biol (2006) 1.97

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep (2009) 3.94

The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell (2006) 3.46

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chem Biol (2002) 3.43

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99

BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res (2008) 2.81

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. J Biol Chem (2003) 2.21

Protein partners of deubiquitinating enzymes. Biochem J (2008) 2.15

Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+]. Genetics (2004) 1.90

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86

Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. J Mol Biol (2009) 1.82

Structural basis for ubiquitin recognition by the Otu1 ovarian tumor domain protein. J Biol Chem (2008) 1.75

DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem (2003) 1.72

Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool. J Biol Chem (2003) 1.69

SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J Cell Biol (2006) 1.67

Recognition of polyubiquitin isoforms by the multiple ubiquitin binding modules of isopeptidase T. J Biol Chem (2008) 1.64

Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene (2005) 1.64

Identification and characterization of DEN1, a deneddylase of the ULP family. J Biol Chem (2003) 1.62

Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci U S A (2009) 1.49

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21. EMBO Rep (2011) 1.47

Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42

Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63. J Virol (2007) 1.39

Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain. Mol Cell Biol (2006) 1.39

Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem Rev (2009) 1.36

Distribution and paralogue specificity of mammalian deSUMOylating enzymes. Biochem J (2010) 1.33

An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochem Biophys (2011) 1.30

Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. J Mol Biol (2005) 1.28

Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Sci (2008) 1.26

Effects of ubiquitin system alterations on the formation and loss of a yeast prion. J Biol Chem (2006) 1.26

Different means, same end-heterochromatin formation by RNAi and RNAi-independent RNA processing factors in fission yeast. Curr Opin Genet Dev (2012) 1.25

Prion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton. Mol Cell (2011) 1.24

Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. J Cell Biol (2008) 1.18

Structure and recognition of polyubiquitin chains of different lengths and linkage. F1000 Biol Rep (2011) 1.08

Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes). Biochem J (2008) 1.08

Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophages. Infect Immun (2009) 1.03

Deubiquitinating enzyme purification, assay inhibitors, and characterization. Methods Mol Biol (2005) 1.00

Identification of a novel 29-linked polyubiquitin binding protein, Ufd3, using polyubiquitin chain analogues. Biochemistry (2004) 0.97

Physiological and environmental control of yeast prions. FEMS Microbiol Rev (2013) 0.97

Two ZnF-UBP domains in isopeptidase T (USP5). Biochemistry (2012) 0.93

Dynamic compartmentalization of base excision repair proteins in response to nuclear and mitochondrial oxidative stress. Mol Cell Biol (2008) 0.91

The ubiquitin signal: assembly, recognition and termination. Symposium on ubiquitin and signaling. EMBO Rep (2005) 0.90

Identification and developmental expression of Xenopus laevis SUMO proteases. PLoS One (2009) 0.90

Modulating huntingtin half-life alters polyglutamine-dependent aggregate formation and cell toxicity. J Neurochem (2004) 0.89

OTU takes the chains OUT. Nat Chem Biol (2008) 0.83

BAP1 is phosphorylated at serine 592 in S-phase following DNA damage. FEBS Lett (2013) 0.81

Signal transduction: aspirin, ubiquitin and cancer. Nature (2003) 0.79

DeTEKting ubiquitination of APC/C substrates. Cell (2008) 0.79

Cell biology: unchaining the condemned. Nature (2002) 0.76

Varshavsky's contributions. Science (2004) 0.75

Quantitative analysis of protein-protein interactions. Methods Mol Biol (2015) 0.75