Published in Structure on December 01, 2003
Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock. J Cheminform (2009) 1.85
Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. J Clin Invest (2013) 1.81
Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc Natl Acad Sci U S A (2006) 1.76
Rho kinase in the regulation of cell death and survival. Arch Immunol Ther Exp (Warsz) (2007) 1.60
Rational approaches to improving selectivity in drug design. J Med Chem (2012) 1.16
STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability. Proc Natl Acad Sci U S A (2012) 1.06
RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response. Cardiovasc Diabetol (2012) 1.04
Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem (2009) 1.02
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc Natl Acad Sci U S A (2012) 0.99
Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. PLoS One (2011) 0.95
Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy. J Mol Cell Cardiol (2007) 0.93
Understanding and targeting the Rho kinase pathway in erectile dysfunction. Nat Rev Urol (2014) 0.93
The oncogene c-Jun impedes somatic cell reprogramming. Nat Cell Biol (2015) 0.91
Rho-kinase in development and heart failure: insights from genetic models. Pediatr Cardiol (2011) 0.91
Calcium channel blocker and Rho-associated kinase activity in patients with hypertension. J Hypertens (2011) 0.91
Remodeling of actin cytoskeleton in mouse periosteal cells under mechanical loading induces periosteal cell proliferation during bone formation. PLoS One (2011) 0.91
Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen. J Med Chem (2012) 0.87
Molecular basis for small molecule inhibition of G protein-coupled receptor kinases. ACS Chem Biol (2014) 0.85
The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes. Exp Diabetes Res (2010) 0.84
Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase. Br J Pharmacol (2007) 0.82
Induction of oligodendrocyte differentiation and in vitro myelination by inhibition of rho-associated kinase. ASN Neuro (2014) 0.82
Altered contribution of RhoA/Rho kinase signaling in contractile activity of myometrium in leptin receptor-deficient mice. Am J Physiol Endocrinol Metab (2011) 0.81
Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J Med Chem (2017) 0.78
RSK2 Binding Models Delineate Key Features for Activity. J Chem Pharm Res (2010) 0.78
The selective Rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat. Urology (2013) 0.78
Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities. Expert Rev Mol Med (2015) 0.78
Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries. J Comp Physiol B (2010) 0.78
5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes. Exp Diabetes Res (2012) 0.78
Rho kinase inhibitors Y27632 and H1152 augment neurite extension in the presence of cultured Schwann cells. J Brachial Plex Peripher Nerve Inj (2008) 0.77
Binding of BIS like and other ligands with the GSK-3β kinase: a combined docking and MM-PBSA study. J Mol Model (2011) 0.77
Novel Insights into the Roles of Rho Kinase in Cancer. Arch Immunol Ther Exp (Warsz) (2016) 0.76
Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem (2016) 0.76
A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation. J Comput Aided Mol Des (2008) 0.75
Heterogeneous Impact of ROCK2 on Carotid and Cerebrovascular Function. Hypertension (2016) 0.75
Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function. Stem Cells Transl Med (2016) 0.75
Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma. BMC Cancer (2016) 0.75
Cell cycle kinases predicted from conserved biophysical properties. Proteins (2009) 0.75
Discovery of novel inhibitors for the treatment of glaucoma. Expert Opin Drug Discov (2015) 0.75
Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors. Pharmaceuticals (Basel) (2010) 0.75
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine. Nature (2002) 3.05
Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second. Opt Express (2010) 3.04
Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head. Invest Ophthalmol Vis Sci (2008) 3.01
The genome sequence of the extreme thermophile Thermus thermophilus. Nat Biotechnol (2004) 2.95
Fighting fruit flies: a model system for the study of aggression. Proc Natl Acad Sci U S A (2002) 2.66
Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser. Opt Express (2011) 2.62
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nat Struct Biol (2003) 2.42
Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography. Opt Express (2008) 2.24
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism. Nature (2008) 2.22
Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range. Opt Express (2009) 2.03
Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c. J Biol Chem (2002) 2.01
HTRA proteases: regulated proteolysis in protein quality control. Nat Rev Mol Cell Biol (2011) 2.01
The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway. Pharmacol Ther (2002) 2.00
Gender-selective patterns of aggressive behavior in Drosophila melanogaster. Proc Natl Acad Sci U S A (2004) 1.99
Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding. J Am Chem Soc (2006) 1.96
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation. Nature (2003) 1.92
Molecular machines for protein degradation. Chembiochem (2005) 1.81
Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities. EMBO J (2002) 1.79
Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis. EMBO J (2004) 1.75
Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem (2002) 1.69
Phase-sensitive optical coherence tomography at up to 370,000 lines per second using buffered Fourier domain mode-locked lasers. Opt Lett (2007) 1.69
K-space linear Fourier domain mode locked laser and applications for optical coherence tomography. Opt Express (2008) 1.62
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism. Proc Natl Acad Sci U S A (2003) 1.62
Improved spectral optical coherence tomography using optical frequency comb. Opt Express (2008) 1.58
Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution. Proc Natl Acad Sci U S A (2002) 1.57
Aggression in invertebrates. Curr Opin Neurobiol (2003) 1.53
A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans. Proc Natl Acad Sci U S A (2003) 1.52
Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective. Brain Res Rev (2007) 1.50
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proc Natl Acad Sci U S A (2008) 1.48
Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease. Proc Natl Acad Sci U S A (2005) 1.47
Gene transfer and genome plasticity in Thermotoga maritima, a model hyperthermophilic species. J Bacteriol (2005) 1.45
Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. J Biol Chem (2003) 1.40
The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link. Proc Natl Acad Sci U S A (2002) 1.38
Multi-MHz retinal OCT. Biomed Opt Express (2013) 1.36
Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach. Biochim Biophys Acta (2004) 1.36
Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase. J Am Chem Soc (2002) 1.36
Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib. PLoS One (2011) 1.35
Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta (2005) 1.34
Expansion of the genetic code enables design of a novel "gold" class of green fluorescent proteins. J Mol Biol (2003) 1.34
Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG. Proc Natl Acad Sci U S A (2004) 1.32
Investigations on the maturation and regulation of archaebacterial proteasomes. J Mol Biol (2003) 1.32
FMS-like tyrosine kinase 3-internal tandem duplication tyrosine kinase inhibitors display a nonoverlapping profile of resistance mutations in vitro. Cancer Res (2009) 1.31
High-resolution positional tracking for long-term analysis of Drosophila sleep and locomotion using the "tracker" program. PLoS One (2012) 1.30
Structure of the stapled p53 peptide bound to Mdm2. J Am Chem Soc (2011) 1.30
HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues. Nat Struct Mol Biol (2010) 1.30
Substrate access and processing by the 20S proteasome core particle. Int J Biochem Cell Biol (2003) 1.29
Protein quality control in the bacterial periplasm. Annu Rev Microbiol (2011) 1.29
Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem (2001) 1.27
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein. Proc Natl Acad Sci U S A (2003) 1.27
Ultrahigh-speed non-invasive widefield angiography. J Biomed Opt (2012) 1.25
Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations. J Mol Biol (2005) 1.25
New isolates and physiological properties of the Aquificales and description of Thermocrinis albus sp. nov. Extremophiles (2002) 1.24
Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization. Proc Natl Acad Sci U S A (2006) 1.24
Crystal structure of the Bse634I restriction endonuclease: comparison of two enzymes recognizing the same DNA sequence. Nucleic Acids Res (2002) 1.24
Gene sequence and the 1.8 A crystal structure of the tungsten-containing formate dehydrogenase from Desulfovibrio gigas. Structure (2002) 1.23
Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides. Structure (2002) 1.20
Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways. Eur J Biochem (2004) 1.20
Flavin mononucleotide-based fluorescent reporter proteins outperform green fluorescent protein-like proteins as quantitative in vivo real-time reporters. Appl Environ Microbiol (2010) 1.19
The unique structure of archaeal 'hami', highly complex cell appendages with nano-grappling hooks. Mol Microbiol (2005) 1.19
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization. J Mol Biol (2003) 1.19
High speed engine gas thermometry by Fourier-domain mode-locked laser absorption spectroscopy. Opt Express (2007) 1.19
Halorhabdus tiamatea sp. nov., a non-pigmented, extremely halophilic archaeon from a deep-sea, hypersaline anoxic basin of the Red Sea, and emended description of the genus Halorhabdus. Int J Syst Evol Microbiol (2008) 1.18
Structural basis of the adaptive molecular recognition by MMP9. J Mol Biol (2002) 1.18
Intravascular optical coherence tomography imaging at 3200 frames per second. Opt Lett (2013) 1.17
Kinetic stabilization of Bacillus licheniformis alpha-amylase through introduction of hydrophobic residues at the surface. J Biol Chem (2003) 1.17
Salinisphaera shabanensis gen. nov., sp. nov., a novel, moderately halophilic bacterium from the brine-seawater interface of the Shaban Deep, Red Sea. Extremophiles (2002) 1.16
Application of NMR in structural proteomics: screening for proteins amenable to structural analysis. Structure (2002) 1.15
Crystal structure of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Bacillus subtilis. J Mol Biol (2003) 1.13
Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity. J Mol Biol (2007) 1.13
Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli. Res Microbiol (2009) 1.12
Molecular structure of the rod domain of dictyostelium filamin. J Mol Biol (2004) 1.12
Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3. Proc Natl Acad Sci U S A (2009) 1.11
Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proc Natl Acad Sci U S A (2006) 1.11
Natural communities of novel archaea and bacteria with a string-of-pearls-like morphology: molecular analysis of the bacterial partners. Appl Environ Microbiol (2002) 1.10
A new lineage of halophilic, wall-less, contractile bacteria from a brine-filled deep of the Red Sea. J Bacteriol (2008) 1.10
Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein. Proc Natl Acad Sci U S A (2009) 1.10
In situ structural and microangiographic assessment of human skin lesions with high-speed OCT. Biomed Opt Express (2012) 1.10
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison. Biol Chem (2003) 1.10
Protein kinase inhibition of clinically important staurosporine analogues. Nat Prod Rep (2010) 1.10
Active site geometry and substrate recognition of the molybdenum hydroxylase quinoline 2-oxidoreductase. Structure (2004) 1.09
Structural aspects of protein kinase control-role of conformational flexibility. Pharmacol Ther (2002) 1.09
Purification, crystallization, and X-ray analysis of the yeast 20S proteasome. Methods Enzymol (2005) 1.08
Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY). Proc Natl Acad Sci U S A (2002) 1.08
Cytochrome c nitrite reductase from Desulfovibrio desulfuricans ATCC 27774. The relevance of the two calcium sites in the structure of the catalytic subunit (NrfA). J Biol Chem (2003) 1.08
Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin. J Mol Biol (2004) 1.07
Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition. Proc Natl Acad Sci U S A (2009) 1.07
Prokaryotic phylogenetic diversity and corresponding geochemical data of the brine-seawater interface of the Shaban Deep, Red Sea. Environ Microbiol (2002) 1.07
Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nat Struct Mol Biol (2010) 1.07
Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. J Mol Biol (2003) 1.06
A variant of the hyperthermophile Archaeoglobus fulgidus adapted to grow at high salinity. FEMS Microbiol Lett (2003) 1.06
1.2 A crystal structure of the serine carboxyl proteinase pro-kumamolisin; structure of an intact pro-subtilase. Structure (2004) 1.05
Crystal structures of active SRC kinase domain complexes. J Mol Biol (2005) 1.05
Crystal structure of the carboxyltransferase subunit of the bacterial sodium ion pump glutaconyl-coenzyme A decarboxylase. EMBO J (2003) 1.04
The endoproteinase furin contains two essential Ca2+ ions stabilizing its N-terminus and the unique S1 specificity pocket. Acta Crystallogr D Biol Crystallogr (2005) 1.03
The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity. J Mol Biol (2005) 1.02
Studies on the reaction mechanism of riboflavin synthase: X-ray crystal structure of a complex with 6-carboxyethyl-7-oxo-8-ribityllumazine. Structure (2002) 1.01
The persisting challenge of selective and specific proteasome inhibition. J Pept Sci (2009) 1.01