Published in Cell Metab on December 07, 2011
Energy metabolism in the liver. Compr Physiol (2014) 1.88
Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J Endocrinol (2014) 1.76
Retracted Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein. J Neurosci (2013) 1.44
Selective leptin resistance revisited. Am J Physiol Regul Integr Comp Physiol (2013) 1.21
FOXO1 in the ventromedial hypothalamus regulates energy balance. J Clin Invest (2012) 1.13
Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle. Diabetes (2013) 1.02
Molecular Basis of Insulin Resistance: The Role of IRS and Foxo1 in the Control of Diabetes Mellitus and Its Complications. Drug Discov Today Dis Mech (2013) 0.97
Central regulation of metabolism by protein tyrosine phosphatases. Front Neurosci (2013) 0.96
Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies. J Lipid Res (2013) 0.96
Evidence against a physiologic role for acute changes in CNS insulin action in the rapid regulation of hepatic glucose production. Cell Metab (2012) 0.95
Metabolic regulation by protein tyrosine phosphatases. J Biomed Res (2014) 0.95
Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase. J Neurosci (2015) 0.88
Evidence for central regulation of glucose metabolism. J Biol Chem (2013) 0.85
Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin. Clin Auton Res (2012) 0.82
Metabolic transceivers: in tune with the central melanocortin system. Trends Endocrinol Metab (2012) 0.80
Central nervous system neuropeptide Y signaling via the Y1 receptor partially dissociates feeding behavior from lipoprotein metabolism in lean rats. Am J Physiol Endocrinol Metab (2012) 0.79
Smell and Taste Dysfunction Is Associated with Higher Serum Total Cholesterol Concentrations in Chinese Adults. J Nutr (2017) 0.76
Findings of research misconduct. NIH Guide Grants Contracts (2014) 0.75
Findings of Research Misconduct. Fed Regist (2014) 0.75
CD18 deficiency improves liver injury in the MCD model of steatohepatitis. PLoS One (2017) 0.75
A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem (1957) 173.99
Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology (2004) 18.86
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab (2008) 7.97
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem (2004) 7.91
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science (2002) 5.89
STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature (2003) 5.27
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest (2008) 5.27
Selective versus total insulin resistance: a pathogenic paradox. Cell Metab (2008) 5.25
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol (1998) 4.74
Mechanisms of leptin action and leptin resistance. Annu Rev Physiol (2008) 4.72
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab (2007) 4.51
Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest (2001) 3.82
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature (2006) 3.71
Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem Sci (2005) 3.45
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest (2005) 3.10
Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med (2008) 2.91
BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE. J Pharmacol Exp Ther (1965) 2.82
Leptin targets in the mouse brain. J Comp Neurol (2009) 2.80
Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79
Application of steady state kinetics to the estimation of synthesis rate and turnover time of tissue catecholamines. J Pharmacol Exp Ther (1966) 2.75
Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339. J Lipid Res (2005) 2.61
Monogenic obesity in humans. Annu Rev Med (2005) 2.53
Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J Neurosci (2010) 2.42
Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J Neurosci (2003) 2.14
Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science (2006) 2.02
Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest (2008) 2.00
Leptin receptor signaling and action in the central nervous system. Obesity (Silver Spring) (2006) 1.92
Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities. Endocrinology (2007) 1.73
Tissue-specific effects of central leptin on the expression of genes involved in lipid metabolism in liver and white adipose tissue. Endocrinology (2007) 1.64
Brain insulin controls adipose tissue lipolysis and lipogenesis. Cell Metab (2011) 1.64
Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes (1999) 1.57
Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically. Proc Natl Acad Sci U S A (2010) 1.51
Purification and crystallization of rat liver fatty acid synthetase. Arch Biochem Biophys (1981) 1.43
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes (2010) 1.29
Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice. Endocrinology (2007) 1.27
Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol (2007) 1.25
Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes (2006) 1.25
Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion. Diabetes (1999) 1.17
The role of the autonomic nervous liver innervation in the control of energy metabolism. Biochim Biophys Acta (2010) 1.11
Plasma lipoproteins and the synthesis and turnover of plasma triglyceride in normal and genetically obese mice. Biochem J (1973) 1.09
Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques. J Clin Endocrinol Metab (1999) 1.05
Leptin regulates peripheral lipid metabolism primarily through central effects on food intake. Endocrinology (2008) 1.01
Norepinephrine turnover in obese (ob/ob) mice: effects of age, fasting, and acute cold. Am J Physiol (1983) 0.81
Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab (2009) 5.32
STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature (2003) 5.27
Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci (2005) 4.44
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest (2007) 3.32
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med (2006) 3.24
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
Molecular and anatomical determinants of central leptin resistance. Nat Neurosci (2005) 2.98
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology (2007) 2.95
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes (2003) 2.90
Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes (2010) 2.80
The role of insulin receptor substrate 2 in hypothalamic and beta cell function. J Clin Invest (2005) 2.40
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol (2008) 2.14
The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2005) 2.13
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron (2012) 2.13
Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology (2003) 1.99
SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms. Mol Endocrinol (2007) 1.96
Leptin receptor signaling and action in the central nervous system. Obesity (Silver Spring) (2006) 1.92
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest (2007) 1.91
Critical role for hypothalamic mTOR activity in energy balance. Cell Metab (2009) 1.90
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci (2009) 1.85
Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab (2011) 1.85
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab (2006) 1.83
Influenza pandemic preparedness action plan for the United States: 2002 update. Clin Infect Dis (2002) 1.82
Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. J Neurosci (2010) 1.73
Critical role of STAT3 in leptin's metabolic actions. Cell Metab (2006) 1.70
Role of GABA release from leptin receptor-expressing neurons in body weight regulation. Endocrinology (2012) 1.68
Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. J Neurosci (2007) 1.66
The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1--blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2009) 1.64
The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab (2003) 1.64
Effects of angiotensin-converting enzyme inhibition in low-risk patients early after coronary artery bypass surgery. Circulation (2007) 1.62
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol (2009) 1.60
LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes (2004) 1.59
Cooperation between brain and islet in glucose homeostasis and diabetes. Nature (2013) 1.59
Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem (2002) 1.57
De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J Neurosci (2010) 1.56
Impact of previous percutaneous transluminal coronary angioplasty and/or stenting revascularization on outcomes after surgical revascularization: insights from the imagine study. Eur Heart J (2008) 1.55
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem (2007) 1.53
Pseudoresistant hypertension attributed to white-coat effect. Hypertension (2012) 1.50
The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2007) 1.49
Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab (2005) 1.48
Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells. Brain Res (2011) 1.46
Retracted Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein. J Neurosci (2013) 1.44
Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol (2004) 1.43
Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci (2010) 1.43
The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part I--Blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2006) 1.42
Gender influence on the dose-ranging of a low-dose perindopril-indapamide combination in hypertension: effect on systolic and pulse pressure. J Hypertens (2002) 1.41
Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A (2003) 1.41
Molecular and neural mediators of leptin action. Physiol Behav (2008) 1.40
The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Can J Cardiol (2011) 1.38
Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo. Proc Natl Acad Sci U S A (2008) 1.34
The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology (2012) 1.33
Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels. J Physiol (2010) 1.29
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes (2010) 1.29
Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs. J Infect Dis (2003) 1.28
Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem (2012) 1.27
The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest (2013) 1.27
Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA. J Neurosci (2013) 1.26
Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. Diabetes (2009) 1.25
Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol (2007) 1.25
Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling. Mol Cell Biol (2006) 1.23
The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. J Biol Chem (2013) 1.23
Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat Med (2012) 1.22
Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol (2004) 1.22
Inflammation-induced lethargy is mediated by suppression of orexin neuron activity. J Neurosci (2011) 1.22
Candidate gene database and transcript map for peach, a model species for fruit trees. Theor Appl Genet (2005) 1.21
Critical roles for the TSC-mTOR pathway in β-cell function. Am J Physiol Endocrinol Metab (2009) 1.20
The 2004 Canadian Hypertension Education Program recommendations for the management of hypertension: Part I--Blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2004) 1.20
Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology (2009) 1.19
Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci (2012) 1.18
A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol (2010) 1.17
Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons. J Neurosci (2010) 1.17
Modulation of the mesolimbic dopamine system by leptin. Brain Res (2010) 1.14
An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann N Y Acad Sci (2009) 1.13
Implementation of a multidisciplinary treatment team for hepatocellular cancer at a Veterans Affairs Medical Center improves survival. HPB (Oxford) (2008) 1.12
Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. Endocrinology (2011) 1.10
Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. Arterioscler Thromb Vasc Biol (2006) 1.08
Intussusception, rotavirus, and oral vaccines: summary of a workshop. Pediatrics (2002) 1.08
Basal cell carcinoma does metastasize. Dermatol Online J (2008) 1.08
Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity. PLoS One (2008) 1.07
The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part I - blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2010) 1.07
Hemorrhagic cholecystitis. Arch Surg (2010) 1.07
Primary prevention drug therapy: can it meet patients' requirements for reduced risk? Med Decis Making (2002) 1.06
Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake. Proc Natl Acad Sci U S A (2009) 1.06
Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology (2012) 1.05
The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit. J Virol (2009) 1.05
The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 - blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2008) 1.05
Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell Metab (2011) 1.04
The 2001 Canadian recommendations for the management of hypertension: Part one--Assessment for diagnosis, cardiovascular risk, causes and lifestyle modification. Can J Cardiol (2002) 1.02
AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice. Endocrinology (2012) 1.02
The role of leptin-->STAT3 signaling in neuroendocrine function: an integrative perspective. J Mol Med (Berl) (2003) 1.00
Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling. Mol Cell Biol (2009) 1.00
Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression. Mol Cell Endocrinol (2003) 1.00