Published in Nat Neurosci on May 01, 2005
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Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB. Nat Med (2011) 3.15
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Intracellular signalling pathways activated by leptin. Biochem J (2006) 2.93
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Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest (2006) 2.40
Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum Mol Genet (2009) 2.16
TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest (2006) 2.04
Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J Clin Invest (2006) 1.94
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PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. J Clin Invest (2010) 1.66
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IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat Cell Biol (2012) 1.63
Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J Biol Chem (2008) 1.59
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Leptin as regulator of pulmonary immune responses: involvement in respiratory diseases. Pulm Pharmacol Ther (2013) 1.54
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Pancreatic signals controlling food intake; insulin, glucagon and amylin. Philos Trans R Soc Lond B Biol Sci (2006) 1.27
Pathways linking socioeconomic status to obesity through depression and lifestyle factors among young US adults. J Affect Disord (2009) 1.26
Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling. Mol Cell Biol (2006) 1.23
Lentivirus-mediated downregulation of hypothalamic insulin receptor expression. Physiol Behav (2007) 1.15
Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats. Endocrinology (2008) 1.14
Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism (2007) 1.13
Exercise induced adipokine changes and the metabolic syndrome. J Diabetes Res (2014) 1.12
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Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Endocrinology (2008) 1.05
Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins. Diabetologia (2006) 1.03
Body mass influences cortical bone mass independent of leptin signaling. Bone (2008) 1.03
Role of depressive symptoms in explaining socioeconomic status disparities in dietary quality and central adiposity among US adults: a structural equation modeling approach. Am J Clin Nutr (2009) 1.02
Leptin: at the crossroads of energy balance and systemic inflammation. Prog Lipid Res (2006) 1.02
Leptin, abdominal obesity, and onset of depression in older men and women. J Clin Psychiatry (2012) 1.01
Obesity and dementia: adipokines interact with the brain. Eur Neuropsychopharmacol (2014) 1.00
Adipocytes: impact on tumor growth and potential sites for therapeutic intervention. Pharmacol Ther (2013) 1.00
Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study. Hum Genet (2008) 1.00
Role of leptin receptor-induced STAT3 signaling in modulation of intestinal and hepatic inflammation in mice. J Leukoc Biol (2008) 1.00
gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Proc Natl Acad Sci U S A (2006) 0.99
The association between depression and leptin is mediated by adiposity. Psychosom Med (2012) 0.99
The Role of Adipokines in Understanding the Associations between Obesity and Depression. J Obes (2010) 0.98
Food for thought: the role of appetitive peptides in age-related cognitive decline. Ageing Res Rev (2013) 0.97
Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status. J Physiol (2009) 0.96
Leptin enhances NMDA-induced spinal excitation in rats: A functional link between adipocytokine and neuropathic pain. Pain (2011) 0.95
Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours. Int J Neuropsychopharmacol (2012) 0.95
Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons. J Biol Chem (2010) 0.94
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The relation between dietary fructose, dietary fat and leptin responsiveness in rats. Physiol Behav (2011) 0.93
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. Am J Physiol Endocrinol Metab (2012) 0.91
Role of proopiomelanocortin neuron Stat3 in regulating arterial pressure and mediating the chronic effects of leptin. Hypertension (2013) 0.91
Obesity/hyperleptinemic phenotype impairs structural and functional plasticity in the rat hippocampus. Physiol Behav (2011) 0.90
Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance. Mol Cell Biol (2010) 0.90
Role of leptin resistance in the development of obesity in older patients. Clin Interv Aging (2013) 0.90
Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models. Peptides (2006) 0.89
Central and peripheral effects of chronic food restriction and weight restoration in the rat. Am J Physiol Endocrinol Metab (2008) 0.88
Leptin signaling: A key pathway in immune responses. Curr Signal Transduct Ther (2009) 0.88
Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med (2014) 0.88
Role of adipokines signaling in the modulation of T cells function. Front Immunol (2013) 0.87
New aspects of melanocortin signaling: a role for PRCP in α-MSH degradation. Front Neuroendocrinol (2010) 0.87
Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function. PLoS One (2011) 0.86
Neural network interactions and ingestive behavior control during anorexia. Physiol Behav (2007) 0.86
Mechanism of attenuation of leptin signaling under chronic ligand stimulation. BMC Biochem (2010) 0.86
Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China. Acta Pharmacol Sin (2011) 0.86
Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation. Am J Physiol Regul Integr Comp Physiol (2014) 0.85
The association between leptin and depressive symptoms is modulated by abdominal adiposity. Psychoneuroendocrinology (2014) 0.85
Consumption of green tea extract results in osteopenia in growing male mice. J Nutr (2009) 0.85
Could there be a fine-tuning role for brain-derived adipokines in the regulation of bodyweight and prevention of obesity? Mcgill J Med (2008) 0.83
The role of novel biomarkers of cardiovascular disease in chronic kidney disease: focus on adiponectin and leptin. Curr Cardiol Rev (2008) 0.83
Hyperleptinemia directly affects testicular maturation at different sexual stages in mice, and suppressor of cytokine signaling 3 is involved in this process. Reprod Biol Endocrinol (2014) 0.83
Obesity hypertension: the regulatory role of leptin. Int J Hypertens (2011) 0.83
Endocrine links between food reward and caloric homeostasis. Appetite (2008) 0.83
Obesity and endoplasmic reticulum (ER) stresses. Front Immunol (2012) 0.82
Serum leptin levels, hepatic leptin receptor transcription, and clinical predictors of non-alcoholic steatohepatitis in obese bariatric surgery patients. Surg Endosc (2007) 0.82
CRP is related to higher leptin levels in minority peripubertal females regardless of adiposity levels. Obesity (Silver Spring) (2011) 0.81
Effects of Gengnianchun on learning and memory ability, neurotransmitter, cytokines, and leptin in ovariectomized rats. Int J Clin Exp Med (2015) 0.80
Effects of leptin on cardiovascular physiology. J Am Soc Hypertens (2010) 0.80
Expression and regulation of corticotropin-releasing factor receptor type 2β in developing and mature mouse skeletal muscle. Mol Endocrinol (2010) 0.80
Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus. Mol Metab (2014) 0.80
Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats. Endocrinology (2014) 0.80
Improved leptin sensitivity as a potential candidate responsible for the spontaneous food restriction of the Lou/C rat. PLoS One (2013) 0.79
Fyn mediates leptin actions in the thymus of rodents. PLoS One (2009) 0.79
Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression. World J Gastroenterol (2016) 0.79
Maternal obesity in sheep increases fatty acid synthesis, upregulates nutrient transporters, and increases adiposity in adult male offspring after a feeding challenge. PLoS One (2015) 0.78
Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance. Front Endocrinol (Lausanne) (2012) 0.78
Sensitivity to the anorectic effects of leptin is retained in rats maintained on a ketogenic diet despite increased adiposity. Neuroendocrinology (2010) 0.78
Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells. Sci Rep (2014) 0.78
pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location. EMBO J (2013) 0.78
Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation. Br J Pharmacol (2016) 0.77
Adipocytokines: The pied pipers. J Pharmacol Pharmacother (2010) 0.77
Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab (2009) 5.32
STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature (2003) 5.27
Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab (2009) 3.07
Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology (2007) 2.95
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes (2003) 2.90
Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes (2010) 2.80
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol (2008) 2.14
The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2005) 2.13
Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology (2003) 1.99
SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms. Mol Endocrinol (2007) 1.96
Leptin receptor signaling and action in the central nervous system. Obesity (Silver Spring) (2006) 1.92
Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest (2007) 1.91
Critical role for hypothalamic mTOR activity in energy balance. Cell Metab (2009) 1.90
General nature of the STAT3-activated anti-inflammatory response. J Immunol (2006) 1.90
Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci (2009) 1.85
Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab (2011) 1.85
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab (2006) 1.83
Influenza pandemic preparedness action plan for the United States: 2002 update. Clin Infect Dis (2002) 1.82
Critical role of STAT3 in leptin's metabolic actions. Cell Metab (2006) 1.70
Role of GABA release from leptin receptor-expressing neurons in body weight regulation. Endocrinology (2012) 1.68
Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. J Neurosci (2007) 1.66
The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1--blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2009) 1.64
The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab (2003) 1.64
Effects of angiotensin-converting enzyme inhibition in low-risk patients early after coronary artery bypass surgery. Circulation (2007) 1.62
Retracted Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metab (2011) 1.60
LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes (2004) 1.59
Cooperation between brain and islet in glucose homeostasis and diabetes. Nature (2013) 1.59
Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem (2002) 1.57
Impact of previous percutaneous transluminal coronary angioplasty and/or stenting revascularization on outcomes after surgical revascularization: insights from the imagine study. Eur Heart J (2008) 1.55
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem (2007) 1.53
Pseudoresistant hypertension attributed to white-coat effect. Hypertension (2012) 1.50
The 2007 Canadian Hypertension Education Program recommendations for the management of hypertension: part 1- blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2007) 1.49
Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab (2005) 1.48
Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells. Brain Res (2011) 1.46
Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol (2004) 1.43
Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci (2010) 1.43
The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension: Part I--Blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2006) 1.42
Gender influence on the dose-ranging of a low-dose perindopril-indapamide combination in hypertension: effect on systolic and pulse pressure. J Hypertens (2002) 1.41
Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc Natl Acad Sci U S A (2003) 1.41
Molecular and neural mediators of leptin action. Physiol Behav (2008) 1.40
The 2011 Canadian Hypertension Education Program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Can J Cardiol (2011) 1.38
Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo. Proc Natl Acad Sci U S A (2008) 1.34
Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis. Diabetes (2010) 1.29
Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs. J Infect Dis (2003) 1.28
Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA. J Neurosci (2013) 1.26
Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. Diabetes (2009) 1.25
Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons. Mol Endocrinol (2007) 1.25
Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling. Mol Cell Biol (2006) 1.23
Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat Med (2012) 1.22
Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol (2004) 1.22
Inflammation-induced lethargy is mediated by suppression of orexin neuron activity. J Neurosci (2011) 1.22
Critical roles for the TSC-mTOR pathway in β-cell function. Am J Physiol Endocrinol Metab (2009) 1.20
The 2004 Canadian Hypertension Education Program recommendations for the management of hypertension: Part I--Blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2004) 1.20
Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology (2009) 1.19
Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci (2012) 1.18
A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake. Am J Physiol Regul Integr Comp Physiol (2010) 1.17
Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons. J Neurosci (2010) 1.17
Modulation of the mesolimbic dopamine system by leptin. Brain Res (2010) 1.14
An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann N Y Acad Sci (2009) 1.13
Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. Endocrinology (2011) 1.10
Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance. Arterioscler Thromb Vasc Biol (2006) 1.08
Intussusception, rotavirus, and oral vaccines: summary of a workshop. Pediatrics (2002) 1.08
Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity. PLoS One (2008) 1.07
The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: part I - blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2010) 1.07
Primary prevention drug therapy: can it meet patients' requirements for reduced risk? Med Decis Making (2002) 1.06
Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology (2012) 1.05
The 2008 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 1 - blood pressure measurement, diagnosis and assessment of risk. Can J Cardiol (2008) 1.05
Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell Metab (2011) 1.04
The 2001 Canadian recommendations for the management of hypertension: Part one--Assessment for diagnosis, cardiovascular risk, causes and lifestyle modification. Can J Cardiol (2002) 1.02
Regulation of Jak2 function by phosphorylation of Tyr317 and Tyr637 during cytokine signaling. Mol Cell Biol (2009) 1.00
The role of leptin-->STAT3 signaling in neuroendocrine function: an integrative perspective. J Mol Med (Berl) (2003) 1.00
Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression. Mol Cell Endocrinol (2003) 1.00
A simple qPCR-based method to detect correct insertion of homologous targeting vectors in murine ES cells. Transgenic Res (2007) 1.00
Role of leptin receptor-induced STAT3 signaling in modulation of intestinal and hepatic inflammation in mice. J Leukoc Biol (2008) 1.00
Neuropeptide Y suppresses anorexigenic output from the ventromedial nucleus of the hypothalamus. J Neurosci (2010) 0.98
Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring) (2008) 0.96
mTOR tells the brain that the body is hungry. Nat Med (2006) 0.96
IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab (2012) 0.95
Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. J Immunol (2010) 0.94
Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice. Gastroenterology (2010) 0.93
Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats. J Neurochem (2010) 0.93
Birthdating of myenteric neuron subtypes in the small intestine of the mouse. J Comp Neurol (2014) 0.93
Glutamate release mediates leptin action on energy expenditure. Mol Metab (2013) 0.91
Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction. Mol Metab (2012) 0.91
Hyperphagia and obesity in female mice lacking tissue inhibitor of metalloproteinase-1. Endocrinology (2008) 0.91
The role of leptin in the regulation of neuroendocrine function and CNS development. Rev Endocr Metab Disord (2007) 0.91
Cardiovascular and sympathetic effects of disrupting tyrosine 985 of the leptin receptor. Hypertension (2011) 0.89
Evaluation of a community-based automated blood pressure measuring device. CMAJ (2002) 0.89
Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes (2010) 0.88
Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity. Mol Endocrinol (2010) 0.87
Vaccine shortages: why they occur and what needs to be done to strengthen vaccine supply. Pediatrics (2006) 0.87
Hitting the target: leptin and perinatal nutrition in the predisposition to obesity. Endocrinology (2005) 0.86
IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells. Mol Cell Endocrinol (2003) 0.86
Policy statement of the world hypertension league on noninvasive blood pressure measurement devices and blood pressure measurement in the clinical or community setting. J Clin Hypertens (Greenwich) (2014) 0.86
Conditional expression of Pomc in the Lepr-positive subpopulation of POMC neurons is sufficient for normal energy homeostasis and metabolism. Endocrinology (2015) 0.85
Automated office blood pressure - being alone and not location is what matters most. Blood Press Monit (2015) 0.85
Acute selective ablation of rat insulin promoter-expressing (RIPHER) neurons defines their orexigenic nature. Proc Natl Acad Sci U S A (2012) 0.85
Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3 signaling. Endocrinology (2010) 0.84
Hypertension analysis of stress reduction using mindfulness meditation and yoga: results from the HARMONY randomized controlled trial. Am J Hypertens (2013) 0.83