Published in J Biol Chem on December 14, 2009
Uridine insertion/deletion editing in trypanosomes: a playground for RNA-guided information transfer. Wiley Interdiscip Rev RNA (2011) 1.29
Mitochondrial RNA editing in trypanosomes: small RNAs in control. Biochimie (2014) 1.07
Endonuclease associations with three distinct editosomes in Trypanosoma brucei. J Biol Chem (2011) 1.07
Mitochondrial poly(A) polymerase and polyadenylation. Biochim Biophys Acta (2011) 1.03
Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody. Nucleic Acids Res (2011) 0.97
Trypanosome RNA editing: the complexity of getting U in and taking U out. Wiley Interdiscip Rev RNA (2015) 0.96
Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. J Struct Biol (2010) 0.95
Additive and transcript-specific effects of KPAP1 and TbRND activities on 3' non-encoded tail characteristics and mRNA stability in Trypanosoma brucei. PLoS One (2012) 0.92
Assembling a protein-protein interaction map of the SSU processome from existing datasets. PLoS One (2011) 0.90
Mutational analysis of Trypanosoma brucei editosome proteins KREPB4 and KREPB5 reveals domains critical for function. RNA (2012) 0.90
The zinc-fingers of KREPA3 are essential for the complete editing of mitochondrial mRNAs in Trypanosoma brucei. PLoS One (2010) 0.89
KREPB6, KREPB7, and KREPB8 are important for editing endonuclease function in Trypanosoma brucei. RNA (2011) 0.87
A novel member of the RNase D exoribonuclease family functions in mitochondrial guide RNA metabolism in Trypanosoma brucei. J Biol Chem (2011) 0.86
Editosome accessory factors KREPB9 and KREPB10 in Trypanosoma brucei. Eukaryot Cell (2012) 0.85
OB-fold domain of KREPA4 mediates high-affinity interaction with guide RNA and possesses annealing activity. RNA (2010) 0.85
Mechanism of U insertion RNA editing in trypanosome mitochondria: the bimodal TUTase activity of the core complex. J Mol Biol (2010) 0.85
U-Insertion/Deletion mRNA-Editing Holoenzyme: Definition in Sight. Trends Parasitol (2015) 0.84
KREX2 is not essential for either procyclic or bloodstream form Trypanosoma brucei. PLoS One (2012) 0.84
The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2. Nucleic Acids Res (2012) 0.82
Uridine insertion/deletion RNA editing in Trypanosomatids: specific stimulation in vitro of Leishmania tarentolae REL1 RNA ligase activity by the MP63 zinc finger protein. Protist (2010) 0.81
Inhibitors of RNA editing as potential chemotherapeutics against trypanosomatid pathogens. Int J Parasitol Drugs Drug Resist (2011) 0.81
Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei. J Biol Chem (2015) 0.81
Mutational analysis of Trypanosoma brucei RNA editing ligase reveals regions critical for interaction with KREPA2. PLoS One (2015) 0.78
Explorations of linked editosome domains leading to the discovery of motifs defining conserved pockets in editosome OB-folds. J Struct Biol (2012) 0.78
Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. Nucleic Acids Res (2015) 0.78
A Protein Complex Map of Trypanosoma brucei. PLoS Negl Trop Dis (2016) 0.77
The oligonucleotide binding (OB)-fold domain of KREPA4 is essential for stable incorporation into editosomes. PLoS One (2012) 0.76
The Architecture of Trypanosoma brucei editosomes. Proc Natl Acad Sci U S A (2016) 0.76
A novel high-throughput activity assay for the Trypanosoma brucei editosome enzyme REL1 and other RNA ligases. Nucleic Acids Res (2015) 0.75
Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res (1992) 34.33
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics (1996) 24.62
A model for RNA editing in kinetoplastid mitochondria: "guide" RNA molecules transcribed from maxicircle DNA provide the edited information. Cell (1990) 6.24
Complex management: RNA editing in trypanosomes. Trends Biochem Sci (2005) 3.69
An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei. Science (2001) 3.52
SSB as an organizer/mobilizer of genome maintenance complexes. Crit Rev Biochem Mol Biol (2008) 3.19
Purification of a functional enzymatic editing complex from Trypanosoma brucei mitochondria. EMBO J (1997) 2.94
RNA editing in kinetoplastid protozoa. Microbiol Mol Biol Rev (1997) 2.58
From RPA to BRCA2: lessons from single-stranded DNA binding by the OB-fold. Curr Opin Struct Biol (2004) 2.48
Association of two novel proteins, TbMP52 and TbMP48, with the Trypanosoma brucei RNA editing complex. Mol Cell Biol (2001) 2.28
Trypanosome mitochondrial 3' terminal uridylyl transferase (TUTase): the key enzyme in U-insertion/deletion RNA editing. Cell (2002) 2.28
Isolation of a U-insertion/deletion editing complex from Leishmania tarentolae mitochondria. EMBO J (2003) 2.12
Mitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing. RNA (2004) 2.06
Unexplained complexity of the mitochondrial genome and transcriptome in kinetoplastid flagellates. Curr Genet (2005) 2.01
The polarity of editing within a multiple gRNA-mediated domain is due to formation of anchors for upstream gRNAs by downstream editing. Cell (1992) 1.99
Four related proteins of the Trypanosoma brucei RNA editing complex. Mol Cell Biol (2001) 1.97
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes Dev (2008) 1.97
An essential RNase III insertion editing endonuclease in Trypanosoma brucei. Proc Natl Acad Sci U S A (2005) 1.96
Separate insertion and deletion subcomplexes of the Trypanosoma brucei RNA editing complex. Mol Cell (2003) 1.94
RNA editing in Trypanosoma brucei requires three different editosomes. Mol Cell Biol (2007) 1.87
Trypanosoma brucei TBRGG1, a mitochondrial oligo(U)-binding protein that co-localizes with an in vitro RNA editing activity. J Biol Chem (1998) 1.87
Structure of the major single-stranded DNA-binding domain of replication protein A suggests a dynamic mechanism for DNA binding. EMBO J (2001) 1.87
A tale of two TUTases. Proc Natl Acad Sci U S A (2003) 1.87
Compositionally and functionally distinct editosomes in Trypanosoma brucei. RNA (2006) 1.86
Disruption of a gene encoding a novel mitochondrial DEAD-box protein in Trypanosoma brucei affects edited mRNAs. Mol Cell Biol (1997) 1.82
Guide RNA-binding complex from mitochondria of trypanosomatids. Mol Cell (2008) 1.75
Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism. Cell (2006) 1.67
High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1. J Mol Biol (2004) 1.67
Structural basis for UTP specificity of RNA editing TUTases from Trypanosoma brucei. EMBO J (2005) 1.61
RNA interference analyses suggest a transcript-specific regulatory role for mitochondrial RNA-binding proteins MRP1 and MRP2 in RNA editing and other RNA processing in Trypanosoma brucei. J Biol Chem (2004) 1.58
A deletion site editing endonuclease in Trypanosoma brucei. Mol Cell (2005) 1.57
RBP16 is a multifunctional gene regulatory protein involved in editing and stabilization of specific mitochondrial mRNAs in Trypanosoma brucei. RNA (2003) 1.53
Comparative analysis of editosome proteins in trypanosomatids. Nucleic Acids Res (2003) 1.52
Characterization of cytochrome c oxidase III transcripts that are edited only in the 3' region. Cell (1988) 1.52
TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex. RNA (2008) 1.47
TbMP44 is essential for RNA editing and structural integrity of the editosome in Trypanosoma brucei. Eukaryot Cell (2003) 1.39
Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis. Crit Rev Biochem Mol Biol (2009) 1.38
TbRGG2, an essential RNA editing accessory factor in two Trypanosoma brucei life cycle stages. J Biol Chem (2008) 1.33
TbMP42, a protein component of the RNA editing complex in African trypanosomes, has endo-exoribonuclease activity. Mol Cell (2005) 1.33
The MRB1 complex functions in kinetoplastid RNA processing. RNA (2008) 1.24
RNA editing-associated protein 1 is an RNA binding protein with specificity for preedited mRNA. Mol Cell (2001) 1.22
KREPA4, an RNA binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA (2006) 1.19
KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA (2007) 1.14
Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei. Int J Parasitol (2008) 1.13
Mechanism of the gBP21-mediated RNA/RNA annealing reaction: matchmaking and charge reduction. Nucleic Acids Res (2002) 1.09
An essential role of KREPB4 in RNA editing and structural integrity of the editosome in Trypanosoma brucei. RNA (2007) 1.08
gRNA/pre-mRNA annealing and RNA chaperone activities of RBP16. RNA (2008) 1.06
Differential functions of two editosome exoUases in Trypanosoma brucei. RNA (2009) 1.06
Snapshots of the RNA editing machine in trypanosomes captured at different assembly stages in vivo. EMBO J (2009) 1.04
Distinct and overlapping functions of MRP1/2 and RBP16 in mitochondrial RNA metabolism. Mol Cell Biol (2009) 1.04
Structure of the core editing complex (L-complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondria. Proc Natl Acad Sci U S A (2009) 1.02
The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei. Mol Cell Biol (2008) 0.99
Disruption of the zinc finger motifs in the Leishmania tarentolae LC-4 (=TbMP63) L-complex editing protein affects the stability of the L-complex. J Biol Chem (2003) 0.99
In Trypanosoma brucei RNA editing, TbMP18 (band VII) is critical for editosome integrity and for both insertional and deletional cleavages. Mol Cell Biol (2006) 0.92
Evidence for U-tail stabilization of gRNA/mRNA interactions in kinetoplastid RNA editing. RNA Biol (2004) 0.92
Functional complementation of Trypanosoma brucei RNA in vitro editing with recombinant RNA ligase. Proc Natl Acad Sci U S A (2005) 0.88
The genome of the kinetoplastid parasite, Leishmania major. Science (2005) 8.64
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (2005) 7.61
Comparative genomics of trypanosomatid parasitic protozoa. Science (2005) 5.37
Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis. J Biol Chem (2004) 2.71
Type II secretion: from structure to function. FEMS Microbiol Lett (2006) 2.51
Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes. Mol Biochem Parasitol (2006) 2.45
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat Struct Mol Biol (2010) 2.34
Structure of the GspK-GspI-GspJ complex from the enterotoxigenic Escherichia coli type 2 secretion system. Nat Struct Mol Biol (2008) 2.19
The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding. Proc Natl Acad Sci U S A (2002) 2.10
The type II secretion system: biogenesis, molecular architecture and mechanism. Nat Rev Microbiol (2012) 1.96
A comprehensive analysis of Trypanosoma brucei mitochondrial proteome. Proteomics (2009) 1.94
Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody. Structure (2009) 1.89
Compositionally and functionally distinct editosomes in Trypanosoma brucei. RNA (2006) 1.86
Sites of interaction between aldolase and thrombospondin-related anonymous protein in plasmodium. Mol Biol Cell (2003) 1.83
Mitochondrial complexes in Trypanosoma brucei: a novel complex and a unique oxidoreductase complex. Mol Cell Proteomics (2007) 1.81
Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei. Proc Natl Acad Sci U S A (2008) 1.73
The 1.6-A crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad. Proc Natl Acad Sci U S A (2003) 1.72
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites. Biochem Biophys Res Commun (2009) 1.67
High resolution crystal structure of a key editosome enzyme from Trypanosoma brucei: RNA editing ligase 1. J Mol Biol (2004) 1.67
Structural basis for the activation of cholera toxin by human ARF6-GTP. Science (2005) 1.66
Structural basis for UTP specificity of RNA editing TUTases from Trypanosoma brucei. EMBO J (2005) 1.61
Secretins: dynamic channels for protein transport across membranes. Trends Biochem Sci (2011) 1.58
Crystal structure of the extracellular protein secretion NTPase EpsE of Vibrio cholerae. J Mol Biol (2003) 1.55
The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1. Structure (2002) 1.51
An improved protocol for rapid freezing of protein samples for long-term storage. Acta Crystallogr D Biol Crystallogr (2003) 1.49
TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex. RNA (2008) 1.47
Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide. Chem Biol (2003) 1.47
Structure of the cholera toxin secretion channel in its closed state. Nat Struct Mol Biol (2010) 1.44
Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures. J Mol Biol (2002) 1.37
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrob Agents Chemother (2011) 1.37
Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J Med Chem (2012) 1.35
Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem (2012) 1.35
A novel active DNA topoisomerase I in Leishmania donovani. J Biol Chem (2002) 1.35
The X-ray structure of the type II secretion system complex formed by the N-terminal domain of EpsE and the cytoplasmic domain of EpsL of Vibrio cholerae. J Mol Biol (2005) 1.33
The power of vanadate in crystallographic investigations of phosphoryl transfer enzymes. FEBS Lett (2004) 1.32
Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite. Proc Natl Acad Sci U S A (2007) 1.31
GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides. Mol Interv (2002) 1.29
Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA gene. Nucleic Acids Res (2003) 1.29
Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency. J Mol Biol (2005) 1.26
Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. J Biomol Screen (2009) 1.25
The MRB1 complex functions in kinetoplastid RNA processing. RNA (2008) 1.24
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Mol Microbiol (2008) 1.22
Synergistic stimulation of EpsE ATP hydrolysis by EpsL and acidic phospholipids. EMBO J (2006) 1.21
Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum. Proc Natl Acad Sci U S A (2013) 1.21
Crystal structures of the response regulator DosR from Mycobacterium tuberculosis suggest a helix rearrangement mechanism for phosphorylation activation. J Mol Biol (2008) 1.20
Structural genomics of pathogenic protozoa: an overview. Methods Mol Biol (2008) 1.20
Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure (2012) 1.18
Nitrile-inducible gene expression in mycobacteria. Tuberculosis (Edinb) (2008) 1.18
The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery. J Mol Biol (2007) 1.15
The F(0)F(1)-ATP synthase complex contains novel subunits and is essential for procyclic Trypanosoma brucei. PLoS Pathog (2009) 1.14
The structure of the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae: an unusual member of the actin-like ATPase superfamily. J Mol Biol (2004) 1.14
The structure of the transition state of the heterodimeric topoisomerase I of Leishmania donovani as a vanadate complex with nicked DNA. J Mol Biol (2006) 1.14
KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei. RNA (2007) 1.14
Structural and functional studies of EpsC, a crucial component of the type 2 secretion system from Vibrio cholerae. J Mol Biol (2006) 1.13
Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein. Proc Natl Acad Sci U S A (2008) 1.13
Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type 3 copper enzymes. Proc Natl Acad Sci U S A (2009) 1.13
Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution. J Mol Biol (2005) 1.13
Structural and functional studies on the interaction of GspC and GspD in the type II secretion system. PLoS Pathog (2011) 1.12
Structure of the minor pseudopilin EpsH from the Type 2 secretion system of Vibrio cholerae. J Mol Biol (2007) 1.12
The role of medical structural genomics in discovering new drugs for infectious diseases. PLoS Comput Biol (2009) 1.11
Evaluation of differential gene expression in Leishmania major Friedlin procyclics and metacyclics using DNA microarray analysis. Mol Biochem Parasitol (2003) 1.11
Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism. Biochemistry (2004) 1.09
Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor. Proc Natl Acad Sci U S A (2006) 1.09
Parasitology. Drugs to combat tropical protozoan parasites. Science (2002) 1.08
Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin. J Am Chem Soc (2002) 1.08
Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes. J Med Chem (2004) 1.07
The crystal structure of a binary complex of two pseudopilins: EpsI and EpsJ from the type 2 secretion system of Vibrio vulnificus. J Mol Biol (2007) 1.07
In vivo cross-linking of EpsG to EpsL suggests a role for EpsL as an ATPase-pseudopilin coupling protein in the Type II secretion system of Vibrio cholerae. Mol Microbiol (2011) 1.07
Calcium is essential for the major pseudopilin in the type 2 secretion system. J Biol Chem (2009) 1.05
Structures of enterococcal glycerol kinase in the absence and presence of glycerol: correlation of conformation to substrate binding and a mechanism of activation by phosphorylation. Biochemistry (2004) 1.05
The crystal structure of the periplasmic domain of the type II secretion system protein EpsM from Vibrio cholerae: the simplest version of the ferredoxin fold. J Mol Biol (2004) 1.04
Isolation and compositional analysis of trypanosomatid editosomes. Methods Enzymol (2007) 1.03
Use of thermal melt curves to assess the quality of enzyme preparations. Anal Biochem (2009) 1.02
Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target. FEMS Microbiol Rev (2004) 1.02
Crystal structure of an RNA purine-rich tetraplex containing adenine tetrads: implications for specific binding in RNA tetraplexes. Structure (2003) 1.02
Functional studies of the Mycobacterium tuberculosis iron-dependent regulator. J Biol Chem (2004) 1.01
Crystal structure of an IdeR-DNA complex reveals a conformational change in activated IdeR for base-specific interactions. J Mol Biol (2004) 1.01
Genomic organization and gene expression in a chromosomal region of Leishmania major. Mol Biochem Parasitol (2004) 1.00
Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. J Am Chem Soc (2002) 1.00
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem (2006) 1.00
The KREPA3 zinc finger motifs and OB-fold domain are essential for RNA editing and survival of Trypanosoma brucei. Mol Cell Biol (2008) 0.99
Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.99
Dyskinetoplastic Trypanosoma brucei contains functional editing complexes. Eukaryot Cell (2003) 0.99
The R1441C mutation alters the folding properties of the ROC domain of LRRK2. Biochim Biophys Acta (2009) 0.98
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J Mol Biol (2008) 0.98
A CC' loop decoy peptide blocks the interaction between Act1 and IL-17RA to attenuate IL-17- and IL-25-induced inflammation. Sci Signal (2011) 0.98
Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5. J Mol Biol (2008) 0.97
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J Mol Biol (2010) 0.97
Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody. Nucleic Acids Res (2011) 0.97
Precursor structure of cephalosporin acylase. Insights into autoproteolytic activation in a new N-terminal hydrolase family. J Biol Chem (2001) 0.96
The binding of cholera toxin to the periplasmic vestibule of the type II secretion channel. Channels (Austin) (2011) 0.96
A new native EcHsp31 structure suggests a key role of structural flexibility for chaperone function. Protein Sci (2004) 0.96
Trypanosoma brucei mitochondrial respiratome: composition and organization in procyclic form. Mol Cell Proteomics (2011) 0.96
Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies. J Struct Biol (2010) 0.95