Published in Ageing Res Rev on December 15, 2011
AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest (2013) 2.44
Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY) (2012) 1.58
Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. PLoS One (2013) 1.20
Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol (2014) 1.15
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol (2013) 1.12
Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. J Physiol (2015) 1.10
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int J Mol Sci (2013) 1.07
Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agents. Cell Cycle (2013) 1.00
Emerging targets in osteoarthritis therapy. Curr Opin Pharmacol (2015) 0.97
The central role of AMP-kinase and energy homeostasis impairment in Alzheimer's disease: a multifactor network analysis. PLoS One (2013) 0.94
Yeast replicative aging: a paradigm for defining conserved longevity interventions. FEMS Yeast Res (2013) 0.94
SIRT3: as simple as it seems? Gerontology (2013) 0.94
Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. J Neuroinflammation (2014) 0.94
Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway. Autophagy (2015) 0.93
Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes. Arthritis Res Ther (2013) 0.91
Stress proteins in aging and life span. Int J Hyperthermia (2013) 0.90
AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging. Cell Metab (2015) 0.90
Sirtuins: from metabolic regulation to brain aging. Front Aging Neurosci (2013) 0.90
Reactive oxygen species, AMP-activated protein kinase, and the transcription cofactor p300 regulate α-tubulin acetyltransferase-1 (αTAT-1/MEC-17)-dependent microtubule hyperacetylation during cell stress. J Biol Chem (2014) 0.89
Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. BMC Genet (2015) 0.88
Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase. Arthritis Rheumatol (2014) 0.87
AMPK-NF-κB axis in the photoreceptor disorder during retinal inflammation. PLoS One (2014) 0.87
Mechanistic insights into aging, cell-cycle progression, and stress response. Front Physiol (2012) 0.87
Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α. Arthritis Rheumatol (2015) 0.85
AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation. Aging Cell (2016) 0.85
Targeted Therapy for Idiopathic Pulmonary Fibrosis: Where To Now? Drugs (2016) 0.85
Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease. EBioMedicine (2015) 0.85
Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes. Mol Cell Proteomics (2016) 0.85
Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells. Stem Cell Res Ther (2015) 0.85
AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain. Exp Neurobiol (2012) 0.84
DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet (2014) 0.84
One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metformin. Aging (Albany NY) (2012) 0.83
17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization. J Gerontol A Biol Sci Med Sci (2016) 0.83
Extending healthy ageing: nutrient sensitive pathway and centenarian population. Immun Ageing (2012) 0.83
Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1. PLoS Genet (2015) 0.82
Ageing, metabolism and cardiovascular disease. J Physiol (2015) 0.82
Activation of AMPKα2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity. PLoS One (2014) 0.82
AMP activated protein kinase is indispensable for myocardial adaptation to caloric restriction in mice. PLoS One (2013) 0.82
The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation. J Neurochem (2015) 0.81
Humulus japonicus extract exhibits antioxidative and anti-aging effects via modulation of the AMPK-SIRT1 pathway. Exp Ther Med (2015) 0.81
Sirtuins, a promising target in slowing down the ageing process. Biogerontology (2017) 0.80
AMP-activated Protein Kinase (AMPK): Does This Master Regulator of Cellular Energy State Distinguish Insulin Sensitive from Insulin Resistant Obesity? Curr Obes Rep (2014) 0.80
Regulation and function of AMPK in physiology and diseases. Exp Mol Med (2016) 0.80
Cellular Senescence as the Causal Nexus of Aging. Front Genet (2016) 0.80
The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine. Antioxid Redox Signal (2017) 0.79
Inflammation and intracellular metabolism: new targets in OA. Osteoarthritis Cartilage (2015) 0.79
Management of anemia of inflammation in the elderly. Anemia (2012) 0.79
Review: Metabolic Regulation of Inflammation in Osteoarthritis. Arthritis Rheumatol (2017) 0.78
β-Guanidinopropionic acid extends the lifespan of Drosophila melanogaster via an AMP-activated protein kinase-dependent increase in autophagy. Aging Cell (2015) 0.78
Cellular ageing mechanisms in osteoarthritis. Mamm Genome (2016) 0.78
The fine line between lifespan extension and shortening in response to caloric restriction. Nucleus (2014) 0.78
Mild electrical stimulation increases stress resistance and suppresses fat accumulation via activation of LKB1-AMPK signaling pathway in C. elegans. PLoS One (2014) 0.78
When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow? Curr Pharmacol Rep (2015) 0.77
Differential Proteomic Analysis of Human Placenta-Derived Mesenchymal Stem Cells Cultured on Normal Tissue Culture Surface and Hyaluronan-Coated Surface. Stem Cells Int (2015) 0.77
Cellular polarity in aging: role of redox regulation and nutrition. Genes Nutr (2013) 0.77
Inflammatory risk factors, biomarkers and associated therapy in ischaemic stroke. Nat Rev Neurol (2016) 0.77
Role of AMP-Activated Protein Kinase (AMPK) in Smoking-Induced Lung Inflammation and Emphysema. Tuberc Respir Dis (Seoul) (2015) 0.77
Absence of AMPKα2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts. Int J Biochem Cell Biol (2015) 0.77
p21(WAF1/CIP1) Expression is Differentially Regulated by Metformin and Rapamycin. Int J Chronic Dis (2014) 0.76
The ER stress regulator Bip mediates cadmium-induced autophagy and neuronal senescence. Sci Rep (2016) 0.76
Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes. Genes Nutr (2015) 0.76
Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from early antral follicles of aged cows. J Reprod Dev (2015) 0.75
Hypoxia promotes AMP-activated protein kinase (AMPK) and induces apoptosis in mouse osteoblasts. Int J Clin Exp Pathol (2015) 0.75
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders. Neurochem Res (2016) 0.75
Combined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue. Redox Biol (2015) 0.75
Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis. J Orthop Res (2016) 0.75
Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway. Nutr Res Pract (2016) 0.75
AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysema. Oncotarget (2017) 0.75
The role of hydrogen sulfide in aging and age-related pathologies. Aging (Albany NY) (2016) 0.75
A Cistanches Herba Fraction/ β -Sitosterol Causes a Redox-Sensitive Induction of Mitochondrial Uncoupling and Activation of Adenosine Monophosphate-Dependent Protein Kinase/Peroxisome Proliferator-Activated Receptor γ Coactivator-1 in C2C12 Myotubes: A Possible Mechanism Underlying the Weight Reduction Effect. Evid Based Complement Alternat Med (2015) 0.75
Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature. Oncotarget (2016) 0.75
Uncovering the mechanisms of Caenorhabditis elegans ageing from global quantification of the underlying landscape. J R Soc Interface (2016) 0.75
Tackling chondrocyte hypertrophy with multifunctional nanoparticles. Gene Ther (2016) 0.75
Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer. Int J Mol Sci (2017) 0.75
GADD34 Keeps the mTOR Pathway Inactivated in Endoplasmic Reticulum Stress Related Autophagy. PLoS One (2016) 0.75
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice. Sci Rep (2017) 0.75
Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis. Circ Res (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) (2011) 2.26
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev (2007) 1.96
Regulation of the aging process by autophagy. Trends Mol Med (2009) 1.69
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal (2013) 1.65
Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY) (2012) 1.58
Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors. Prog Neurobiol (2009) 1.57
ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J Neuroinflammation (2009) 1.46
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD). Immunol Lett (2012) 1.46
Celastrol: Molecular targets of Thunder God Vine. Biochem Biophys Res Commun (2010) 1.45
Maturation of autophagosomes and endosomes: a key role for Rab7. Biochim Biophys Acta (2012) 1.43
Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal (2011) 1.41
Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers. Acta Ophthalmol Suppl (Oxf ) (2008) 1.39
Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling. Cell Signal (2009) 1.34
Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration. Acta Ophthalmol (2011) 1.31
SIRT1: regulation of longevity via autophagy. Cell Signal (2009) 1.29
Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication. Acta Ophthalmol (2010) 1.29
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype. Eur J Neurosci (2011) 1.26
Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization. Mol Med (2010) 1.22
Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. PLoS One (2013) 1.20
Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma. Graefes Arch Clin Exp Ophthalmol (2006) 1.19
Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cell Mol Life Sci (2012) 1.19
Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90. Immunol Lett (2008) 1.18
SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation? Bioessays (2008) 1.17
Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology. J Cell Mol Med (2008) 1.16
Regulatory role of HIF-1alpha in the pathogenesis of age-related macular degeneration (AMD). Ageing Res Rev (2009) 1.16
AMP-activated protein kinase: a potential player in Alzheimer's disease. J Neurochem (2011) 1.16
Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells. J Cell Mol Med (2008) 1.14
Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration. Int J Mol Sci (2013) 1.13
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. Prog Neurobiol (2013) 1.12
Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging. Cell Signal (2010) 1.11
NF-kappaB signaling in the aging process. J Clin Immunol (2009) 1.10
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process. Int J Mol Sci (2013) 1.07
cDNA array reveals mechanosensitive genes in chondrocytic cells under hydrostatic pressure. Biochim Biophys Acta (2002) 1.06
ER stress and hormetic regulation of the aging process. Ageing Res Rev (2010) 1.04
Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process. Ageing Res Rev (2012) 1.03
Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration. PLoS One (2008) 1.03
Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Prog Neurobiol (2011) 1.02
Comparison of three intraocular pressure measurement methods including biomechanical properties of the cornea. Invest Ophthalmol Vis Sci (2014) 1.01
Apoptosis and aging: increased resistance to apoptosis enhances the aging process. Cell Mol Life Sci (2010) 1.01
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Prog Neurobiol (2010) 0.99
Efflux protein expression in human retinal pigment epithelium cell lines. Pharm Res (2009) 0.97
Symptom score questionnaire for nasolacrimal duct obstruction in adults--a novel tool to assess the outcome after endoscopic dacryocystorhinostomy. Rhinology (2010) 0.97
p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells. Mol Vis (2010) 0.95
Retinal arterial macroaneurysms. Acta Ophthalmol (2013) 0.95
Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells. Biochem Biophys Res Commun (2007) 0.93
Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD). Biogerontology (2013) 0.92
Siglec receptors and hiding plaques in Alzheimer's disease. J Mol Med (Berl) (2009) 0.90
A prospective study on postoperative pain after cataract surgery. Clin Ophthalmol (2013) 0.90
Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process. J Cell Physiol (2010) 0.90
Structure and barrier properties of human embryonic stem cell-derived retinal pigment epithelial cells are affected by extracellular matrix protein coating. Tissue Eng Part A (2014) 0.90
Cellular and molecular mechanisms of age-related macular degeneration: from impaired autophagy to neovascularization. Int J Biochem Cell Biol (2013) 0.89
The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells. Immunol Lett (2007) 0.89
The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells. Mol Vis (2012) 0.88
Regression of necrotizing scleritis in Wegener's granulomatosis after infliximab treatment. Acta Ophthalmol (2009) 0.88
Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells. Eur J Pharmacol (2008) 0.88
Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney. Antioxid Redox Signal (2007) 0.87
Immunolocalization of EMMPRIN (CD147) in the human eye and detection of soluble form of EMMPRIN in ocular fluids. Curr Eye Res (2006) 0.87
Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process. Int J Cell Biol (2012) 0.87
Phospholipase A2 in chamber angle of normal eyes and patients with primary open angle glaucoma and exfoliation glaucoma. Mol Vis (2007) 0.86
Postoperative pain after cataract surgery. J Cataract Refract Surg (2013) 0.85
Imiquimod in the treatment of eyelid basal cell carcinoma. Acta Ophthalmol Scand (2007) 0.85
Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells. Pharmacol Res (2011) 0.85
ROCK, PAK, and Toll of synapses in Alzheimer's disease. Biochem Biophys Res Commun (2008) 0.85
Strong expression of HSP47 in metaplastic nasal mucosa may predict a poor outcome after primary endoscopic dacryocystorhinostomy: a prospective study. Acta Ophthalmol (2011) 0.85
Hydrostatic pressure-induced changes in cellular protein synthesis. Biorheology (2004) 0.84
Protein-oxidized phospholipid interactions in cellular signaling for cell death: from biophysics to clinical correlations. Biochim Biophys Acta (2012) 0.84
Autophagy--hot topic in AMD. Acta Ophthalmol (2010) 0.84
Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process. J Mol Med (Berl) (2014) 0.84
Gene expression profiles in chondrosarcoma cells subjected to cyclic stretching and hydrostatic pressure. A cDNA array study. Biorheology (2003) 0.83
Filter-cultured ARPE-19 cells as outer blood-retinal barrier model. Eur J Pharm Sci (2010) 0.83
Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process. Curr Opin Clin Nutr Metab Care (2012) 0.83
Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process. Ageing Res Rev (2009) 0.83
Genetic variability in DNA repair proteins in age-related macular degeneration. Int J Mol Sci (2012) 0.83
Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro. Mol Vis (2011) 0.82
NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes? Biochem Biophys Res Commun (2008) 0.82
SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree. Biochem Biophys Res Commun (2008) 0.82
ADAMTS9 locus associates with increased risk of wet AMD. Acta Ophthalmol (2014) 0.81
5'-Adenosine monophosphate-activated protein kinase--mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration. Rejuvenation Res (2011) 0.81
Mitomycin C in revision endoscopic dacryocystorhinostomy: a prospective randomized study. Am J Rhinol Allergy (2011) 0.80
Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops. J Gene Med (2007) 0.80
Altered calcium signaling in an experimental model of glaucoma. Invest Ophthalmol Vis Sci (2010) 0.80
Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19). Eur J Pharmacol (2010) 0.79
Potential of epigenetic mechanisms in AMD pathology. Front Biosci (Schol Ed) (2013) 0.79
Histopathology of the three implanted degradable biopolymers in rabbit eye. J Biomed Mater Res A (2009) 0.79
Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function. Cell Mol Life Sci (2013) 0.79
Efflux protein expression in human stem cell-derived retinal pigment epithelial cells. PLoS One (2012) 0.79
Increased IL-6 levels are not related to NF-κB or HIF-1α transcription factors activity in the vitreous of proliferative diabetic retinopathy. J Diabetes Complications (2011) 0.79
Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure. Biochim Biophys Acta (2005) 0.78
Bilberries potentially alleviate stress-related retinal gene expression induced by a high-fat diet in mice. Mol Vis (2012) 0.78
Visual recovery of the amblyopic eye in an adult patient after loss of the dominant eye. Acta Ophthalmol Scand (2003) 0.78
Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90. Neurochem Res (2008) 0.78
High pressure effects on cellular expression profile and mRNA stability. A cDNA array analysis. Biorheology (2002) 0.77