PubRank

Christopher P Austin

Author PubWeight™ 193.04‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Prepublication data sharing. Nature 2009 12.24
2 Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A 2006 9.92
3 High-throughput screening assays for the identification of chemical probes. Nat Chem Biol 2007 4.50
4 The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Sci Transl Med 2011 3.80
5 Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol 2012 3.40
6 Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. Science 2011 3.30
7 Compound cytotoxicity profiling using quantitative high-throughput screening. Environ Health Perspect 2008 3.11
8 A high-throughput screen for aggregation-based inhibition in a large compound library. J Med Chem 2007 2.97
9 Improving the human hazard characterization of chemicals: a Tox21 update. Environ Health Perspect 2013 2.95
10 Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med 2008 2.90
11 Fluorescence spectroscopic profiling of compound libraries. J Med Chem 2008 2.53
12 Characterization of chemical libraries for luciferase inhibitory activity. J Med Chem 2008 2.53
13 High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A 2014 2.50
14 DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. Hum Mol Genet 2003 2.39
15 Compound Management for Quantitative High-Throughput Screening. JALA Charlottesv Va 2008 2.11
16 A robotic platform for quantitative high-throughput screening. Assay Drug Dev Technol 2008 1.90
17 Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase. J Med Chem 2008 1.81
18 Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease. Proc Natl Acad Sci U S A 2007 1.70
19 Toxicity testing in the 21st century: implications for human health risk assessment. Risk Anal 2008 1.64
20 Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A 2009 1.61
21 Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem 2010 1.61
22 Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. PLoS Negl Trop Dis 2008 1.58
23 Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. Environ Health Perspect 2011 1.57
24 Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity. Environ Sci Technol 2010 1.54
25 Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol 2009 1.52
26 Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochem Pharmacol 2010 1.52
27 A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res 2009 1.49
28 Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease. J Med Chem 2010 1.45
29 The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform. Drug Discov Today 2010 1.43
30 A role for the melanocortin 4 receptor in sexual function. Proc Natl Acad Sci U S A 2002 1.38
31 Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect 2015 1.37
32 Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett 2010 1.37
33 High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A 2012 1.35
34 A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. J Med Chem 2009 1.34
35 Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 2009 1.32
36 Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nat Biotechnol 2009 1.30
37 Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry 2009 1.28
38 Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition. Cancer Res 2009 1.27
39 Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor. J Biomol Screen 2008 1.25
40 Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chem Res Toxicol 2008 1.25
41 A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker. Toxicol In Vitro 2008 1.24
42 δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders. J Biol Chem 2012 1.23
43 Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics 2002 1.22
44 A dual-fluorescence high-throughput cell line system for probing multidrug resistance. Assay Drug Dev Technol 2009 1.22
45 The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality. Drug Discov Today 2013 1.21
46 Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening. Assay Drug Dev Technol 2009 1.20
47 Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics 2002 1.20
48 Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR. Gene 2002 1.19
49 Collaborative development of 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick type C1 disease. Curr Top Med Chem 2014 1.19
50 Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Res 2014 1.19
51 Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction. Anal Biochem 2007 1.18
52 Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership. Cancer Res 2012 1.16
53 Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A 2012 1.16
54 Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes 2004 1.16
55 Localization of PPARdelta in murine central nervous system: expression in oligodendrocytes and neurons. Brain Res 2003 1.15
56 Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci 2009 1.14
57 Identification of clinically used drugs that activate pregnane X receptors. Drug Metab Dispos 2010 1.14
58 Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory. Proc Natl Acad Sci U S A 2009 1.13
59 Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci 2012 1.12
60 Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria. ACS Med Chem Lett 2011 1.12
61 Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Perspect 2014 1.12
62 A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel. Anal Biochem 2009 1.11
63 Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay. Mol Cancer Ther 2009 1.11
64 Paradigm shift in toxicity testing and modeling. AAPS J 2012 1.07
65 High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase. PLoS One 2012 1.07
66 Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorg Med Chem Lett 2009 1.06
67 Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. J Med Chem 2009 1.05
68 A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression. Anal Biochem 2007 1.05
69 Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicol Sci 2009 1.05
70 High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. Antimicrob Agents Chemother 2010 1.05
71 Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity. J Med Chem 2011 1.05
72 Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem 2010 1.04
73 Application of a homogenous membrane potential assay to assess mitochondrial function. Physiol Genomics 2012 1.03
74 Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes. Am J Nephrol 2008 1.02
75 A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor. Assay Drug Dev Technol 2007 1.01
76 Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol 2011 1.00
77 A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Res 2009 1.00
78 Differentiating Alzheimer disease-associated aggregates with small molecules. Neurobiol Dis 2007 1.00
79 Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format. Curr Chem Genomics 2008 0.99
80 Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format. Methods Enzymol 2006 0.99
81 Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening. Comb Chem High Throughput Screen 2008 0.99
82 Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1. Anal Bioanal Chem 2012 0.99
83 A class of tricyclic compounds blocking malaria parasite oocyst development and transmission. Antimicrob Agents Chemother 2012 0.98
84 Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ Mol Mutagen 2011 0.98
85 A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction. Comb Chem High Throughput Screen 2008 0.96
86 Evaluation of cholesterol reduction activity of methyl-β-cyclodextrin using differentiated human neurons and astrocytes. J Biomol Screen 2012 0.95
87 Monitoring compound integrity with cytochrome P450 assays and qHTS. J Biomol Screen 2009 0.95
88 Bisphenol A affects androgen receptor function via multiple mechanisms. Chem Biol Interact 2013 0.95
89 Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorg Med Chem 2009 0.95
90 The pilot phase of the NIH Chemical Genomics Center. Curr Top Med Chem 2009 0.94
91 Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators. Eur J Med Chem 2010 0.94
92 A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase. Assay Drug Dev Technol 2008 0.93
93 Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone. J Biol Chem 2011 0.93
94 Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules. Mol Inform 2012 0.93
95 Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data. J Chem Inf Model 2011 0.92
96 Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene 2002 0.92
97 Discovery, synthesis, and biological evaluation of novel SMN protein modulators. J Med Chem 2011 0.91
98 Identification of small molecule compounds that inhibit the HIF-1 signaling pathway. Mol Cancer 2009 0.91
99 A high-throughput approach for identification of novel general anesthetics. PLoS One 2009 0.91
100 Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening. Chem Res Toxicol 2013 0.91
101 An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction. J Biomol Screen 2009 0.90
102 Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther 2013 0.90
103 A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries. Mol Biosyst 2009 0.90
104 Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors. ACS Med Chem Lett 2013 0.90
105 N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease. Bioorg Med Chem Lett 2007 0.89
106 A new resorufin-based alpha-glucosidase assay for high-throughput screening. Anal Biochem 2009 0.89
107 A cell-based PDE4 assay in 1536-well plate format for high-throughput screening. J Biomol Screen 2008 0.89
108 Presenilin-dependent gamma-secretase activity modulates neurite outgrowth. Neurobiol Dis 2002 0.89
109 Innovation in therapeutics development at the NCATS. Neuropsychopharmacology 2014 0.89
110 A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS. Comb Chem High Throughput Screen 2008 0.88
111 A multiplex calcium assay for identification of GPCR agonists and antagonists. Assay Drug Dev Technol 2010 0.88
112 Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase. Anal Bioanal Chem 2009 0.88
113 Identification of a potent new chemotype for the selective inhibition of PDE4. Bioorg Med Chem Lett 2008 0.86
114 A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J Neurosci 2013 0.86
115 Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach. Environ Health Perspect 2012 0.86
116 High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Hum Mol Genet 2013 0.86
117 Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study. J Comp Neurol 2003 0.85
118 Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells. Curr Chem Genomics 2011 0.85
119 Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format. Cell Mol Neurobiol 2011 0.84
120 Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors. Bioorg Med Chem Lett 2011 0.84
121 Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorg Med Chem Lett 2007 0.83
122 A novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biology. PLoS One 2013 0.83
123 Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening. J Transl Med 2012 0.83
124 A high-throughput screening assay for determining cellular levels of total tau protein. Curr Alzheimer Res 2013 0.83
125 Selective Modulation of Gq/Gs pathways by Naphtho Pyrano Pyrimidines as antagonists of the Neuropeptide S Receptor. ACS Chem Neurosci 2010 0.82
126 Neuropeptide FF receptor 2 (NPFF2) is localized to pain-processing regions in the primate spinal cord and the lower level of the medulla oblongata. J Chem Neuroanat 2003 0.82
127 Identification of small molecule modulators of gene transcription with anticancer activity. ACS Chem Biol 2014 0.82
128 Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay. Mol Endocrinol 2014 0.81
129 Are hERG channel blockers also phospholipidosis inducers? Bioorg Med Chem Lett 2013 0.81
130 Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs. PLoS One 2013 0.81
131 Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. J Biomol Screen 2013 0.81
132 Automated high-content screening for compounds that disassemble the perinucleolar compartment. J Biomol Screen 2009 0.81
133 Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorg Med Chem Lett 2009 0.80
134 Structure based model for the prediction of phospholipidosis induction potential of small molecules. J Chem Inf Model 2012 0.79
135 A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2. J Biomol Screen 2011 0.78
136 Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research. Environ Health Perspect 2015 0.78
137 High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model. Curr Chem Genomics 2012 0.77
138 A Cell-based beta-Lactamase Reporter Gene Assay for the CREB Signaling Pathway. Curr Chem Genomics 2009 0.77
139 The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists. Medchemcomm 2011 0.76
140 Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents. Pharmacol Biochem Behav 2011 0.76
141 Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor. J Med Chem 2013 0.75
142 Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification. Assay Drug Dev Technol 2007 0.75
143 Measure, mine, model, and manipulate: the future for HTS and chemoinformatics? Drug Discov Today 2006 0.75