Published in PLoS One on January 12, 2012
Higher serum chloride concentrations are associated with acute kidney injury in unselected critically ill patients. BMC Nephrol (2013) 1.56
Paclitaxel ameliorates lipopolysaccharide-induced kidney injury by binding myeloid differentiation protein-2 to block Toll-like receptor 4-mediated nuclear factor-κB activation and cytokine production. J Pharmacol Exp Ther (2013) 1.02
Aldose reductase inhibition prevents allergic airway remodeling through PI3K/AKT/GSK3β pathway in mice. PLoS One (2013) 0.87
Quantitative biodistribution and pharmacokinetics of multimodal gadolinium-based nanoparticles for lungs using ultrashort TE MRI. MAGMA (2013) 0.85
The Role of Autophagy in Kidney Inflammatory Injury via the NF-κB Route Induced by LPS. Int J Med Sci (2015) 0.83
Licochalcone A Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting NF-κB Activation. Inflammation (2016) 0.82
Renoprotective approaches and strategies in acute kidney injury. Pharmacol Ther (2016) 0.82
Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia. PLoS One (2015) 0.77
Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury. Am J Physiol Renal Physiol (2014) 0.76
Protection by Huang-Lian-Jie-Du decoction and its constituent herbs of lipopolysaccharide-induced acute kidney injury. FEBS Open Bio (2017) 0.75
Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat. Korean J Physiol Pharmacol (2015) 0.75
The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury. PLoS One (2015) 0.75
Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization. Br J Pharmacol (2017) 0.75
Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury. FEBS J (2017) 0.75
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA (1995) 9.54
Acute renal failure and sepsis. N Engl J Med (2004) 7.18
The enigma of sepsis. J Clin Invest (2003) 4.32
Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury. J Clin Invest (1996) 3.73
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest (2005) 3.48
Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture. Shock (2000) 3.12
NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury. J Immunol (2007) 2.92
TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways. J Immunol (2007) 2.32
Inflammation in acute kidney injury. Nephron Exp Nephrol (2008) 2.32
Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist. J Pharmacol Exp Ther (2003) 1.75
Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications. Pharmacol Rev (1998) 1.75
Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2007) 1.61
Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Am J Physiol Renal Physiol (2007) 1.59
Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion. J Clin Invest (2006) 1.57
Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications. Diabetes (2005) 1.49
Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase. Kidney Int (2001) 1.41
Mechanism of diabetic neuropathy: Where are we now and where to go? J Diabetes Investig (2011) 1.25
Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats. J Clin Invest (1997) 1.25
Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase. Circ Res (2000) 1.24
Central role for aldose reductase pathway in myocardial ischemic injury. FASEB J (2004) 1.19
Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation (2006) 1.17
Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury. Diabetes (1997) 1.08
Aldose reductase inhibitors improve myocardial reperfusion injury in mice by a dual mechanism. J Pharmacol Sci (2006) 1.05
Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase. J Biol Chem (1999) 1.04
Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury. FASEB J (2005) 1.02
Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage. Free Radic Biol Med (2007) 1.01
Aldose reductase in diabetic microvascular complications. Curr Drug Targets (2005) 1.01
Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages. Free Radic Biol Med (2007) 1.00
Vasoactive hormones in the renal response to systemic sepsis. Am J Kidney Dis (1988) 0.97
Acute renal failure and the sepsis syndrome. Kidney Int (2002) 0.96
Metabolic effects of aldose reductase inhibition during low-flow ischemia and reperfusion. Am J Physiol (1998) 0.95
Novel role for aldose reductase in mediating acute inflammatory responses in the lung. J Immunol (2009) 0.94
Deletion of aldose reductase leads to protection against cerebral ischemic injury. J Cereb Blood Flow Metab (2007) 0.93
Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis. Cytokine (2009) 0.93
Arterial norepinephrine changes in patients with septic shock. Circ Shock (1992) 0.89
Osmotic response element is required for the induction of aldose reductase by tumor necrosis factor-alpha. J Biol Chem (1999) 0.89
Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury. Exp Eye Res (2007) 0.89
The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice. J Pathol (2010) 0.83
ARF, AKI, or ATN? Nat Rev Nephrol (2010) 0.82
A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia. Am J Physiol Heart Circ Physiol (2005) 0.78
Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med (2010) 2.98
Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc Natl Acad Sci U S A (2003) 2.56
Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles. Cancer Res (2002) 1.53
MACC 1 as a marker for vascular invasive hepatocellular carcinoma. Anticancer Res (2011) 1.48
Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions. Proc Natl Acad Sci U S A (2005) 1.43
MACC 1 as a marker for peritoneal-disseminated gastric carcinoma. Anticancer Res (2010) 1.42
Neuroendocrine differentiation in hyalinizing trabecular tumor of the thyroid. Virchows Arch (2003) 1.40
Molecular pathophysiology in Tay-Sachs and Sandhoff diseases as revealed by gene expression profiling. Hum Mol Genet (2002) 1.34
Apoptosis accompanied by up-regulation of TNF-alpha death pathway genes in the brain of Niemann-Pick type C disease. Mol Genet Metab (2005) 1.32
Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. J Leukoc Biol (2002) 1.29
Loss of ARID1A expression is an early molecular event in tumor progression from ovarian endometriotic cyst to clear cell and endometrioid carcinoma. Int J Gynecol Cancer (2012) 1.26
Role of advanced glycation end products and their receptors in development of diabetic neuropathy. Ann N Y Acad Sci (2005) 1.23
MACC1 as a marker for advanced colorectal carcinoma. Anticancer Res (2010) 1.21
Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment. Blood (2004) 1.18
Localized amyloidosis at the site of repeated insulin injection in a diabetic patient. Intern Med (2010) 1.14
Vimentin methylation as a marker for advanced colorectal carcinoma. Anticancer Res (2009) 1.13
Expression of p16 protein and hypermethylation status of its promoter gene in adenoid cystic carcinoma of the head and neck. ORL J Otorhinolaryngol Relat Spec (2003) 1.12
Role of advanced glycation end products in diabetic neuropathy. Curr Pharm Des (2008) 1.06
Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix. Hum Pathol (2005) 1.04
Correction of protein kinase C activity and macrophage migration in peripheral nerve by pioglitazone, peroxisome proliferator activated-gamma-ligand, in insulin-deficient diabetic rats. J Neurochem (2007) 1.04
Aberrant methylation of the HACE1 gene is frequently detected in advanced colorectal cancer. Anticancer Res (2008) 1.04
The possible role of tumor necrosis factor-alpha in diabetic polyneuropathy. Exp Diabesity Res (2003) 0.99
Methylation of HACE1 in gastric carcinoma. Anticancer Res (2009) 0.99
Pancreatic malignant fibrous histiocytoma, inflammatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis: characterization and differential diagnosis. Virchows Arch (2006) 0.97
Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats. Eur J Pharmacol (2012) 0.95
The femoral insertion of the anterior cruciate ligament: discrepancy between macroscopic and histological observations. Arthroscopy (2012) 0.95
Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of β-cell mass in Japanese type 2 diabetic patients. Diabetes Care (2014) 0.95
Efficacy of adipose tissue-derived mesenchymal stem cells for fulminant hepatitis in mice induced by concanavalin A. J Gastroenterol Hepatol (2012) 0.94
Methylation of TFPI2 gene is frequently detected in advanced well-differentiated colorectal cancer. Anticancer Res (2010) 0.92
Pheochromocytoma with histologic transformation to composite type, complicated by watery diarrhea, hypokalemia, and achlorhydria syndrome. Endocr Pract (2012) 0.91
Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci (2007) 0.90
Expression of retinoic acid-inducible gene-I (RIG-I) in macrophages: possible involvement of RIG-I in atherosclerosis. J Atheroscler Thromb (2007) 0.90
Peripheral neuropathy and microangiopathy in rats with insulinoma: association with chronic hyperinsulinemia. Diabetes Metab Res Rev (2003) 0.90
Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma. Life Sci (2004) 0.89
Methylation of the MGMT gene is frequently detected in advanced gastric carcinoma. Anticancer Res (2009) 0.89
Aberrant methylation of the p16 gene is frequently detected in advanced colorectal cancer. Anticancer Res (2009) 0.88
Demethylation of the CDH3 gene is frequently detected in advanced colorectal cancer. Anticancer Res (2009) 0.88
Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice. Diabetes (2004) 0.88
Promoter methylation and protein expression of the E-cadherin gene in the clinicopathologic assessment of adenoid cystic carcinoma. Mod Pathol (2004) 0.88
Methylation of the p16 gene is frequently detected in lymphatic-invasive gastric cancer. Anticancer Res (2010) 0.88
Exendin-4 improves β-cell function in autophagy-deficient β-cells. Endocrinology (2013) 0.88
Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats. Virchows Arch (2008) 0.87
Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors. Pancreas (2010) 0.87
Frequent methylation of Vimentin in well-differentiated gastric carcinoma. Anticancer Res (2009) 0.87
Inflammatory pseudotumour (plasma cell granuloma) arising in the maxillary sinus. Acta Otolaryngol (2005) 0.87
Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer. World J Surg (2009) 0.86
Reduced cell replication and induction of apoptosis by advanced glycation end products in rat Schwann cells. Biochem Biophys Res Commun (2004) 0.86
Down-regulation of Tip60 gene as a potential marker for the malignancy of colorectal cancer. Anticancer Res (2009) 0.85
Demethylation of the CD133 gene is frequently detected in advanced colorectal cancer. Anticancer Res (2009) 0.85
Neurotrophin-3-induced production of nerve growth factor is suppressed in Schwann cells exposed to high glucose: involvement of the polyol pathway. J Neurochem (2004) 0.85
Methylation of the DFNA5 gene is frequently detected in colorectal cancer. Anticancer Res (2012) 0.84
Methylation of the DCC gene is lost in advanced gastric cancer. Anticancer Res (2010) 0.84
Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice. J Neurochem (2003) 0.84
Intraepidermal nerve fiber density and nerve conduction study parameters correlate with clinical staging of diabetic polyneuropathy. Diabetes Res Clin Pract (2012) 0.84
Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats. Eur J Clin Invest (2010) 0.84
Aberrant methylation of the Vimentin gene in hepatocellular carcinoma. Anticancer Res (2011) 0.84
Global gene expression in a type 2 Gaucher disease brain. Mol Genet Metab (2004) 0.84
Peripheral nerve endoneurial microangiopathy and necrosis in rats with insulinoma. Acta Neuropathol (2004) 0.84
Decreased blood glucose excursion by nateglinide ameliorated neuropathic changes in Goto-Kakizaki rats, an animal model of non-obese type 2 diabetes. Metabolism (2002) 0.83
The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice. J Pathol (2010) 0.83
Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications. BMC Cancer (2009) 0.83
Aberrant methylation of the UNC5C gene is frequently detected in advanced colorectal cancer. Anticancer Res (2009) 0.83
Methylation of the WNT5A gene is frequently detected in early gastric carcinoma. Hepatogastroenterology (2012) 0.83
Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes. Biochem Biophys Res Commun (2002) 0.83
Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients. Amyloid (2014) 0.82
Prolapse into the bile duct and expansive growth is characteristic behavior of mucinous cystic neoplasm of the liver: report of two cases and review of the literature. Clin J Gastroenterol (2015) 0.82
Distinctive histopathologic findings of pancreatic hamartomas suggesting their "hamartomatous" nature: a study of 9 cases. Am J Surg Pathol (2013) 0.82
[A case of esophageal squamous cell carcinoma with an adenocarcinoma component that dedifferentiated after chemotherapy]. Gan To Kagaku Ryoho (2014) 0.82
Frequent CDH3 demethylation in advanced gastric carcinoma. Anticancer Res (2009) 0.82
CD133 gene overexpression is frequently observed in early colorectal carcinoma. Hepatogastroenterology (2009) 0.82
Mesenchymal stem cell isolation and characterization from human spinal ligaments. Biochem Biophys Res Commun (2011) 0.81
Tissue kallikrein inhibits retinal neovascularization via the cleavage of vascular endothelial growth factor-165. Arterioscler Thromb Vasc Biol (2011) 0.81
Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma. Tohoku J Exp Med (2004) 0.81
MGMT gene is aberrantly methylated from the early stages of colorectal cancers. Hepatogastroenterology (2010) 0.81
Nitric oxide generation and poly(ADP ribose) polymerase activation precede beta-cell death in rats with a single high-dose injection of streptozotocin. Virchows Arch (2004) 0.81
Changes in UNC5C gene methylation during human gastric carcinogenesis. Anticancer Res (2009) 0.81
Sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration: a TDP-43 immunohistochemical study. Neuropathology (2009) 0.80
Methylation of the homeobox gene, HOPX, is frequently detected in poorly differentiated colorectal cancer. Anticancer Res (2011) 0.80
Methylation of the TFPI2 gene is frequently detected in advanced gastric carcinoma. Anticancer Res (2010) 0.80
Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma. BMC Cancer (2008) 0.80
FBN2 methylation is detected in the serum of colorectal cancer patients with hepatic metastasis. Anticancer Res (2012) 0.80
Intracytoplasmic immunoglobulin crystals in follicular lymphoma. Hum Pathol (2002) 0.80
Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve. Brain Res (2010) 0.80