Transcriptional programming of the dendritic cell network.

PubWeight™: 1.70‹?› | Rank: Top 3%

🔗 View Article (PMID 22273772)

Published in Nat Rev Immunol on January 25, 2012

Authors

Gabrielle T Belz1, Stephen L Nutt

Author Affiliations

1: Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3052, Australia. belz@wehi.edu.au; nutt@wehi.edu.au

Articles citing this

Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med (2012) 2.74

Re(de)fining the dendritic cell lineage. Nat Immunol (2012) 2.17

Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity (2015) 1.75

The multifaceted biology of plasmacytoid dendritic cells. Nat Rev Immunol (2015) 1.52

Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis. Nat Immunol (2015) 1.42

The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells. Nat Immunol (2013) 1.36

The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat Immunol (2013) 1.22

Dendritic cells: arbiters of immunity and immunological tolerance. Cold Spring Harb Perspect Biol (2012) 1.20

Human dendritic cell functional specialization in steady-state and inflammation. Front Immunol (2014) 1.16

IL-1R1 is required for dendritic cell-mediated T cell reactivation within the CNS during West Nile virus encephalitis. J Exp Med (2013) 1.09

The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. Blood (2012) 1.07

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells. J Exp Med (2013) 1.03

The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation. J Exp Med (2014) 1.00

Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity. Front Immunol (2012) 0.98

Transcriptional Control of Dendritic Cell Development. Annu Rev Immunol (2015) 0.97

IL-34 and CSF-1: similarities and differences. J Bone Miner Metab (2013) 0.96

Brain dendritic cells: biology and pathology. Acta Neuropathol (2012) 0.96

miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1. Nat Commun (2013) 0.95

Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks. J Exp Med (2013) 0.94

Plenary perspective: the complexity of constitutive and inducible gene expression in mononuclear phagocytes. J Leukoc Biol (2012) 0.93

Dendritic cell-based vaccination in cancer: therapeutic implications emerging from murine models. Front Immunol (2015) 0.91

Intestinal antigen-presenting cells in mucosal immune homeostasis: crosstalk between dendritic cells, macrophages and B-cells. World J Gastroenterol (2014) 0.90

Dendritic cells a double-edge sword in autoimmune responses. Front Immunol (2012) 0.87

Plasmacytoid dendritic cells: no longer an enigma and now key to transplant tolerance? Am J Transplant (2013) 0.87

Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis. Proc Natl Acad Sci U S A (2015) 0.86

Helminths: Immunoregulation and Inflammatory Diseases-Which Side Are Trichinella spp. and Toxocara spp. on? J Parasitol Res (2013) 0.85

RANKL-RANK interaction in immune regulatory systems. World J Orthop (2012) 0.85

The role of dendritic cells in tissue-specific autoimmunity. J Immunol Res (2014) 0.84

Dendritic cell biology in human cytomegalovirus infection and the clinical consequences for host immunity and pathology. Virulence (2012) 0.84

Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder. Blood (2014) 0.84

Fas signal promotes the immunosuppressive function of regulatory dendritic cells via the ERK/β-catenin pathway. J Biol Chem (2013) 0.84

C/EBPα is required for development of dendritic cell progenitors. Blood (2013) 0.83

Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. PLoS One (2014) 0.83

Diversity, function, and transcriptional regulation of gut innate lymphocytes. Front Immunol (2013) 0.83

CD8α dendritic cells drive establishment of HSV-1 latency. PLoS One (2014) 0.83

Regulatory myeloid cells in transplantation. Transplantation (2014) 0.83

Dendritic cells as gatekeepers of tolerance. Semin Immunopathol (2016) 0.83

Role of Dendritic Cells in the Induction of Lymphocyte Tolerance. Front Immunol (2015) 0.83

Induction of innate and adaptive immunity by delivery of poly dA:dT to dendritic cells. Nat Chem Biol (2013) 0.83

Atherosclerosis and the role of immune cells. World J Clin Cases (2015) 0.83

Dendritic cells in the periphery control antigen-specific natural and induced regulatory T cells. Front Immunol (2013) 0.83

Differential requirement for Hoxa9 in the development and differentiation of B, NK, and DC-lineage cells from Flt3+ multipotential progenitors. BMC Immunol (2013) 0.82

Diversification of dendritic cell subsets: Emerging roles for STAT proteins. JAKSTAT (2013) 0.81

CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis. Nat Commun (2015) 0.81

Adrenomedullin, a neuropeptide with immunoregulatory properties induces semi-mature tolerogenic dendritic cells. Immunology (2012) 0.81

MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells. Front Immunol (2013) 0.81

Classical dendritic cells as a unique immune cell lineage. J Exp Med (2012) 0.81

Identification of the Common Origins of Osteoclasts, Macrophages, and Dendritic Cells in Human Hematopoiesis. Stem Cell Reports (2015) 0.80

Pulmonary dendritic cell development and antigen acquisition. Immunol Res (2013) 0.80

Microbial activation of gut dendritic cells and the control of mucosal immunity. J Interferon Cytokine Res (2013) 0.80

IRF4 and IRF8 Act in CD11c+ Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells. J Immunol (2016) 0.80

Promotion of Expansion and Differentiation of Hematopoietic Stem Cells by Interleukin-27 into Myeloid Progenitors to Control Infection in Emergency Myelopoiesis. PLoS Pathog (2016) 0.80

Coregulatory interactions among CD8α dendritic cells, the latency-associated transcript, and programmed death 1 contribute to higher levels of herpes simplex virus 1 latency. J Virol (2014) 0.80

Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells. Immunobiology (2014) 0.80

Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development. J Immunol (2013) 0.79

PU.1 is essential for CD11c expression in CD8(+)/CD8(-) lymphoid and monocyte-derived dendritic cells during GM-CSF or FLT3L-induced differentiation. PLoS One (2012) 0.79

A STATus report on DC development. J Leukoc Biol (2012) 0.79

Epigenetic program and transcription factor circuitry of dendritic cell development. Nucleic Acids Res (2015) 0.78

Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Sci Signal (2016) 0.77

Pros and Cons of Antigen-Presenting Cell Targeted Tumor Vaccines. J Immunol Res (2015) 0.77

Transcriptional Regulation of Mononuclear Phagocyte Development. Front Immunol (2015) 0.77

Dendritic cell development requires histone deacetylase activity. Eur J Immunol (2014) 0.77

Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells. J Immunol (2015) 0.77

Vitamin A and dendritic cell differentiation. Immunology (2014) 0.77

Elevated postinjury thrombospondin 1-CD47 triggering aids differentiation of patients' defective inflammatory CD1a+dendritic cells. J Leukoc Biol (2014) 0.77

Activation of B cells by a dendritic cell-targeted oral vaccine. Curr Pharm Biotechnol (2013) 0.76

NOD mice are functionally deficient in the capacity of cross-presentation. Immunol Cell Biol (2015) 0.76

Impact of Toxoplasma gondii on Dendritic Cell Subset Function in the Intestinal Mucosa. J Immunol (2015) 0.76

Cross-presentation of cutaneous melanoma antigen by migratory XCR1(+)CD103(-) and XCR1(+)CD103(+) dendritic cells. Oncoimmunology (2015) 0.76

Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9. Clin Exp Immunol (2014) 0.75

MiR-34a promotes DCs development and inhibits their function on T cell activation by targeting WNT1. Oncotarget (2017) 0.75

Dynamic expression of BCL6 in murine conventional dendritic cells during in vivo development and activation. PLoS One (2014) 0.75

Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma japonicum. Parasit Vectors (2017) 0.75

Maturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified aromatic-turmerone (AR). Hum Vaccin Immunother (2012) 0.75

Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen. Eur J Microbiol Immunol (Bp) (2014) 0.75

The Novel Toll-Like Receptor 2 Agonist SUP3 Enhances Antigen Presentation and T Cell Activation by Dendritic Cells. Front Immunol (2017) 0.75

Hierarchical decomposition of dynamically evolving regulatory networks. BMC Bioinformatics (2015) 0.75

TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity. Proc Natl Acad Sci U S A (2017) 0.75

Revealing the diversity of extracellular vesicles using high-dimensional flow cytometry analyses. Sci Rep (2016) 0.75

Dendritic cell development-History, advances, and open questions. Semin Immunol (2016) 0.75

Substrates of the ASB2α E3 ubiquitin ligase in dendritic cells. Sci Rep (2015) 0.75

Analysis of the developmental stages, kinetics, and phenotypes exhibited by myeloid cells driven by GM-CSF in vitro. PLoS One (2017) 0.75

Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors. Nat Immunol (2017) 0.75

Articles cited by this

(truncated to the top 100)

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell (2010) 23.97

Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86

Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell (2005) 8.37

Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science (2008) 7.87

CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J Exp Med (2000) 7.46

TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection. Immunity (2003) 7.33

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. Immunity (2010) 6.48

Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature (1999) 6.23

BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol (2000) 6.04

Origin of the lamina propria dendritic cell network. Immunity (2009) 5.95

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (2005) 5.88

Langerhans cells arise from monocytes in vivo. Nat Immunol (2006) 5.46

Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity (2009) 5.43

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med (2008) 5.42

Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell (2010) 5.28

Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol (2007) 5.20

Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood (2000) 5.06

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell (2010) 5.05

Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells. Science (2003) 5.00

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med (2006) 4.91

Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol (2007) 4.91

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol (2008) 4.86

The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med (2009) 4.79

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell (1996) 4.74

Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. Immunity (2007) 4.65

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J Exp Med (1992) 4.58

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J Exp Med (2010) 4.56

Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol (2006) 4.53

Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science (2000) 4.53

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol (2009) 4.51

CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J Immunol (2000) 4.41

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol (2010) 4.32

Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. J Exp Med (2010) 4.17

A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood (2002) 4.06

Expression of relB is required for the development of thymic medulla and dendritic cells. Nature (1995) 3.99

Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med (2008) 3.97

The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J Exp Med (2002) 3.91

Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med (2010) 3.84

Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science (2008) 3.83

Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med (2003) 3.74

Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proc Natl Acad Sci U S A (2004) 3.61

Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol (2005) 3.47

Plasmacytoid dendritic cells: recent progress and open questions. Annu Rev Immunol (2011) 3.32

IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med (2011) 3.29

The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development. Nat Immunol (2009) 3.27

Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity (2009) 3.18

Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood (2011) 3.16

IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity. J Immunol (2005) 3.15

Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell (2008) 3.12

Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8- dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells. J Immunol (2001) 3.05

Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display. PLoS Pathog (2005) 3.01

The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. J Exp Med (2011) 2.96

ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells. J Exp Med (2002) 2.92

Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol (2003) 2.91

Origin and development of dendritic cells. Immunol Rev (2010) 2.90

Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses. J Immunol (2004) 2.87

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity (2010) 2.79

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med (2009) 2.77

Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood (2001) 2.75

Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J Exp Med (2008) 2.73

TCR-Mediated internalization of peptide-MHC complexes acquired by T cells. Science (1999) 2.70

Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses. PLoS One (2009) 2.70

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes Dev (1998) 2.69

The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J Exp Med (2003) 2.65

The signal transducer STAT5 inhibits plasmacytoid dendritic cell development by suppressing transcription factor IRF8. Immunity (2008) 2.55

STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity (2003) 2.54

The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity (2010) 2.53

CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity (2011) 2.50

Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood (2000) 2.45

Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Identification of the anti-viral activity as interferon and characterization of the human effector lymphocyte subpopulation. J Exp Med (1978) 2.43

RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity (1998) 2.42

Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors. J Exp Med (2005) 2.39

TRAF6 is a critical factor for dendritic cell maturation and development. Immunity (2003) 2.36

Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo. J Exp Med (2002) 2.32

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J Exp Med (2009) 2.26

Id2 and Id3 inhibit development of CD34(+) stem cells into predendritic cell (pre-DC)2 but not into pre-DC1. Evidence for a lymphoid origin of pre-DC2. J Exp Med (2000) 2.25

Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells. J Immunol (2003) 2.21

A leukocyte subset bearing HLA-DR antigens is responsible for in vitro alpha interferon production in response to viruses. Nat Immun Cell Growth Regul (1985) 2.17

Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development. Proc Natl Acad Sci U S A (2004) 2.08

The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol (1997) 2.08

CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes. Immunity (2011) 1.99

Migratory and lymphoid-resident dendritic cells cooperate to efficiently prime naive CD4 T cells. Immunity (2008) 1.95

CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. J Exp Med (2011) 1.95

CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2010) 1.94

An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages. J Immunol (2000) 1.82

Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development. J Exp Med (2006) 1.75

The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse. Blood (2007) 1.73

Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells. Immunity (2010) 1.73

Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells. Proc Natl Acad Sci U S A (2008) 1.73

The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J Exp Med (2004) 1.71

The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis. Blood (2009) 1.66

B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos. Oncogene (2000) 1.65

Development and functional specialization of CD103+ dendritic cells. Immunol Rev (2010) 1.65

Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1. J Immunol (2003) 1.63

IRF4: Immunity. Malignancy! Therapy? Clin Cancer Res (2009) 1.61

Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate. Blood (2004) 1.59

Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity (2003) 1.58

CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling. Immunity (2000) 1.57

Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage. Immunity (1997) 1.56

Identification of the earliest NK-cell precursor in the mouse BM. Blood (2011) 1.54

Articles by these authors

Tumor growth need not be driven by rare cancer stem cells. Science (2007) 10.34

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med (2010) 4.04

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 3.97

Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity (2009) 3.66

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol (2011) 3.44

Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance. Nat Immunol (2006) 3.09

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity (2009) 2.89

Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med (2004) 2.76

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature (2013) 2.74

Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1. Immunity (2007) 2.61

The transcription factor PU.1 controls dendritic cell development and Flt3 cytokine receptor expression in a dose-dependent manner. Immunity (2010) 2.53

Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization. J Exp Med (2005) 2.51

The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat Immunol (2013) 2.48

Mcl-1 is essential for germinal center formation and B cell memory. Science (2010) 2.42

PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J Exp Med (2005) 2.34

Positive feedback between PU.1 and the cell cycle controls myeloid differentiation. Science (2013) 2.31

NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. J Immunol (2007) 2.26

High affinity germinal center B cells are actively selected into the plasma cell compartment. J Exp Med (2006) 2.19

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse. Nat Immunol (2012) 2.14

IL-21 induces the functional maturation of murine NK cells. J Immunol (2004) 2.00

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol (2007) 1.97

Functional subsets of mouse natural killer cells. Immunol Rev (2006) 1.95

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses. Nat Immunol (2011) 1.94

FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin. Immunity (2007) 1.90

Mcl-1 is essential for the survival of plasma cells. Nat Immunol (2013) 1.73

The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway. Nat Immunol (2013) 1.70

Plasma cell development: from B-cell subsets to long-term survival niches. Semin Immunol (2008) 1.68

Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells. Genes Dev (2006) 1.61

Identification of the earliest NK-cell precursor in the mouse BM. Blood (2011) 1.54

PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain. Blood (2004) 1.53

IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immunol (2009) 1.51

Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. J Exp Med (2006) 1.51

Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat Immunol (2009) 1.49

Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells. J Exp Med (2007) 1.49

Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. Development (2007) 1.49

Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages. EMBO J (2011) 1.41

Critical roles for c-Myb in hematopoietic progenitor cells. Semin Immunol (2008) 1.37

Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J Exp Med (2005) 1.35

A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells. J Exp Med (2005) 1.35

Identification of Pax5 target genes in early B cell differentiation. J Immunol (2008) 1.28

A role for Blimp1 in the transcriptional network controlling natural killer cell maturation. Blood (2010) 1.26

Terminal differentiation of lymphocytes depends on Blimp-1. Curr Opin Immunol (2007) 1.24

Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system. Proc Natl Acad Sci U S A (2002) 1.23

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development (2010) 1.22

PU.1 regulates TCR expression by modulating GATA-3 activity. J Immunol (2009) 1.20

Differentiation and function of Foxp3(+) effector regulatory T cells. Trends Immunol (2012) 1.18

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation. J Cell Biol (2004) 1.18

Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment. Genes Dev (2006) 1.17

The development of functional B lymphocytes in conditional PU.1 knock-out mice. Blood (2005) 1.16

CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3. Blood (2013) 1.14

Differential requirement for OBF-1 during antibody-secreting cell differentiation. J Exp Med (2005) 1.10

Critical roles for c-Myb in lymphoid priming and early B-cell development. Blood (2010) 1.09

The interactions of multiple cytokines control NK cell maturation. J Immunol (2010) 1.09

Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene. J Immunol (2007) 1.07

Surprising new roles for PU.1 in the adaptive immune response. Immunol Rev (2010) 1.07

Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish. Curr Biol (2006) 1.06

CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis. J Virol (2011) 1.05

Is PU.1 a dosage-sensitive regulator of haemopoietic lineage commitment and leukaemogenesis? Trends Immunol (2007) 1.04

CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc Natl Acad Sci U S A (2009) 1.04

Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Mol Cell Biol (2007) 1.03

The regulation of the B-cell gene expression programme by Pax5. Immunol Cell Biol (2007) 1.03

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene. Blood (2007) 1.01

High rate of antibody secretion is not integral to plasma cell differentiation as revealed by XBP-1 deficiency. J Immunol (2012) 1.00

Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation. J Immunol (2013) 0.96

The unique features of follicular T cell subsets. Cell Mol Life Sci (2013) 0.96

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood (2009) 0.96

Endogenous microglia regulate development of embryonic cortical precursor cells. J Neurosci Res (2011) 0.95

Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks. J Exp Med (2013) 0.94

Transient Notch signaling induces NK cell potential in Pax5-deficient pro-B cells. Eur J Immunol (2006) 0.91

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production. J Exp Med (2012) 0.91

Blimp1 is limiting for transformation in a mouse plasmacytoma model. Blood (2009) 0.88

Transcription factor IRF4 regulates germinal center cell formation through a B cell-intrinsic mechanism. J Immunol (2014) 0.87

Regulation of murine natural killer cell commitment. Front Immunol (2013) 0.86

Losing B cell identity. Bioessays (2008) 0.86

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma. Blood (2013) 0.84

Inhibition of human B-cell development into plasmablasts by histone deacetylase inhibitor valproic acid. J Allergy Clin Immunol (2013) 0.84

SUMOylation of Blimp-1 promotes its proteasomal degradation. FEBS Lett (2011) 0.84

Bach2: plasma-cell differentiation takes a break. EMBO J (2010) 0.81

NK cells promote peritoneal xenograft rejection through an IFN-gamma-dependent mechanism. Xenotransplantation (2006) 0.80

Blimp1: driving terminal differentiation to a T. Adv Exp Med Biol (2011) 0.80

Pax5 maintains cellular identity by repressing gene expression throughout B cell differentiation. Cell Cycle (2006) 0.79

Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction. J Immunol (2013) 0.79

Give and take in the germinal center. Nat Immunol (2010) 0.79

The transcription factor PU.1 regulates γδ T cell homeostasis. PLoS One (2011) 0.78

Deciphering the epigenetic code of T lymphocytes. Immunol Rev (2014) 0.77

Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. Nat Immunol (2015) 0.77

Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. J Clin Invest (2016) 0.77

Transcriptional control of pre-B cell development and leukemia prevention. Curr Top Microbiol Immunol (2014) 0.76

Correction: Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology. PLoS Pathog (2016) 0.75

B cells need their flip-flops. Immunol Cell Biol (2011) 0.75

IL-7 and the thymus dictate the NK cell 'labor market'. Nat Immunol (2006) 0.75

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. Elife (2017) 0.75

Lymphocyte activation and effector functions. Editorial overview. Curr Opin Immunol (2012) 0.75

Pillars Article: Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999. 401: 556-562. J Immunol (2015) 0.75