The origin and development of nonlymphoid tissue CD103+ DCs.

PubWeight™: 4.79‹?› | Rank: Top 1%

🔗 View Article (PMC 2806447)

Published in J Exp Med on December 14, 2009

Authors

Florent Ginhoux1, Kang Liu, Julie Helft, Milena Bogunovic, Melanie Greter, Daigo Hashimoto, Jeremy Price, Na Yin, Jonathan Bromberg, Sergio A Lira, E Richard Stanley, Michel Nussenzweig, Miriam Merad

Author Affiliations

1: Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

Articles citing this

(truncated to the top 100)

Monocyte recruitment during infection and inflammation. Nat Rev Immunol (2011) 7.55

Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209(+) dendritic cells for immune T cell areas. Cell (2010) 5.28

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol (2013) 4.75

Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J Exp Med (2010) 4.56

Deciphering the transcriptional network of the dendritic cell lineage. Nat Immunol (2012) 4.17

Cross-presentation by dendritic cells. Nat Rev Immunol (2012) 3.95

Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat Neurosci (2013) 3.94

Type I interferon is selectively required by dendritic cells for immune rejection of tumors. J Exp Med (2011) 3.85

Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells. J Exp Med (2010) 3.84

Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells. Immunity (2012) 3.58

Dendritic cell and macrophage heterogeneity in vivo. Immunity (2011) 3.41

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell (2014) 3.40

The role of retinoic acid in tolerance and immunity. Immunity (2011) 3.16

The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. J Exp Med (2011) 2.96

Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat Rev Immunol (2014) 2.82

Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med (2012) 2.74

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med (2012) 2.69

IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity (2013) 2.69

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity (2011) 2.61

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med (2012) 2.51

The light and dark sides of intestinal intraepithelial lymphocytes. Nat Rev Immunol (2011) 2.46

Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev (2010) 2.44

Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature (2012) 2.25

Re(de)fining the dendritic cell lineage. Nat Immunol (2012) 2.17

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nat Immunol (2014) 2.14

Mammalian target of rapamycin controls dendritic cell development downstream of Flt3 ligand signaling. Immunity (2010) 2.05

Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nat Rev Immunol (2010) 2.02

CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes. Immunity (2011) 1.99

GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Immunity (2012) 1.98

CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen. J Exp Med (2011) 1.95

Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia. Immunity (2012) 1.95

Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol (2011) 1.93

Regulating the adaptive immune response to respiratory virus infection. Nat Rev Immunol (2012) 1.87

The renal mononuclear phagocytic system. J Am Soc Nephrol (2011) 1.84

Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes. J Immunol (2010) 1.78

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J Exp Med (2011) 1.78

Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity (2015) 1.75

Transcriptomic analyses of murine resolution-phase macrophages. Blood (2011) 1.75

CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation. Nat Immunol (2015) 1.73

In vivo function of Langerhans cells and dermal dendritic cells. Trends Immunol (2010) 1.71

Transcriptional programming of the dendritic cell network. Nat Rev Immunol (2012) 1.70

The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice. J Clin Invest (2012) 1.69

Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition. Immunity (2016) 1.69

Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow. Blood (2014) 1.60

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection. J Clin Invest (2012) 1.57

Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice. J Clin Invest (2011) 1.56

Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow. J Exp Med (2015) 1.55

Early immune events in the induction of allergic contact dermatitis. Nat Rev Immunol (2012) 1.54

Structure and function of renal macrophages and dendritic cells from lupus-prone mice. Arthritis Rheumatol (2014) 1.54

Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells. J Leukoc Biol (2014) 1.54

GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization. J Exp Med (2010) 1.52

The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice. J Clin Invest (2012) 1.52

Classical Flt3L-dependent dendritic cells control immunity to protein vaccine. J Exp Med (2014) 1.52

The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells. Eur J Immunol (2011) 1.51

Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks. Nat Rev Immunol (2013) 1.50

Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Dev Cell (2015) 1.48

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med (2011) 1.43

Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1. J Exp Med (2011) 1.43

Peripheral Lymphoid Volume Expansion and Maintenance Are Controlled by Gut Microbiota via RALDH(+) Dendritic Cells. Immunity (2016) 1.43

Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages. EMBO J (2011) 1.41

Circulating precursors of human CD1c+ and CD141+ dendritic cells. J Exp Med (2015) 1.37

The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells. Nat Immunol (2013) 1.36

Specialized role of migratory dendritic cells in peripheral tolerance induction. J Clin Invest (2013) 1.33

Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal Immunol (2011) 1.32

Human dendritic cell deficiency: the missing ID? Nat Rev Immunol (2011) 1.32

Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection. PLoS Pathog (2011) 1.28

Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism. J Exp Med (2013) 1.27

Mechanisms regulating dendritic cell specification and development. Immunol Rev (2010) 1.26

A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritis. J Immunol (2011) 1.25

Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization. PLoS One (2011) 1.25

Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium. J Exp Med (2013) 1.24

Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation. Front Immunol (2012) 1.23

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow. Nat Immunol (2015) 1.23

Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-β. Immunity (2013) 1.23

CCR2(+)CD103(-) intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells. Mucosal Immunol (2014) 1.20

Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state. J Exp Med (2012) 1.19

IRF4 promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation. J Immunol (2012) 1.18

Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood (2013) 1.16

NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature (2012) 1.16

Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. Nat Med (2013) 1.14

IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients. Mol Ther (2012) 1.14

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming. EMBO J (2014) 1.12

A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes. Immunity (2014) 1.11

Alveolar epithelial cells orchestrate DC function in murine viral pneumonia. J Clin Invest (2012) 1.11

Complexity of dendritic cell subsets and their function in the host immune system. Immunology (2011) 1.11

Dendritic cell subsets in the intestinal lamina propria: ontogeny and function. Eur J Immunol (2013) 1.08

Antigen presentation events in autoimmune diabetes. Curr Opin Immunol (2011) 1.08

Characterization of Langerin-expressing dendritic cell subsets in the normal cornea. Invest Ophthalmol Vis Sci (2011) 1.08

The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development. Blood (2012) 1.07

Kidney dendritic cells in acute and chronic renal disease. Int J Exp Pathol (2010) 1.06

Guardians of the Gut - Murine Intestinal Macrophages and Dendritic Cells. Front Immunol (2015) 1.06

Flt3 ligand expands CD103⁺ dendritic cells and FoxP3⁺ T regulatory cells, and attenuates Crohn's-like murine ileitis. Gut (2011) 1.06

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells. J Exp Med (2013) 1.03

Transcription factor networks in dendritic cell development. Semin Immunol (2011) 1.03

Viral-induced encephalitis initiates distinct and functional CD103+ CD11b+ brain dendritic cell populations within the olfactory bulb. Proc Natl Acad Sci U S A (2012) 1.02

Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. J Immunol (2013) 1.01

The mononuclear phagocyte system in homeostasis and disease: a role for heme oxygenase-1. Antioxid Redox Signal (2014) 1.01

An updated view of the intracellular mechanisms regulating cross-presentation. Front Immunol (2013) 1.01

Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function. Proc Natl Acad Sci U S A (2012) 1.00

Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression. J Clin Invest (2013) 0.98

Articles cited by this

Immunobiology of dendritic cells. Annu Rev Immunol (2000) 23.65

Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity (2003) 21.56

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol (2000) 14.74

F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol (1981) 12.96

Mouse and human dendritic cell subtypes. Nat Rev Immunol (2002) 10.01

Differential antigen processing by dendritic cell subsets in vivo. Science (2007) 8.42

Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science (2008) 7.87

Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A (2001) 7.58

Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity (2005) 6.48

In vivo analysis of dendritic cell development and homeostasis. Science (2009) 6.42

Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature (1999) 6.23

Origin of the lamina propria dendritic cell network. Immunity (2009) 5.95

A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (2005) 5.88

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature (1994) 5.73

Langerhans cells arise from monocytes in vivo. Nat Immunol (2006) 5.46

Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol (2007) 5.31

Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nat Immunol (2007) 5.20

Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood (2000) 5.06

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med (2006) 4.91

Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol (2007) 4.91

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol (2008) 4.86

A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. J Immunol (2006) 4.61

Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood (2002) 4.59

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nat Immunol (2009) 4.51

Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med (2005) 4.47

Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol (2008) 4.17

Identification of a novel population of Langerin+ dendritic cells. J Exp Med (2007) 4.13

CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol (2004) 4.02

Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol Rev (2004) 3.98

Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells. J Exp Med (2008) 3.97

Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med (2003) 3.74

Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. J Exp Med (2007) 3.64

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity (1995) 3.37

The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J Exp Med (2007) 3.24

Distinct differentiation potential of blood monocyte subsets in the lung. J Immunol (2007) 3.16

Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations. J Immunol (2008) 3.04

Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol (2003) 2.91

Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells. Blood (2002) 2.77

Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene. J Leukoc Biol (2004) 2.74

Signal regulatory proteins in the immune system. J Immunol (2005) 2.48

Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse. J Cell Sci (1993) 2.15

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci U S A (2009) 2.12

Early thymocyte development is regulated by modulation of E2A protein activity. J Exp Med (2001) 2.05

Relationships between distinct blood monocyte subsets and migrating intestinal lymph dendritic cells in vivo under steady-state conditions. J Immunol (2006) 1.79

A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice. J Exp Med (2005) 1.74

The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse. Blood (2007) 1.73

The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis. Blood (2009) 1.66

The role of the interferon regulatory factor (IRF) family in dendritic cell development and function. Cytokine Growth Factor Rev (2007) 1.38

Flt3 in regulation of type I interferon-producing cell and dendritic cell development. Ann N Y Acad Sci (2007) 1.18

Adenovirus transduction induces expression of multiple chemokines and chemokine receptors in murine beta cells and pancreatic islets. Am J Transplant (2003) 1.08

No defect in T-cell priming, secondary response, or tolerance induction in response to inhaled antigens in Fms-like tyrosine kinase 3 ligand-deficient mice. J Allergy Clin Immunol (2005) 0.85

Articles by these authors

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature (2003) 22.89

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature (2010) 15.28

Development of monocytes, macrophages, and dendritic cells. Science (2010) 12.86

Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science (2010) 12.15

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest (2007) 9.09

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell (2010) 8.70

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature (2005) 8.53

Differential antigen processing by dendritic cell subsets in vivo. Science (2007) 8.42

Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci (2006) 8.25

A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors. Cancer Res (2004) 7.56

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol (2012) 7.32

Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res (2006) 7.02

H2AX: the histone guardian of the genome. DNA Repair (Amst) (2004) 6.65

Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res (2007) 6.60

In vivo analysis of dendritic cell development and homeostasis. Science (2009) 6.42

Origin of the lamina propria dendritic cell network. Immunity (2009) 5.95

Blimp1 is a critical determinant of the germ cell lineage in mice. Nature (2005) 5.49

Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity (2013) 5.47

Langerhans cells arise from monocytes in vivo. Nat Immunol (2006) 5.46

Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol (2007) 5.31

Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol (2006) 5.00

Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science (2013) 4.94

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues. Nat Immunol (2008) 4.86

The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J Exp Med (2002) 4.78

The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol (2013) 4.75

Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood (2002) 4.59

Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med (2005) 4.42

Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res (2005) 4.33

Deciphering the transcriptional network of the dendritic cell lineage. Nat Immunol (2012) 4.17

B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity (2006) 4.04

CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol (2004) 4.02

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89

Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med (2011) 3.88

Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell (2006) 3.79

Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med (2003) 3.74

Colony-stimulating factor-1 in immunity and inflammation. Curr Opin Immunol (2005) 3.67

Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. J Exp Med (2007) 3.64

The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med (2004) 3.59

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol (2005) 3.44

Immature monocytes acquire antigens from other cells in the bone marrow and present them to T cells after maturing in the periphery. J Exp Med (2006) 3.43

Dendritic cell and macrophage heterogeneity in vivo. Immunity (2011) 3.41

PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proc Natl Acad Sci U S A (2008) 3.35

Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity (2009) 3.32

Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity. Nat Immunol (2004) 3.25

Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology (2009) 3.20

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease. Nat Med (2004) 3.17

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med (2009) 3.13

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science (2014) 3.13

Blood monocyte subsets differentially give rise to CD103+ and CD103- pulmonary dendritic cell populations. J Immunol (2008) 3.04

The chemokine receptor D6 limits the inflammatory response in vivo. Nat Immunol (2005) 2.98

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell (2007) 2.78

Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature (2012) 2.77

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature (2013) 2.74

Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes. J Exp Med (2008) 2.73

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J Leukoc Biol (2010) 2.71

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med (2012) 2.69

IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity (2013) 2.69

Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. J Exp Med (2004) 2.68

Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Immunity (2006) 2.62

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity (2011) 2.61

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood (2008) 2.52

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med (2012) 2.51

Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat Cell Biol (2007) 2.50

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature (2004) 2.49

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin. Nat Immunol (2012) 2.40