Published in Mol Cell Biol on August 01, 2003
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J (2009) 3.89
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol (2007) 2.92
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci U S A (2006) 2.71
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Mol Cell Biol (2005) 2.37
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding. Structure (2008) 2.17
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. Proc Natl Acad Sci U S A (2007) 2.09
Involvement of novel autophosphorylation sites in ATM activation. EMBO J (2006) 1.94
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem (2009) 1.91
trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining. Mol Cell Biol (2007) 1.80
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Res (2004) 1.77
Common mechanisms of PIKK regulation. DNA Repair (Amst) (2009) 1.73
ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress. Mol Cell Biol (2006) 1.73
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair (Amst) (2010) 1.71
ATR autophosphorylation as a molecular switch for checkpoint activation. Mol Cell (2011) 1.70
The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain. Mol Cell Biol (2006) 1.64
DNA double strand break repair via non-homologous end-joining. Transl Cancer Res (2013) 1.61
DNA-PKcs function regulated specifically by protein phosphatase 5. Proc Natl Acad Sci U S A (2004) 1.60
Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. Int J Radiat Oncol Biol Phys (2013) 1.57
The role of DNA dependent protein kinase in synapsis of DNA ends. Nucleic Acids Res (2003) 1.51
DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? J Cell Biol (2007) 1.48
Pathways for genome integrity in G2 phase of the cell cycle. Biomolecules (2012) 1.44
Retracted DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance. Cell (2009) 1.37
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol (2011) 1.36
The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining. DNA Repair (Amst) (2008) 1.35
Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation. Mol Cell Biol (2011) 1.32
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst) (2014) 1.31
DNA-PKcs and ATM co-regulate DNA double-strand break repair. DNA Repair (Amst) (2009) 1.27
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Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Res (2009) 1.23
Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). Proc Natl Acad Sci U S A (2005) 1.23
Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res (2013) 1.20
Choosing the right path: does DNA-PK help make the decision? Mutat Res (2011) 1.18
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability. Proc Natl Acad Sci U S A (2008) 1.18
HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase. J Biol Chem (2008) 1.18
DNA-PK is involved in repairing a transient surge of DNA breaks induced by deceleration of DNA replication. J Mol Biol (2007) 1.17
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase. J Biol Chem (2011) 1.16
A human XRCC4-XLF complex bridges DNA. Nucleic Acids Res (2012) 1.15
Involvement of DNA-dependent protein kinase in normal cell cycle progression through mitosis. J Biol Chem (2011) 1.13
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine. Nucleic Acids Res (2004) 1.11
Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci. J Biol Chem (2012) 1.10
Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway. Proc Natl Acad Sci U S A (2007) 1.09
Role of DNA-dependent protein kinase catalytic subunit in cancer development and treatment. Transl Cancer Res (2012) 1.08
PRKDC mutations in a SCID patient with profound neurological abnormalities. J Clin Invest (2013) 1.06
Non-homologous end joining: emerging themes and unanswered questions. DNA Repair (Amst) (2014) 1.05
Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis. Nucleic Acids Res (2006) 1.04
Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts. Nucleic Acids Res (2007) 1.04
The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends. Mol Cell Biol (2008) 1.03
Oversized AAV transductifon is mediated via a DNA-PKcs-independent, Rad51C-dependent repair pathway. Mol Ther (2013) 1.02
Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops. Aging (Albany NY) (2010) 1.02
XRCC4's interaction with XLF is required for coding (but not signal) end joining. Nucleic Acids Res (2012) 1.01
The leucine rich region of DNA-PKcs contributes to its innate DNA affinity. Nucleic Acids Res (2005) 1.00
Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1. Proc Natl Acad Sci U S A (2005) 1.00
Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition. Proc Natl Acad Sci U S A (2013) 0.98
Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma. Cell Death Dis (2011) 0.98
A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining. Nucleic Acids Res (2008) 0.98
Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice. PLoS One (2011) 0.97
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Prog Biophys Mol Biol (2014) 0.96
Diseases associated with defective responses to DNA damage. Cold Spring Harb Perspect Biol (2012) 0.94
The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Res (2009) 0.94
Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability. Radiat Res (2010) 0.93
The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining. Mol Cell Biol (2011) 0.93
DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). J Biol Chem (2013) 0.93
Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks. Cell Cycle (2010) 0.91
PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase. J Biol Chem (2012) 0.91
Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis. Biosci Rep (2014) 0.90
Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Mol Cell Biol (2013) 0.88
Unraveling the complexities of DNA-dependent protein kinase autophosphorylation. Mol Cell Biol (2014) 0.87
The effect of DNA-dependent protein kinase on adeno-associated virus replication. PLoS One (2010) 0.86
BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle. Nucleic Acids Res (2014) 0.85
Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic Acids Res (2011) 0.85
Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase. BMC Mol Biol (2007) 0.85
In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining. Mol Cell Biol (2004) 0.84
Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining. J Nucleic Acids (2010) 0.84
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Res (2011) 0.84
Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes. Mutat Res (2014) 0.84
Scanning fluorescence correlation spectroscopy techniques to quantify the kinetics of DNA double strand break repair proteins after γ-irradiation and bleomycin treatment. Nucleic Acids Res (2013) 0.83
Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase. Nucleic Acids Res (2008) 0.83
Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases. DNA Repair (Amst) (2013) 0.82
Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic. Oncotarget (2015) 0.82
Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase. J Biol Chem (2011) 0.82
DNA Damage and Pulmonary Hypertension. Int J Mol Sci (2016) 0.81
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks. Aging (Albany NY) (2014) 0.81
The role of RecQ helicases in non-homologous end-joining. Crit Rev Biochem Mol Biol (2014) 0.81
Response to DNA damage: why do we need to focus on protein phosphatases? Front Oncol (2013) 0.81
Two-Stage Synapsis of DNA Ends during Non-homologous End Joining. Mol Cell (2016) 0.81
Smarcal1 promotes double-strand-break repair by nonhomologous end-joining. Nucleic Acids Res (2015) 0.80
Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons. Cell Death Differ (2010) 0.79
Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles. PLoS One (2014) 0.79
Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining. J Nucleic Acids (2010) 0.78
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. Cell Death Dis (2013) 0.78
Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value. Br J Cancer (2013) 0.77
Effects of targeted phosphorylation site mutations in the DNA-PKcs phosphorylation domain on low and high LET radiation sensitivity. Oncol Lett (2015) 0.76
Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining. J Immunol (2016) 0.76
Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3'-phosphoglycolate termini in SCAN1 cells. Nucleic Acids Res (2013) 0.76
Reversion of the ErbB malignant phenotype and the DNA damage response. Exp Mol Pathol (2012) 0.76
Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G0/G1 Phase Cells. Radiat Res (2017) 0.75
The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends. J Immunol (2016) 0.75
Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound. Int J Mol Sci (2016) 0.75
Modifying the function of DNA repair nanomachines for therapeutic benefit. Nanomedicine (2006) 0.75
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