Published in Free Radic Biol Med on February 15, 2012
P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite. J Neuroinflammation (2015) 1.48
Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. J Hepatol (2012) 1.04
Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. Toxicol Sci (2013) 0.94
The effect of tert-butyl hydroperoxide-induced oxidative stress on lean and steatotic rat hepatocytes in vitro. Oxid Med Cell Longev (2014) 0.93
Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity. Toxicol Appl Pharmacol (2013) 0.90
Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases. Mol Cells (2014) 0.90
CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. Toxicol Appl Pharmacol (2013) 0.86
Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol (2013) 0.85
Immuno-spin trapping from biochemistry to medicine: advances, challenges, and pitfalls. Focus on protein-centered radicals. Biochim Biophys Acta (2013) 0.83
P2X7 receptor as a key player in oxidative stress-driven cell fate in nonalcoholic steatohepatitis. Oxid Med Cell Longev (2015) 0.81
NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity. Am J Physiol Renal Physiol (2015) 0.76
Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis. Biochim Biophys Acta (2015) 0.75
Steatohepatitis: a tale of two "hits"? Gastroenterology (1998) 13.21
Nitric oxide and macrophage function. Annu Rev Immunol (1997) 12.77
Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology (2006) 9.34
How dying cells alert the immune system to danger. Nat Rev Immunol (2008) 8.63
Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science (2010) 5.84
Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol (2003) 4.25
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res (2011) 2.89
Kupffer cells in non-alcoholic fatty liver disease: the emerging view. J Hepatol (2009) 2.26
Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R. Nat Med (2010) 2.17
Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest (1995) 1.98
P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J Biol Chem (2003) 1.87
Role of Kupffer cells in the pathogenesis of liver disease. World J Gastroenterol (2006) 1.84
Extracellular ATP in the immune system: more than just a "danger signal". Sci Signal (2009) 1.78
Pathological mechanisms in carbon tetrachloride hepatotoxicity. J Free Radic Biol Med (1985) 1.72
The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med (2001) 1.69
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. Proc Natl Acad Sci U S A (1996) 1.63
Extracellular ATP triggers tumor necrosis factor-alpha release from rat microglia. J Neurochem (2000) 1.63
Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Gastroenterology (1998) 1.58
Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. J Biol Chem (2005) 1.53
Role of mitochondria in non-alcoholic fatty liver disease. J Gastroenterol Hepatol (2007) 1.52
Hepatic fibrosis and cirrhosis after chronic administration of alcohol and "low-dose" carbon tetrachloride vapor in the rat. Hepatology (1991) 1.51
Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Hepatology (2001) 1.46
Monoclonal antibody to tumor necrosis factor-alpha modulates hepatocellular Ca2+ homeostasis during hemorrhagic shock in the rat. J Mol Med (Berl) (1999) 1.42
A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes. J Immunol (2008) 1.39
Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev (2008) 1.33
Phosphatidylinositol 3-kinase contributes to cell volume regulation through effects on ATP release. J Biol Chem (1998) 1.32
Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and Kupffer cells. Gastroenterology (1996) 1.32
Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress. Diabetes (2004) 1.26
The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism. Front Biosci (2008) 1.24
Murine hepatic accessory cells support the proliferation of Th1 but not Th2 helper T lymphocyte clones. J Exp Med (1989) 1.22
Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P450, compared with three further P450-isoenzymes, NADPH P450-reductase, glutathione transferases and microsomal epoxide hydrolase. Carcinogenesis (1984) 1.20
Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharmacol Exp Ther (1990) 1.10
Hepatic complications of obesity. Gastroenterol Clin North Am (2010) 1.09
Expression of co-stimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology. Hepatology (1998) 1.09
Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice. Free Radic Biol Med (2008) 1.08
Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology (2010) 1.08
Enhanced expression of CD80 (B7-1), CD86 (B7-2), and CD40 and their ligands CD28 and CD154 in fulminant hepatic failure. Am J Pathol (1999) 1.06
Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis. Free Radic Biol Med (2011) 1.04
Dioxin receptor and C/EBP regulate the function of the glutathione S-transferase Ya gene xenobiotic response element. Mol Cell Biol (1993) 1.04
P2X(7) receptors on microglial cells mediate injury to cortical neurons in vitro. Glia (2006) 1.02
Toxicant-associated steatohepatitis in vinyl chloride workers. Hepatology (2010) 1.02
Reactive oxygen species are essential mediators in antigen presentation by Kupffer cells. Immunol Cell Biol (2005) 0.97
P2X(7) receptor-mediated reactive oxygen and nitrogen species formation: from receptor to generators. Biochem Soc Trans (2007) 0.96
Inhibition by perhexiline of oxidative phosphorylation and the beta-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions. Hepatology (1994) 0.95
Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity. Hepatology (2007) 0.95
Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II. J Pharmacol Exp Ther (1990) 0.93
Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes. Chem Biol Interact (2000) 0.91
Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol (2009) 0.91
Immunochemical detection of nitric oxide and nitrogen dioxide trapping of the tyrosyl radical and the resulting nitrotyrosine in sperm whale myoglobin. Free Radic Biol Med (2005) 0.90
Nitric oxide trapping of the tyrosyl radical-chemistry and biochemistry. Toxicology (2002) 0.88
Kupffer cells required for high affinity peptide-induced deletion, not retention, of activated CD8+ T cells by mouse liver. Hepatology (2004) 0.87
Protective effect of C-phycocyanin against carbon tetrachloride-induced hepatocyte damage in vitro and in vivo. Chem Biol Interact (2010) 0.87
Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. Dev Cell (2002) 4.94
The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol Med (2012) 2.14
Requirement of arsenic biomethylation for oxidative DNA damage. J Natl Cancer Inst (2009) 1.96
Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharmacol (2009) 1.81
Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci (2008) 1.72
Protein radical formation on thyroid peroxidase during turnover as detected by immuno-spin trapping. Free Radic Biol Med (2006) 1.67
The oxidation of 2',7'-dichlorofluorescin to reactive oxygen species: a self-fulfilling prophesy? Free Radic Biol Med (2005) 1.60
Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroenterology (2003) 1.59
Immunological identification of the heart myoglobin radical formed by hydrogen peroxide. Free Radic Biol Med (2002) 1.52
In vivo lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS. FASEB J (2002) 1.42
DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Chem Res Toxicol (2002) 1.39
Identification of free radicals on hemoglobin from its self-peroxidation using mass spectrometry and immuno-spin trapping: observation of a histidinyl radical. J Biol Chem (2003) 1.22
Protein oxidation of cytochrome C by reactive halogen species enhances its peroxidase activity. J Biol Chem (2002) 1.13
Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein. Biochem J (2005) 1.12
Immunochemical detection of hemoglobin-derived radicals formed by reaction with hydrogen peroxide: involvement of a protein-tyrosyl radical. Free Radic Biol Med (2003) 1.11
A novel protocol to identify and quantify all spin trapped free radicals from in vitro/in vivo interaction of HO(.-) and DMSO: LC/ESR, LC/MS, and dual spin trapping combinations. Free Radic Biol Med (2005) 1.10
Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine. Arch Biochem Biophys (2002) 1.09
Identification of the myoglobin tyrosyl radical by immuno-spin trapping and its dimerization. Free Radic Biol Med (2005) 1.09
Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice. Free Radic Biol Med (2008) 1.08
Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins: spin trapping analysis. J Am Chem Soc (2007) 1.08
Free radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin. Proc Natl Acad Sci U S A (2006) 1.08
Sperm-associated antigen 9, a novel cancer testis antigen, is a potential target for immunotherapy in epithelial ovarian cancer. Clin Cancer Res (2007) 1.08
Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes. Free Radic Biol Med (2006) 1.07
Immuno-spin trapping of DNA radicals. Nat Methods (2006) 1.07
Copper-catalyzed protein oxidation and its modulation by carbon dioxide: enhancement of protein radicals in cells. J Biol Chem (2005) 1.06
Separation and identification of DMPO adducts of oxygen-centered radicals formed from organic hydroperoxides by HPLC-ESR, ESI-MS and MS/MS. J Am Soc Mass Spectrom (2003) 1.06
Photooxidation of Amplex Red to resorufin: implications of exposing the Amplex Red assay to light. Free Radic Biol Med (2012) 1.05
Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis. Free Radic Biol Med (2011) 1.04
Immuno-spin trapping analyses of DNA radicals. Nat Protoc (2007) 1.04
Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation. Proc Natl Acad Sci U S A (2008) 1.04
Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. J Hepatol (2012) 1.04
Involvement of protein radical, protein aggregation, and effects on NO metabolism in the hypochlorite-mediated oxidation of mitochondrial cytochrome c. Free Radic Biol Med (2004) 1.03
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radic Biol Med (2008) 1.03
Mechanism of hydrogen peroxide-induced Cu,Zn-superoxide dismutase-centered radical formation as explored by immuno-spin trapping: the role of copper- and carbonate radical anion-mediated oxidations. Free Radic Biol Med (2005) 1.02
Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. Am J Physiol Endocrinol Metab (2008) 1.02
Identification of protein-derived tyrosyl radical in the reaction of cytochrome c and hydrogen peroxide: characterization by ESR spin-trapping, HPLC and MS. Biochem J (2002) 1.02
Site-specific radical formation in DNA induced by Cu(II)-H₂O₂ oxidizing system, using ESR, immuno-spin trapping, LC-MS, and MS/MS. Free Radic Biol Med (2011) 1.02
Immuno-spin trapping of protein and DNA radicals: "tagging" free radicals to locate and understand the redox process. Free Radic Biol Med (2009) 1.01
Identification of protein radicals formed in the human neuroglobin-H2O2 reaction using immuno-spin trapping and mass spectrometry. Biochemistry (2008) 1.00
Spin trapping investigation of peroxide- and isoniazid-induced radicals in Mycobacterium tuberculosis catalase-peroxidase. Biochemistry (2008) 0.99
Prevention of hepatic ischemia-reperfusion injury by green tea extract. Am J Physiol Gastrointest Liver Physiol (2002) 0.99
Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals. J Biol Chem (2003) 0.99
Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha. Mol Pharmacol (2008) 0.98
Identification of all classes of spin-trapped carbon-centered radicals in soybean lipoxygenase-dependent lipid peroxidations of omega-6 polyunsaturated fatty acids via LC/ESR, LC/MS, and tandem MS. Free Radic Biol Med (2003) 0.98
Phototoxicity of nano titanium dioxides in HaCaT keratinocytes--generation of reactive oxygen species and cell damage. Toxicol Appl Pharmacol (2012) 0.97
Free radical-dependent dysfunction of small-for-size rat liver grafts: prevention by plant polyphenols. Gastroenterology (2005) 0.97
The Mechanism by which 4-hydroxy-2,2,6,6-tetramethylpiperidene-1-oxyl (tempol) diverts peroxynitrite decomposition from nitrating to nitrosating species. Chem Res Toxicol (2002) 0.96
Formation of reactive sulfite-derived free radicals by the activation of human neutrophils: an ESR study. Free Radic Biol Med (2012) 0.96
Synergistic production of lung free radicals by diesel exhaust particles and endotoxin. Am J Respir Crit Care Med (2004) 0.95
Immuno-spin trapping of hemoglobin and myoglobin radicals derived from nitrite-mediated oxidation. Free Radic Biol Med (2005) 0.95
Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation (2008) 0.95
Protein Radical Formation Resulting from Eosinophil Peroxidase-catalyzed Oxidation of Sulfite. J Biol Chem (2010) 0.95
Top-down and bottom-up mass spectrometric characterization of human myoglobin-centered free radicals induced by oxidative damage. Anal Chem (2007) 0.94
Mechanism in the reaction of cytochrome c oxidase with organic hydroperoxides: an ESR spin-trapping investigation. Biochem J (2002) 0.94
Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. Toxicol Sci (2013) 0.94
Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo. Am J Physiol Renal Physiol (2002) 0.93
Obesity-induced tissue free radical generation: an in vivo immuno-spin trapping study. Free Radic Biol Med (2012) 0.93
Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical. J Biol Chem (2004) 0.93
Immunological detection of N-formylkynurenine in oxidized proteins. Free Radic Biol Med (2009) 0.93
Polyphenols from Camellia sinenesis prevent primary graft failure after transplantation of ethanol-induced fatty livers from rats. Free Radic Biol Med (2004) 0.93
The fidelity of spin trapping with DMPO in biological systems. Magn Reson Chem (2011) 0.93
In vivo identification of aflatoxin-induced free radicals in rat bile. Free Radic Biol Med (2003) 0.92
Characterization of the high-resolution ESR spectra of superoxide radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO). Analysis of conformational exchange. Free Radic Res (2005) 0.92
Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol (2008) 0.92
Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. Free Radic Biol Med (2003) 0.92
Identifying the site of spin trapping in proteins by a combination of liquid chromatography, ELISA, and off-line tandem mass spectrometry. Free Radic Biol Med (2007) 0.91
In vivo copper-mediated free radical production: an ESR spin-trapping study. Spectrochim Acta A Mol Biomol Spectrosc (2002) 0.91
The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice. Free Radic Biol Med (2003) 0.91
New insights into the detection of sulfur trioxide anion radical by spin trapping: radical trapping versus nucleophilic addition. Free Radic Biol Med (2009) 0.91
Myeloperoxidase-induced genomic DNA-centered radicals. J Biol Chem (2010) 0.91
Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol (2009) 0.91
Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol (2007) 0.90
Immunochemical detection of nitric oxide and nitrogen dioxide trapping of the tyrosyl radical and the resulting nitrotyrosine in sperm whale myoglobin. Free Radic Biol Med (2005) 0.90
Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical. Free Radic Biol Med (2004) 0.90
Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity. Toxicol Appl Pharmacol (2013) 0.90
Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice. Free Radic Biol Med (2002) 0.89
(Bi)sulfite oxidation by copper, zinc-superoxide dismutase: Sulfite-derived, radical-initiated protein radical formation. Environ Health Perspect (2010) 0.89
Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol Appl Pharmacol (2012) 0.88
A case of autoimmune myopathy in pregnancy. Indian J Med Sci (2005) 0.88
Nitric oxide trapping of the tyrosyl radical-chemistry and biochemistry. Toxicology (2002) 0.88