Published in J Biol Chem on January 27, 2003
ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem (2006) 4.33
Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci (2006) 3.17
Pharmacology of P2X channels. Pflugers Arch (2006) 2.14
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol (2006) 1.87
Microglial activation in stroke: therapeutic targets. Neurotherapeutics (2010) 1.84
Discovery of P2X7 receptor-selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states. Br J Pharmacol (2007) 1.77
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Microglia during development and aging. Pharmacol Ther (2013) 1.30
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ATP release and purinergic signaling in NLRP3 inflammasome activation. Front Immunol (2013) 1.23
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Dexamethasone inhibits the Nox-dependent ROS production via suppression of MKP-1-dependent MAPK pathways in activated microglia. BMC Neurosci (2011) 1.09
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The role of reactive-oxygen-species in microbial persistence and inflammation. Int J Mol Sci (2011) 1.08
Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation. Br J Pharmacol (2006) 1.08
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Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation. Free Radic Biol Med (2007) 1.05
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P2X7 receptor activation induces reactive oxygen species formation and cell death in murine EOC13 microglia. Mediators Inflamm (2013) 1.02
Inflammatory responses are not sufficient to cause delayed neuronal death in ATP-induced acute brain injury. PLoS One (2010) 1.00
Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus. J Neuroinflammation (2012) 1.00
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Purinergic P2X7 receptor regulates lung surfactant secretion in a paracrine manner. J Cell Sci (2011) 0.97
The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein. J Biol Chem (2010) 0.96
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ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation. Glia (2012) 0.94
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P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice. Free Radic Biol Med (2012) 0.93
The role of P2X₇ in pain and inflammation. Purinergic Signal (2007) 0.93
The P2X(7) receptor and intracellular pathogens: a continuing struggle. Purinergic Signal (2009) 0.93
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P2 purinergic receptor modulation of cytokine production. Purinergic Signal (2007) 0.93
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Reactive oxygen species contribute to the presynaptic action of extracellular ATP at the frog neuromuscular junction. J Physiol (2005) 0.92
Activation of P2X receptors induces apoptosis in human retinal pigment epithelium. Invest Ophthalmol Vis Sci (2011) 0.91
P2X(7) nucleotide receptors mediate caspase-8/9/3-dependent apoptosis in rat primary cortical neurons. Purinergic Signal (2005) 0.91
Cell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking. Purinergic Signal (2009) 0.91
Inflammasomes: molecular regulation and implications for metabolic and cognitive diseases. Mol Cells (2014) 0.90
Potential for developing purinergic drugs for gastrointestinal diseases. Inflamm Bowel Dis (2014) 0.90
Mechanisms and potential therapeutic applications of microglial activation after brain injury. CNS Neurosci Ther (2014) 0.89
A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury. Exp Neurol (2011) 0.89
Nucleotide receptor signalling and the generation of reactive oxygen species. Purinergic Signal (2007) 0.89
P2X7 receptor regulates leukocyte infiltrations in rat frontoparietal cortex following status epilepticus. J Neuroinflammation (2010) 0.89
Purinergic modulation of microglial cell activation. Purinergic Signal (2006) 0.87
Cross talk between P2 purinergic receptors modulates extracellular ATP-mediated interleukin-10 production in rat microglial cells. Exp Mol Med (2008) 0.87
New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders. Purinergic Signal (2007) 0.87
Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor. Mol Vis (2008) 0.87
Inflammatory Pathways in Parkinson's Disease; A BNE Microarray Study. Parkinsons Dis (2012) 0.86
Involvement of P2X and P2Y receptors in microglial activation in vivo. Purinergic Signal (2007) 0.86
Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression. Am J Physiol Lung Cell Mol Physiol (2016) 0.84
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Pharmacological evidence for the stimulation of NADPH oxidase by P2X(7) receptors in mouse submandibular glands. Purinergic Signal (2008) 0.83
Regulation of ATP-gated P2X channels: from redox signaling to interactions with other proteins. Antioxid Redox Signal (2013) 0.83
P2X7 receptor as a key player in oxidative stress-driven cell fate in nonalcoholic steatohepatitis. Oxid Med Cell Longev (2015) 0.81
Inhibition of neuronal cell death after retinoic acid-induced down-regulation of P2X7 nucleotide receptor expression. Mol Cell Biochem (2009) 0.81
Pharmacological properties of the rhesus macaque monkey P2X7 receptor. Br J Pharmacol (2011) 0.81
Block of P2X7 receptors could partly reverse the delayed neuronal death in area CA1 of the hippocampus after transient global cerebral ischemia. Purinergic Signal (2013) 0.80
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Involvement of connexin43 hemichannel in ATP release after γ-irradiation. J Radiat Res (2012) 0.79
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Microglial P2X₇ receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease. Exp Mol Med (2011) 0.79
P2X(7) Receptors in Neurological and Cardiovascular Disorders. Cardiovasc Psychiatry Neurol (2009) 0.78
The roles of P2X7 receptor in regional-specific microglial responses in the rat brain following status epilepticus. Neurol Sci (2011) 0.78
P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential. CNS Neurol Disord Drug Targets (2012) 0.77
P2X7 receptor-mediated PARP1 activity regulates astroglial death in the rat hippocampus following status epilepticus. Front Cell Neurosci (2015) 0.77
P2X receptors in neuroglia. Wiley Interdiscip Rev Membr Transp Signal (2012) 0.77
Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer's disease. Cell Death Differ (2016) 0.77
NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice. Neuroscience (2013) 0.77
Possible protective role of the 489C>T P2X7R polymorphism in Alzheimer's disease. Exp Gerontol (2014) 0.76
P2X(7) Receptors as a Transducer in the Co-Occurrence of Neurological/Psychiatric and Cardiovascular Disorders: A Hypothesis. Cardiovasc Psychiatry Neurol (2009) 0.76
Methamphetamine alters microglial immune function through P2X7R signaling. J Neuroinflammation (2016) 0.76
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Adenosine 5'-triphosphate stimulates the increase of TGF-beta1 in rat mesangial cells under high-glucose conditions via reactive oxygen species and ERK1/2. Acta Pharmacol Sin (2009) 0.75
Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production. PLoS One (2016) 0.75
Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release. ACS Med Chem Lett (2013) 0.75
Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice. J Neuroimmunol (2015) 0.75
Purinergic receptors as potential therapeutic targets in Alzheimer's disease. Neuropharmacology (2015) 0.75
Microglial Function across the Spectrum of Age and Gender. Int J Mol Sci (2017) 0.75
Role of P2X7 and P2Y2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation "in vivo" by P2X7 receptor. Comput Struct Biotechnol J (2015) 0.75
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A low-glycemic load diet facilitates greater weight loss in overweight adults with high insulin secretion but not in overweight adults with low insulin secretion in the CALERIE Trial. Diabetes Care (2005) 1.14
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The effects of the dietary glycemic load on type 2 diabetes risk factors during weight loss. Obesity (Silver Spring) (2006) 1.09
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Relative influence of diet and physical activity on body composition in urban Chinese adults. Am J Clin Nutr (2003) 1.03
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Energy requirements in nonobese men and women: results from CALERIE. Am J Clin Nutr (2013) 1.01
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Predictors of being overweight or obese in survivors of pediatric acute lymphoblastic leukemia (ALL). Pediatr Blood Cancer (2014) 1.00
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The doubly labeled water method produces highly reproducible longitudinal results in nutrition studies. J Nutr (2014) 0.97
The accuracy of stated energy contents of reduced-energy, commercially prepared foods. J Am Diet Assoc (2010) 0.96
Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women. J Gerontol A Biol Sci Med Sci (2009) 0.96
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Fermentable and nonfermentable fiber supplements did not alter hunger, satiety or body weight in a pilot study of men and women consuming self-selected diets. J Nutr (2003) 0.93
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The energy content of restaurant foods without stated calorie information. JAMA Intern Med (2013) 0.85
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Energy expenditure is very high in extremely obese women. J Nutr (2004) 0.82
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RNA template-mediated inhibition of hepatitis C virus RNA-dependent RNA polymerase activity. Arch Biochem Biophys (2007) 0.81
Interstitial glucose level is a significant predictor of energy intake in free-living women with healthy body weight. J Nutr (2005) 0.81
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Amino-caprolactam derivatives as gamma-secretase inhibitors. Bioorg Med Chem Lett (2007) 0.80
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Low Levels of Energy Expenditure in Childhood Cancer Survivors: Implications for Obesity Prevention. J Pediatr Hematol Oncol (2015) 0.79
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The association of eating behavior with risk for morbidity in older women. J Gerontol A Biol Sci Med Sci (2002) 0.78
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The synthesis of novel heteroaryl-fused 7,8,9,10-tetrahydro-6H-azepino[1,2-a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Effective inhibitors of HCV NS5B polymerase. Org Biomol Chem (2011) 0.76
Influence of glycemic index/load on glycemic response, appetite, and food intake in healthy humans. Diabetes Care (2006) 0.76
2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of gamma-secretase. Bioorg Med Chem Lett (2004) 0.76
Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase. Bioorg Med Chem Lett (2011) 0.76
Energy Contents of Frequently Ordered Restaurant Meals and Comparison with Human Energy Requirements and US Department of Agriculture Database Information: A Multisite Randomized Study. J Acad Nutr Diet (2016) 0.76
Assessing Dietary Intake in Childhood Cancer Survivors: Food Frequency Questionnaire Versus 24-Hour Diet Recalls. J Pediatr Gastroenterol Nutr (2015) 0.75
Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase. Bioorg Med Chem Lett (2007) 0.75
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Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase. Bioorg Med Chem Lett (2007) 0.75
Independent, additive effects of five dietary variables on ad libitum energy intake in a residential study. Obesity (Silver Spring) (2014) 0.75
Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. Med Sci Sports Exerc (2017) 0.75
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Evaluation and optimization of compound solubilization and delivery methods in a two-tiered ion channel lead optimization triage. Assay Drug Dev Technol (2011) 0.75
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